Details of the Target

General Information of Target

Target ID LDTP05007
Target Name GTP-binding nuclear protein Ran (RAN)
Gene Name RAN
Gene ID 5901
Synonyms
ARA24; GTP-binding nuclear protein Ran; EC 3.6.5.-; Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIK
FNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLC
GNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMP
ALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ran family
Subcellular location
Nucleus
Function
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis . Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Uniprot ID
P62826
Ensemble ID
ENST00000392369.6
HGNC ID
HGNC:9846
ChEMBL ID
CHEMBL1741190

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 60 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.33  LDD0402  [1]
A-EBA
 Probe Info  		3.69  LDD0215  [2]
CHEMBL5175495
 Probe Info  		6.28  LDD0196  [3]
CY-1
 Probe Info  		2.91  LDD0243  [4]
CY4
 Probe Info  		3.70  LDD0244  [4]
C-Sul
 Probe Info  		2.68  LDD0066  [5]
TH211
 Probe Info  		Y155(12.34)  LDD0257  [6]
TH214
 Probe Info  		Y147(9.06); Y39(6.04); Y155(5.15)  LDD0258  [6]
TH216
 Probe Info  		Y146(12.15); Y155(6.90)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		K28(0.00); K60(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K71(2.74); K99(2.78); K134(4.19)  LDD3494  [9]
Probe 1
 Probe Info  		Y146(56.53); Y147(54.69)  LDD3495  [10]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [11]
THZ1-DTB
 Probe Info  		C120(1.11); C112(1.08)  LDD0460  [11]
AZ-9
 Probe Info  		9.61  LDD2154  [12]
HHS-482
 Probe Info  		Y146(0.80); Y147(0.86); Y155(1.08); Y39(1.75)  LDD0285  [13]
HHS-475
 Probe Info  		Y155(0.85); Y98(1.60)  LDD0264  [14]
HHS-465
 Probe Info  		Y146(10.00); Y147(7.67); Y155(7.91); Y39(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C112(4.27); C120(4.27)  LDD0080  [16]
5E-2FA
 Probe Info  		H48(0.00); H53(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		K38(0.00); K71(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K38(0.00); K71(0.00); K142(0.00); K134(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C120(0.00); C112(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C112(0.00); C120(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C85(0.00); C120(0.00); C112(0.00)  LDD0037  [19]
Alkyne tyramide
 Probe Info  		N.A.  LDD0003  [22]
ATP probe
 Probe Info  		K152(0.00); K127(0.00)  LDD0035  [23]
BTD
 Probe Info  		N.A.  LDD0004  [22]
JW-RF-010
 Probe Info  		C112(0.00); C120(0.00)  LDD0026  [24]
NAIA_4
 Probe Info  		N.A.  LDD2226  [25]
TFBX
 Probe Info  		C120(0.00); C112(0.00)  LDD0027  [24]
WYneC
 Probe Info  		C120(0.00); C112(0.00)  LDD0014  [22]
WYneO
 Probe Info  		C120(0.00); C112(0.00)  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [26]
Compound 10
 Probe Info  		C112(0.00); C120(0.00)  LDD2216  [27]
Compound 11
 Probe Info  		N.A.  LDD2213  [27]
IPM
 Probe Info  		C120(0.00); C112(0.00)  LDD0005  [22]
NHS
 Probe Info  		K142(0.00); K99(0.00); K12(0.00); K60(0.00)  LDD0010  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
PF-06672131
 Probe Info  		C112(0.00); C120(0.00)  LDD0017  [28]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
SF
 Probe Info  		Y155(0.00); K142(0.00); K134(0.00); Y39(0.00)  LDD0028  [29]
STPyne
 Probe Info  		K71(0.00); K142(0.00); K60(0.00); K99(0.00)  LDD0009  [22]
VSF
 Probe Info  		C112(0.00); C120(0.00)  LDD0007  [22]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [30]
Ox-W18
 Probe Info  		W163(0.00); W64(0.00); W104(0.00)  LDD2175  [31]
1c-yne
 Probe Info  		K60(0.00); K152(0.00)  LDD0228  [26]
Acrolein
 Probe Info  		C112(0.00); H30(0.00); C120(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [32]
Crotonaldehyde
 Probe Info  		H105(0.00); C120(0.00); H30(0.00)  LDD0219  [32]
Methacrolein
 Probe Info  		C112(0.00); H30(0.00); C120(0.00)  LDD0218  [32]
W1
 Probe Info  		N.A.  LDD0236  [33]
AOyne
 Probe Info  		4.60  LDD0443  [34]
MPP-AC
 Probe Info  		N.A.  LDD0428  [35]
NAIA_5
 Probe Info  		C85(0.00); C112(0.00); C120(0.00)  LDD2223  [25]
TER-AC
 Probe Info  		N.A.  LDD0426  [35]
TPP-AC
 Probe Info  		N.A.  LDD0427  [35]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.75  LDD0472  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
STS-1
 Probe Info  		N.A.  LDD0069  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C120(0.60); C112(0.88)  LDD2142  [40]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C120(0.63)  LDD2112  [40]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C120(0.92); C112(0.66)  LDD2095  [40]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C120(1.17); C112(0.90)  LDD2130  [40]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C120(0.77); C112(1.17)  LDD2117  [40]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C120(1.12); C112(1.09)  LDD2152  [40]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C112(1.10)  LDD2103  [40]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C120(0.74); C112(0.73)  LDD2132  [40]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C112(0.59)  LDD2131  [40]
 LDCM0025  4SU-RNA HEK-293T C112(5.08)  LDD0371  [41]
 LDCM0214  AC1 HCT 116 C112(0.92); C120(0.76)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C112(1.04); C120(0.92)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C112(0.86); C120(0.94)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C112(0.76); C120(0.67)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C112(0.73); C120(0.71)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C112(0.62); C120(0.50)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C112(0.74); C120(0.67)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C112(0.68); C120(0.61)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C112(0.64); C120(0.62)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C112(0.79); C120(0.74)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C112(0.79); C120(0.95)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C112(0.79); C120(0.96)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C112(0.95); C120(0.87)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C112(0.73); C120(0.72)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C112(0.77); C120(0.76)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C112(0.74); C120(0.62)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C112(0.95); C120(1.04)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C112(0.86); C120(0.80)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C112(0.74); C120(0.66)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C112(0.75); C120(0.64)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C112(0.91); C120(0.86)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C112(0.93); C120(0.88)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C112(0.77); C120(0.82)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C112(1.10); C120(1.14)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C112(0.92); C120(0.82)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C112(0.96); C120(1.04)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C112(0.83); C120(0.86)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C112(1.18); C120(1.21)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C112(0.99); C120(0.99)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C112(0.94); C120(1.00)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C112(0.79); C120(0.78)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C112(0.85); C120(0.81)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C112(1.14); C120(1.35)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C112(1.34); C120(1.58)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C112(1.16); C120(1.25)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C112(1.10); C120(1.18)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C112(1.05); C120(1.11)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C112(1.08); C120(1.07)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C112(1.03); C120(0.89)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C112(1.01); C120(0.95)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C112(0.98); C120(0.98)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C112(1.07); C120(1.15)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C112(0.99); C120(0.85)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C112(0.83); C120(0.74)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C112(1.00); C120(0.88)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C112(0.88); C120(0.74)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C112(0.88); C120(0.76)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C112(1.07); C120(1.02)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C120(0.88); C112(0.89)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C112(0.69); C120(0.81)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C112(0.92); C120(1.19)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C112(0.64); C120(0.75)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C112(0.65); C120(0.74)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C112(0.50); C120(0.69)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C112(0.56); C120(0.57)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C120(0.87); C112(1.08)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C112(0.91); C120(0.98)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C120(0.85); C112(0.87)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C112(0.71); C120(0.73)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C112(0.44); C120(0.60)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C112(0.69); C120(0.92)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C112(0.73); C120(0.94)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C112(1.20); C120(1.25)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C112(1.05); C120(1.27)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C120(1.11); C112(1.39)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C120(0.84); C112(1.01)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C120(1.01); C112(1.19)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C120(0.82); C112(1.04)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C120(1.15); C112(1.18)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C112(1.06); C120(1.12)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C112(1.11); C120(1.17)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C120(1.21); C112(1.23)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C120(1.24); C112(1.32)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C120(0.99); C112(1.04)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C120(0.76); C112(1.32)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C120(0.75); C112(0.85)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C120(0.86); C112(1.14)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C120(0.54); C112(1.02)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C120(0.87); C112(0.93)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C120(0.50); C112(0.99)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C120(0.80); C112(1.04)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C120(0.52); C112(1.03)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C120(0.61); C112(0.94)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C120(0.64); C112(0.88)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C112(1.17); C120(1.36)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C120(1.33); C112(1.38)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C112(1.18); C120(1.19)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C112(0.95); C120(1.19)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C112(1.02); C120(1.18)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C112(0.83); C120(0.84)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C112(0.78); C120(0.84)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C120(1.05); C112(1.15)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C120(0.92); C112(0.94)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C120(0.83); C112(0.85)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C120(1.06); C112(1.17)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C112(0.99); C120(1.06)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C112(0.90); C120(0.93)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C112(0.86); C120(0.88)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C112(0.78); C120(0.89)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C120(0.56); C112(0.67)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C120(0.84); C112(0.94)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C120(0.63); C112(0.73)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C112(1.12); C120(1.38)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C112(0.95); C120(0.96)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C120(0.77); C112(0.85)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C120(0.82); C112(0.91)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C120(0.67); C112(0.71)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C120(0.44); C112(0.55)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C120(0.59); C112(0.67)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C120(0.55); C112(0.64)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C120(0.49); C112(0.61)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C120(0.74); C112(0.83)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C120(0.50); C112(0.64)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C120(0.54); C112(0.65)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C120(0.56); C112(0.59)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C120(0.67); C112(0.73)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C120(0.55); C112(0.66)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C120(0.52); C112(0.69)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C120(0.57); C112(0.80)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C120(0.36); C112(0.49)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C112(0.85); C120(0.89)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C120(0.90); C112(0.96)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C120(0.92); C112(0.98)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C120(0.62); C112(0.73)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C120(1.08); C112(1.22)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C120(0.81); C112(0.88)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C120(0.47); C112(0.60)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C120(0.62); C112(0.71)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C120(0.45); C112(0.58)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C120(0.81); C112(0.94)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C120(0.75); C112(0.91)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C112(0.96); C120(0.96)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C120(0.83); C112(1.24)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C120(0.86); C112(0.98)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C120(0.85); C112(0.98)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C120(0.99); C112(1.21)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C120(0.45); C112(0.48)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C120(0.44); C112(0.60)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C120(0.47); C112(0.58)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C120(0.60); C112(0.68)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C120(0.63); C112(0.74)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C112(0.82); C120(0.85)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C112(0.69); C120(0.72)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C120(0.52); C112(0.52)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C112(0.81); C120(1.22)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C120(0.45); C112(0.54)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C112(0.45); C120(0.48)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C112(0.60); C120(0.70)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C112(0.77); C120(0.79)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C120(0.58); C112(0.68)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C112(0.56); C120(0.64)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C120(0.47); C112(0.60)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C120(0.26); C112(0.39)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C112(0.75); C120(0.76)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C120(0.56); C112(1.03)  LDD2138  [40]
 LDCM0520  AKOS000195272 MDA-MB-231 C120(0.80); C112(0.77)  LDD2113  [40]
 LDCM0248  AKOS034007472 HCT 116 C112(0.98); C120(0.98)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C120(0.94); C112(1.03)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C120(0.56); C112(0.66)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C112(1.18)  LDD2171  [16]
 LDCM0151  AZ-11 HeLa 9.61  LDD2154  [12]
 LDCM0498  BS-3668 MDA-MB-231 C120(1.00); C112(1.50)  LDD2091  [40]
 LDCM0108  Chloroacetamide HeLa C112(0.00); H30(0.00); H139(0.00); C120(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C112(0.84); C112(0.80); C112(0.71)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C112(0.82); C120(0.97)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C120(0.61); C112(0.73)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C120(0.70); C112(0.88)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C120(0.81); C112(1.00)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C120(0.96); C112(1.07)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C120(1.05); C112(1.19)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C120(0.95); C112(1.17)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C120(0.99); C112(1.02)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C120(0.87); C112(0.89)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C120(0.87); C112(0.91)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C120(0.78); C112(0.94)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C120(0.82); C112(1.15)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C120(0.67); C112(0.72)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C120(0.86); C112(1.06)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C112(0.86); C120(0.89)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C120(0.97); C112(1.21)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C120(0.57); C112(1.25)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C120(0.49); C112(0.86)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C120(0.51); C112(1.72)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C120(0.59); C112(1.05)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C120(0.66); C112(0.69)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C120(0.94); C112(1.01)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C120(0.87); C112(0.95)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C120(0.52); C112(0.69)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C112(0.99); C120(1.09)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C112(1.03); C120(1.13)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C120(0.77); C112(0.89)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C112(0.76); C120(0.81)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C120(0.63); C112(0.74)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C120(0.85); C112(1.00)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C120(0.67); C112(1.12)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C120(0.69); C112(0.91)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C120(0.57); C112(0.59)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C120(0.68); C112(0.71)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C112(0.72); C120(0.77)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C120(0.76); C112(0.80)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C120(0.69); C112(0.96)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C120(0.86); C112(1.00)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C120(0.61); C112(0.97)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C120(0.74); C112(1.08)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C112(0.93); C120(1.05)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C120(0.57); C112(0.93)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C120(0.62); C112(0.82)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C120(0.47); C112(0.75)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C120(0.67); C112(0.90)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C112(0.79); C120(0.54)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C112(0.82); C120(0.61)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C112(0.93); C120(0.70)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C112(0.93); C120(0.71)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C112(0.87); C120(0.56)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C112(0.89); C120(0.60)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C112(0.98); C120(1.02)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C112(1.01); C120(0.88)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C112(1.02); C120(0.86)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C112(0.96); C120(0.56)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C112(0.90); C120(0.64)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C112(0.76); C120(0.48)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C112(0.91); C120(0.49)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C112(0.91); C120(0.65)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C112(0.72); C120(0.48)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C112(0.83); C120(0.63)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C112(0.89); C120(0.84)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C112(0.98); C120(0.62)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C112(0.95); C120(0.62)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C112(0.91); C120(0.64)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C112(0.87); C120(0.57)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C112(0.73); C120(0.53)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C112(0.75); C120(0.56)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C112(1.06); C120(1.37)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C112(1.18); C120(1.25)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C112(1.23); C120(1.40)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C112(1.00); C120(1.10)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C112(0.91); C120(0.90)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C112(1.15); C120(1.29)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C112(0.99); C120(1.19)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C112(0.95); C120(0.96)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C112(1.08); C120(1.19)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C112(1.07); C120(1.32)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C112(1.36); C120(1.57)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C112(1.15); C120(1.16)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C112(1.01); C120(1.16)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C112(1.28); C120(1.29)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C112(0.95); C120(1.10)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C112(0.73); C120(0.69)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C112(1.07); C120(1.01)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C112(0.88); C120(0.90)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C112(0.70); C120(0.77)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C112(0.71); C120(0.74)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C112(0.63); C120(0.61)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C112(0.84); C120(0.88)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C112(0.64); C120(0.58)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C112(0.81); C120(0.76)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C112(0.79); C120(0.62)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C112(0.70); C120(0.62)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C112(0.68); C120(0.68)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C112(0.82); C120(0.69)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C112(0.74); C120(0.71)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C112(0.78); C120(0.74)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C112(0.75); C120(0.71)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C112(0.81); C120(0.66)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C112(1.03); C120(0.93)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C112(1.14); C120(1.07)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C112(0.98); C120(0.92)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C112(1.30); C120(0.77)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C112(0.64); C120(0.57)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C112(1.06); C120(0.88)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C112(1.04); C120(1.00)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C112(1.05); C120(1.02)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C112(0.95); C120(0.96)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C112(0.87); C120(0.68)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C112(0.92); C120(0.88)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C112(1.28); C120(1.04)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C112(0.98); C120(1.14)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C112(1.00); C120(1.15)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C112(0.75); C120(0.70)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C112(0.69); C120(0.71)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C112(1.35); C120(1.15)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C112(1.06); C120(0.97)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C112(1.07); C120(1.11)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C112(1.03); C120(1.19)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C112(0.81); C120(0.68)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C112(0.84); C120(0.95)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C112(0.88); C120(0.85)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C112(0.88); C120(0.78)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C112(0.84); C120(0.71)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C112(0.87); C120(0.76)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C85(1.05); C112(0.98)  LDD1698  [42]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C120(5.47)  LDD1702  [40]
 LDCM0625  F8 Ramos 0.72  LDD2187  [43]
 LDCM0572  Fragment10 Ramos 0.59  LDD2189  [43]
 LDCM0573  Fragment11 Ramos 0.15  LDD2190  [43]
 LDCM0574  Fragment12 Ramos 0.56  LDD2191  [43]
 LDCM0575  Fragment13 Ramos 1.40  LDD2192  [43]
 LDCM0576  Fragment14 Ramos 0.91  LDD2193  [43]
 LDCM0579  Fragment20 Ramos 0.49  LDD2194  [43]
 LDCM0580  Fragment21 Ramos 1.02  LDD2195  [43]
 LDCM0582  Fragment23 Ramos 1.29  LDD2196  [43]
 LDCM0578  Fragment27 Ramos 1.55  LDD2197  [43]
 LDCM0586  Fragment28 Ramos 0.84  LDD2198  [43]
 LDCM0588  Fragment30 Ramos 1.06  LDD2199  [43]
 LDCM0589  Fragment31 Ramos 1.63  LDD2200  [43]
 LDCM0590  Fragment32 Ramos 0.53  LDD2201  [43]
 LDCM0468  Fragment33 HCT 116 C112(0.84); C120(0.66)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos 0.91  LDD2203  [43]
 LDCM0566  Fragment4 Ramos 0.91  LDD2184  [43]
 LDCM0427  Fragment51 HCT 116 C112(0.73); C120(0.58)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos 1.67  LDD2204  [43]
 LDCM0614  Fragment56 Ramos 1.23  LDD2205  [43]
 LDCM0569  Fragment7 Ramos 0.54  LDD2186  [43]
 LDCM0571  Fragment9 Ramos 0.45  LDD2188  [43]
 LDCM0116  HHS-0101 DM93 Y155(0.85); Y98(1.60)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y155(0.76); Y98(1.29)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y155(0.79); Y98(1.38)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y155(0.87); Y98(1.48)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y155(0.83); Y98(1.89)  LDD0268  [14]
 LDCM0107  IAA HeLa H30(0.00); C112(0.00); C120(0.00); H139(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y146(0.80); Y147(0.86); Y155(1.08); Y39(1.75)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y146(0.36); Y147(1.09); Y155(0.45); Y39(1.13)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y146(1.25); Y147(0.91); Y155(1.13); Y39(1.41)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y146(5.28); Y147(2.40); Y155(2.35); Y39(2.55)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y146(2.07); Y147(2.56); Y155(1.06); Y39(3.32)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y146(1.28); Y147(0.66); Y155(0.91); Y39(15.74)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y146(0.54); Y147(0.68); Y155(0.36); Y39(0.37)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y146(0.68); Y147(0.72); Y155(0.84); Y39(2.02)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C112(4.27); C120(4.27)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C112(8.55); C120(8.55)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C112(5.48); C120(5.48)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C120(1.04); C112(1.09)  LDD2102  [40]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C120(0.96); C112(1.89)  LDD2121  [40]
 LDCM0109  NEM HeLa H30(0.00); H139(0.00); C120(0.00); H48(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C120(1.01); C112(1.53)  LDD2089  [40]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C120(1.21)  LDD2090  [40]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C120(1.13); C112(0.78)  LDD2092  [40]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C120(1.02); C112(1.22)  LDD2093  [40]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C120(1.44); C112(0.85)  LDD2094  [40]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C120(0.02)  LDD2096  [40]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C120(1.01); C112(1.07)  LDD2097  [40]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C120(0.89); C112(0.86)  LDD2098  [40]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C120(1.05); C112(1.23)  LDD2099  [40]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C120(0.73); C112(0.94)  LDD2100  [40]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C120(0.90); C112(0.92)  LDD2101  [40]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C120(0.54)  LDD2104  [40]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C120(1.62); C112(1.54)  LDD2105  [40]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C120(0.45)  LDD2106  [40]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C112(1.04)  LDD2107  [40]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C120(0.65); C112(0.94)  LDD2108  [40]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C112(0.81)  LDD2109  [40]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C120(0.55); C112(0.59)  LDD2110  [40]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C120(1.00); C112(1.05)  LDD2111  [40]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C120(0.50); C112(0.82)  LDD2114  [40]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C112(0.44)  LDD2115  [40]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C120(1.09); C112(1.45)  LDD2116  [40]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C120(0.02)  LDD2118  [40]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C120(0.94)  LDD2120  [40]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C120(0.51); C112(0.93)  LDD2122  [40]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C112(0.83)  LDD2123  [40]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C120(0.76)  LDD2124  [40]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C120(0.61); C112(0.90)  LDD2125  [40]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C112(0.92)  LDD2127  [40]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C120(1.06)  LDD2128  [40]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C120(0.97); C112(1.04)  LDD2129  [40]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C120(0.59); C112(0.57)  LDD2133  [40]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C120(0.63); C112(0.61)  LDD2134  [40]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C112(1.38)  LDD2135  [40]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C112(1.40)  LDD2136  [40]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C120(0.74); C112(0.79)  LDD2137  [40]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C120(1.65)  LDD1700  [40]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C112(1.03)  LDD2140  [40]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C120(0.64); C112(0.75)  LDD2141  [40]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C120(0.81)  LDD2143  [40]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C120(2.65); C112(1.88)  LDD2144  [40]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C120(1.92)  LDD2145  [40]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C120(0.96)  LDD2146  [40]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C120(2.24)  LDD2147  [40]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C112(0.40)  LDD2148  [40]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C120(0.04)  LDD2149  [40]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C120(1.01); C112(1.24)  LDD2150  [40]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C120(0.14)  LDD2151  [40]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C120(2.22)  LDD2153  [40]
 LDCM0627  NUDT7-COV-1 HEK-293T C112(0.40)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C112(1.36); C112(0.88); C112(0.74)  LDD2207  [44]
 LDCM0131  RA190 MM1.R C112(1.19); C120(1.19)  LDD0304  [45]
 LDCM0021  THZ1 HeLa S3 C120(1.11); C112(1.08)  LDD0460  [11]
 LDCM0111  W14 Hep-G2 K142(0.92)  LDD0238  [33]
 LDCM0112  W16 Hep-G2 N143(0.92)  LDD0239  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
DNA-directed RNA polymerases I and III subunit RPAC2 (POLR1D) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family P0DPB6
DNA-directed RNA polymerase II subunit RPB9 (POLR2I) Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family P36954
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) ATG10 family Q9H0Y0
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Putative C->U-editing enzyme APOBEC-4 (APOBEC4) Cytidine and deoxycytidylate deaminase family Q8WW27
DNA polymerase alpha subunit B (POLA2) DNA polymerase alpha subunit B family Q14181
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Calpain-2 catalytic subunit (CAPN2) Peptidase C2 family P17655
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
E3 SUMO-protein ligase RanBP2 (RANBP2) RanBP2 E3 ligase family P49792
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
Ribonuclease SLFN12 (SLFN12) Schlafen family Q8IYM2
Zinc-regulated GTPase metalloprotein activator 1C (ZNG1C) SIMIBI class G3E GTPase family Q5JTY5
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTP-binding protein Rheb (RHEB) Rheb family Q15382
SPRY domain-containing SOCS box protein 1 (SPSB1) SPSB family Q96BD6
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Cholinesterase (BCHE) Type-B carboxylesterase/lipase family P06276
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
ATPase PAAT (PAAT) . Q9H8K7
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
E3 ubiquitin-protein ligase PPP1R11 (PPP1R11) . O60927
Telomerase-binding protein EST1A (SMG6) . Q86US8
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exportin-7 (XPO7) Exportin family Q9UIA9
Exportin-T (XPOT) Exportin family O43592
Huntingtin (HTT) Huntingtin family P42858
Importin-13 (IPO13) Importin beta family O94829
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Alpha-synuclein (SNCA) Synuclein family P37840
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RelA-associated inhibitor (PPP1R13L) IASPP family Q8WUF5
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 597 (ZNF597) Krueppel C2H2-type zinc-finger protein family Q96LX8
Achaete-scute homolog 4 (ASCL4) . Q6XD76
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Transcription factor p65 (RELA) . Q04206
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myosin-binding protein H-like (MYBPHL) MyBP family A2RUH7
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-like protein 7B (ACTL7B) Actin family Q9Y614
Annexin A4 (ANXA4) Annexin family P09525
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Nuclear nucleic acid-binding protein C1D (C1D) C1D family Q13901
Putative elongation factor 1-delta-like protein (EEF1DP3) EF-1-beta/EF-1-delta family Q658K8
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Small ribosomal subunit protein eS4, X isoform (RPS4X) Eukaryotic ribosomal protein eS4 family P62701
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
HAUS augmin-like complex subunit 8 (HAUS8) HAUS8 family Q9BT25
Histone H3.3C (H3-5) Histone H3 family Q6NXT2
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Keratin-like protein KRT222 (KRT222) Intermediate filament family Q8N1A0
Jupiter microtubule associated homolog 1 (JPT1) JUPITER family Q9UK76
Leucine-rich repeat-containing protein 56 (LRRC56) LRRC56 family Q8IYG6
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Protein CIMAP1D (CIMAP1D) ODF3 family Q3SX64
PHD finger protein 23 (PHF23) PHF23 family Q9BUL5
Charged multivesicular body protein 7 (CHMP7) SNF7 family Q8WUX9
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
CST complex subunit TEN1 (TEN1) TEN1 family Q86WV5
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
Protein YIF1A (YIF1A) YIF1 family O95070
Ankyrin repeat domain-containing protein 49 (ANKRD49) . Q8WVL7
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) . Q6ZNL6
Methylosome protein WDR77 (WDR77) . Q9BQA1
Nuclear transport factor 2 (NUTF2) . P61970
Period circadian protein homolog 1 (PER1) . O15534
Putative apolipoprotein(a)-like protein 2 (LPAL2) . Q16609
Putative uncharacterized protein encoded by LINC00518 (LINC00518) . Q8N0U6
Putative uncharacterized protein RUSC1-AS1 (RUSC1-AS1) . Q66K80
Regulator of chromosome condensation (RCC1) . P18754
Serine/Arginine-related protein 53 (RSRC1) . Q96IZ7
Spermatogenesis-associated serine-rich protein 1 (SPATS1) . Q496A3
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Telethonin (TCAP) . O15273
TP53-binding protein 1 (TP53BP1) . Q12888
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
WW domain binding protein 1-like (WBP1L) . Q9NX94

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
28 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
29 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
30 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
31 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
32 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
33 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
34 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
35 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
40 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
41 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
42 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
43 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
44 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
45 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.