Details of the Target

General Information of Target

Target ID LDTP03847
Target Name Transaldolase (TALDO1)
Gene Name TALDO1
Gene ID 6888
Synonyms
TAL; TALDO; TALDOR; Transaldolase; EC 2.2.1.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQE
LVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVA
RARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAE
AGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRN
TGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNE
DQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK
Target Bioclass
Enzyme
Family
Transaldolase family, Type 1 subfamily
Subcellular location
Cytoplasm; Nucleus
Function
Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm.
Uniprot ID
P37837
Ensemble ID
ENST00000319006.8
HGNC ID
HGNC:11559

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.L308F .
HT115 SNV: p.D116Y DBIA    Probe Info 
IGROV1 SNV: p.L15P .
LNCaP clone FGC SNV: p.A65T .
MOLT4 SNV: p.R329Ter IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P3
 Probe Info  		1.77  LDD0450  [1]
P8
 Probe Info  		3.40  LDD0451  [1]
A-EBA
 Probe Info  		3.09  LDD0215  [2]
CHEMBL5175495
 Probe Info  		7.58  LDD0196  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y206(20.00)  LDD0260  [5]
C-Sul
 Probe Info  		2.19  LDD0066  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
AZ-9
 Probe Info  		D283(10.00)  LDD2209  [8]
ONAyne
 Probe Info  		K292(0.00); K277(0.00); K115(0.00); K321(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K321(0.79)  LDD3494  [10]
THZ1-DTB
 Probe Info  		C250(1.05)  LDD0460  [11]
SAHA-CA-4PAP
 Probe Info  		5.00  LDD0360  [12]
BTD
 Probe Info  		C250(0.70)  LDD2091  [13]
DBIA
 Probe Info  		C250(1.11)  LDD0531  [14]
ATP probe
 Probe Info  		K269(0.00); K277(0.00); K314(0.00); K321(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
ATP probe
 Probe Info  		K97(0.00); K277(0.00)  LDD0035  [19]
IPM
 Probe Info  		N.A.  LDD0025  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
NHS
 Probe Info  		K277(0.00); K321(0.00); K71(0.00); K81(0.00)  LDD0010  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
SF
 Probe Info  		N.A.  LDD0028  [24]
STPyne
 Probe Info  		K321(0.00); K277(0.00); K215(0.00)  LDD0009  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [25]
1c-yne
 Probe Info  		K307(0.00); K86(0.00)  LDD0228  [26]
1d-yne
 Probe Info  		N.A.  LDD0357  [26]
Acrolein
 Probe Info  		C250(0.00); H288(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [27]
Methacrolein
 Probe Info  		N.A.  LDD0218  [27]
NAIA_5
 Probe Info  		C250(0.00); C178(0.00); C164(0.00)  LDD2223  [28]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [29]
STS-1
 Probe Info  		N.A.  LDD0069  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.64)  LDD2142  [13]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.48)  LDD2112  [13]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C250(0.94)  LDD2130  [13]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C250(0.74)  LDD2132  [13]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C250(0.87)  LDD2131  [13]
 LDCM0214  AC1 HCT 116 C250(1.11)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C250(0.62)  LDD0532  [14]
 LDCM0226  AC11 HCT 116 C250(0.53)  LDD0543  [14]
 LDCM0237  AC12 HCT 116 C250(0.89)  LDD0554  [14]
 LDCM0246  AC128 HCT 116 C250(0.55)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C250(1.06)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C250(0.80)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C250(1.00)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C250(1.56)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C250(1.27)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C250(0.95)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C250(1.03)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C250(1.18)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C250(1.38)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C250(1.27)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C250(1.41)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C250(1.08)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C250(1.16)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C250(1.38)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C250(1.86)  LDD0579  [14]
 LDCM0263  AC143 HEK-293T C250(1.25)  LDD0861  [14]
 LDCM0264  AC144 HEK-293T C250(0.84)  LDD0862  [14]
 LDCM0265  AC145 HEK-293T C250(1.14)  LDD0863  [14]
 LDCM0266  AC146 HEK-293T C250(0.97)  LDD0864  [14]
 LDCM0267  AC147 HEK-293T C250(0.94)  LDD0865  [14]
 LDCM0268  AC148 HEK-293T C250(1.67)  LDD0866  [14]
 LDCM0269  AC149 HEK-293T C250(1.55)  LDD0867  [14]
 LDCM0270  AC15 HCT 116 C250(0.54)  LDD0587  [14]
 LDCM0271  AC150 HEK-293T C250(1.15)  LDD0869  [14]
 LDCM0272  AC151 HEK-293T C250(1.08)  LDD0870  [14]
 LDCM0273  AC152 HEK-293T C250(0.99)  LDD0871  [14]
 LDCM0274  AC153 HEK-293T C250(0.89)  LDD0872  [14]
 LDCM0621  AC154 HEK-293T C250(0.88)  LDD2162  [14]
 LDCM0622  AC155 HEK-293T C250(1.07)  LDD2163  [14]
 LDCM0623  AC156 HEK-293T C250(1.08)  LDD2164  [14]
 LDCM0624  AC157 HEK-293T C250(0.97)  LDD2165  [14]
 LDCM0276  AC17 HCT 116 C250(1.00)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C250(0.45)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C250(0.78)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C250(1.01)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C250(0.99)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C250(0.85)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C250(0.89)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C250(0.91)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C250(1.03)  LDD0601  [14]
 LDCM0285  AC25 HEK-293T C250(0.93)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C250(1.09)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C250(1.11)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C250(1.11)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C250(1.10)  LDD1528  [31]
 LDCM0290  AC3 HCT 116 C250(1.11)  LDD0607  [14]
 LDCM0291  AC30 HEK-293T C250(1.11)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C250(1.14)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C250(1.08)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C250(1.03)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C250(1.12)  LDD1534  [31]
 LDCM0296  AC35 HCT 116 C250(1.06)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C250(1.11)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C250(0.85)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C250(0.83)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C250(0.73)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C250(0.90)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C250(1.12)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C250(1.18)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C250(1.04)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C250(1.13)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C250(1.15)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C250(1.06)  LDD0624  [14]
 LDCM0308  AC46 PaTu 8988t C250(1.24)  LDD1187  [14]
 LDCM0309  AC47 PaTu 8988t C250(1.26)  LDD1188  [14]
 LDCM0310  AC48 PaTu 8988t C250(0.73)  LDD1189  [14]
 LDCM0311  AC49 PaTu 8988t C250(0.74)  LDD1190  [14]
 LDCM0312  AC5 HCT 116 C250(1.07)  LDD0629  [14]
 LDCM0313  AC50 PaTu 8988t C250(0.81)  LDD1192  [14]
 LDCM0314  AC51 PaTu 8988t C250(1.14)  LDD1193  [14]
 LDCM0315  AC52 PaTu 8988t C250(0.73)  LDD1194  [14]
 LDCM0316  AC53 PaTu 8988t C250(0.45)  LDD1195  [14]
 LDCM0317  AC54 PaTu 8988t C250(0.12)  LDD1196  [14]
 LDCM0318  AC55 PaTu 8988t C250(1.14)  LDD1197  [14]
 LDCM0319  AC56 PaTu 8988t C250(0.34)  LDD1198  [14]
 LDCM0320  AC57 HEK-293T C250(0.68)  LDD0918  [14]
 LDCM0321  AC58 HEK-293T C250(0.81)  LDD0919  [14]
 LDCM0322  AC59 HEK-293T C250(0.71)  LDD0920  [14]
 LDCM0323  AC6 HCT 116 C250(0.51)  LDD0640  [14]
 LDCM0324  AC60 HEK-293T C250(0.69)  LDD0922  [14]
 LDCM0325  AC61 HEK-293T C250(0.74)  LDD0923  [14]
 LDCM0326  AC62 HEK-293T C250(0.87)  LDD0924  [14]
 LDCM0327  AC63 HEK-293T C250(0.53)  LDD0925  [14]
 LDCM0328  AC64 HEK-293T C250(0.94)  LDD0926  [14]
 LDCM0329  AC65 HEK-293T C250(0.97)  LDD0927  [14]
 LDCM0330  AC66 HEK-293T C250(0.66)  LDD0928  [14]
 LDCM0331  AC67 HEK-293T C250(0.28)  LDD0929  [14]
 LDCM0332  AC68 HCT 116 C250(0.82)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C250(1.50)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C250(0.85)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C250(1.49)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C250(1.82)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C250(1.71)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C250(1.01)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C250(1.26)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C250(1.90)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C250(0.98)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C250(1.50)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C250(1.56)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C250(1.80)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C250(0.65)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C250(1.48)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C250(1.30)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C250(1.40)  LDD0665  [14]
 LDCM0248  AKOS034007472 HCT 116 C250(1.07)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C250(0.95)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C250(0.06)  LDD0592  [14]
 LDCM0498  BS-3668 MDA-MB-231 C250(0.70)  LDD2091  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C250(0.30)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C250(1.00)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C250(1.31)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C250(0.80)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C250(0.48)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C250(0.91)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C250(0.86)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C250(0.86)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C250(0.60)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C250(0.32)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C250(0.21)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C250(0.13)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C250(0.49)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C250(0.99)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C250(0.38)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C250(0.75)  LDD0698  [14]
 LDCM0382  CL112 HEK-293T C250(0.93)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C250(1.03)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C250(0.95)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C250(0.96)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C250(1.04)  LDD1590  [31]
 LDCM0387  CL117 HCT 116 C250(0.72)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C250(1.15)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C250(1.08)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C250(0.36)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C250(1.04)  LDD0708  [14]
 LDCM0392  CL121 PaTu 8988t C250(1.06)  LDD1271  [14]
 LDCM0393  CL122 PaTu 8988t C250(0.27)  LDD1272  [14]
 LDCM0394  CL123 PaTu 8988t C250(0.37)  LDD1273  [14]
 LDCM0395  CL124 PaTu 8988t C250(0.77)  LDD1274  [14]
 LDCM0396  CL125 HEK-293T C250(0.81)  LDD0994  [14]
 LDCM0397  CL126 HEK-293T C250(0.77)  LDD0995  [14]
 LDCM0398  CL127 HEK-293T C250(0.77)  LDD0996  [14]
 LDCM0399  CL128 HEK-293T C250(0.95)  LDD0997  [14]
 LDCM0400  CL13 HCT 116 C250(0.99)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C250(0.87)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C250(1.03)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C250(0.87)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C250(1.01)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C250(1.73)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C250(0.86)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C250(1.28)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C250(0.16)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C250(0.11)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C250(0.05)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C250(0.29)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C250(0.08)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C250(0.12)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C250(0.39)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C250(0.56)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C250(0.27)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C250(0.23)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C250(0.89)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C250(0.76)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C250(0.67)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C250(1.00)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C250(0.90)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C250(0.42)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C250(0.37)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C250(0.37)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C250(0.25)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C250(0.33)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C250(1.28)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C250(0.32)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C250(0.47)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C250(0.32)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C250(0.35)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C250(0.51)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C250(0.40)  LDD0752  [14]
 LDCM0436  CL46 HEK-293T C250(1.17)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C250(1.10)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C250(1.01)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C250(1.08)  LDD1643  [31]
 LDCM0440  CL5 HCT 116 C250(0.88)  LDD0757  [14]
 LDCM0441  CL50 HEK-293T C250(0.93)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C250(0.95)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C250(0.76)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C250(0.94)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C250(1.07)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C250(1.06)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C250(0.92)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C250(1.05)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C250(1.01)  LDD1653  [31]
 LDCM0451  CL6 HCT 116 C250(1.23)  LDD0768  [14]
 LDCM0452  CL60 HEK-293T C250(1.12)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C250(1.02)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C250(1.07)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C250(1.00)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C250(0.92)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C250(0.87)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C250(1.02)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C250(1.01)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C250(1.07)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C250(1.04)  LDD1664  [31]
 LDCM0462  CL7 HCT 116 C250(1.07)  LDD0779  [14]
 LDCM0463  CL70 HEK-293T C250(1.08)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C250(1.08)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C250(0.97)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C250(1.08)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C250(1.08)  LDD1670  [31]
 LDCM0469  CL76 HCT 116 C250(1.05)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C250(0.74)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C250(0.50)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C250(0.10)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C250(0.75)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C250(2.64)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C250(0.36)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C250(0.05)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C250(0.06)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C250(0.04)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C250(0.42)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C250(4.32)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C250(0.51)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C250(0.07)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C250(0.04)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C250(0.94)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C250(1.07)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C250(0.53)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C250(1.09)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C250(1.06)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C250(0.83)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C250(0.94)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C250(0.97)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C250(0.97)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C250(0.94)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C250(1.04)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C250(0.96)  LDD1698  [31]
 LDCM0625  F8 Ramos C250(0.58)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C250(0.59)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C250(0.05)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C250(0.71)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C250(0.97)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C250(0.49)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C250(0.61)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C250(1.00)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C250(1.36)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C250(1.21)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C250(0.79)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C250(1.00)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C250(1.43)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C250(0.49)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C250(1.12)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C250(1.01)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C250(1.08)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C250(0.25)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C250(0.94)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C250(1.09)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C250(0.71)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C250(0.57)  LDD2188  [32]
 LDCM0107  IAA HeLa C250(0.00); H298(0.00); H197(0.00)  LDD0221  [27]
 LDCM0022  KB02 HEK-293T C250(0.96)  LDD1492  [31]
 LDCM0023  KB03 HEK-293T C250(1.04)  LDD1497  [31]
 LDCM0024  KB05 G361 C250(1.64)  LDD3311  [33]
 LDCM0109  NEM HeLa C250(0.00); H298(0.00); H197(0.00)  LDD0223  [27]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C250(0.98)  LDD2099  [13]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C250(0.45)  LDD2100  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C250(0.56)  LDD2104  [13]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C250(0.57)  LDD2106  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C250(0.64)  LDD2109  [13]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C250(1.03)  LDD2110  [13]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C250(0.91)  LDD2114  [13]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C250(0.74)  LDD2123  [13]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C250(0.98)  LDD2125  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C250(1.17)  LDD2136  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C250(0.75)  LDD2137  [13]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C250(0.43)  LDD2141  [13]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C250(0.55)  LDD2145  [13]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C250(0.92)  LDD2150  [13]
 LDCM0131  RA190 MM1.R C250(1.17)  LDD0304  [34]
 LDCM0096  SAHA K562 5.00  LDD0360  [12]
 LDCM0021  THZ1 HeLa S3 C250(1.05)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.