Details of the Target

General Information of Target

Target ID LDTP02796
Target Name Nucleoside diphosphate kinase A (NME1)
Gene Name NME1
Gene ID 4830
Synonyms
NDPKA; NM23; Nucleoside diphosphate kinase A; NDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPF
FAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVESAEKEIGLWFHPEELVDYTSCAQNWIYE
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
NDK family
Subcellular location
Cytoplasm
Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
TTD ID
T42533
Uniprot ID
P15531
DrugMap ID
TTDY8JH
Ensemble ID
ENST00000013034.3
HGNC ID
HGNC:7849
ChEMBL ID
CHEMBL2159

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH82 SNV: p.M41V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P3
 Probe Info  		1.67  LDD0450  [2]
CY-1
 Probe Info  		8.51  LDD0243  [3]
CY4
 Probe Info  		9.43  LDD0244  [3]
AZ-9
 Probe Info  		D98(1.19); E93(1.12)  LDD2208  [4]
OPA-S-S-alkyne
 Probe Info  		K12(5.24); K26(7.27)  LDD3494  [5]
Probe 1
 Probe Info  		Y52(15.12)  LDD3495  [6]
AF-1
 Probe Info  		2.65  LDD0456  [2]
DBIA
 Probe Info  		C170(0.67)  LDD3331  [7]
JZ128-DTB
 Probe Info  		C109(0.00); C145(0.00)  LDD0462  [8]
THZ1-DTB
 Probe Info  		C109(1.04); C145(1.03)  LDD0460  [8]
AHL-Pu-1
 Probe Info  		C109(2.25)  LDD0169  [9]
HHS-465
 Probe Info  		Y52(10.00); Y67(6.97)  LDD2237  [10]
5E-2FA
 Probe Info  		H51(0.00); H118(0.00); H69(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K100(0.00); K56(0.00); K49(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C145(0.00); C109(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C145(0.00); C109(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
ATP probe
 Probe Info  		K85(0.00); K100(0.00)  LDD0035  [16]
IPM
 Probe Info  		C4(0.00); C109(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
1d-yne
 Probe Info  		K85(0.00); K100(0.00)  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [18]
NHS
 Probe Info  		K12(0.00); K100(0.00); K56(0.00)  LDD0010  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
STPyne
 Probe Info  		K100(0.00); K12(0.00)  LDD0009  [18]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		C109(0.00); C4(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
Acrolein
 Probe Info  		H118(0.00); H51(0.00); H69(0.00)  LDD0217  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
W1
 Probe Info  		C109(0.00); K12(0.00); Q17(0.00)  LDD0236  [23]
AOyne
 Probe Info  		15.00  LDD0443  [24]
NAIA_5
 Probe Info  		C145(0.00); C4(0.00)  LDD2223  [25]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C269
 Probe Info  		9.00  LDD1939  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]
STS-1
 Probe Info  		N.A.  LDD0068  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C109(2.25)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C145(0.86)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C145(0.81)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C145(0.97)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C145(0.98)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C145(0.80)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C145(1.06)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C145(0.99)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C145(0.74)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C145(0.85)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C145(0.90)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C145(0.95)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C145(1.18)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C145(0.93)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C145(1.17)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C145(0.92)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C145(1.03)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C145(0.89)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C145(1.02)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C145(0.91)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C145(1.00)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C145(1.05)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C145(0.96)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C145(1.01)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C145(1.00)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C145(0.99)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C145(0.75)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C145(0.98)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C145(0.89)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C145(0.95)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C145(0.91)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C145(0.99)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C145(0.94)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C145(0.89)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C145(0.99)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C145(0.74)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C145(0.98)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C145(0.89)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C145(0.97)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C145(1.09)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C145(0.94)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C145(1.13)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C145(0.89)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C145(1.15)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C145(0.79)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C145(0.98)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C145(0.88)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C145(1.19)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C145(1.03)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C145(0.93)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C145(1.13)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C145(0.85)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C145(0.81)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C145(0.97)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C145(0.92)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C145(0.86)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C145(1.04)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C145(0.83)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C145(0.91)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C145(0.94)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C145(0.98)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C145(0.92)  LDD1569  [31]
 LDCM0166  Afatinib A431 2.65  LDD0456  [2]
 LDCM0248  AKOS034007472 HEK-293T C145(1.11)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C145(1.00)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C145(1.10)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 13.28  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H118(0.00); H69(0.00); H51(0.00)  LDD0222  [22]
 LDCM0367  CL1 HEK-293T C145(0.78)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C145(0.79)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C145(0.79)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C145(0.95)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C145(0.79)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C145(1.02)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C145(0.81)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C145(1.10)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C145(0.88)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C145(0.93)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C145(0.91)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C145(0.97)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C145(0.96)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C145(0.97)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C145(0.87)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C145(0.90)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C145(0.93)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C145(1.06)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C145(1.00)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C145(0.83)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C145(1.01)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C145(0.93)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C145(0.99)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C145(0.91)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C145(0.83)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C145(1.07)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C145(1.02)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C145(0.91)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C145(0.77)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C145(0.95)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C145(0.90)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C145(0.87)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C145(0.84)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C145(0.93)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C145(0.90)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C145(0.93)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C145(0.95)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C145(0.99)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C145(0.80)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C145(0.97)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C145(0.97)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C145(0.99)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C145(1.00)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C145(0.91)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C145(0.98)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C145(1.02)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C145(0.59)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C145(0.88)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C145(1.02)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C145(0.92)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C145(1.00)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C145(1.16)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C145(0.96)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C145(0.96)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C145(1.02)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C145(0.81)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C145(0.80)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C145(0.97)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C145(0.92)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C145(0.87)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C145(0.99)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C145(0.86)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C145(0.90)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C145(0.84)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C145(0.73)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C145(0.96)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C145(1.00)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C145(1.03)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C145(0.89)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C145(1.06)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C145(1.01)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C145(0.87)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C145(0.97)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C145(1.00)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C145(0.80)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C145(0.89)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C145(0.61)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C145(0.95)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C145(0.91)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C145(0.88)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C145(0.86)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C145(0.90)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C145(0.63)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C145(0.95)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C145(0.95)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C145(0.89)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C145(1.05)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C145(0.77)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C145(0.86)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C145(0.86)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C145(1.04)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C145(0.94)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C145(1.05)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C145(0.96)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C145(0.94)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C145(0.96)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C145(0.86)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C145(0.95)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C145(1.03)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C145(0.97)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C145(0.89)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C145(0.79)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C145(0.95)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C145(0.68)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C145(1.02)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C145(1.26)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C145(1.07)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C145(0.96)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C145(1.11)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C145(0.86)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C145(1.01)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C145(0.91)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C145(0.92)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C145(0.93)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C145(1.12)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C145(0.60)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C145(0.99)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C145(0.77)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C145(0.93)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C145(0.76)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C145(0.81)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C145(0.69)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C145(0.82)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C145(0.93)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C145(1.04)  LDD1697  [31]
 LDCM0495  E2913 HEK-293T C145(1.04)  LDD1698  [31]
 LDCM0625  F8 Ramos C109(0.50)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C109(0.62)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C109(0.04)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C109(0.43)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C109(0.70)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C109(0.45)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C109(0.35)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C109(0.71)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C109(1.24)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C109(0.65)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C109(1.53)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C109(0.78)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C109(1.08)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C109(0.40)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C145(0.89)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C109(1.05)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C109(1.19)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C145(0.97)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C109(1.06)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C109(0.87)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C109(0.75)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C109(0.32)  LDD2188  [32]
 LDCM0107  IAA HeLa H118(0.00); H51(0.00)  LDD0221  [22]
 LDCM0179  JZ128 PC-3 C109(0.00); C145(0.00)  LDD0462  [8]
 LDCM0022  KB02 HEK-293T C145(1.05)  LDD1492  [31]
 LDCM0023  KB03 HEK-293T C145(0.96)  LDD1497  [31]
 LDCM0024  KB05 MKN-1 C170(0.67)  LDD3331  [7]
 LDCM0109  NEM HeLa H118(0.00); H51(0.00); H69(0.00)  LDD0223  [22]
 LDCM0021  THZ1 HeLa S3 C109(1.04); C145(1.03)  LDD0460  [8]
 LDCM0110  W12 Hep-G2 K26(0.63); R27(0.63)  LDD0237  [23]
 LDCM0112  W16 Hep-G2 R18(0.89); Q17(0.89); K12(0.91); R27(1.26)  LDD0239  [23]
 LDCM0113  W17 Hep-G2 K31(0.55); Q30(0.55)  LDD0240  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Nucleoside diphosphate kinase 3 (NME3) NDK family Q13232
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Nucleoside diphosphate kinase B (NME2) NDK family P22392
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Exopolyphosphatase PRUNE1 (PRUNE1) PPase class C family Q86TP1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transportin-2 (TNPO2) Importin beta family O14787
Transportin-3 (TNPO3) . Q9Y5L0
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Proto-oncogene DBL (MCF2) MCF2 family P10911
Serine-threonine kinase receptor-associated protein (STRAP) WD repeat STRAP family Q9Y3F4
Nuclear transport factor 2 (NUTF2) . P61970
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2
PTB-containing, cubilin and LRP1-interacting protein (PID1) . Q7Z2X4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyclovir Small molecular drug DB00787
Adefovir Dipivoxil Small molecular drug DB00718
Adenosine Small molecular drug DB00640
Decitabine Small molecular drug DB01262
Gemcitabine Small molecular drug DB00441
Lamivudine Small molecular drug DB00709
Sofosbuvir Small molecular drug DB08934
Tenofovir Alafenamide Small molecular drug DB09299
Tenofovir Disoproxil Small molecular drug DB00300
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Investigative
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Tenofovir Small molecular drug DB14126
2'-deoxyguanosine-5'-diphosphate . DB03491
2'-deoxyguanosine-5'-triphosphate . DB02181
2'3'-dehydro-2'3'-deoxy-thymidine 5'-diphosphate . DB02569
2'3'-dideoxy-3'-fluoro-urididine-5'-diphosphate . DB04068
3'-deoxy 3'-amino Adenosine-5'-diphosphate . DB04366
Adenosine Phosphonoacetic Acid . DB02607
Selenocysteine . DB02345
Stavudine Triphosphate . DB02887
Thymidine-5'- Diphosphate . DB03103
Zidovudine Diphosphate . DB04542

References

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3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578