Details of the Target

General Information of Target

Target ID LDTP03591
Target Name Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1)
Gene Name CPS1
Gene ID 1373
Synonyms
Carbamoyl-phosphate synthase [ammonia], mitochondrial; EC 6.3.4.16; Carbamoyl-phosphate synthetase I; CPSase I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYS
FGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKY
LESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTML
GKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGA
EVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLIT
GLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLFVNVNDQT
NEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKPALVASRV
EVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQAD
TVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES
IMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGIC
PNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHT
GDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLS
RSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDR
FHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLR
KELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMT
EETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYV
TYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETV
STDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSP
LQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMN
VVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAG
VHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRA
SRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRD
ADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQ
LHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPN
NNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
Target Type
Successful
Target Bioclass
Enzyme
Subcellular location
Mitochondrion
Function Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TTD ID
T25163
Uniprot ID
P31327
DrugMap ID
TT42M75
Ensemble ID
ENST00000233072.10
HGNC ID
HGNC:2323
ChEMBL ID
CHEMBL2362990

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.A800T .
COLO792 SNV: p.L1464F DBIA    Probe Info 
DU145 SNV: p.N1063K .
EFO21 SNV: p.L504Ter DBIA    Probe Info 
HCT15 SNV: p.V664I .
HT Deletion: p.L878CfsTer8 .
HT115 SNV: p.N216D .
IGR1 SNV: p.G19R DBIA    Probe Info 
KP4 SNV: p.P81S .
MCC13 SNV: p.M1076I .
MEWO SNV: p.Q810Ter; p.P1125L; p.L1152I .
MIAPACA2 SNV: p.L323S .
MKN1 Deletion: p.L933Ter .
MOLM16 SNV: p.K1356M .
NCIH1666 SNV: p.E1290K DBIA    Probe Info 
NCIH1703 SNV: p.P705T .
NCIH1993 SNV: p.E1087V ATP probe    Probe Info 
NCIH2286 SNV: p.R814L .
NCIH716 Substitution: p.A669P .
SUPT1 SNV: p.A1235V .
SW837 Substitution: p.A669S DBIA    Probe Info 
TE10 SNV: p.P563A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0455  [1]
STPyne
 Probe Info  		K935(1.09)  LDD0277  [2]
DBIA
 Probe Info  		C606(1.82); C767(1.73); C231(1.82)  LDD3343  [3]
THZ1-DTB
 Probe Info  		C1337(1.16); C1327(1.14); C1126(1.09); C761(1.06)  LDD0460  [4]
5E-2FA
 Probe Info  		H47(0.00); H1343(0.00); H1382(0.00); H1447(0.00)  LDD2235  [5]
m-APA
 Probe Info  		H47(0.00); H1382(0.00); H1447(0.00); H243(0.00)  LDD2231  [5]
IA-alkyne
 Probe Info  		C516(0.00); C1049(0.00); C1126(0.00); C1327(0.00)  LDD0162  [6]
ATP probe
 Probe Info  		K1486(0.00); K1309(0.00); K1471(0.00); K908(0.00)  LDD0035  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
IPM
 Probe Info  		C761(0.00); C225(0.00); C816(0.00); C1256(0.00)  LDD0025  [9]
JW-RF-010
 Probe Info  		C225(0.00); C920(0.00); C816(0.00); C1256(0.00)  LDD0026  [9]
TFBX
 Probe Info  		C920(0.00); C761(0.00); C225(0.00); C1256(0.00)  LDD0027  [9]
WYneN
 Probe Info  		C600(0.00); C920(0.00)  LDD0021  [8]
WYneO
 Probe Info  		C600(0.00); C761(0.00)  LDD0022  [8]
Acrolein
 Probe Info  		H47(0.00); H1292(0.00); H1382(0.00); C761(0.00)  LDD0217  [10]
Cinnamaldehyde
 Probe Info  		C225(0.00); C816(0.00); C761(0.00); C600(0.00)  LDD0220  [10]
Crotonaldehyde
 Probe Info  		C761(0.00); C600(0.00); H1162(0.00); H47(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		C600(0.00); C761(0.00); C225(0.00); C920(0.00)  LDD0218  [10]
TPP-AC
 Probe Info  		N.A.  LDD0427  [11]
HHS-465
 Probe Info  		Y1069(0.00); Y120(0.00); Y872(0.00); Y162(0.00)  LDD2240  [12]
HHS-475
 Probe Info  		Y136(0.70); Y1450(1.18); Y1491(0.76); Y162(0.57)  LDD2238  [13]
HHS-482
 Probe Info  		Y1132(0.64); Y120(0.49); Y140(0.43); Y1450(0.48)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0069  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1256(0.39); C920(1.31)  LDD2142  [15]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C920(1.04)  LDD2112  [15]
 LDCM0214  AC1 HEK-293T C225(0.81); C600(0.97); C761(0.95); C1126(0.96)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C225(0.92); C600(0.96); C761(1.00); C1126(1.06)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C225(0.94); C600(0.95); C761(1.05); C1126(1.02)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C225(1.06); C600(0.97); C761(1.02); C516(1.10)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C225(0.92); C600(1.16); C761(0.97); C1126(1.07)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C225(1.00); C600(0.98); C761(1.01); C516(1.01)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C225(0.96); C600(1.00); C761(1.04); C1126(1.00)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C225(0.95); C600(1.02); C761(0.99); C1126(1.01)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C225(0.90); C600(1.00); C761(0.95); C1126(0.89)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C225(0.93); C600(1.02); C761(0.90); C1126(0.94)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C225(1.01); C600(1.09); C761(1.01); C516(1.11)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C225(1.04); C600(0.98); C761(1.00); C1126(1.00)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C225(1.00); C600(1.12); C761(0.98); C1126(1.26)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C225(0.98); C600(1.06); C761(0.93); C516(0.95)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C225(1.01); C600(1.02); C761(1.03); C1126(1.12)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C225(0.97); C600(1.01); C761(1.01); C1126(1.06)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C225(0.99); C600(1.03); C761(0.97); C1126(0.87)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C225(0.98); C600(0.93); C761(0.98); C1126(0.92)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C225(0.95); C600(0.94); C761(1.06); C516(1.14)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C225(1.06); C600(0.97); C761(1.00); C1126(0.96)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C225(0.92); C600(0.97); C761(0.98); C1126(1.00)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C225(1.02); C600(1.03); C761(1.05); C1126(1.12)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C225(0.97); C600(1.08); C761(0.96); C516(1.03)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C225(0.99); C600(0.91); C761(1.01); C1126(1.00)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C225(0.81); C600(0.99); C761(0.99); C1126(1.02)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C225(0.92); C600(1.07); C761(1.00); C1126(1.12)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C225(0.91); C600(1.00); C761(0.98); C1126(1.01)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C225(0.98); C600(1.04); C761(1.12); C516(1.00)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C225(0.98); C600(1.03); C761(1.01); C1126(0.99)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C225(0.89); C600(1.13); C761(1.07); C1126(1.18)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C225(0.95); C600(1.17); C761(1.02); C516(1.04)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C225(0.99); C600(1.06); C761(1.03); C516(1.05)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C225(0.99); C600(1.09); C761(1.00); C1126(1.12)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C225(0.82); C600(0.92); C761(0.98); C1126(0.97)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C225(0.90); C600(1.03); C761(1.00); C1126(1.11)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C225(0.89); C600(0.97); C761(0.99); C1126(1.07)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C225(1.02); C600(0.98); C761(1.06); C516(1.01)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C225(1.00); C600(1.19); C761(1.01); C1126(1.09)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C225(0.95); C600(1.06); C761(1.02); C1126(1.07)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C225(0.99); C600(0.99); C761(1.01); C516(1.08)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C225(0.89); C600(0.84); C761(1.03); C1126(1.11)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C225(0.78); C600(0.96); C761(1.04); C1126(0.94)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C225(0.98); C600(0.94); C761(1.08); C1126(1.06)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C225(0.89); C600(0.99); C761(0.97); C1126(1.13)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C225(0.85); C600(1.00); C761(0.95); C1126(1.03)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C225(1.02); C600(1.07); C761(1.05); C516(1.02)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C225(0.95); C600(0.98); C761(0.98); C1126(1.11)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C225(0.90); C600(1.08); C761(1.01); C1126(1.00)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C225(0.98); C600(0.99); C761(0.95); C516(0.93)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C225(0.97); C600(0.97); C761(1.05); C1126(1.08)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C225(0.84); C600(1.03); C761(1.00); C1126(0.93)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C225(0.97); C600(0.92); C761(0.99); C1126(1.15)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C225(0.94); C600(0.98); C761(0.94); C1126(0.99)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C225(0.88); C600(1.01); C761(0.99); C1126(1.15)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C225(0.99); C600(1.11); C761(0.98); C516(1.13)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C225(1.04); C600(1.08); C761(1.00); C1126(1.02)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C225(0.94); C600(1.02); C761(1.06); C1126(1.01)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C225(0.97); C600(0.99); C761(0.99); C516(1.07)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C225(0.97); C600(0.98); C761(0.99); C1126(1.09)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C225(0.98); C600(1.01); C761(0.96); C516(0.96)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C225(0.99); C600(0.98); C761(1.02); C1126(1.08)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C600(0.72); C920(0.69)  LDD2113  [15]
 LDCM0248  AKOS034007472 HEK-293T C225(1.02); C600(1.01); C761(0.98); C1126(1.23)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C225(0.83); C600(0.95); C761(0.99); C1126(0.97)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C225(1.02); C600(0.93); C761(0.99); C1126(1.19)  LDD1514  [16]
 LDCM0498  BS-3668 MDA-MB-231 C600(0.74)  LDD2091  [15]
 LDCM0108  Chloroacetamide HeLa H1292(0.00); H47(0.00); C1126(0.00); H1190(0.00)  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C225(1.05); C600(0.97); C761(0.97); C1126(1.09)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C225(1.05); C600(0.94); C761(1.02); C1126(1.10)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C225(0.98); C600(0.86); C761(1.02); C1126(1.07)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C225(1.01); C600(1.02); C761(0.96); C1126(1.04)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C225(0.96); C600(0.88); C761(1.00); C1126(0.98)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C225(0.89); C600(0.91); C761(0.96); C1126(1.06)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C225(1.09); C600(0.91); C761(1.04); C1126(1.04)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C225(0.99); C600(0.96); C761(0.94); C1126(1.14)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C225(0.89); C600(0.98); C761(0.97); C1126(0.95)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C225(0.97); C600(0.86); C761(1.03); C1126(0.98)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C225(1.07); C600(1.04); C761(1.04); C1126(1.09)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C225(0.97); C600(0.97); C761(0.93); C1126(1.23)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C225(1.05); C600(1.00); C761(1.01); C516(1.06)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C225(1.00); C600(0.98); C761(0.98); C1126(1.01)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C225(0.98); C600(0.95); C761(1.00); C1126(1.05)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C225(1.04); C600(0.97); C761(1.06); C1126(1.05)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C225(0.98); C600(0.96); C761(0.97); C1126(1.01)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C225(0.94); C600(0.96); C761(0.94); C1126(0.95)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C225(0.91); C600(0.93); C761(0.93); C1126(1.12)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C225(1.03); C600(0.94); C761(1.02); C1126(1.03)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C225(0.99); C600(1.04); C761(0.91); C1126(1.11)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C225(0.93); C600(1.01); C761(1.06); C1126(0.97)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C225(0.95); C600(1.07); C761(0.99); C1126(1.11)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C225(1.07); C600(0.98); C761(1.05); C1126(1.45)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C225(1.04); C600(0.92); C761(0.95); C1126(1.09)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C225(1.03); C600(0.86); C761(0.99); C1126(1.01)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C225(0.94); C600(0.99); C761(1.00); C1126(1.05)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C225(1.06); C600(1.00); C761(1.03); C1126(1.08)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C225(1.06); C600(0.91); C761(1.07); C1126(1.01)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C225(0.94); C600(1.04); C761(0.93); C1126(1.10)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C225(0.91); C600(0.94); C761(0.96); C1126(1.00)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C225(0.96); C600(1.09); C761(1.08); C1126(1.07)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C225(1.07); C600(1.07); C761(1.04); C1126(1.01)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C225(0.97); C600(0.93); C761(0.94); C1126(0.89)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C225(0.87); C600(0.99); C761(1.04); C1126(1.04)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C225(0.89); C600(0.83); C761(0.96); C1126(1.10)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C225(1.04); C600(0.87); C761(1.11); C1126(1.08)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C225(0.80); C600(0.88); C761(0.95); C1126(1.14)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C225(0.93); C600(1.02); C761(0.97); C1126(0.88)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C225(0.85); C600(1.05); C761(1.08); C1126(0.99)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C225(0.94); C600(0.98); C761(0.98); C1126(0.97)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C225(1.09); C600(1.08); C761(0.98); C516(1.10)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C225(1.15); C600(0.99); C761(0.98); C1126(0.90)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C225(0.89); C600(1.06); C761(1.12); C1126(0.94)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C225(1.02); C600(1.10); C761(1.04); C516(1.06)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C225(1.06); C600(0.99); C761(0.97); C1126(1.29)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C225(1.05); C600(1.06); C761(1.05); C1126(1.05)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C225(0.93); C600(0.99); C761(1.02); C1126(0.94)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C225(0.97); C600(0.92); C761(1.03); C1126(1.06)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C225(1.03); C600(1.03); C761(1.12); C1126(1.02)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C225(0.83); C600(1.00); C761(1.02); C1126(0.97)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C225(0.94); C600(0.87); C761(1.01); C1126(1.11)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C225(0.98); C600(0.99); C761(0.99); C1126(0.84)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C225(0.94); C600(0.99); C761(1.09); C1126(1.06)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C225(1.07); C600(0.98); C761(1.05); C516(1.12)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C225(1.24); C600(1.07); C761(0.97); C1126(0.99)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C225(1.03); C600(0.96); C761(0.98); C1126(1.02)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C225(1.05); C600(1.04); C761(0.94); C516(1.08)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C225(1.01); C600(0.95); C761(0.92); C1126(1.44)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C225(0.99); C600(0.89); C761(0.95); C1126(1.16)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C225(0.95); C600(0.89); C761(1.02); C1126(1.03)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C225(1.08); C600(0.77); C761(1.04); C1126(1.08)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C225(1.10); C600(0.94); C761(1.08); C1126(1.09)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C225(0.88); C600(0.89); C761(1.00); C1126(1.04)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C225(0.97); C600(0.96); C761(1.04); C1126(0.94)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C225(0.96); C600(1.05); C761(0.96); C1126(1.16)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C225(1.08); C600(1.01); C761(1.04); C516(1.03)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C225(1.10); C600(1.01); C761(0.98); C1126(0.87)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C225(0.96); C600(1.05); C761(0.99); C1126(1.02)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C225(1.07); C600(1.13); C761(0.97); C516(1.01)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C225(1.06); C600(0.83); C761(0.95); C1126(1.37)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C225(0.98); C600(1.00); C761(0.86); C1126(1.23)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C225(0.90); C600(1.01); C761(1.02); C1126(1.02)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C225(0.94); C600(0.96); C761(1.06); C1126(1.01)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C225(1.07); C600(0.92); C761(1.13); C1126(1.07)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C225(0.79); C600(0.86); C761(1.00); C1126(1.09)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C225(1.02); C600(0.98); C761(1.09); C1126(1.05)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C225(0.96); C600(1.03); C761(1.15); C1126(1.16)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C225(1.05); C600(0.95); C761(1.04); C516(1.15)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C225(1.13); C600(0.96); C761(0.99); C1126(0.98)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C225(1.00); C600(1.02); C761(0.96); C1126(0.96)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C225(1.04); C600(1.19); C761(0.97); C516(1.12)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C225(0.92); C600(0.94); C761(0.91); C1126(0.88)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C225(1.03); C600(0.99); C761(0.92); C1126(1.45)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C225(0.97); C600(1.13); C761(0.92); C1126(0.96)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C225(0.94); C600(1.04); C761(0.98); C1126(1.02)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C225(0.91); C600(1.05); C761(0.99); C1126(1.07)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C225(1.09); C600(1.01); C761(1.00); C1126(1.09)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C225(0.87); C600(0.92); C761(1.01); C1126(1.06)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C225(0.93); C600(0.94); C761(0.97); C1126(0.90)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C225(0.91); C600(1.00); C761(1.03); C1126(1.10)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C225(1.02); C600(1.07); C761(1.07); C516(1.09)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C225(1.17); C600(1.01); C761(1.01); C1126(0.95)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C225(0.96); C600(0.98); C761(1.09); C1126(1.13)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C225(0.94); C600(1.22); C761(0.98); C1126(1.10)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C225(0.91); C600(1.16); C761(1.05); C516(1.12)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C225(0.93); C600(1.04); C761(1.00); C1126(1.47)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C225(1.01); C600(0.88); C761(0.90); C1126(0.96)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C225(0.91); C600(1.06); C761(1.02); C1126(0.95)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C225(1.06); C600(1.07); C761(1.02); C1126(1.06)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C225(0.79); C600(0.93); C761(1.05); C1126(1.06)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C225(0.95); C600(1.03); C761(1.02); C1126(0.97)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C225(0.94); C600(1.05); C761(1.10); C1126(1.17)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C225(1.39); C600(0.96); C761(1.09); C516(1.56)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C225(1.03); C600(0.98); C761(1.03); C516(1.04)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C225(1.14); C600(1.03); C761(0.99); C1126(1.00)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C225(0.96); C600(1.07); C761(0.98); C1126(1.11)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C225(1.05); C600(1.06); C761(0.94); C516(1.15)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C225(1.00); C600(1.01); C761(0.99); C1126(1.36)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C225(1.04); C600(0.98); C761(0.86); C1126(1.13)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C225(0.87); C600(0.94); C761(1.07); C1126(0.88)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C225(0.92); C600(1.01); C761(0.99); C1126(1.09)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C225(1.04); C600(0.85); C761(1.02); C1126(1.03)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C225(0.84); C600(1.05); C761(0.98); C1126(0.99)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C225(1.07); C600(1.06); C761(0.96); C1126(0.92)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C225(0.97); C600(0.97); C761(0.89); C1126(0.85)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C225(0.89); C600(1.05); C761(0.92); C1126(1.05)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C225(1.17); C600(1.07); C761(1.00); C516(1.15)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C225(1.15); C600(1.11); C761(1.04); C1126(1.11)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C225(0.83); C600(1.16); C761(0.99); C1126(1.02)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C225(1.06); C600(0.87); C761(0.94); C516(1.37)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C225(0.96); C600(0.94); C761(0.99); C1126(1.23)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C225(1.00); C600(0.98); C761(0.94); C1126(1.14)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C225(0.93); C600(0.93); C761(0.98); C1126(0.88)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C225(0.88); C600(1.08); C761(0.93); C1126(1.04)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C225(0.88); C600(0.87); C761(0.95); C1126(1.11)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C600(2.56); C920(1.89)  LDD1702  [15]
 LDCM0468  Fragment33 HEK-293T C225(0.92); C600(1.06); C761(0.99); C1126(1.05)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C225(0.91); C600(1.00); C761(1.01); C1126(1.00)  LDD1631  [16]
 LDCM0107  IAA HeLa C1015(0.00); H1292(0.00); H47(0.00); H1382(0.00)  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C600(1.09); C761(0.93)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C600(1.02); C761(1.00)  LDD1497  [16]
 LDCM0024  KB05 NCI-H1299 C606(1.82); C767(1.73); C231(1.82)  LDD3343  [3]
 LDCM0109  NEM HeLa H1190(0.00); H1292(0.00); H47(0.00); H1382(0.00)  LDD0223  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C600(1.15); C1256(0.90)  LDD2090  [15]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C600(1.01)  LDD2092  [15]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C600(0.83); C1256(0.75)  LDD2098  [15]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C920(0.79); C761(3.53)  LDD2100  [15]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C600(0.91)  LDD2101  [15]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C600(1.05); C920(0.76)  LDD2104  [15]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1256(0.98)  LDD2105  [15]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1256(0.60)  LDD2106  [15]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C600(0.69); C920(1.08)  LDD2108  [15]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1256(0.86)  LDD2110  [15]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C920(1.40); C761(4.39)  LDD2114  [15]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C600(0.74)  LDD2115  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1256(0.70)  LDD2118  [15]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C600(0.53)  LDD2134  [15]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1256(0.25); C920(0.88); C761(3.20)  LDD2141  [15]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C600(0.84)  LDD2148  [15]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C600(1.45)  LDD2153  [15]
 LDCM0021  THZ1 HeLa S3 C1337(1.16); C1327(1.14); C1126(1.09); C761(1.06)  LDD0460  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Carglumic Acid Small molecular drug D0Z0MG
Polidocanol - Bioform Medical/Chemische Fabrik Kreussler & Co Small molecular drug D0LW9U

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402