Details of the Target

General Information of Target

Target ID LDTP02592
Target Name Ribose-phosphate pyrophosphokinase 2 (PRPS2)
Gene Name PRPS2
Gene ID 5634
Synonyms
Ribose-phosphate pyrophosphokinase 2; EC 2.7.6.1; PPRibP; Phosphoribosyl pyrophosphate synthase II; PRS-II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC
GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTS
IADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAI
RRTHNGESVSYLFSHVPL
Target Bioclass
Enzyme
Family
Ribose-phosphate pyrophosphokinase family
Function Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Uniprot ID
P11908
Ensemble ID
ENST00000380668.10
HGNC ID
HGNC:9465

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RKO SNV: p.V309L .
TOV21G SNV: p.V271I .
WM2664 Insertion: p.V309RfsTer41 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.54  LDD0402  [1]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [2]
ONAyne
 Probe Info  		K212(1.20)  LDD0274  [3]
STPyne
 Probe Info  		K194(5.56); K235(10.00); K282(8.26)  LDD0277  [3]
DBIA
 Probe Info  		C233(1.50)  LDD3342  [4]
THZ1-DTB
 Probe Info  		C91(1.06)  LDD0460  [5]
HHS-465
 Probe Info  		Y94(1.79)  LDD2237  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K176(0.00); K29(0.00); K194(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C165(0.00); C226(0.00); C230(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C226(0.00); C165(0.00); C91(0.00)  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C165(0.00); C226(0.00); C230(0.00)  LDD0037  [10]
BTD
 Probe Info  		N.A.  LDD0004  [13]
IPM
 Probe Info  		N.A.  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
TFBX
 Probe Info  		C165(0.00); C91(0.00)  LDD0027  [14]
WYneN
 Probe Info  		C165(0.00); C91(0.00)  LDD0021  [13]
PF-06672131
 Probe Info  		N.A.  LDD0017  [16]
AOyne
 Probe Info  		9.20  LDD0443  [17]
NAIA_5
 Probe Info  		C165(0.00); C91(0.00); C230(0.00); C226(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]
DA-2
 Probe Info  		N.A.  LDD0070  [20]
STS-1
 Probe Info  		N.A.  LDD0069  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C284(1.12)  LDD2117  [22]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C284(1.99)  LDD2152  [22]
 LDCM0214  AC1 HEK-293T C165(0.83); C60(0.94)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C165(1.12); C60(0.98)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C165(1.19); C60(0.89)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C165(1.11); C60(0.97)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C165(1.08); C60(1.02)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C165(0.99); C60(0.98)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C165(0.95); C60(0.96)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C165(1.10); C60(0.95)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C165(0.64); C60(0.83)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C165(1.02); C60(0.97)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C165(1.06); C60(0.93)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C165(1.02); C60(1.00)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C165(0.99); C60(1.07)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C165(1.00); C60(1.01)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C165(1.14); C60(0.99)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C165(0.88); C60(0.98)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C165(1.09); C60(0.92)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C165(1.05); C60(0.86)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C165(1.02); C60(0.98)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C165(1.04); C60(0.96)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C165(0.92); C60(0.88)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C165(1.03); C60(1.03)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C165(1.01); C60(0.93)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C165(1.12); C60(1.02)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C165(0.89); C60(1.04)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C165(0.98); C60(1.00)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C165(0.99); C60(1.06)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C165(1.01); C60(0.94)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C165(1.15); C60(1.09)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C165(1.05); C60(1.09)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C165(1.04); C60(1.00)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C165(1.05); C60(0.94)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C165(0.91); C60(1.06)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C165(0.85); C60(1.05)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C165(1.00); C60(0.91)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C165(1.02); C60(0.93)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C165(1.06); C60(1.04)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C165(1.00); C60(1.00)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C165(1.07); C60(0.99)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C165(1.14); C60(0.92)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C165(1.15); C60(1.08)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C165(0.91); C60(0.92)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C165(1.09); C60(1.00)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C165(1.00); C60(0.95)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C165(0.95); C60(1.04)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C165(1.05); C60(0.97)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C165(1.10); C60(1.07)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C165(1.06); C60(0.96)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C165(1.11); C60(0.90)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C165(1.15); C60(1.03)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C165(0.83); C60(1.02)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C165(0.97); C60(0.96)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C165(1.04); C60(1.00)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C165(1.00); C60(0.99)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C165(1.01); C60(0.98)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C165(0.97); C60(0.99)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C165(0.95); C60(1.09)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C165(0.97); C60(0.98)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C165(1.05); C60(1.04)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C165(1.03); C60(0.95)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C165(0.95); C60(1.07)  LDD1569  [23]
 LDCM0248  AKOS034007472 HEK-293T C165(1.09); C60(1.09)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C165(0.90); C60(0.93)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C165(1.08); C60(1.00)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C165(0.95); C60(0.86)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C165(0.69); C60(1.29)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C165(0.96); C60(0.86)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C165(0.93); C60(0.88)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C165(0.94); C60(0.99)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C165(1.03); C60(1.01)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C165(1.14); C60(1.04)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C165(1.00); C60(0.96)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C165(1.04); C60(0.99)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C165(1.08); C60(0.98)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C165(1.09); C60(0.96)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C165(0.93); C60(0.87)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C165(1.15); C60(1.09)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C165(0.85); C60(0.91)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C165(1.00); C60(0.90)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C165(1.02); C60(0.95)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C165(0.92); C60(0.96)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C165(0.81); C60(0.98)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C165(0.95); C60(0.98)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C165(1.01); C60(1.02)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C165(0.94); C60(0.88)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C165(1.09); C60(0.91)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C165(1.06); C60(1.00)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C165(1.06); C60(1.23)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C165(0.99); C60(1.00)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C165(0.98); C60(0.89)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C165(1.03); C60(0.93)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C165(0.92); C60(0.90)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C165(1.13); C60(0.91)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C165(0.98); C60(0.96)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C165(0.96); C60(1.02)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C165(0.98); C60(1.00)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C165(1.02); C60(1.04)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C165(0.87); C60(0.86)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C165(1.01); C60(0.96)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C165(1.05); C60(0.88)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C165(1.06); C60(0.97)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C165(0.81); C60(1.12)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C165(1.26); C60(1.05)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C165(1.08); C60(0.99)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C165(0.94); C60(0.99)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C165(1.28); C60(1.12)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C165(0.98); C60(1.10)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C165(1.20); C60(1.26)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C165(1.18); C60(1.14)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C165(1.13); C60(1.45)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C165(1.02); C60(0.82)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C165(1.00); C60(0.99)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C165(1.13); C60(0.98)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C165(1.02); C60(1.03)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C165(1.10); C60(0.88)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C165(1.09); C60(0.96)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C165(1.18); C60(1.05)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C165(1.06); C60(0.91)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C165(1.21); C60(0.98)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C165(0.92); C60(1.00)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C165(1.15); C60(1.16)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C165(1.29); C60(1.18)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C165(1.21); C60(1.10)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C165(1.03); C60(0.93)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C165(0.96); C60(0.95)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C165(0.97); C60(0.95)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C165(1.14); C60(1.05)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C165(0.92); C60(0.88)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C165(1.05); C60(0.94)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C165(1.15); C60(1.05)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C165(1.13); C60(1.02)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C165(0.95); C60(1.13)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C165(1.23); C60(1.17)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C165(1.17); C60(1.00)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C165(1.14); C60(1.22)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C165(0.98); C60(0.93)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C165(0.89); C60(1.06)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C165(0.83); C60(0.98)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C165(0.99); C60(1.02)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C165(0.83); C60(0.92)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C165(1.10); C60(0.84)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C165(1.05); C60(1.00)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C165(1.21); C60(1.03)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C165(0.92); C60(1.03)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C165(1.20); C60(1.27)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C165(1.30); C60(1.04)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C165(1.05); C60(0.91)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C165(1.09); C60(1.26)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C165(1.11); C60(0.98)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C165(1.01); C60(1.13)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C165(1.10); C60(1.02)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C165(0.95); C60(1.06)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C165(0.93); C60(1.06)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C165(1.08); C60(0.94)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C165(1.03); C60(1.14)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C165(1.29); C60(1.02)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C165(1.13); C60(1.19)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C165(0.96); C60(1.07)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C165(1.08); C60(1.20)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C165(1.22); C60(1.15)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C165(1.17); C60(1.15)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C165(0.94); C60(0.88)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C165(1.18); C60(1.15)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C165(1.07); C60(1.00)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C165(0.79); C60(0.96)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C165(1.35); C60(1.01)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C165(1.12); C60(1.00)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C165(0.83); C60(0.84)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C165(1.18); C60(1.13)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C165(1.08); C60(1.11)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C165(1.24); C60(1.05)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C165(1.02); C60(0.98)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C165(1.01); C60(1.03)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C165(0.93); C60(1.00)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C165(1.05); C60(0.97)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C165(0.93); C60(0.96)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C165(1.04); C60(0.95)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C165(0.97); C60(1.05)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C165(1.12); C60(1.09)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C165(0.82); C60(0.85)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C165(1.22); C60(1.05)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C165(1.06); C60(0.99)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C165(1.02); C60(0.94)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C165(1.00); C60(1.10)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C165(0.68); C60(0.86)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C165(0.88); C60(1.23)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C165(0.84); C60(0.91)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C165(0.99); C60(1.01)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C165(0.98); C60(1.00)  LDD1697  [23]
 LDCM0634  CY-0357 Hep-G2 C91(0.37)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C165(1.08); C60(0.94)  LDD1698  [23]
 LDCM0468  Fragment33 HEK-293T C165(1.07); C60(0.96)  LDD1671  [23]
 LDCM0427  Fragment51 HEK-293T C165(1.11); C60(0.82)  LDD1631  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C165(1.03)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C165(0.97)  LDD1497  [23]
 LDCM0024  KB05 NCI-H1155 C233(1.50)  LDD3342  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C284(1.46)  LDD2093  [22]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C284(1.22)  LDD2099  [22]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C284(1.39)  LDD2107  [22]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C284(0.88)  LDD2109  [22]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C284(1.10)  LDD2123  [22]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C284(0.96)  LDD2127  [22]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C284(0.93)  LDD2137  [22]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C284(0.82)  LDD2140  [22]
 LDCM0021  THZ1 HeLa S3 C91(1.06)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1) Ribose-phosphate pyrophosphokinase family Q14558
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPSAP2) Ribose-phosphate pyrophosphokinase family O60256
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ribose-phosphate pyrophosphokinase 2 (PRPS2) Ribose-phosphate pyrophosphokinase family P11908
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
RING finger protein 11 (RNF11) . Q9Y3C5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
21 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402