Details of the Target

General Information of Target

Target ID LDTP14323
Target Name Small ribosomal subunit protein uS2B (RPSA2)
Gene Name RPSA2
Synonyms
RPSA; RPSAP58; Small ribosomal subunit protein uS2B; 37 kDa laminin receptor precursor; 37LRP; 37/67 kDa laminin receptor; LRP/LR; 40S ribosomal protein SA; 40S ribosomal protein SA2; 67 kDa laminin receptor; 67LR; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLF
QISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRR
IKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSS
VDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEEL
ALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV
Target Bioclass
Other
Family
Universal ribosomal protein uS2 family
Subcellular location
Cell membrane
Function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {|HAMAP-Rule:MF_03016}.
Uniprot ID
A0A8I5KQE6
Ensemble ID
ENST00000484897.4
HGNC ID
HGNC:36809

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0451  [1]
DBIA
 Probe Info  		C163(2.78)  LDD3311  [2]
NAIA_5
 Probe Info  		C148(0.00); C163(0.00)  LDD2224  [3]
MPP-AC
 Probe Info  		N.A.  LDD0428  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0069  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C148(1.37); C163(3.02)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C148(1.71); C163(3.60)  LDD2660  [2]
 LDCM0024  KB05 G361 C163(2.78)  LDD3311  [2]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
5 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.