Details of the Target

General Information of Target

Target ID LDTP14956
Target Name Putative heat shock protein HSP 90-beta 2 (HSP90AB2P)
Gene Name HSP90AB2P
Synonyms
HSP90BB; Putative heat shock protein HSP 90-beta 2; Heat shock protein 90-beta b; Heat shock protein 90Bb
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEEVHHGEEEVETFAFQAEIAQLISLIINTFYSNEEIFLQELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLALVDTGIGMTKADLINNLRTIAKSGTKACMEALQAE
KLVVITKHNDDEQYAWESSAGGSFTVHADHGEPIGRGTKVILHLKEDQTEYLEERRVKEV
VKKHSQFIGYPITLYLEKEQDKEISDDEAEEEKGEKEEEDKDDEEKPKIKDVGSDEEDDS
KEYGEFYKSLTSDWEDHLAVKHFSVEGQLEFRALLFSPRRAPFDLFENKKKKNNIKLYVR
RVFIMDSCDELIPEYLNFIHGVVDSEDLPLNISREMLQQSKILKYVSHMKETQKSTYYIT
GESKEQVANSAFVERVRKQGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDE
EEKKKMEESKEKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMEQIMK
AQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVVLLFETALLSSG
FSLEDPQTHSNHIYHMIKLGLGTDEDEVAAEEPSDAVPDEIPPLEGDEDASRMEEVD
Target Bioclass
Other
Family
Heat shock protein 90 family
Subcellular location
Cytoplasm
Function Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Uniprot ID
Q58FF8
HGNC ID
HGNC:32537
ChEMBL ID
CHEMBL4105858

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C564(8.71)  LDD3314  [1]
HHS-475
 Probe Info  		Y138(0.62); Y56(0.71); Y260(0.80); Y198(0.85)  LDD0264  [2]
HHS-465
 Probe Info  		Y133(10.00); Y138(1.13); Y198(10.00); Y260(6.65)  LDD2237  [3]
ATP probe
 Probe Info  		K332(0.00); K107(0.00)  LDD0199  [4]
AZ-9
 Probe Info  		N.A.  LDD0395  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
Ox-W18
 Probe Info  		N.A.  LDD2175  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0071  [9]
STS-1
 Probe Info  		N.A.  LDD0069  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y138(0.62); Y56(0.71); Y260(0.80); Y198(0.85)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y138(0.49); Y260(0.70); Y198(0.80); Y56(0.91)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y56(0.62); Y260(0.78); Y138(0.85); Y198(0.88)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y138(0.57); Y260(0.60); Y56(0.65); Y198(0.81)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y260(0.49); Y138(0.51); Y56(0.70); Y198(0.78)  LDD0268  [2]
 LDCM0022  KB02 42-MG-BA C564(2.88)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C564(5.51)  LDD2661  [1]
 LDCM0024  KB05 IGR37 C564(8.71)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
10 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.