Details of the Target

General Information of Target

Target ID LDTP02776
Target Name Arylsulfatase A (ARSA)
Gene Name ARSA
Gene ID 410
Synonyms
Arylsulfatase A; ASA; EC 3.1.6.8; Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
EDPALQICCHPGCTPRPACCHCPDPHA
Target Type
Successful
Target Bioclass
Enzyme
Family
Sulfatase family
Subcellular location
Endoplasmic reticulum
Function Hydrolyzes cerebroside sulfate.
TTD ID
T98157
Uniprot ID
P15289
DrugMap ID
TTYQANR
Ensemble ID
ENST00000453344.6
HGNC ID
HGNC:713
ChEMBL ID
CHEMBL2193

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.02  LDD0324  [1]
DBIA
 Probe Info  		C493(1.17); C489(1.02)  LDD1507  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C073
 Probe Info  		5.62  LDD1769  [5]
C170
 Probe Info  		11.31  LDD1850  [5]
C171
 Probe Info  		6.50  LDD1851  [5]
C223
 Probe Info  		10.70  LDD1897  [5]
C225
 Probe Info  		5.90  LDD1898  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C493(1.17); C489(1.02)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C493(0.98); C488(1.22)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C493(1.10)  LDD1512  [2]
 LDCM0276  AC17 HEK-293T C493(1.10); C489(1.13)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C493(1.03); C488(0.87)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C493(1.17); C488(1.44)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C493(0.96)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C493(0.92)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C489(0.82); C500(0.97)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C493(1.46); C489(1.14)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C493(1.06); C488(0.80)  LDD1525  [2]
 LDCM0289  AC29 HEK-293T C493(0.99)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C493(0.72)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C489(0.93); C500(0.82)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C493(1.93); C489(1.21)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C493(1.02); C488(1.94)  LDD1534  [2]
 LDCM0298  AC37 HEK-293T C493(1.01)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C493(1.06)  LDD1538  [2]
 LDCM0302  AC40 HEK-293T C489(0.78); C500(0.99)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C493(1.15); C489(1.31)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C493(1.00); C488(1.53)  LDD1543  [2]
 LDCM0307  AC45 HEK-293T C493(1.12)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C493(1.01)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C489(0.88); C500(1.00)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C493(1.19); C489(1.01)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C493(0.87)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C493(0.88); C488(1.35)  LDD1552  [2]
 LDCM0316  AC53 HEK-293T C493(0.97)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C493(0.87)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C489(0.74); C500(0.91)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C493(1.47); C489(1.17)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C493(1.14); C488(0.95)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C493(0.71)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C493(0.90)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C493(0.77)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C489(0.83); C500(0.94)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C489(0.85); C500(0.91)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C493(0.93)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C493(1.08); C489(1.00)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C489(0.82); C500(1.15)  LDD1514  [2]
 LDCM0368  CL10 HEK-293T C493(0.84)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C493(1.12); C489(1.15)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C493(1.02)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C493(1.29); C489(0.97)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C493(1.14); C489(1.03)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C493(0.97)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C493(0.77); C489(1.26)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C493(1.01); C489(1.31)  LDD1581  [2]
 LDCM0380  CL110 HEK-293T C493(1.40)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C493(0.95); C489(0.84)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C493(0.92); C489(1.09)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C493(1.23)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C493(0.88); C489(1.06)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C493(1.00); C489(1.01)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C493(1.37)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C493(0.89); C489(0.93)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C489(0.77); C500(0.96)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C493(1.20); C489(0.95)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C493(1.13)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C493(1.16); C489(1.42)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C493(1.17); C489(1.23)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C493(1.19)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C493(0.96); C489(1.05)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C493(1.02); C489(1.05)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C493(1.10)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C493(1.00); C489(1.04)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C493(1.08); C489(0.99)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C493(1.55); C489(1.00)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C493(0.94); C488(0.90)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C493(1.12)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C493(1.14)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C493(0.67)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C489(1.17); C500(1.18)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C493(0.95)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C493(0.76); C489(1.60)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C493(0.90); C489(1.02)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C493(1.19); C489(1.42)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C493(0.86); C489(0.96)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C493(1.06); C488(0.98)  LDD1623  [2]
 LDCM0422  CL33 HEK-293T C493(0.83)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C493(0.72)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C489(0.97); C500(0.91)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C493(0.82); C489(1.11)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C493(1.09); C489(0.89)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C493(1.03); C489(1.15)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C493(1.44); C489(1.00)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C493(0.95); C488(1.14)  LDD1636  [2]
 LDCM0435  CL45 HEK-293T C493(1.05)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C493(1.14)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C489(1.05); C500(1.01)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C493(1.03); C489(1.12)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C493(1.19)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C493(1.01); C489(1.05)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C493(1.63); C489(1.61)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C493(0.93); C488(0.95)  LDD1648  [2]
 LDCM0448  CL57 HEK-293T C493(0.78)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C493(1.25)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C493(0.83); C488(0.88)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C489(1.15); C500(0.88)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C493(1.12)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C493(1.08); C489(0.88)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C493(1.24); C489(1.70)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C493(1.46); C489(1.22)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C493(1.01); C488(1.58)  LDD1661  [2]
 LDCM0461  CL69 HEK-293T C493(0.83)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C493(0.90)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C489(1.26); C500(0.83)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C493(1.12)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C493(1.09); C489(0.85)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C493(1.09); C489(1.07)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C493(0.92); C488(1.25)  LDD1674  [2]
 LDCM0475  CL81 HEK-293T C493(0.84)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C493(0.94)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C489(0.72); C500(1.01)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C493(1.17)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C493(0.66); C489(1.04)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C493(1.10); C489(0.94)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C493(0.99); C489(1.06)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C493(1.03)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C493(0.90); C488(1.01)  LDD1688  [2]
 LDCM0488  CL93 HEK-293T C493(0.92)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C493(0.96)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C489(0.97); C500(1.12)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C493(1.35)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C493(0.66); C489(0.97)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C493(0.94); C489(1.16)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C493(0.78); C489(1.01)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C493(1.35)  LDD1631  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A11 (ANXA11) Annexin family P50995
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Pituitary-specific positive transcription factor 1 (POU1F1) POU transcription factor family P28069
Homeobox protein VENTX (VENTX) . O95231
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
EP300-interacting inhibitor of differentiation 2B (EID2B) . Q96D98

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Otl-200 Gene therapy DQ4TO3
Micafungin Small molecular drug DB01141
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hgt-1111 . D0E5RA
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Suramin Small molecular drug DB04786
2-amino-3-hydroxy-3-phosphonooxy-propionic Acid . DB03821
4-nitrocatechol Sulfate . DB01800

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587