Details of the Target

General Information of Target

Target ID LDTP00776
Target Name Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)
Gene Name AKR7A2
Gene ID 8574
Synonyms
AFAR; AFAR1; AKR7; Aflatoxin B1 aldehyde reductase member 2; EC 1.1.1.n11; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV
RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR
SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE
ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE
DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY
HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR
Target Bioclass
Enzyme
Family
Aldo/keto reductase family, Aldo/keto reductase 2 subfamily
Subcellular location
Mitochondrion
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Uniprot ID
O43488
Ensemble ID
ENST00000235835.8
HGNC ID
HGNC:389

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.57  LDD0402  [1]
TH211
 Probe Info  		Y237(20.00); Y260(20.00); Y239(7.49)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K236(3.08); K242(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y237(27.09); Y239(76.88)  LDD3495  [5]
HHS-482
 Probe Info  		Y225(0.88); Y237(0.96); Y239(0.77); Y260(0.91)  LDD0285  [6]
HHS-475
 Probe Info  		Y225(0.80); Y239(0.85); Y260(0.90)  LDD0264  [7]
HHS-465
 Probe Info  		Y225(10.00); Y239(10.00); Y260(10.00)  LDD2237  [8]
Acrolein
 Probe Info  		H268(0.00); C214(0.00); H269(0.00)  LDD0221  [9]
DBIA
 Probe Info  		C214(1.28)  LDD0531  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C98(0.00); C214(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C156(0.00); C132(0.00); C214(0.00); C98(0.00)  LDD0036  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		C132(0.00); C214(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C98(0.00); C214(0.00)  LDD0037  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		Y225(0.00); Y260(0.00)  LDD0028  [15]
AOyne
 Probe Info  		11.70  LDD0443  [16]
NAIA_5
 Probe Info  		C98(0.00); C214(0.00); C156(0.00); C132(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0070  [18]
STS-1
 Probe Info  		N.A.  LDD0069  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C214(1.28)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C214(1.37)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C132(0.81); C156(0.81); C214(0.98)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C132(0.59); C156(0.59); C214(0.69)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C132(0.69); C156(0.69); C214(0.80)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C132(0.61); C156(0.61); C214(0.63)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C132(0.66); C156(0.66); C214(0.75)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C132(0.62); C156(0.62); C214(0.68)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C132(0.59); C156(0.59); C214(0.87)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C132(0.53); C156(0.53); C214(0.79)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C132(0.66); C156(0.66); C214(0.72)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C132(0.84); C156(0.84); C214(0.76)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C214(1.81)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C132(0.62); C156(0.62); C214(0.68)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C132(0.54); C156(0.54); C214(0.53)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C132(0.48); C156(0.48); C214(0.47)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C132(1.50); C156(1.50); C214(1.32)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C132(1.04); C156(0.92); C214(0.97)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C132(0.82); C156(0.71); C214(0.82)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C132(0.87); C156(0.73); C214(0.88)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C132(0.96); C156(0.95); C214(1.18)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C132(0.98); C156(0.93); C214(1.26)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C132(0.93); C156(0.86); C214(1.08)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C214(2.29)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C132(1.16); C156(1.15); C214(0.96)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C132(1.15); C156(1.03); C214(1.53)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C132(0.69); C156(0.72); C214(0.93)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C132(1.20); C156(1.06); C214(1.49)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C132(1.17); C156(1.19); C214(1.52)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C132(1.21); C156(1.18); C214(1.37)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C132(0.80); C156(0.79); C214(1.11)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C132(0.88); C156(0.72); C214(1.10)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C132(0.78); C156(0.78); C214(2.40)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C132(1.19); C156(1.19); C214(1.71)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C132(0.63); C156(0.63); C214(1.38)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C132(1.26); C156(1.26); C214(1.12)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C132(0.86); C156(0.86); C214(0.76)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C132(0.76); C156(0.76); C214(1.15)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C132(0.63); C156(0.63); C214(0.67)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C132(0.59); C156(0.59); C214(0.85)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C132(0.65); C156(0.65); C214(0.58)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C132(0.74); C156(0.74); C214(0.70)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C132(0.64); C156(0.64); C214(0.45)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C132(0.56); C156(0.56); C214(0.47)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C214(1.60)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C132(0.53); C156(0.53); C214(0.48)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C132(0.61); C156(0.61); C214(0.46)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C132(0.72); C156(0.72); C214(0.62)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C132(0.84); C156(0.84); C214(0.53)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C132(0.36); C156(0.36); C214(0.59)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C132(0.67); C156(0.67); C214(0.75)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C132(0.21); C156(0.21); C214(0.60)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C132(0.34); C156(0.34); C214(0.81)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C132(0.11); C156(0.11); C214(0.54)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C132(0.21); C156(0.21); C214(0.60)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C214(1.22)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C214(0.63); C132(0.97); C156(0.97)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C214(0.66); C132(0.88); C156(0.88)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C132(0.32); C156(0.32); C214(0.55)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C132(0.09); C156(0.09); C214(0.38)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C132(0.42); C156(0.42); C214(0.55)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C132(0.49); C156(0.49); C214(0.50)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C132(1.03); C156(1.03); C214(0.62)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C132(1.13); C156(1.13); C214(0.43)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C214(1.23); C132(1.50); C156(1.50)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C132(0.58); C156(0.58); C214(0.77)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C214(1.15); C132(1.34); C156(1.34)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C214(0.98)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C132(1.10); C156(1.10); C214(1.14)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C214(0.99); C132(0.99); C156(0.99)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C132(1.03); C156(1.03); C214(1.29)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C132(1.02); C156(1.02); C214(1.12)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C214(1.43); C132(2.10); C156(2.10)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C132(0.90); C156(0.90); C214(1.15)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C214(0.47); C132(0.60); C156(0.60)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C214(0.47); C132(0.70); C156(0.70)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C214(0.46); C132(0.63); C156(0.63)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C214(0.24); C132(0.54); C156(0.54)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C214(1.39)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C214(0.23); C132(0.52); C156(0.52)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C214(0.38); C132(0.51); C156(0.51)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C214(0.25); C132(0.42); C156(0.42)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C214(0.65); C132(0.75); C156(0.75)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C214(0.58); C132(0.78); C156(0.78)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C214(1.15); C132(1.19); C156(1.19)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C214(0.61); C132(1.21); C156(1.21)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C214(0.74); C132(1.14); C156(1.14)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C214(0.78); C132(1.26); C156(1.26)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C132(0.86); C156(0.86); C214(1.09)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C214(1.79)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C214(0.75); C132(0.89); C156(0.89)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C214(0.31); C132(0.95); C156(0.95)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C214(0.59); C132(0.97); C156(0.97)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C214(0.40); C132(0.60); C156(0.60)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C214(0.33); C132(0.93); C156(0.93)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C214(0.34); C132(0.70); C156(0.70)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C214(0.69); C132(0.71); C156(0.71)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C132(0.70); C156(0.70); C214(0.80)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C132(0.36); C156(0.36); C214(0.43)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C214(0.37); C132(0.45); C156(0.45)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C214(1.58)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C132(0.46); C156(0.46); C214(0.47)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C214(0.86); C132(0.87); C156(0.87)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C214(0.80); C132(0.86); C156(0.86)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C214(0.60); C132(0.68); C156(0.68)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C132(0.68); C156(0.68); C214(0.73)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C214(0.56); C132(0.57); C156(0.57)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C214(0.30); C132(0.38); C156(0.38)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C214(1.15)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C214(0.89)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C214(1.21)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C214(0.68)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C214(1.22)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C214(1.08)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C214(1.21)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C214(1.46)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C214(1.44)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C214(1.23)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C214(0.88)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C214(1.10)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C132(0.50); C156(0.50); C214(0.66)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C132(0.33); C156(0.33); C214(0.64)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C214(0.92)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C132(0.27); C156(0.27); C214(0.43)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C132(0.56); C156(0.56); C214(1.11)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C214(0.59); C132(0.64); C156(0.64)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C132(0.18); C156(0.18); C214(0.40)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C132(0.20); C156(0.20); C214(0.96)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C132(0.16); C156(0.16); C214(0.35)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C132(0.43); C156(0.43); C214(0.93)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C132(0.35); C156(0.35); C214(0.51)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C132(0.31); C156(0.31); C214(0.56)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C214(0.70); C132(0.75); C156(0.75)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C214(0.90)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C132(0.58); C156(0.58); C214(1.58)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C214(0.95); C132(1.02); C156(1.02)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C132(0.19); C156(0.19); C214(0.78)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C132(0.43); C156(0.43); C214(0.87)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C132(0.39); C156(0.39); C214(0.69)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C132(0.46); C156(0.46); C214(0.73)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C132(0.26); C156(0.26); C214(0.64)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C132(0.31); C156(0.31); C214(0.87)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C132(0.30); C156(0.30); C214(0.85)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C132(0.29); C156(0.29); C214(0.64)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C132(0.22); C156(0.22); C214(0.61)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C132(0.72); C156(0.72); C214(0.91)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C132(0.58); C156(0.58); C214(1.02)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C132(0.33); C156(0.33); C214(0.74)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C132(0.55); C156(0.55); C214(1.52)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C132(0.20); C156(0.20); C214(0.83)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C132(0.46); C156(0.46); C214(1.37)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C132(0.27); C156(0.27); C214(0.54)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C132(0.33); C156(0.33); C214(0.33)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C132(0.65); C156(0.65); C214(0.71)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C214(1.56)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C214(1.80)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C214(0.65)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 13.71  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C214(0.00); H268(0.00)  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C214(0.91)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C214(0.88)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C214(0.78)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C214(0.95)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C214(1.85)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C214(2.16)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C214(1.40)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C132(0.65); C156(0.65); C214(0.92)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C132(0.26); C156(0.26); C214(0.65)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C132(0.61); C156(0.61); C214(0.81)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C132(0.46); C156(0.46); C214(0.84)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C132(0.72); C156(0.72); C214(0.80)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C214(1.72)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C132(0.59); C156(0.59); C214(0.80)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C214(0.92); C132(1.30); C156(1.30)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C214(0.57); C132(0.91); C156(0.91)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C214(0.26); C132(0.50); C156(0.50)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C214(0.23); C132(0.75); C156(0.75)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C214(0.37); C132(0.68); C156(0.68)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C214(0.60); C132(0.79); C156(0.79)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C132(0.37); C156(0.37); C214(1.30)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C214(0.70); C132(0.98); C156(0.98)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C214(0.49); C132(0.84); C156(0.84)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C214(1.13)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C214(0.42); C132(0.99); C156(0.99)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C214(0.52); C132(0.88); C156(0.88)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C214(0.44); C132(0.49); C156(0.49)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C214(0.60); C132(0.65); C156(0.65)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C214(0.45); C132(0.52); C156(0.52)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C214(0.96)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C214(0.82)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C214(0.84)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C214(0.91)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C214(1.44)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C214(0.82)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C214(1.65)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C214(0.66)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C214(0.38)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C214(0.18)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C214(0.28)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C214(0.86)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C214(0.44)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C214(0.25)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C214(0.15)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C214(0.55)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C214(0.33)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C214(0.42)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C214(0.49)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C214(0.56)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C214(0.29)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C214(0.34)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C214(0.80)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C214(0.48)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C132(0.80); C156(0.80); C214(0.78)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C132(0.32); C156(0.32); C214(0.47)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C132(0.49); C156(0.49); C214(0.45)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C132(0.36); C156(0.36); C214(0.53)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C132(0.50); C156(0.50); C214(0.63)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C132(0.53); C156(0.53); C214(0.60)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C132(0.38); C156(0.38); C214(0.55)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C132(0.50); C156(0.50); C214(0.55)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C214(1.19)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C132(0.51); C156(0.51); C214(0.57)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C132(0.59); C156(0.59); C214(0.70)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C132(0.20); C156(0.20); C214(0.47)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C132(0.32); C156(0.32); C214(0.47)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C132(0.36); C156(0.36); C214(0.52)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C132(0.26); C156(0.26); C214(0.49)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C214(2.03)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C214(1.63)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C214(1.85)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C214(1.46)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C214(1.10)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C214(2.01)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C214(1.90)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C214(1.45)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C214(1.85)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C214(1.50)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C214(1.88)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C214(1.21)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C214(1.47)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C214(1.68)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C214(1.51)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C214(0.80)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C214(1.36)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C132(0.80); C156(0.80); C214(0.96)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C132(0.68); C156(0.68); C214(0.93)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C132(0.55); C156(0.55); C214(0.69)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C132(0.57); C156(0.57); C214(0.77)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C132(0.80); C156(0.80); C214(0.96)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C132(0.30); C156(0.30); C214(0.67)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C132(0.39); C156(0.39); C214(0.63)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C132(0.26); C156(0.26); C214(0.51)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C132(0.41); C156(0.41); C214(0.58)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C214(1.43)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C132(0.34); C156(0.34); C214(0.53)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C132(0.54); C156(0.54); C214(0.89)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C132(0.93); C156(0.93); C214(0.95)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C132(1.05); C156(1.05); C214(0.68)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C132(0.59); C156(0.59); C214(0.74)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C132(0.44); C156(0.44); C214(0.51)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C132(1.27); C156(1.27); C214(0.54)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C132(0.88); C156(0.88); C214(0.75)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C132(0.56); C156(0.56); C214(0.68)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C214(0.89)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C132(0.46); C156(0.46); C214(0.62)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C132(0.84); C156(0.84); C214(0.84)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C132(0.32); C156(0.32); C214(0.56)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C132(0.38); C156(0.38); C214(0.58)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C132(0.24); C156(0.24); C214(0.55)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C132(0.68); C156(0.68); C214(0.67)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C132(0.85); C156(0.85); C214(0.86)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C132(0.63); C156(0.63); C214(0.69)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C132(0.41); C156(0.41); C214(0.44)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C132(0.21); C156(0.21); C214(0.43)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C214(1.00)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C132(1.00); C156(1.00); C214(0.83)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C214(1.35)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C214(1.49)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C214(2.04)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C214(0.82)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C214(1.73)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C214(1.64)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C214(1.16)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C214(0.91)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C214(1.20)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C214(0.91); C98(0.97)  LDD1698  [20]
 LDCM0572  Fragment10 Ramos C214(0.31)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C214(0.74)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C214(0.19)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C214(0.36)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C214(0.77)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C214(0.16)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C214(0.42)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C214(0.29)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C214(1.37)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C214(0.70)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C214(0.89)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C214(0.77)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C214(0.73)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C132(0.53); C156(0.53); C214(0.74)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C214(0.16)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C214(0.64)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C132(0.22); C156(0.22); C214(0.49)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C214(0.56)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C214(0.53)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C214(0.38)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C214(0.40)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y225(0.80); Y239(0.85); Y260(0.90)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y260(0.88); Y225(0.99); Y239(1.08)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y239(0.75); Y225(0.79); Y260(0.91)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y260(0.85); Y239(0.92); Y225(1.06)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y225(0.61); Y239(0.98); Y260(1.54)  LDD0268  [7]
 LDCM0107  IAA HeLa H268(0.00); C214(0.00); H269(0.00)  LDD0221  [9]
 LDCM0123  JWB131 DM93 Y225(0.88); Y237(0.96); Y239(0.77); Y260(0.91)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y225(0.55); Y237(0.88); Y239(3.21); Y260(0.92)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y225(1.09); Y237(0.76); Y239(1.10); Y260(1.24)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y225(2.36); Y237(1.71); Y239(3.20); Y260(3.49)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y225(1.44); Y237(1.16); Y239(2.53); Y260(1.78)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y225(0.54); Y237(0.16); Y239(0.14); Y260(0.82)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y225(0.32); Y237(0.82); Y239(0.95); Y260(0.49)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y225(0.84); Y237(0.92); Y239(0.86); Y260(0.67)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C214(0.92); C132(1.04)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C214(1.01); C132(1.05)  LDD1497  [20]
 LDCM0024  KB05 HEK-293T C214(1.01); C132(0.85)  LDD1502  [20]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) Aldo/keto reductase family O95154
Cytoglobin (CYGB) Globin family Q8WWM9
Ataxin-3 (ATXN3) . P54252
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 1 (ZBTB1) . Q9Y2K1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
19 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578