Details of the Target

General Information of Target

Target ID LDTP11074
Target Name Tubulin alpha-1C chain (TUBA1C)
Gene Name TUBA1C
Gene ID 84790
Synonyms
TUBA6; Tubulin alpha-1C chain; EC 3.6.5.-; Alpha-tubulin 6; Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQDDPVEALTELRERRLGALELLQAAAGSGLAAYAVWALLLQPGFRRVPLRLQVPYVGA
SARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWR
AGCAGSVCYRRKDLWKVSLRDCRNVSVFLAPSVLPLLEDKLRTELPAGARVVSGRFPLPT
WQPVTAVGEGLDRVWAYDVPEGGQAGEAASSRIPIQAAPGPSSAPIPGGLISQAS
Target Bioclass
Enzyme
Family
Tubulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Uniprot ID
Q9BQE3
Ensemble ID
ENST00000301072.11
HGNC ID
HGNC:20768
ChEMBL ID
CHEMBL3797011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		50.00  LDD0214  [1]
TH211
 Probe Info  		Y272(16.02); Y282(10.50)  LDD0257  [2]
TH214
 Probe Info  		Y282(14.11)  LDD0258  [2]
TH216
 Probe Info  		Y282(5.25)  LDD0259  [2]
ONAyne
 Probe Info  		K304(1.15)  LDD0274  [3]
STPyne
 Probe Info  		K304(4.51)  LDD0277  [3]
JZ128-DTB
 Probe Info  		C376(0.00); C295(0.00)  LDD0462  [4]
THZ1-DTB
 Probe Info  		C376(1.05); C295(0.99)  LDD0460  [4]
BTD
 Probe Info  		C376(0.79)  LDD2091  [5]
AZ-9
 Probe Info  		7.39  LDD2154  [6]
AHL-Pu-1
 Probe Info  		C295(2.12)  LDD0171  [7]
HHS-482
 Probe Info  		Y282(0.97)  LDD0285  [8]
HHS-475
 Probe Info  		Y408(0.57); Y103(0.64); Y399(0.65); Y262(0.67)  LDD0264  [9]
HHS-465
 Probe Info  		Y103(10.00); Y108(10.00); Y161(7.71); Y224(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C376(2.01)  LDD0080  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C376(0.00); C295(0.00); C129(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C315(0.00); C316(0.00); C295(0.00); C347(0.00)  LDD0032  [15]
IPIAA_L
 Probe Info  		C20(0.00); C200(0.00); C376(0.00); C4(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C376(0.00); C295(0.00); C129(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		K96(0.00); K60(0.00); K112(0.00); K311(0.00)  LDD0035  [17]
JW-RF-010
 Probe Info  		C316(0.00); C347(0.00); C376(0.00); C295(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		C295(0.00); C376(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C316(0.00); C295(0.00); C376(0.00); C347(0.00)  LDD0027  [18]
aHNE
 Probe Info  		N.A.  LDD0001  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
IPM
 Probe Info  		C315(0.00); C376(0.00); C316(0.00); C295(0.00)  LDD0005  [20]
PF-06672131
 Probe Info  		C295(0.00); C347(0.00); C376(0.00)  LDD0017  [22]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		C347(0.00); C305(0.00); C25(0.00); C315(0.00)  LDD0018  [23]
Ox-W18
 Probe Info  		N.A.  LDD2175  [24]
1c-yne
 Probe Info  		C295(0.00); C376(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C295(0.00); C376(0.00); H283(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		C316(0.00); C315(0.00); C376(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C295(0.00); C376(0.00); C316(0.00); C315(0.00)  LDD0218  [26]
W1
 Probe Info  		C347(0.00); C295(0.00); K336(0.00); K401(0.00)  LDD0236  [27]
NAIA_5
 Probe Info  		C376(0.00); C295(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [28]
FFF probe13
 Probe Info  		17.77  LDD0476  [28]
FFF probe3
 Probe Info  		20.00  LDD0465  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
Diazir
 Probe Info  		E77(0.00); E71(0.00); Y357(0.00); E55(0.00)  LDD0011  [20]
LD-F
 Probe Info  		L378(0.00); M377(0.00)  LDD0015  [30]
STS-1
 Probe Info  		N.A.  LDD0069  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C295(1.22)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C295(0.87)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C376(0.99)  LDD2130  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C295(0.82); C376(0.61)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C295(0.82)  LDD2131  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C295(2.12)  LDD0171  [7]
 LDCM0561  Abegg_cp(-)-10 HeLa C347(2.01)  LDD0312  [18]
 LDCM0214  AC1 HCT 116 C129(1.47); C20(0.68); C295(1.16); C315(1.16)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C129(1.15); C295(0.85); C315(1.27); C316(1.24)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C295(0.92); C315(0.88); C316(0.89); C347(0.96)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C295(0.89); C315(0.87); C316(0.82); C347(0.96)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C295(0.96); C315(0.96); C316(0.96); C347(1.16)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C295(1.02); C315(1.12); C316(1.07); C347(1.18)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C295(0.93); C315(1.01); C316(1.01); C347(1.13)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C295(1.08); C315(1.21); C316(1.17); C347(1.28)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C295(1.00); C315(0.86); C316(0.82); C347(1.34)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C295(0.89); C315(1.07); C316(1.10); C347(1.14)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C295(0.84); C315(0.88); C316(0.91); C347(1.32)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C295(0.80); C315(0.84); C316(0.91); C347(1.04)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C129(1.09); C295(0.97); C315(1.25); C316(1.24)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C295(0.88); C315(0.94); C316(0.91); C347(0.99)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C295(0.87); C315(0.94); C316(0.95); C347(1.01)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C295(0.89); C315(0.96); C316(0.99); C347(1.06)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C129(1.18); C295(1.05); C315(1.03); C316(1.05)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C129(1.18); C295(1.07); C315(1.34); C316(1.42)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C129(1.39); C295(1.30); C315(1.28); C316(1.36)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C129(0.95); C295(1.01); C315(1.12); C316(1.23)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C129(1.03); C295(1.02); C315(1.06); C316(1.23)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C129(0.80); C295(0.88); C315(1.06); C316(1.15)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C129(0.90); C295(0.93); C315(1.14); C316(1.26)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C129(1.14); C295(0.91); C315(1.17); C316(1.16)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C129(1.10); C295(1.01); C315(0.90); C316(0.84)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C129(0.74); C295(0.83); C315(1.00); C316(1.18)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C129(1.00); C295(0.95); C315(1.20); C316(1.39)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C129(1.06); C295(1.03); C315(1.10); C316(1.24)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C129(1.20); C295(1.01); C315(1.06); C316(1.11)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C129(0.91); C295(0.85); C315(1.07); C316(1.07)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C129(1.16); C295(1.03); C315(1.25); C316(1.49)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C129(0.94); C295(1.06); C315(1.20); C316(1.37)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C129(0.80); C295(1.03); C315(1.25); C316(1.45)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C129(0.92); C295(0.80); C315(1.18); C316(1.27)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C129(0.92); C295(0.89); C315(1.21); C316(1.45)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C129(0.71); C295(0.92); C315(1.03); C316(1.09)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C129(1.22); C295(0.92); C315(1.24); C316(1.37)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C129(0.85); C295(0.87); C315(1.29); C316(1.54)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C129(0.94); C295(0.88); C315(1.60); C316(1.92)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C129(1.03); C295(0.84); C315(1.29); C316(1.55)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C129(0.79); C295(0.84); C315(1.09); C316(1.18)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C129(0.98); C295(1.05); C315(1.15); C316(1.22)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C129(0.83); C295(0.91); C315(1.37); C316(1.48)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C129(1.18); C295(0.95); C315(1.26); C316(1.51)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C129(1.26); C295(1.00); C315(1.46); C316(1.46)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C129(1.05); C295(1.00); C315(1.30); C316(1.41)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C129(0.93); C295(0.80); C315(1.25); C316(1.37)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C129(0.67); C295(0.78); C315(1.00); C316(1.13)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C129(0.68); C295(0.74); C376(0.86); C347(0.99)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C295(1.02); C376(1.11); C129(1.19); C347(1.30)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C295(0.83); C347(1.02); C376(1.05); C129(1.22)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C129(0.85); C376(1.02); C347(1.07); C295(1.29)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C295(1.19); C376(1.22); C347(1.37); C316(1.55)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C295(1.22); C376(1.23); C129(1.48); C347(1.71)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C129(0.97); C376(1.09); C347(1.23); C295(1.35)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C295(0.94); C347(1.05); C376(1.21); C316(1.32)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C129(0.85); C376(0.88); C295(0.92); C347(0.99)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C129(0.67); C295(0.84); C347(0.88); C376(0.90)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C295(1.22); C347(1.22); C129(1.28); C376(1.31)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C295(1.18); C129(1.18); C376(1.25); C347(1.62)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C129(1.53); C295(1.41); C315(1.63); C316(1.62)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C129(1.77); C295(1.22); C315(1.28); C316(1.27)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C129(1.16); C295(1.13); C315(1.12); C316(1.08)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C129(1.17); C295(1.17); C315(1.17); C316(1.16)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C20(0.54); C4(0.54); C129(0.71); C295(0.82)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C20(0.66); C4(0.66); C316(0.68); C376(0.86)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C20(0.50); C4(0.50); C347(0.92); C295(0.93)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C20(0.96); C4(0.96); C347(1.10); C376(1.17)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C295(0.81); C376(0.88); C129(0.94); C315(0.97)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C295(0.75); C316(0.75); C20(0.76); C4(0.76)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C129(0.59); C295(0.70); C376(0.83); C315(0.85)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C20(0.63); C4(0.63); C129(0.75); C295(0.76)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C20(0.70); C4(0.70); C129(0.94); C347(0.97)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C129(0.82); C20(0.98); C4(0.98); C295(0.99)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C20(0.74); C4(0.74); C129(1.09); C376(1.09)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C20(0.82); C4(0.82); C129(0.98); C295(1.07)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C20(0.34); C4(0.34); C315(1.09); C316(1.09)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C20(1.00); C4(1.00); C129(1.10); C316(1.18)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C20(0.65); C4(0.65); C347(1.13); C376(1.26)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C20(0.90); C4(0.90); C129(0.92); C376(1.12)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C20(0.91); C4(0.91); C129(0.94); C376(1.12)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C20(0.86); C4(0.86); C129(1.18); C376(1.27)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C376(1.01); C20(1.08); C4(1.08); C129(1.15)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C20(0.91); C4(0.91); C376(1.09); C129(1.31)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C295(0.51); C316(0.72); C376(0.80); C347(0.84)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C295(0.74); C347(0.91); C376(0.94); C316(0.97)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C295(0.72); C347(0.80); C376(0.86); C315(0.96)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C295(0.81); C347(0.87); C316(0.93); C315(0.95)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C295(0.81); C347(0.90); C315(0.93); C376(0.93)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C20(0.75); C4(0.75); C347(1.18); C295(1.27)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C295(0.78); C347(0.91); C376(0.98); C315(1.11)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C295(0.84); C347(0.89); C376(1.04); C315(1.11)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C295(0.78); C347(0.93); C376(1.00); C315(1.10)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C295(0.82); C347(0.92); C315(1.02); C376(1.03)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C347(0.79); C295(0.97); C376(0.97); C315(1.13)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C347(0.87); C295(0.94); C376(1.08); C315(1.09)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C129(0.83); C316(0.96); C295(0.99); C315(0.99)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C129(0.69); C316(0.95); C295(0.96); C315(0.97)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C129(0.91); C315(0.96); C316(1.06); C376(1.18)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C295(1.09); C129(1.23); C316(1.24); C315(1.26)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C20(0.75); C4(0.75); C376(1.12); C347(1.20)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C129(0.89); C295(1.15); C315(1.18); C316(1.20)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C129(0.75); C347(0.85); C315(0.89); C316(0.96)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C129(0.79); C295(0.89); C315(0.97); C316(0.98)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C347(0.99); C295(1.03); C129(1.04); C316(1.07)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C129(0.82); C295(0.88); C316(1.04); C347(1.05)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C129(0.81); C295(1.02); C347(1.08); C315(1.16)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C129(0.74); C295(1.03); C315(1.26); C376(1.28)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C129(0.65); C295(0.91); C347(1.14); C376(1.23)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C295(1.05); C347(1.20); C129(1.24); C376(1.32)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C129(0.94); C295(1.17); C347(1.19); C376(1.29)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C295(1.03); C347(1.12); C376(1.18); C129(1.18)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C129(0.97); C295(1.15); C347(1.21); C376(1.43)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C295(0.89); C347(1.06); C129(1.13); C376(1.13)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C295(1.09); C347(1.23); C129(1.36); C376(1.37)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C129(0.83); C295(0.84); C376(1.08); C347(1.18)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C295(1.12); C129(1.13); C347(1.26); C376(1.42)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C295(1.16); C129(1.18); C347(1.37); C376(1.38)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C129(0.70); C295(0.93); C347(1.17); C376(1.21)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C129(1.01); C295(1.02); C347(1.34); C376(1.38)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C295(0.93); C129(1.00); C376(1.01); C20(1.02)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C295(0.82); C20(0.86); C4(0.86); C316(1.04)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C295(0.91); C376(0.96); C347(1.04); C129(1.06)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C129(1.02); C295(1.05); C376(1.05); C316(1.08)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C20(0.86); C4(0.86); C376(0.98); C295(1.00)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C295(1.01); C316(1.09); C315(1.15); C20(1.15)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C20(0.93); C4(0.93); C295(0.99); C129(1.07)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C295(0.94); C20(0.98); C4(0.98); C129(1.12)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C295(0.81); C20(0.82); C4(0.82); C129(1.04)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C20(0.84); C4(0.84); C295(0.97); C129(1.13)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C20(0.85); C4(0.85); C295(0.88); C129(0.89)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C129(0.69); C295(0.72); C20(0.80); C4(0.80)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C295(0.84); C129(0.97); C376(1.04); C316(1.05)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C295(1.06); C376(1.14); C347(1.15); C129(1.20)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C295(0.82); C20(0.85); C4(0.85); C129(0.98)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C316(0.81); C295(0.82); C376(0.88); C129(0.92)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C295(0.73); C129(0.87); C20(1.01); C4(1.01)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C20(0.52); C4(0.52); C316(1.25); C376(1.27)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C20(0.57); C4(0.57); C316(1.20); C315(1.23)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C20(0.51); C4(0.51); C316(1.10); C315(1.11)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C20(0.43); C4(0.43); C315(1.13); C316(1.13)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C20(0.39); C4(0.39); C315(1.00); C316(1.00)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C20(0.43); C4(0.43); C316(1.17); C376(1.17)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C20(0.42); C4(0.42); C315(1.20); C316(1.20)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C20(0.44); C4(0.44); C376(0.98); C315(1.02)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C20(0.39); C4(0.39); C315(1.30); C316(1.32)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C20(0.36); C4(0.36); C316(1.32); C315(1.32)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C20(0.38); C4(0.38); C316(1.06); C315(1.07)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C20(0.35); C4(0.35); C315(0.98); C316(0.99)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C20(0.40); C4(0.40); C315(1.04); C316(1.06)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C20(0.47); C4(0.47); C376(1.15); C315(1.15)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C20(0.38); C4(0.38); C315(1.11); C316(1.13)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C295(0.84); C316(0.98); C315(1.08); C376(1.13)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C316(0.87); C315(0.89); C376(0.90); C295(0.98)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C129(1.09); C295(0.77); C315(1.10); C316(1.07)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C295(0.74); C347(0.91); C129(0.96); C376(1.01)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C295(1.01); C347(1.31); C376(1.36); C129(1.38)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C347(1.04); C295(1.23); C305(1.23); C376(0.93)  LDD2171  [11]
 LDCM0151  AZ-11 HeLa 7.39  LDD2154  [6]
 LDCM0498  BS-3668 MDA-MB-231 C376(0.79)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C213(1.79); C25(1.58); C347(1.43); C376(1.42)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa C295(0.00); C376(0.00); C315(0.00); C316(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C376(0.67); C295(0.02)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C129(0.64); C315(0.72); C316(0.79); C295(0.79)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C347(0.77); C376(1.05); C295(1.06); C316(1.24)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C20(0.75); C4(0.75); C347(1.16); C295(1.20)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C295(0.94); C347(1.01); C376(1.07); C129(1.10)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C295(0.80); C347(0.88); C376(0.96); C129(0.97)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C347(0.85); C295(0.85); C129(0.86); C376(0.90)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C295(0.84); C129(0.86); C347(0.90); C376(1.00)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C20(0.70); C4(0.70); C129(0.72); C295(0.74)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C20(0.51); C4(0.51); C295(0.86); C347(0.92)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C20(0.66); C4(0.66); C295(0.93); C347(0.99)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C20(0.58); C4(0.58); C295(0.77); C347(0.88)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C20(0.74); C4(0.74); C295(0.94); C347(0.96)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C295(1.03); C347(1.04); C376(1.05); C315(1.18)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C20(0.75); C4(0.75); C347(0.81); C295(0.95)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C20(0.74); C4(0.74); C376(0.84); C295(0.88)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C129(0.74); C20(0.82); C4(0.82); C376(0.90)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C129(0.91); C20(0.96); C4(0.96); C376(1.25)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C129(0.83); C20(0.89); C4(0.89); C376(1.01)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C129(0.96); C295(1.05); C20(1.12); C4(1.12)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C20(0.98); C4(0.98); C129(1.03); C295(1.11)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C295(0.85); C376(1.07); C347(1.08); C315(1.21)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C347(0.91); C295(0.96); C316(1.02); C376(1.03)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C295(0.94); C376(0.95); C347(0.96); C315(1.00)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C129(0.95); C347(1.01); C295(1.06); C376(1.13)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C295(0.79); C347(0.85); C376(0.94); C315(0.94)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C129(0.74); C376(0.82); C295(0.96); C347(1.01)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C129(0.82); C295(0.88); C315(0.99); C316(1.04)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C129(0.82); C315(0.99); C316(1.01); C295(1.09)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C129(0.83); C295(1.02); C315(1.06); C316(1.10)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C129(0.60); C295(0.83); C376(0.91); C347(0.95)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C295(0.80); C347(0.94); C376(1.08); C316(1.15)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C129(0.91); C295(0.97); C376(1.06); C347(1.06)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C295(1.06); C376(1.20); C129(1.20); C347(1.21)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C347(0.97); C129(0.99); C295(1.01); C376(1.06)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C347(0.82); C295(1.02); C376(1.07); C315(1.14)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C347(0.94); C129(0.94); C295(1.02); C376(1.03)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C376(0.98); C347(1.10); C316(1.14); C295(1.17)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C376(0.88); C295(0.98); C347(0.98); C316(1.01)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C347(1.01); C295(1.05); C376(1.06); C315(1.22)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C295(1.03); C347(1.06); C376(1.07); C316(1.22)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C129(0.67); C295(0.84); C315(0.93); C376(0.95)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C295(1.03); C315(1.06); C347(1.09); C316(1.12)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C295(1.04); C376(1.07); C347(1.11); C315(1.36)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C295(1.27); C347(1.31); C376(1.32); C316(1.65)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C376(1.18); C347(1.20); C316(1.27); C295(1.31)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C295(1.36); C315(1.47); C316(1.45); C347(1.23)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C295(1.16); C315(1.57); C316(1.44); C347(1.08)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C295(1.19); C315(1.42); C316(1.29); C347(1.13)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C295(1.05); C315(1.23); C316(1.25); C347(1.07)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C295(1.02); C315(1.36); C316(1.32); C347(1.06)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C295(1.07); C315(1.37); C316(1.33); C347(1.07)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C129(0.83); C295(0.94); C315(0.97); C316(0.98)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C295(1.00); C315(1.04); C316(1.00); C347(1.03)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C129(1.36); C295(1.15); C315(1.15); C316(1.01)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C129(1.57); C295(1.60); C315(1.34); C316(1.10)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C129(2.27); C295(1.55); C315(1.54); C316(1.05)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C129(2.51); C295(1.91); C315(1.46); C316(1.20)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C129(2.08); C295(2.16); C315(1.81); C316(1.37)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C129(2.10); C295(1.44); C315(1.47); C316(1.25)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C129(1.65); C295(1.62); C315(1.68); C316(1.62)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C129(1.60); C295(1.26); C315(1.21); C316(1.12)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C129(1.18); C295(0.99); C315(0.91); C316(1.00)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C129(1.56); C295(1.29); C315(1.63); C316(1.23)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C129(2.01); C295(1.56); C315(1.57); C316(1.19)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C129(1.87); C295(1.48); C315(1.87); C316(1.82)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C129(2.42); C295(1.83); C315(1.64); C316(1.21)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C129(1.91); C295(1.38); C315(1.79); C316(1.21)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C129(2.08); C295(1.88); C315(1.40); C316(1.34)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C129(0.86); C295(0.91); C315(0.79); C316(0.88)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C129(0.72); C295(0.92); C315(0.84); C316(0.88)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C129(1.15); C295(1.07); C315(0.95); C316(0.95)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C129(0.92); C295(1.06); C315(1.01); C316(1.05)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C129(0.82); C295(1.03); C315(1.08); C316(1.08)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C129(0.75); C295(1.05); C315(0.93); C316(0.97)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C129(0.70); C295(0.95); C315(0.88); C316(0.97)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C129(1.09); C295(0.93); C315(0.90); C316(0.99)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C129(0.54); C295(1.02); C315(0.99); C316(1.01)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C129(0.88); C295(1.16); C315(0.94); C316(1.05)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C129(0.73); C295(1.01); C315(0.94); C316(0.95)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C129(1.00); C295(0.92); C315(0.94); C316(0.98)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C129(0.99); C295(0.95); C315(0.96); C316(1.02)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C129(1.00); C295(0.90); C315(0.88); C316(0.94)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C129(1.23); C295(1.17); C315(1.02); C316(1.03)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C129(0.94); C295(1.09); C315(1.03); C316(1.16)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C129(1.37); C295(1.06); C315(1.04); C316(1.06)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C129(0.96); C20(0.49); C295(1.03); C315(1.09)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C129(0.99); C20(0.61); C295(1.11); C315(1.13)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C129(1.08); C20(1.16); C295(0.96); C315(1.11)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C129(1.12); C20(0.71); C295(1.00); C315(1.12)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C129(1.04); C20(0.97); C295(0.96); C315(1.24)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C129(1.32); C20(0.73); C295(1.13); C315(1.24)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C129(1.28); C20(1.03); C295(1.09); C315(1.33)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C129(1.24); C20(1.46); C295(1.07); C315(1.45)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C129(0.78); C20(0.71); C295(0.91); C315(1.05)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C129(1.25); C295(1.19); C315(1.06); C316(1.07)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C129(1.18); C20(0.57); C295(1.08); C315(1.36)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C129(1.21); C20(0.78); C295(0.94); C315(1.27)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C129(1.01); C20(1.08); C295(0.89); C315(1.05)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C129(1.30); C20(1.20); C295(1.02); C315(1.18)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C129(1.24); C20(1.18); C295(1.05); C315(1.37)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C129(0.90); C295(0.86); C315(1.06); C316(1.19)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C129(1.30); C295(0.94); C315(1.01); C316(1.05)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C129(0.91); C295(0.87); C315(1.06); C316(1.15)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C129(1.21); C295(1.11); C315(1.26); C316(1.38)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C129(1.36); C295(0.96); C315(1.28); C316(1.23)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C129(0.96); C295(0.92); C315(0.96); C316(0.96)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C129(1.12); C295(1.01); C315(1.17); C316(1.27)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C129(1.33); C295(1.17); C315(1.38); C316(1.50)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C129(1.31); C295(1.05); C315(1.31); C316(1.41)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C129(1.35); C295(1.01); C315(1.24); C316(1.31)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C129(1.02); C295(1.00); C315(1.16); C316(1.25)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C129(0.91); C295(0.81); C315(0.94); C316(1.01)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C129(0.90); C295(0.83); C315(1.09); C316(1.24)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C129(1.25); C295(1.05); C315(1.36); C316(1.47)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C129(1.26); C295(1.05); C315(1.51); C316(1.69)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C129(1.08); C295(0.99); C315(1.03); C316(1.08)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C129(0.77); C295(0.75); C315(0.80); C316(0.86)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C129(1.11); C20(0.95); C295(1.25); C315(1.15)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C129(0.99); C20(1.15); C295(0.95); C315(1.04)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C129(1.01); C20(0.84); C295(1.00); C315(0.99)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C129(1.39); C20(0.92); C295(1.17); C315(1.21)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C129(1.21); C20(0.82); C295(0.96); C315(1.15)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C129(1.05); C20(0.93); C295(0.91); C315(1.03)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C129(1.18); C20(0.89); C295(1.09); C315(1.14)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C129(1.51); C20(0.64); C295(1.37); C315(1.26)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C129(1.67); C20(0.62); C295(1.05); C315(1.23)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C295(0.87); C376(1.00); C315(0.99); C316(1.09)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C376(3.88)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C129(1.15); C20(1.02); C295(0.84); C315(1.38)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C129(1.92); C295(1.40); C315(1.48); C316(1.49)  LDD0744  [11]
 LDCM0116  HHS-0101 DM93 Y408(0.57); Y103(0.64); Y399(0.65); Y262(0.67)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y399(0.53); Y161(0.53); Y103(0.60); Y312(0.60)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y312(0.52); Y262(0.52); Y399(0.61); Y272(0.64)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y272(0.39); Y312(0.42); Y262(0.44); Y399(0.49)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y103(0.40); Y272(0.47); Y262(0.52); Y312(0.53)  LDD0268  [9]
 LDCM0107  IAA HeLa H283(0.00); C376(0.00); C295(0.00); C315(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y282(0.97)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y282(0.61)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y282(1.16)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y282(3.08)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y282(1.55)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y282(1.08)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y282(0.41)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y282(0.90)  LDD0292  [8]
 LDCM0179  JZ128 PC-3 C376(0.00); C295(0.00)  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C376(2.01)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C376(4.27)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C376(3.03)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C376(0.90)  LDD2121  [5]
 LDCM0109  NEM HeLa H283(0.00); C376(0.00); C316(0.00); K304(0.00)  LDD0223  [26]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C295(1.09)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C295(0.92)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C295(0.88)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C376(0.92)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C295(0.59); C376(0.87)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C295(0.95)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C295(1.76); C376(1.21)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C295(0.89); C376(0.80)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C295(0.98)  LDD2110  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C295(0.87)  LDD2114  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C295(0.82)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C376(0.18)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C295(0.84); C376(0.92)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C376(0.18)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C295(1.49); C376(1.06)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C295(1.10)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C295(0.92)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C295(1.08)  LDD2129  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C376(1.23)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C295(1.00); C376(0.87)  LDD2137  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C295(0.86)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C295(1.81)  LDD2144  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C376(1.94)  LDD2147  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C376(0.56)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C295(1.09)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C129(1.00); C376(0.94); C200(0.20); C213(0.20)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C295(1.05); C376(0.96); C315(0.83); C315(0.78)  LDD2207  [34]
 LDCM0021  THZ1 HeLa S3 C376(1.05); C295(0.99)  LDD0460  [4]
 LDCM0110  W12 Hep-G2 C347(1.62)  LDD0237  [27]
 LDCM0111  W14 Hep-G2 C347(0.70)  LDD0238  [27]
 LDCM0113  W17 Hep-G2 H107(0.93)  LDD0240  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
Translationally-controlled tumor protein (TPT1) TCTP family P13693

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epothilone D Small molecular drug DB01873
Patupilone Small molecular drug DB03010
2-mercapto-n-[12310-tetramethoxy-9-oxo-5679-tetrahydro-benzo[A]Heptalen-7-yl]Acetamide . DB07574
Cyt997 . DB05147

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.