Details of the Target

General Information of Target

Target ID LDTP03380
Target Name Stomatin (STOM)
Gene Name STOM
Gene ID 2040
Synonyms
BND7; EPB72; Stomatin; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2; Protein 7.2b
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEY
ERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDG
VVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDD
ATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMV
ITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Target Bioclass
Transporter and channel
Family
Band 7/mec-2 family
Subcellular location
Cell membrane
Function Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Uniprot ID
P27105
Ensemble ID
ENST00000286713.7
HGNC ID
HGNC:3383

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.Y252Ter DBIA    Probe Info 
HEC1 SNV: p.A219T .
HEC1B SNV: p.A219T .
TYKNU SNV: p.T157I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [2]
AZ-9
 Probe Info  		E225(10.00)  LDD2209  [3]
OPA-S-S-alkyne
 Probe Info  		K235(4.28); K198(5.83); K58(6.87)  LDD3494  [4]
DBIA
 Probe Info  		C87(3.07)  LDD3315  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
MPP-AC
 Probe Info  		N.A.  LDD0428  [8]
TER-AC
 Probe Info  		N.A.  LDD0426  [8]
PAL-AfBPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		14.93  LDD1728  [9]
C045
 Probe Info  		4.99  LDD1744  [9]
C063
 Probe Info  		10.56  LDD1760  [9]
C064
 Probe Info  		6.02  LDD1761  [9]
C070
 Probe Info  		12.13  LDD1766  [9]
C072
 Probe Info  		9.45  LDD1768  [9]
C106
 Probe Info  		27.47  LDD1793  [9]
C107
 Probe Info  		10.78  LDD1794  [9]
C108
 Probe Info  		11.08  LDD1795  [9]
C112
 Probe Info  		39.67  LDD1799  [9]
C115
 Probe Info  		5.50  LDD1802  [9]
C130
 Probe Info  		7.16  LDD1812  [9]
C134
 Probe Info  		28.84  LDD1816  [9]
C135
 Probe Info  		9.71  LDD1817  [9]
C140
 Probe Info  		8.22  LDD1822  [9]
C141
 Probe Info  		16.22  LDD1823  [9]
C143
 Probe Info  		17.88  LDD1825  [9]
C153
 Probe Info  		18.90  LDD1834  [9]
C163
 Probe Info  		7.26  LDD1843  [9]
C170
 Probe Info  		18.00  LDD1850  [9]
C177
 Probe Info  		7.89  LDD1856  [9]
C178
 Probe Info  		17.88  LDD1857  [9]
C187
 Probe Info  		30.91  LDD1865  [9]
C194
 Probe Info  		13.83  LDD1870  [9]
C197
 Probe Info  		10.56  LDD1873  [9]
C198
 Probe Info  		13.64  LDD1874  [9]
C201
 Probe Info  		36.76  LDD1877  [9]
C208
 Probe Info  		7.46  LDD1883  [9]
C211
 Probe Info  		8.75  LDD1885  [9]
C220
 Probe Info  		14.22  LDD1894  [9]
C223
 Probe Info  		8.75  LDD1897  [9]
C225
 Probe Info  		6.92  LDD1898  [9]
C226
 Probe Info  		6.06  LDD1899  [9]
C280
 Probe Info  		10.34  LDD1950  [9]
C282
 Probe Info  		14.83  LDD1952  [9]
C287
 Probe Info  		9.78  LDD1957  [9]
C293
 Probe Info  		24.25  LDD1963  [9]
C296
 Probe Info  		14.83  LDD1966  [9]
C299
 Probe Info  		5.70  LDD1968  [9]
C302
 Probe Info  		5.46  LDD1971  [9]
C314
 Probe Info  		11.88  LDD1981  [9]
C343
 Probe Info  		12.21  LDD2005  [9]
C346
 Probe Info  		16.56  LDD2007  [9]
C348
 Probe Info  		9.92  LDD2009  [9]
C349
 Probe Info  		10.41  LDD2010  [9]
C350
 Probe Info  		35.26  LDD2011  [9]
C362
 Probe Info  		40.22  LDD2023  [9]
C363
 Probe Info  		22.94  LDD2024  [9]
C364
 Probe Info  		17.15  LDD2025  [9]
C376
 Probe Info  		7.57  LDD2036  [9]
C382
 Probe Info  		8.82  LDD2041  [9]
C399
 Probe Info  		8.00  LDD2058  [9]
STS-1
 Probe Info  		N.A.  LDD0137  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C87(1.00)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C87(0.99)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C87(0.87)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C87(1.14)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C87(1.02)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C87(1.01)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C87(1.07)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C87(0.95)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C87(0.74)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C87(0.97)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C87(1.08)  LDD1519  [12]
 LDCM0282  AC22 HEK-293T C87(1.09)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C87(0.96)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C87(0.94)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C87(1.02)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C87(0.89)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C87(0.81)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C87(1.00)  LDD1527  [12]
 LDCM0290  AC3 HEK-293T C87(0.92)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C87(0.94)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C87(1.00)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C87(1.00)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C87(1.00)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C87(0.97)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C87(0.83)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C87(0.97)  LDD1536  [12]
 LDCM0299  AC38 HEK-293T C87(0.86)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C87(0.98)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C87(0.98)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C87(1.01)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C87(1.00)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C87(0.99)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C87(0.98)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C87(1.00)  LDD1545  [12]
 LDCM0308  AC46 HEK-293T C87(0.90)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C87(1.05)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C87(1.01)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C87(1.08)  LDD1550  [12]
 LDCM0313  AC50 HEK-293T C87(1.00)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C87(0.98)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C87(1.03)  LDD1554  [12]
 LDCM0317  AC54 HEK-293T C87(0.96)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C87(0.98)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C87(1.08)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C87(1.06)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C87(1.02)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C87(0.94)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C87(0.89)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C87(1.15)  LDD1563  [12]
 LDCM0326  AC62 HEK-293T C87(1.03)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C87(1.07)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C87(1.01)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C87(0.92)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C87(0.97)  LDD1569  [12]
 LDCM0356  AKOS034007680 HEK-293T C87(1.06)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C87(1.08)  LDD1514  [12]
 LDCM0367  CL1 HEK-293T C87(1.27)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C87(1.23)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C87(1.15)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C87(1.06)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C87(1.09)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C87(0.87)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C87(1.11)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C87(1.01)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C87(1.04)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C87(0.99)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C87(0.97)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C87(1.13)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C87(1.13)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C87(1.09)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C87(1.16)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C87(0.82)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C87(0.99)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C87(1.25)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C87(0.87)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C87(0.83)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C87(1.00)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C87(1.14)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C87(0.94)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C87(1.11)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C87(0.82)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C87(1.04)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C87(1.06)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C87(1.31)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C87(1.06)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C87(1.10)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C87(1.08)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C87(1.07)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C87(1.03)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C87(1.07)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C87(1.14)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C87(1.35)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C87(1.07)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C87(1.33)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C87(1.03)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C87(0.99)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C87(1.00)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C87(1.16)  LDD1612  [12]
 LDCM0410  CL22 HEK-293T C87(1.13)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C87(1.06)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C87(1.26)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C87(1.37)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C87(1.16)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C87(0.87)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C87(0.98)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C87(0.96)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C87(1.03)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C87(0.96)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C87(0.90)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C87(1.13)  LDD1625  [12]
 LDCM0423  CL34 HEK-293T C87(1.11)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C87(1.16)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C87(1.16)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C87(1.11)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C87(0.93)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C87(0.87)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C87(0.84)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C87(1.17)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C87(0.98)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C87(0.91)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C87(1.05)  LDD1638  [12]
 LDCM0436  CL46 HEK-293T C87(1.03)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C87(1.06)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C87(1.23)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C87(1.09)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C87(1.07)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C87(1.06)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C87(0.96)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C87(1.16)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C87(1.51)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C87(1.06)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C87(1.01)  LDD1650  [12]
 LDCM0449  CL58 HEK-293T C87(1.08)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C87(1.12)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C87(1.11)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C87(1.07)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C87(1.13)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C87(1.12)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C87(0.98)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C87(0.88)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C87(1.01)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C87(1.00)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C87(1.07)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C87(1.10)  LDD1663  [12]
 LDCM0462  CL7 HEK-293T C87(0.95)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C87(0.94)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C87(1.00)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C87(1.07)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C87(1.18)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C87(1.23)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C87(0.88)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C87(1.24)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C87(0.97)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C87(0.91)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C87(2.27)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C87(0.99)  LDD1677  [12]
 LDCM0476  CL82 HEK-293T C87(0.93)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C87(1.20)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C87(1.01)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C87(1.10)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C87(1.07)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C87(0.95)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C87(1.06)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C87(1.00)  LDD1686  [12]
 LDCM0485  CL90 HEK-293T C87(1.37)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C87(0.83)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C87(1.08)  LDD1690  [12]
 LDCM0489  CL94 HEK-293T C87(1.05)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C87(1.23)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C87(1.12)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C87(1.17)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C87(1.03)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C87(1.04)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C87(0.91)  LDD1698  [12]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0468  Fragment33 HEK-293T C87(0.90)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C87(1.11)  LDD1631  [12]
 LDCM0022  KB02 A2058 C87(1.25)  LDD2253  [5]
 LDCM0023  KB03 A2058 C87(2.23)  LDD2670  [5]
 LDCM0024  KB05 IGR39 C87(3.07)  LDD3315  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol lipase-alpha (DAGLA) Lipase family Q9Y4D2
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Pepsin A-4 (PGA4) Peptidase A1 family P0DJD7
Matrix metalloproteinase-14 (MMP14) Peptidase M10A family P50281
Complement C2 (C2) Peptidase S1 family P06681
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Carbohydrate sulfotransferase 1 (CHST1) Sulfotransferase 1 family O43916
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) V-ATPase proteolipid subunit family P27449
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) V-ATPase proteolipid subunit family Q99437
Transporter and channel
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Band 3 anion transport protein (SLC4A1) Anion exchanger (TC 2.A.31) family P02730
Apolipoprotein A-II (APOA2) Apolipoprotein A2 family P02652
Stomatin (STOM) Band 7/mec-2 family P27105
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Clarin-2 (CLRN2) Clarin family A0PK11
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Sideroflexin-1 (SFXN1) Sideroflexin family Q9H9B4
Syntaxin-6 (STX6) Syntaxin family O43752
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Potassium channel subfamily K member 1 (KCNK1) Two pore domain potassium channel (TC 1.A.1.8) family O00180
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) X(+)/potassium ATPases subunit beta family P54709
Transmembrane protein 203 (TMEM203) . Q969S6
Transmembrane protein 60 (TMEM60) . Q9H2L4
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) . Q9BVC6
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin-like protein 1 (STOML1) Band 7/mec-2 family Q9UBI4
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LEM family P42167
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Protein reprimo (RPRM) Reprimo family Q9NS64
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Sideroflexin-5 (SFXN5) Sideroflexin family Q8TD22
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Transmembrane protein 98 (TMEM98) TMEM98 family Q9Y2Y6
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane protein 140 (TMEM140) . Q9NV12
Transmembrane protein 254 (TMEM254) . Q8TBM7
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402