Details of the Target

General Information of Target

Target ID LDTP12820
Target Name Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)
Gene Name TERF2IP
Gene ID 54386
Synonyms
DRIP5; RAP1; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRap1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRL
HIKFKDSVINVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATAR
PAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHIN
SNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISW
WGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVEST
AAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC
SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVAL
AKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQL
LKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKN
FHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGR
SLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVD
SGVGGPQQTVGEVGLPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDP
EIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPE
SSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGS
VASISHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEF
SFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVK
SPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDV
IQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSD
TEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCG
NVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS
Target Bioclass
Transcription factor
Family
RAP1 family
Subcellular location
Nucleus
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Uniprot ID
Q9NYB0
Ensemble ID
ENST00000300086.5
HGNC ID
HGNC:19246
ChEMBL ID
CHEMBL3751647

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K165(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y238(31.69); Y359(18.29)  LDD3495  [3]
DBIA
 Probe Info  		C54(2.32)  LDD3315  [4]
HHS-465
 Probe Info  		Y32(10.00)  LDD2237  [5]
5E-2FA
 Probe Info  		H193(0.00); H48(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C54(0.00); C87(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		C54(0.00); C87(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C223
 Probe Info  		6.73  LDD1897  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C54(0.80)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C54(0.84)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C54(0.96)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C54(0.82)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C54(1.01)  LDD1512  [12]
 LDCM0276  AC17 HEK-293T C54(1.07)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C54(0.86)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C54(0.90)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C54(0.89)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C54(1.01)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C54(1.03)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C54(0.93)  LDD1521  [12]
 LDCM0284  AC24 HEK-293T C54(1.15)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C54(0.91)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C54(1.00)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C54(1.09)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C54(0.91)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C54(0.98)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C54(1.01)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C54(1.06)  LDD1530  [12]
 LDCM0293  AC32 HEK-293T C54(0.95)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C54(0.95)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C54(0.88)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C54(1.13)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C54(1.11)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C54(1.22)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C54(1.09)  LDD1538  [12]
 LDCM0301  AC4 HEK-293T C54(0.88)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C54(0.96)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C54(0.97)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C54(0.84)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C54(1.02)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C54(0.80)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C54(1.13)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C54(0.98)  LDD1547  [12]
 LDCM0310  AC48 HEK-293T C54(1.00)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C54(0.85)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C54(1.15)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C54(0.80)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C54(1.05)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C54(1.10)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C54(1.12)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C54(0.90)  LDD1556  [12]
 LDCM0319  AC56 HEK-293T C54(0.95)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C54(0.93)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C54(0.95)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C54(1.05)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C54(1.01)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C54(0.99)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C54(1.00)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C54(0.98)  LDD1565  [12]
 LDCM0328  AC64 HEK-293T C54(1.08)  LDD1567  [12]
 LDCM0345  AC8 HEK-293T C54(1.07)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C54(1.09)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C54(0.98)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C54(1.01)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C54(0.96)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C54(0.98)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C54(0.91)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C54(0.97)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C54(0.95)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C54(0.90)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C54(1.00)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C54(1.06)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C54(0.94)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C54(0.99)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C54(0.94)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C54(0.95)  LDD1582  [12]
 LDCM0380  CL110 HEK-293T C54(0.89)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C54(1.04)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C54(1.00)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C54(0.99)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C54(0.88)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C54(1.06)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C54(1.04)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C54(1.08)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C54(1.04)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C54(1.07)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C54(1.01)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C54(1.11)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C54(0.97)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C54(0.96)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C54(0.81)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C54(0.94)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C54(1.02)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C54(0.97)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C54(0.96)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C54(1.02)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C54(0.89)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C54(1.00)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C54(0.89)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C54(1.09)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C54(0.77)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C54(0.79)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C54(1.02)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C54(1.06)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C54(1.10)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C54(0.92)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C54(1.05)  LDD1614  [12]
 LDCM0412  CL24 HEK-293T C54(1.11)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C54(0.85)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C54(1.02)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C54(1.09)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C54(1.04)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C54(0.96)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C54(0.97)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C54(0.89)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C54(0.95)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C54(1.03)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C54(0.93)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C54(1.09)  LDD1627  [12]
 LDCM0425  CL36 HEK-293T C54(1.02)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C54(0.90)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C54(1.07)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C54(1.02)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C54(1.03)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C54(1.08)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C54(0.79)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C54(0.98)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C54(1.26)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C54(0.91)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C54(1.13)  LDD1640  [12]
 LDCM0438  CL48 HEK-293T C54(0.97)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C54(1.04)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C54(0.83)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C54(0.98)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C54(1.01)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C54(0.80)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C54(0.84)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C54(1.14)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C54(0.69)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C54(1.03)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C54(1.17)  LDD1652  [12]
 LDCM0451  CL6 HEK-293T C54(0.75)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C54(1.05)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C54(1.12)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C54(1.16)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C54(1.07)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C54(0.91)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C54(0.91)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C54(0.87)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C54(1.13)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C54(0.94)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C54(1.03)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C54(0.99)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C54(1.07)  LDD1666  [12]
 LDCM0465  CL72 HEK-293T C54(1.03)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C54(1.02)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C54(1.03)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C54(1.06)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C54(0.91)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C54(0.90)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C54(1.01)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C54(0.91)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C54(1.21)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C54(1.03)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C54(1.15)  LDD1679  [12]
 LDCM0478  CL84 HEK-293T C54(1.07)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C54(0.93)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C54(0.92)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C54(0.97)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C54(0.98)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C54(0.98)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C54(0.95)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C54(0.64)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C54(0.97)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C54(1.05)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C54(1.07)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C54(1.10)  LDD1692  [12]
 LDCM0491  CL96 HEK-293T C54(0.87)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C54(0.88)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C54(0.95)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C54(1.02)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C54(1.16)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C54(1.05)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C54(0.97)  LDD1631  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C54(0.97)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C54(0.96)  LDD1497  [12]
 LDCM0024  KB05 IGR39 C54(2.32)  LDD3315  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aldo-keto reductase family 1 member A1 (AKR1A1) Aldo/keto reductase family P14550
Aldo-keto reductase family 1 member B10 (AKR1B10) Aldo/keto reductase family O60218
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) Aldo/keto reductase family O95154
Selenocysteine lyase (SCLY) Class-V pyridoxal-phosphate-dependent aminotransferase family Q96I15
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38) DEAD box helicase family Q92620
DNA polymerase delta catalytic subunit (POLD1) DNA polymerase type-B family P28340
6-phosphogluconolactonase (PGLS) Glucosamine/galactosamine-6-phosphate isomerase family O95336
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
DNA replication licensing factor MCM2 (MCM2) MCM family P49736
Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) Glyoxalase II family Q16775
8-oxo-dGDP phosphatase NUDT18 (NUDT18) Nudix hydrolase family Q6ZVK8
Uridine diphosphate glucose pyrophosphatase NUDT14 (NUDT14) Nudix hydrolase family O95848
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Serine hydrolase RBBP9 (RBBP9) RBBP9 family O75884
Transaldolase (TALDO1) Transaldolase family P37837
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein B3 (HMGB3) HMGB family O15347
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
SWI/SNF complex subunit SMARCC2 (SMARCC2) SMARCC family Q8TAQ2
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-1 receptor antagonist protein (IL1RN) IL-1 family P18510
Other
Click To Hide/Show 45 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coactosin-like protein (COTL1) Actin-binding proteins ADF family Q14019
Twinfilin-2 (TWF2) Actin-binding proteins ADF family Q6IBS0
BRISC and BRCA1-A complex member 1 (BABAM1) BABAM1 family Q9NWV8
B-cell CLL/lymphoma 7 protein family member B (BCL7B) BCL7 family Q9BQE9
Calmodulin-like protein 3 (CALML3) Calmodulin family P27482
Fatty acid-binding protein, intestinal (FABP2) Fatty-acid binding protein (FABP) family P12104
Copine-2 (CPNE2) Copine family Q96FN4
Adapter molecule crk (CRK) CRK family P46108
Guanine nucleotide exchange factor MSS4 (RABIF) DSS4/MSS4 family P47224
Protein enabled homolog (ENAH) Ena/VASP family Q8N8S7
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) EPS8 family Q8TE68
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR1) FAM122 family Q96E09
G antigen 5 (GAGE5) GAGE family Q13069
X antigen family member 2 (XAGE2) GAGE family Q96GT9
High mobility group nucleosome-binding domain-containing protein 4 (HMGN4) HMGN family O00479
LanC-like protein 2 (LANCL2) LanC-like protein family Q9NS86
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Metallothionein-1X (MT1X) Type 1 family P80297
Metallothionein-3 (MT3) Type 1 family P25713
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Nuclear autoantigenic sperm protein (NASP) NASP family P49321
Opioid growth factor receptor (OGFR) Opioid growth factor receptor family Q9NZT2
Calmodulin regulator protein PCP4 (PCP4) PCP4 family P48539
Periaxin (PRX) Periaxin family Q9BXM0
Prothymosin alpha (PTMA) Pro/parathymosin family P06454
Repulsive guidance molecule A (RGMA) Repulsive guidance molecule (RGM) family Q96B86
Protein S100-P (S100P) S-100 family P25815
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) SAPS family Q5H9R7
Structure-specific endonuclease subunit SLX4 (SLX4) SLX4 family Q8IY92
Charged multivesicular body protein 2b (CHMP2B) SNF7 family Q9UQN3
Tubulin-specific chaperone A (TBCA) TBCA family O75347
Thymosin beta-4, Y-chromosomal (TMSB4Y) Thymosin beta family O14604
Splicing factor C9orf78 (C9orf78) TLS1 family Q9NZ63
Torsin-1A-interacting protein 1 (TOR1AIP1) TOR1AIP family Q5JTV8
U5 small nuclear ribonucleoprotein TSSC4 (TSSC4) TSSC4 family Q9Y5U2
mRNA turnover protein 4 homolog (MRTO4) Universal ribosomal protein uL10 family Q9UKD2
UPF0688 protein C1orf174 (C1orf174) UPF0688 family Q8IYL3
Transcription cofactor vestigial-like protein 4 (VGLL4) Vestigial family Q14135
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Astrocytic phosphoprotein PEA-15 (PEA15) . Q15121
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Nuclear mitotic apparatus protein 1 (NUMA1) . Q14980
PEST proteolytic signal-containing nuclear protein (PCNP) . Q8WW12
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402