Details of the Target

General Information of Target

Target ID LDTP12180
Target Name Retinol dehydrogenase 14 (RDH14)
Gene Name RDH14
Gene ID 57665
Synonyms
PAN2; SDR7C4; Retinol dehydrogenase 14; EC 1.1.1.300; Alcohol dehydrogenase PAN2; Short chain dehydrogenase/reductase family 7C member 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPP
EPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPR
QVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLA
CVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMK
VND
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Function
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid.
Uniprot ID
Q9HBH5
Ensemble ID
ENST00000381249.4
HGNC ID
HGNC:19979

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.89  LDD0402  [1]
Dasatinib-CA-4PAP
 Probe Info  		5.40  LDD0270  [2]
DBIA
 Probe Info  		C97(1.19); C74(1.92)  LDD3310  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C74(1.06)  LDD2099  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C126(0.00); C74(0.00); C216(0.00); C148(0.00)  LDD0162  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		13.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		12.04  LDD1782  [13]
C094
 Probe Info  		23.10  LDD1785  [13]
C134
 Probe Info  		20.82  LDD1816  [13]
C228
 Probe Info  		14.62  LDD1901  [13]
C231
 Probe Info  		15.67  LDD1904  [13]
C232
 Probe Info  		34.54  LDD1905  [13]
C235
 Probe Info  		17.39  LDD1908  [13]
C293
 Probe Info  		16.34  LDD1963  [13]
FFF probe11
 Probe Info  		20.00  LDD0472  [14]
FFF probe3
 Probe Info  		18.63  LDD0464  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
BD-F
 Probe Info  		N.A.  LDD0024  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C74(0.74)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C74(1.03)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C126(0.77)  LDD0812  [17]
 LDCM0215  AC10 HEK-293T C126(1.65)  LDD0813  [17]
 LDCM0226  AC11 HEK-293T C126(1.10)  LDD0824  [17]
 LDCM0230  AC113 HEK-293T C126(0.58)  LDD0828  [17]
 LDCM0231  AC114 HEK-293T C126(0.65)  LDD0829  [17]
 LDCM0232  AC115 HEK-293T C126(1.06)  LDD0830  [17]
 LDCM0233  AC116 HEK-293T C126(0.77)  LDD0831  [17]
 LDCM0234  AC117 HEK-293T C126(0.91)  LDD0832  [17]
 LDCM0235  AC118 HEK-293T C126(0.70)  LDD0833  [17]
 LDCM0236  AC119 HEK-293T C126(0.89)  LDD0834  [17]
 LDCM0237  AC12 HEK-293T C126(1.30)  LDD0835  [17]
 LDCM0238  AC120 HEK-293T C126(1.78)  LDD0836  [17]
 LDCM0239  AC121 HEK-293T C126(0.81)  LDD0837  [17]
 LDCM0240  AC122 HEK-293T C126(0.77)  LDD0838  [17]
 LDCM0241  AC123 HEK-293T C126(0.91)  LDD0839  [17]
 LDCM0242  AC124 HEK-293T C126(0.81)  LDD0840  [17]
 LDCM0243  AC125 HEK-293T C126(0.92)  LDD0841  [17]
 LDCM0244  AC126 HEK-293T C126(0.54)  LDD0842  [17]
 LDCM0245  AC127 HEK-293T C126(0.25)  LDD0843  [17]
 LDCM0259  AC14 HEK-293T C126(1.66)  LDD0857  [17]
 LDCM0270  AC15 HEK-293T C126(1.46)  LDD0868  [17]
 LDCM0276  AC17 HEK-293T C97(1.03); C148(0.95); C306(1.11)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C97(1.10); C148(0.97); C306(1.15)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C97(1.01); C148(0.88); C306(0.89)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C126(1.19)  LDD0877  [17]
 LDCM0280  AC20 HEK-293T C148(0.86); C306(1.21)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C97(0.91); C148(0.87); C306(1.10)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C97(0.96); C148(0.90); C306(1.14)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C97(1.03); C148(0.89); C306(1.09)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C97(0.96); C148(0.81); C306(1.09)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C126(0.94)  LDD0883  [17]
 LDCM0286  AC26 HEK-293T C126(1.18)  LDD0884  [17]
 LDCM0287  AC27 HEK-293T C126(1.22)  LDD0885  [17]
 LDCM0288  AC28 HEK-293T C126(1.05)  LDD0886  [17]
 LDCM0289  AC29 HEK-293T C126(0.96)  LDD0887  [17]
 LDCM0290  AC3 HEK-293T C126(0.93)  LDD0888  [17]
 LDCM0291  AC30 HEK-293T C126(1.09)  LDD0889  [17]
 LDCM0292  AC31 HEK-293T C126(0.91)  LDD0890  [17]
 LDCM0293  AC32 HEK-293T C126(1.23)  LDD0891  [17]
 LDCM0294  AC33 HEK-293T C126(1.07)  LDD0892  [17]
 LDCM0295  AC34 HEK-293T C126(1.17)  LDD0893  [17]
 LDCM0296  AC35 HEK-293T C97(0.97); C148(0.90); C306(1.29)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C148(0.96); C306(1.14)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C97(0.96); C148(0.89); C306(1.13)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C97(1.14); C148(0.82); C306(1.12)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C97(1.00); C148(0.82); C306(0.96)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C126(0.77)  LDD0899  [17]
 LDCM0302  AC40 HEK-293T C97(0.91); C148(0.81); C306(1.01)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C97(0.94); C148(0.91); C306(1.12)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C97(1.02); C148(1.05); C306(1.22)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C97(1.01); C148(1.08); C306(1.14)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C148(0.86); C306(1.11)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C97(1.13); C148(0.88); C306(1.15)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C126(0.95)  LDD0906  [17]
 LDCM0309  AC47 HEK-293T C126(1.24)  LDD0907  [17]
 LDCM0310  AC48 HEK-293T C126(0.99)  LDD0908  [17]
 LDCM0311  AC49 HEK-293T C126(1.03)  LDD0909  [17]
 LDCM0312  AC5 HEK-293T C126(0.85)  LDD0910  [17]
 LDCM0313  AC50 HEK-293T C126(0.88)  LDD0911  [17]
 LDCM0314  AC51 HEK-293T C126(0.87)  LDD0912  [17]
 LDCM0315  AC52 HEK-293T C126(0.94)  LDD0913  [17]
 LDCM0316  AC53 HEK-293T C126(0.98)  LDD0914  [17]
 LDCM0317  AC54 HEK-293T C126(1.00)  LDD0915  [17]
 LDCM0318  AC55 HEK-293T C126(0.90)  LDD0916  [17]
 LDCM0319  AC56 HEK-293T C126(1.12)  LDD0917  [17]
 LDCM0320  AC57 HEK-293T C126(0.68)  LDD0918  [17]
 LDCM0321  AC58 HEK-293T C126(0.81)  LDD0919  [17]
 LDCM0322  AC59 HEK-293T C126(0.99)  LDD0920  [17]
 LDCM0323  AC6 HEK-293T C126(1.58)  LDD0921  [17]
 LDCM0324  AC60 HEK-293T C126(0.72)  LDD0922  [17]
 LDCM0325  AC61 HEK-293T C126(0.86)  LDD0923  [17]
 LDCM0326  AC62 HEK-293T C126(0.79)  LDD0924  [17]
 LDCM0327  AC63 HEK-293T C126(0.65)  LDD0925  [17]
 LDCM0328  AC64 HEK-293T C126(1.03)  LDD0926  [17]
 LDCM0329  AC65 HEK-293T C126(0.67)  LDD0927  [17]
 LDCM0330  AC66 HEK-293T C126(0.69)  LDD0928  [17]
 LDCM0331  AC67 HEK-293T C126(0.89)  LDD0929  [17]
 LDCM0334  AC7 HEK-293T C126(1.50)  LDD0932  [17]
 LDCM0345  AC8 HEK-293T C126(1.11)  LDD0943  [17]
 LDCM0349  AC83 HEK-293T C126(1.21)  LDD0947  [17]
 LDCM0350  AC84 HEK-293T C126(1.53)  LDD0948  [17]
 LDCM0351  AC85 HEK-293T C126(1.77)  LDD0949  [17]
 LDCM0352  AC86 HEK-293T C126(0.81)  LDD0950  [17]
 LDCM0353  AC87 HEK-293T C126(1.31)  LDD0951  [17]
 LDCM0354  AC88 HEK-293T C126(1.88)  LDD0952  [17]
 LDCM0355  AC89 HEK-293T C126(0.96)  LDD0953  [17]
 LDCM0357  AC90 HEK-293T C126(1.03)  LDD0955  [17]
 LDCM0358  AC91 HEK-293T C126(1.26)  LDD0956  [17]
 LDCM0359  AC92 HEK-293T C126(1.96)  LDD0957  [17]
 LDCM0360  AC93 HEK-293T C126(1.24)  LDD0958  [17]
 LDCM0361  AC94 HEK-293T C126(1.01)  LDD0959  [17]
 LDCM0362  AC95 HEK-293T C126(0.82)  LDD0960  [17]
 LDCM0363  AC96 HEK-293T C126(1.24)  LDD0961  [17]
 LDCM0364  AC97 HEK-293T C126(0.84)  LDD0962  [17]
 LDCM0248  AKOS034007472 HEK-293T C126(1.57)  LDD0846  [17]
 LDCM0356  AKOS034007680 HEK-293T C126(1.56)  LDD0954  [17]
 LDCM0275  AKOS034007705 HEK-293T C126(1.59)  LDD0873  [17]
 LDCM0156  Aniline NCI-H1299 14.83  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C126(0.82)  LDD0965  [17]
 LDCM0368  CL10 HEK-293T C126(0.71)  LDD0966  [17]
 LDCM0369  CL100 HEK-293T C126(0.93)  LDD0967  [17]
 LDCM0370  CL101 HEK-293T C126(1.18)  LDD0968  [17]
 LDCM0371  CL102 HEK-293T C126(1.11)  LDD0969  [17]
 LDCM0372  CL103 HEK-293T C126(1.27)  LDD0970  [17]
 LDCM0373  CL104 HEK-293T C126(1.49)  LDD0971  [17]
 LDCM0374  CL105 HEK-293T C97(0.98); C148(0.89); C306(1.09)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C97(1.30); C148(0.99); C306(1.00)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C97(0.90); C148(0.91); C306(1.09)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C97(1.01); C148(1.07); C306(1.20)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C97(0.97); C148(1.08); C306(1.07)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C126(0.99)  LDD0977  [17]
 LDCM0380  CL110 HEK-293T C97(1.31); C148(1.02); C306(0.93)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C97(1.10); C148(0.94); C306(1.04)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C126(1.02)  LDD0980  [17]
 LDCM0383  CL113 HEK-293T C126(1.13)  LDD0981  [17]
 LDCM0384  CL114 HEK-293T C126(0.80)  LDD0982  [17]
 LDCM0385  CL115 HEK-293T C126(1.18)  LDD0983  [17]
 LDCM0386  CL116 HEK-293T C126(1.09)  LDD0984  [17]
 LDCM0387  CL117 HEK-293T C97(0.99); C148(1.04); C306(1.28)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C97(1.13); C148(0.96); C306(1.06)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C97(0.99); C148(0.91); C306(1.15)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C126(1.28)  LDD0988  [17]
 LDCM0391  CL120 HEK-293T C97(0.84); C148(1.01); C306(1.16)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C126(0.87)  LDD0990  [17]
 LDCM0393  CL122 HEK-293T C126(0.68)  LDD0991  [17]
 LDCM0394  CL123 HEK-293T C126(0.79)  LDD0992  [17]
 LDCM0395  CL124 HEK-293T C126(0.91)  LDD0993  [17]
 LDCM0396  CL125 HEK-293T C126(0.73)  LDD0994  [17]
 LDCM0397  CL126 HEK-293T C126(0.73)  LDD0995  [17]
 LDCM0398  CL127 HEK-293T C126(0.70)  LDD0996  [17]
 LDCM0399  CL128 HEK-293T C126(0.76)  LDD0997  [17]
 LDCM0400  CL13 HEK-293T C126(0.85)  LDD0998  [17]
 LDCM0401  CL14 HEK-293T C126(1.26)  LDD0999  [17]
 LDCM0402  CL15 HEK-293T C126(0.89)  LDD1000  [17]
 LDCM0403  CL16 HEK-293T C126(0.94)  LDD1001  [17]
 LDCM0404  CL17 HEK-293T C126(0.76)  LDD1002  [17]
 LDCM0405  CL18 HEK-293T C126(1.15)  LDD1003  [17]
 LDCM0406  CL19 HEK-293T C126(0.99)  LDD1004  [17]
 LDCM0407  CL2 HEK-293T C126(1.08)  LDD1005  [17]
 LDCM0408  CL20 HEK-293T C126(1.51)  LDD1006  [17]
 LDCM0409  CL21 HEK-293T C126(0.82)  LDD1007  [17]
 LDCM0410  CL22 HEK-293T C126(0.85)  LDD1008  [17]
 LDCM0411  CL23 HEK-293T C126(0.99)  LDD1009  [17]
 LDCM0412  CL24 HEK-293T C126(1.26)  LDD1010  [17]
 LDCM0413  CL25 HEK-293T C126(0.56)  LDD1011  [17]
 LDCM0414  CL26 HEK-293T C126(0.85)  LDD1012  [17]
 LDCM0415  CL27 HEK-293T C126(0.74)  LDD1013  [17]
 LDCM0416  CL28 HEK-293T C126(1.05)  LDD1014  [17]
 LDCM0417  CL29 HEK-293T C126(0.93)  LDD1015  [17]
 LDCM0418  CL3 HEK-293T C126(0.79)  LDD1016  [17]
 LDCM0419  CL30 HEK-293T C126(1.02)  LDD1017  [17]
 LDCM0420  CL31 HEK-293T C126(0.85)  LDD1018  [17]
 LDCM0421  CL32 HEK-293T C126(0.86)  LDD1019  [17]
 LDCM0422  CL33 HEK-293T C126(0.82)  LDD1020  [17]
 LDCM0423  CL34 HEK-293T C126(0.74)  LDD1021  [17]
 LDCM0424  CL35 HEK-293T C126(1.03)  LDD1022  [17]
 LDCM0425  CL36 HEK-293T C126(0.88)  LDD1023  [17]
 LDCM0426  CL37 HEK-293T C126(0.98)  LDD1024  [17]
 LDCM0428  CL39 HEK-293T C126(0.76)  LDD1026  [17]
 LDCM0429  CL4 HEK-293T C126(1.17)  LDD1027  [17]
 LDCM0430  CL40 HEK-293T C126(0.90)  LDD1028  [17]
 LDCM0431  CL41 HEK-293T C126(0.72)  LDD1029  [17]
 LDCM0432  CL42 HEK-293T C126(0.82)  LDD1030  [17]
 LDCM0433  CL43 HEK-293T C126(0.90)  LDD1031  [17]
 LDCM0434  CL44 HEK-293T C126(1.14)  LDD1032  [17]
 LDCM0435  CL45 HEK-293T C126(0.73)  LDD1033  [17]
 LDCM0436  CL46 HEK-293T C126(0.78)  LDD1034  [17]
 LDCM0437  CL47 HEK-293T C126(0.90)  LDD1035  [17]
 LDCM0438  CL48 HEK-293T C126(0.82)  LDD1036  [17]
 LDCM0439  CL49 HEK-293T C126(0.77)  LDD1037  [17]
 LDCM0440  CL5 HEK-293T C126(0.98)  LDD1038  [17]
 LDCM0441  CL50 HEK-293T C126(0.59)  LDD1039  [17]
 LDCM0442  CL51 HEK-293T C126(0.62)  LDD1040  [17]
 LDCM0443  CL52 HEK-293T C126(1.09)  LDD1041  [17]
 LDCM0444  CL53 HEK-293T C126(0.81)  LDD1042  [17]
 LDCM0445  CL54 HEK-293T C126(0.97)  LDD1043  [17]
 LDCM0446  CL55 HEK-293T C126(0.97)  LDD1044  [17]
 LDCM0447  CL56 HEK-293T C126(0.79)  LDD1045  [17]
 LDCM0448  CL57 HEK-293T C126(0.54)  LDD1046  [17]
 LDCM0449  CL58 HEK-293T C126(0.85)  LDD1047  [17]
 LDCM0450  CL59 HEK-293T C126(0.84)  LDD1048  [17]
 LDCM0451  CL6 HEK-293T C126(0.93)  LDD1049  [17]
 LDCM0452  CL60 HEK-293T C126(0.79)  LDD1050  [17]
 LDCM0453  CL61 HEK-293T C126(1.18)  LDD1051  [17]
 LDCM0454  CL62 HEK-293T C126(1.21)  LDD1052  [17]
 LDCM0455  CL63 HEK-293T C126(1.68)  LDD1053  [17]
 LDCM0456  CL64 HEK-293T C126(0.70)  LDD1054  [17]
 LDCM0457  CL65 HEK-293T C126(1.68)  LDD1055  [17]
 LDCM0458  CL66 HEK-293T C126(1.11)  LDD1056  [17]
 LDCM0459  CL67 HEK-293T C126(0.88)  LDD1057  [17]
 LDCM0460  CL68 HEK-293T C126(1.41)  LDD1058  [17]
 LDCM0461  CL69 HEK-293T C126(1.11)  LDD1059  [17]
 LDCM0462  CL7 HEK-293T C126(1.17)  LDD1060  [17]
 LDCM0463  CL70 HEK-293T C126(1.47)  LDD1061  [17]
 LDCM0464  CL71 HEK-293T C126(0.97)  LDD1062  [17]
 LDCM0465  CL72 HEK-293T C126(1.46)  LDD1063  [17]
 LDCM0466  CL73 HEK-293T C126(0.96)  LDD1064  [17]
 LDCM0467  CL74 HEK-293T C126(1.17)  LDD1065  [17]
 LDCM0469  CL76 HEK-293T C126(1.25)  LDD1067  [17]
 LDCM0470  CL77 HEK-293T C126(1.07)  LDD1068  [17]
 LDCM0471  CL78 HEK-293T C126(2.04)  LDD1069  [17]
 LDCM0472  CL79 HEK-293T C126(1.65)  LDD1070  [17]
 LDCM0473  CL8 HEK-293T C126(0.95)  LDD1071  [17]
 LDCM0474  CL80 HEK-293T C126(1.17)  LDD1072  [17]
 LDCM0475  CL81 HEK-293T C126(1.38)  LDD1073  [17]
 LDCM0476  CL82 HEK-293T C126(1.29)  LDD1074  [17]
 LDCM0477  CL83 HEK-293T C126(1.02)  LDD1075  [17]
 LDCM0478  CL84 HEK-293T C126(1.54)  LDD1076  [17]
 LDCM0479  CL85 HEK-293T C126(1.44)  LDD1077  [17]
 LDCM0480  CL86 HEK-293T C126(1.78)  LDD1078  [17]
 LDCM0481  CL87 HEK-293T C126(1.57)  LDD1079  [17]
 LDCM0482  CL88 HEK-293T C126(1.31)  LDD1080  [17]
 LDCM0483  CL89 HEK-293T C126(1.79)  LDD1081  [17]
 LDCM0484  CL9 HEK-293T C126(1.09)  LDD1082  [17]
 LDCM0485  CL90 HEK-293T C126(1.07)  LDD1083  [17]
 LDCM0486  CL91 HEK-293T C126(0.81)  LDD1084  [17]
 LDCM0487  CL92 HEK-293T C126(0.96)  LDD1085  [17]
 LDCM0488  CL93 HEK-293T C126(0.69)  LDD1086  [17]
 LDCM0489  CL94 HEK-293T C126(0.66)  LDD1087  [17]
 LDCM0490  CL95 HEK-293T C126(0.88)  LDD1088  [17]
 LDCM0491  CL96 HEK-293T C126(0.78)  LDD1089  [17]
 LDCM0492  CL97 HEK-293T C126(0.73)  LDD1090  [17]
 LDCM0493  CL98 HEK-293T C126(1.06)  LDD1091  [17]
 LDCM0494  CL99 HEK-293T C126(0.81)  LDD1092  [17]
 LDCM0097  Dasatinib K562 5.40  LDD0270  [2]
 LDCM0495  E2913 HEK-293T C97(0.99); C148(0.81); C306(1.16)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C74(5.02); C306(3.36)  LDD1702  [5]
 LDCM0625  F8 Ramos C306(1.15); C126(1.94)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C306(0.57); C126(0.87)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C306(0.17); C126(2.83)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C306(0.62); C126(1.03)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C306(1.00); C126(1.27)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C306(0.81); C126(0.69)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C306(0.68); C126(0.81)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C306(0.78); C126(1.03)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C306(0.57); C126(1.25)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C306(0.81); C126(1.31)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C306(0.68)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C306(0.82); C126(0.98)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C306(0.48); C126(0.89)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C306(0.50); C126(0.71)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C126(1.06)  LDD1066  [17]
 LDCM0596  Fragment38 Ramos C306(0.63); C126(0.97)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C306(0.62); C126(1.20)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C126(0.96)  LDD1025  [17]
 LDCM0610  Fragment52 Ramos C306(1.10)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C306(0.96); C126(1.00)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C306(0.56); C126(1.23)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C306(0.71); C126(0.85)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HEK-293T C126(0.96); C97(1.03); C306(1.12); C148(1.00)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C126(0.97); C97(1.03); C306(0.99); C148(0.84)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C97(1.19); C74(1.92)  LDD3310  [3]
 LDCM0109  NEM HeLa N.A.  LDD0225  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C74(1.06)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(0.93)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C74(0.87)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C74(1.07)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(2.16)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C74(0.97)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C74(0.79)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(0.78)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C74(0.90)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C74(1.79)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C74(1.09)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C74(0.87)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C74(1.08)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C74(2.08)  LDD2144  [5]
 LDCM0131  RA190 MM1.R C97(1.43)  LDD0304  [20]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin A Small molecular drug DB00162

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.