Details of the Target

General Information of Target

Target ID LDTP04951
Target Name Nuclear transport factor 2 (NUTF2)
Gene Name NUTF2
Gene ID 10204
Synonyms
NTF2; Nuclear transport factor 2; NTF-2; Placental protein 15; PP15
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLP
FQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFR
LALHNFG
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
Uniprot ID
P61970
Ensemble ID
ENST00000219169.9
HGNC ID
HGNC:13722

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K55(7.34)  LDD0277  [1]
THZ1-DTB
 Probe Info  		C114(1.09)  LDD0460  [2]
BTD
 Probe Info  		C114(0.90)  LDD2123  [3]
DA-P3
 Probe Info  		5.86  LDD0183  [4]
DBIA
 Probe Info  		C114(1.47); C38(1.03)  LDD0080  [5]
CY-1
 Probe Info  		N.A.  LDD0246  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C80(0.00); C114(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C80(0.00); C114(0.00)  LDD0036  [7]
IPIAA_H
 Probe Info  		C114(0.00); C80(0.00)  LDD0030  [8]
IPIAA_L
 Probe Info  		C114(0.00); C80(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C80(0.00); C114(0.00)  LDD0037  [7]
IPM
 Probe Info  		C80(0.00); C114(0.00); C38(0.00)  LDD2156  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
Acrolein
 Probe Info  		C114(0.00); C80(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
NAIA_5
 Probe Info  		C80(0.00); C114(0.00); C38(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [14]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C243
 Probe Info  		11.79  LDD1916  [15]
C420
 Probe Info  		31.78  LDD2075  [15]
C430
 Probe Info  		7.78  LDD2085  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		18.15  LDD0463  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C80(0.75)  LDD2132  [3]
 LDCM0214  AC1 HEK-293T C114(0.76)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C114(0.96)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C114(0.52)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C114(0.85)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C114(0.85)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C114(0.60)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C114(0.47)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C114(0.49)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C114(0.71)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C114(0.53)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C114(0.71)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C114(0.51)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C114(1.14)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C114(0.63)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C114(0.40)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C114(0.49)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C114(0.80)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C114(0.95)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C114(1.25)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C114(0.84)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C114(0.71)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C114(1.05)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C114(1.04)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C114(1.07)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C114(1.21)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C114(1.81)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C114(1.54)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C114(2.55)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C114(1.12)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C114(1.53)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C114(2.34)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C114(1.72)  LDD0843  [5]
 LDCM0246  AC128 PaTu 8988t C114(0.83); C38(1.16)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C114(0.77); C38(0.97)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C114(0.99); C38(1.01)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C114(0.82); C38(1.00)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C114(0.76); C38(1.08)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C114(0.74); C38(1.05)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C114(0.80); C38(1.04)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C114(0.69); C38(0.95)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C114(0.83); C38(1.28)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C114(0.72); C38(1.04)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C114(0.75); C38(1.02)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C114(0.92); C38(1.29)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C114(1.00)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C114(0.94); C38(1.09)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C114(0.73); C38(0.85)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C114(0.72); C38(1.06)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C114(0.60); C38(1.17)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C114(0.90); C38(1.05)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C114(0.96); C38(1.07)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C114(0.81); C38(1.06)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C114(0.93); C38(1.44)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C114(0.67); C38(1.16)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C114(0.61); C38(1.11)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C114(0.93)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C114(0.87); C38(1.11)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C114(0.59); C38(1.05)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C114(0.72); C38(1.11)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C114(0.68); C38(1.27)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C114(0.74); C38(1.23)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C114(1.08); C38(1.11)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C114(0.79); C38(1.14)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C114(0.69); C38(1.07)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C114(0.65)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C114(0.90)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C114(0.69)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C114(1.09)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C114(0.91)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C114(0.68)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C114(0.73)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C114(0.61)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C114(0.68)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C114(1.07); C38(0.87)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C114(1.40); C38(1.23)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C114(1.38); C38(1.20)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C114(1.05); C38(0.93)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C114(1.66); C38(1.28)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C114(1.34)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C114(1.53); C38(1.33)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C114(1.60); C38(1.14)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C114(1.34); C38(1.63)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C114(1.23); C38(1.27)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C114(1.17); C38(1.77)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C114(1.14)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C114(1.08)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C114(1.09)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C114(1.17)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C114(1.08)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C114(0.94)  LDD0899  [5]
 LDCM0302  AC40 HCT 116 C114(0.99)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C114(0.87)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C114(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C114(1.14)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C114(0.84)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C114(0.88)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C114(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C114(1.07)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C114(0.83)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C114(0.77)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C114(1.29)  LDD0910  [5]
 LDCM0313  AC50 HCT 116 C114(0.79)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C114(1.39)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C114(1.15)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C114(0.90)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C114(0.74)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C114(0.69)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C114(0.54)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C114(0.98)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C114(0.98)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C114(1.07)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C114(0.99)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C114(1.05)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C114(1.06)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C114(1.00)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C114(1.00)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C114(0.95)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C114(1.01)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C114(0.78)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C114(1.08)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C114(0.76)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C114(0.69)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C114(1.06)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C114(0.56)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C114(0.87)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C114(0.76)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C114(0.54)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C114(0.46)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C114(0.44)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C114(0.75)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C114(0.70)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C114(0.70)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C114(0.67)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C114(0.67)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C114(0.67)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C114(0.71)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C114(0.21)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C114(1.16)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C114(2.65)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C114(1.60)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C114(1.09)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C114(1.21)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C114(1.16)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C114(1.37)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C114(1.85)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C114(1.31)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C114(2.53)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C114(1.46)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C114(1.30)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C114(1.08)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C114(1.36)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C114(1.66)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C114(0.14)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C114(0.99)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C114(1.11)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C114(0.96)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C114(0.91)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa C80(0.00); C114(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C114(0.79)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C114(0.54)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C114(0.88)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C114(1.13)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C114(1.13)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C114(0.97)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C114(1.17)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C114(0.85)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C114(0.61)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C114(0.61)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C114(0.66)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C114(0.49)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C114(0.56)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C114(0.56)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C114(0.59)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C114(1.28); C38(1.48)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C114(1.64); C38(1.53)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C114(1.72); C38(1.80)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C114(1.19); C38(2.14)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C114(1.29); C38(1.34)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C114(0.82)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C114(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C114(1.00)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C114(0.71)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C114(1.03)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C114(0.90)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C114(0.94)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C114(0.86)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C114(0.81)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C114(1.07)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C114(1.04)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C114(1.13)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C114(1.00)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C114(0.59)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C114(0.97)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C114(0.15)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C114(0.76)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C114(1.06)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C114(0.77)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C114(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C114(0.76)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C114(1.17)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C114(0.68)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C114(0.70)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C114(1.06)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C114(0.96)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C114(1.17)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C114(0.95)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C114(1.37)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C114(0.85)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C114(1.06)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C114(0.77)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C114(1.09)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C114(0.97)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C114(0.63)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C114(0.51)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C114(0.71)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C114(0.85)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C114(0.84)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C114(0.77)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C114(0.71)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C114(0.85)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C114(0.73)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C114(1.10)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C114(0.71)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C114(0.70)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C114(0.82)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C114(0.74)  LDD0752  [5]
 LDCM0436  CL46 PaTu 8988t C114(0.82); C38(0.94)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C114(0.89); C38(0.98)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C114(1.01); C38(0.98)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C114(1.02); C38(1.03)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C114(0.93)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C114(0.77); C38(1.03)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C114(0.85); C38(0.97)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C114(0.91); C38(1.10)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C114(0.84); C38(1.02)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C114(0.90); C38(0.98)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C114(0.82); C38(1.04)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C114(0.51); C38(0.79)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C114(0.69); C38(1.09)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C114(0.87); C38(1.02)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C114(0.62); C38(0.97)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C114(0.78)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C114(0.76); C38(1.10)  LDD1331  [5]
 LDCM0453  CL61 HEK-293T C38(0.79)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C38(1.08)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C38(1.12)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C38(1.00)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C38(0.95)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C38(1.05)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C38(1.09)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C38(1.08)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C38(1.20)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C114(0.73)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C38(1.03)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C38(1.44)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C38(1.48)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C38(1.43)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C38(2.57)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C114(0.98)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C114(0.82)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C114(1.16)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C114(1.02)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C114(0.66)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C114(0.88)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C114(0.92)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C114(0.82)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C114(0.99)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C114(0.68)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C114(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C114(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C114(0.97)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C114(0.92)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C114(0.51)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C114(0.77)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C114(1.19)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C114(0.69)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C114(0.63)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C114(0.98)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C114(1.01)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C114(0.92)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C114(0.66)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C114(1.01)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C114(0.95)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C114(0.84)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C114(0.90); C38(1.18)  LDD1698  [17]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.86  LDD0183  [4]
 LDCM0625  F8 Ramos C114(0.50); C80(0.79)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C114(0.57)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C114(0.04); C80(0.15)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C114(0.63)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C114(0.92)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C114(0.61); C80(1.05)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C114(0.48)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C114(0.74)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C114(1.17)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C114(0.98)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C114(1.23); C80(0.90)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C114(1.17)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C114(1.38)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C114(0.59)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C38(2.59)  LDD1066  [5]
 LDCM0596  Fragment38 Ramos C114(0.78)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C114(0.53); C80(0.64)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C114(0.64)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C114(1.14)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C114(1.18)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C114(0.48); C80(0.53)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C114(0.47)  LDD2188  [18]
 LDCM0107  IAA HeLa C114(0.00); C80(0.00)  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C114(1.47); C38(1.03)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C114(1.47); C38(1.15)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C114(1.49); C38(1.16)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C114(0.90)  LDD2123  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C114(0.37)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C114(0.69)  LDD2207  [19]
 LDCM0131  RA190 MM1.R C80(1.59); C114(1.27); C38(1.21)  LDD0304  [20]
 LDCM0021  THZ1 HeLa S3 C114(1.09)  LDD0460  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) ATP:guanido phosphotransferase family P12532
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) Phosphofructokinase type A (PFKA) family Q01813
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Nuclear receptor-interacting protein 3 (NRIP3) . Q9NQ35
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
High mobility group protein 20A (HMG20A) . Q9NP66
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Proliferating cell nuclear antigen (PCNA) PCNA family P12004
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Nuclear transport factor 2 (NUTF2) . P61970
PHD finger protein 11 (PHF11) . Q9UIL8
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.