Details of the Target

General Information of Target

Target ID LDTP05073
Target Name Actin, alpha skeletal muscle (ACTA1)
Gene Name ACTA1
Gene ID 58
Synonyms
ACTA; Actin, alpha skeletal muscle; EC 3.6.4.-; Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
MSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIT
KQEYDEAGPSIVHRKCF
Target Bioclass
Enzyme
Family
Actin family
Subcellular location
Cytoplasm, cytoskeleton
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Uniprot ID
P68133
Ensemble ID
ENST00000366684.7
HGNC ID
HGNC:129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.81  LDD0402  [1]
P2
 Probe Info  		1.67  LDD0449  [2]
P8
 Probe Info  		2.53  LDD0451  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
D3
 Probe Info  		7.90  LDD0325  [4]
TH211
 Probe Info  		Y71(8.60)  LDD0257  [5]
STPyne
 Probe Info  		K70(10.00)  LDD0277  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
HHS-475
 Probe Info  		Y93(0.53); Y242(0.75); Y55(0.77); Y71(0.79)  LDD0264  [8]
HHS-465
 Probe Info  		Y190(10.00); Y242(10.00); Y55(10.00); Y71(9.20)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0222  [10]
DBIA
 Probe Info  		C219(0.97)  LDD1492  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
ATP probe
 Probe Info  		K52(0.00); K63(0.00); K330(0.00); K86(0.00)  LDD0035  [14]
AZ-9
 Probe Info  		D27(0.00); E243(0.00)  LDD0395  [15]
SF
 Probe Info  		Y71(0.00); K63(0.00); K52(0.00); K193(0.00)  LDD0028  [16]
Crotonaldehyde
 Probe Info  		H373(0.00); C219(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		Y71(0.00); N80(0.00); H75(0.00)  LDD0236  [17]
AOyne
 Probe Info  		7.90  LDD0443  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [19]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.06  LDD0472  [20]
FFF probe13
 Probe Info  		5.79  LDD0475  [20]
FFF probe3
 Probe Info  		5.32  LDD0465  [20]
JN0003
 Probe Info  		5.13  LDD0469  [20]
DA-2
 Probe Info  		N.A.  LDD0071  [21]
STS-1
 Probe Info  		N.A.  LDD0069  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C219(1.02); C259(0.99)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C219(0.93); C259(0.95)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C219(0.98); C259(1.03)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C219(1.20); C259(1.04)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C219(1.02); C259(1.17)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C219(0.97)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C219(0.95); C259(1.06)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C219(0.95); C259(0.79)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C219(1.05); C259(0.97)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C219(0.87); C259(0.99)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C219(1.08); C259(0.80)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C219(0.99); C259(0.89)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C219(1.05); C259(1.18)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C219(0.81)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C219(1.00)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C219(0.96); C259(1.02)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C219(0.97); C259(1.02)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C219(1.01); C259(0.86)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C219(1.11); C259(1.03)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C219(1.02); C259(0.96)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C219(0.96); C259(0.96)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C219(1.03); C259(0.96)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C219(0.82)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C219(1.05)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C219(0.99); C259(1.19)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C219(0.90); C259(1.12)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C219(0.97); C259(1.03)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C219(1.05); C259(0.84)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C219(1.03); C259(1.12)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C219(1.07); C259(1.00)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C219(0.86)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C219(1.03); C259(1.08)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C219(0.99)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C219(0.94); C259(0.92)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C219(0.94); C259(0.98)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C219(0.99); C259(0.78)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C219(0.99); C259(0.84)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C219(1.08); C259(0.87)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C219(1.13); C259(1.03)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C219(0.94)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C219(1.05)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C219(0.98); C259(0.84)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C219(1.00); C259(0.84)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C219(0.97); C259(0.88)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C219(1.03); C259(0.97)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C219(0.95); C259(0.81)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C219(1.05); C259(0.99)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C219(1.09); C259(0.99)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C219(0.93)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C219(1.00)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C219(1.01); C259(1.17)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C219(0.93); C259(0.87)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C219(0.97); C259(0.89)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C219(1.02); C259(0.80)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C219(1.08); C259(1.10)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C219(1.05); C259(0.92)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C219(1.12); C259(0.85)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C219(0.84)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C219(0.97)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C219(0.85)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C219(1.06)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C219(1.00); C259(0.83)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C219(0.93); C259(0.93)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C219(1.02)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 8.46  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C219(0.90)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C219(0.98); C259(2.13)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C219(0.98); C259(0.96)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C219(1.08)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C219(1.04); C259(0.98)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C219(1.02); C259(0.99)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C219(0.92); C259(0.94)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C219(0.97)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C219(0.96); C259(0.88)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C219(1.04); C259(0.74)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C219(1.00); C259(0.88)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C219(0.89)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C219(0.77)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C219(1.05); C259(0.89)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C219(0.95); C259(0.92)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C219(1.00); C259(0.85)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C219(0.92)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C219(0.98); C259(0.79)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C219(0.94); C259(0.85)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C219(0.93); C259(0.99)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C219(0.96)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C219(1.09); C259(0.93)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C219(1.03); C259(0.96)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C219(1.08)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C219(1.01); C259(1.08)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C219(0.99)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C219(0.93); C259(0.95)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C219(0.98); C259(1.23)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C219(0.84); C259(0.80)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C219(1.01)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C219(0.97); C259(0.69)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C219(1.04); C259(0.76)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C219(0.84); C259(0.86)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C219(0.96)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C219(1.08); C259(0.74)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C219(1.12); C259(0.92)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C219(0.96); C259(0.83)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C219(1.08); C259(1.13)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C219(0.93); C259(0.94)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C219(1.03); C259(0.89)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C219(1.02); C259(1.04)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C219(1.03); C259(1.09)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C219(1.07); C259(1.10)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C219(1.07); C259(1.03)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C219(0.97)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C219(1.03)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C219(1.00)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C219(1.02); C259(0.88)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C219(1.01); C259(0.92)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C219(0.88); C259(0.90)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C219(1.04); C259(1.03)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C219(1.07); C259(0.85)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C219(0.97); C259(0.86)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C219(0.99); C259(1.00)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C219(1.00); C259(1.04)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C219(1.01); C259(1.73)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C219(1.06); C259(1.06)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C219(0.94)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C219(0.90)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C219(0.95)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C219(0.90); C259(1.11)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C219(1.02); C259(0.81)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C219(0.87); C259(0.98)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C219(0.98); C259(1.08)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C219(0.96); C259(0.70)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C219(0.99); C259(0.86)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C219(1.02); C259(0.94)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C219(0.94); C259(1.32)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C219(0.98); C259(1.07)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C219(0.90)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C219(1.04)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C219(1.02)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C219(1.16); C259(0.89)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C219(0.89); C259(1.00)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C219(0.84); C259(0.95)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C219(1.06); C259(1.39)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C219(0.91); C259(1.24)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C219(0.99); C259(1.10)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C219(0.97); C259(0.95)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C219(1.06); C259(1.17)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C219(1.04); C259(1.03)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C219(0.89)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C219(0.78); C259(0.89)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C219(1.06)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C219(0.95)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C219(0.91); C259(0.72)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C219(1.02); C259(0.81)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C219(0.86); C259(0.85)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C219(0.96); C259(1.12)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C219(0.84); C259(0.93)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C219(1.01); C259(1.14)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C219(0.97); C259(1.10)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C219(0.99); C259(1.03)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C219(1.07); C259(0.99)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C219(1.10); C259(0.97)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C219(0.90)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C219(0.95)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C219(0.96)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C219(0.95); C259(0.82)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C219(0.83); C259(0.89)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C219(1.00); C259(1.03)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C219(0.93); C259(0.84)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C219(1.02); C259(0.73)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C219(1.21); C259(1.12)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C219(0.99); C259(0.81)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C219(1.03); C259(0.76)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C219(1.06); C259(0.91)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C219(0.91)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C219(1.07)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C219(0.98)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C219(0.97); C259(0.56)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C219(1.01); C259(0.89)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C219(0.91); C259(0.79)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C219(1.04); C259(0.79)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C219(1.03); C259(1.19)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C219(0.98); C259(1.87)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C219(1.04); C259(0.56)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C219(1.00); C259(1.29)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C219(1.01); C259(0.88)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C219(1.00); C259(1.08)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C219(0.79)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C219(1.03)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C219(1.00)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C219(0.95); C259(0.94)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C219(0.90); C259(0.97)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C219(0.96); C259(0.93)  LDD1698  [11]
 LDCM0625  F8 Ramos C287(0.78)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C287(0.41)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C287(1.04)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C287(0.22)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C287(1.13)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C287(0.26)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C287(0.55)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C287(0.74)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C287(0.36)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C287(0.50)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C287(0.41)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C287(0.33)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C287(0.22)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C219(1.00); C259(0.94)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C287(0.29)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C287(0.39)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C219(0.96); C259(0.99)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C287(0.11)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C287(0.39)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C287(0.61)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C287(0.82)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y93(0.53); Y242(0.75); Y55(0.77); Y71(0.79)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y93(0.38); Y242(0.62); Y55(0.67); Y71(0.73)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y55(0.71); Y93(0.73); Y71(0.85); Y190(1.11)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y93(0.72); Y242(0.73); Y55(0.75); Y71(0.80)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y93(0.38); Y242(0.52); Y55(0.71); Y190(1.00)  LDD0268  [8]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C219(0.97)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C219(0.92)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C219(0.90)  LDD1502  [11]
 LDCM0109  NEM HeLa N.A.  LDD0224  [10]
 LDCM0111  W14 Hep-G2 Y71(2.19)  LDD0238  [17]
 LDCM0112  W16 Hep-G2 H75(1.08); Y71(1.08)  LDD0239  [17]
 LDCM0113  W17 Hep-G2 Y71(1.75)  LDD0240  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Achaete-scute homolog 4 (ASCL4) . Q6XD76
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sucrose Small molecular drug DB02772
Investigative
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-methylhistidine . DB04151
Aplyronine A . DB04629
Jaspisamide A . DB03850
Kabiramide C . DB03616
Latrunculin A . DB02621
Latrunculin B . DB08080
Phosphoaminophosphonic Acid-adenylate Ester . DB04395
Reidispongiolide A . DB04774
Reidispongiolide C . DB04775
Sphinxolide B . DB04783
Tmr . DB03903
Ulapualide A . DB03021

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578