Details of the Target

General Information of Target

Target ID LDTP15845
Target Name Transmembrane 9 superfamily member 2 (TM9SF2)
Gene Name TM9SF2
Gene ID 9375
Synonyms
Transmembrane 9 superfamily member 2; p76
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPYPGSGGGSEVKCVGGRGASVPWDFLPGLMVKAPSGPCLQAQRKEKSRNAARSRRGK
ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAAGPPAGLA
PGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGS
SVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTPEIEASLTKVPPSS
LVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALGHTLPPAPLAELPL
HGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDK
GQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQL
PASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGD
EDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCTPG
TIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLPRKGD
Target Bioclass
Transporter and channel
Family
Nonaspanin (TM9SF) (TC 9.A.2) family
Subcellular location
Endosome membrane
Function In the intracellular compartments, may function as a channel or small molecule transporter.
Uniprot ID
Q99805
Ensemble ID
ENST00000376387.5
HGNC ID
HGNC:11865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.39  LDD0197  [1]
FBPP2
 Probe Info  		2.72  LDD0318  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
W1
 Probe Info  		13.00  LDD0235  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K234(0.52)  LDD0274  [6]
STPyne
 Probe Info  		K143(2.86); K187(9.77); K234(8.15); K328(1.25)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K328(0.93); K495(4.38)  LDD3494  [7]
BTD
 Probe Info  		C194(3.69); C56(3.05)  LDD1700  [8]
IPM
 Probe Info  		C194(4.10); C174(2.13)  LDD1701  [8]
DBIA
 Probe Info  		C174(1.19); C182(1.22)  LDD0531  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
Acrolein
 Probe Info  		C194(0.00); H129(0.00); H352(0.00); C47(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C47(0.00); H201(0.00); C182(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		9.00  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.63  LDD1728  [17]
C040
 Probe Info  		8.40  LDD1740  [17]
C041
 Probe Info  		11.88  LDD1741  [17]
C106
 Probe Info  		18.90  LDD1793  [17]
C107
 Probe Info  		6.11  LDD1794  [17]
C108
 Probe Info  		7.89  LDD1795  [17]
C112
 Probe Info  		23.10  LDD1799  [17]
C159
 Probe Info  		17.03  LDD1839  [17]
C161
 Probe Info  		12.73  LDD1841  [17]
C169
 Probe Info  		25.46  LDD1849  [17]
C170
 Probe Info  		11.00  LDD1850  [17]
C218
 Probe Info  		12.30  LDD1892  [17]
C219
 Probe Info  		5.03  LDD1893  [17]
C220
 Probe Info  		14.42  LDD1894  [17]
C228
 Probe Info  		15.03  LDD1901  [17]
C231
 Probe Info  		14.42  LDD1904  [17]
C246
 Probe Info  		13.09  LDD1919  [17]
C285
 Probe Info  		24.08  LDD1955  [17]
C287
 Probe Info  		12.21  LDD1957  [17]
C288
 Probe Info  		8.11  LDD1958  [17]
C289
 Probe Info  		45.89  LDD1959  [17]
C290
 Probe Info  		6.68  LDD1960  [17]
C307
 Probe Info  		5.03  LDD1975  [17]
C310
 Probe Info  		34.06  LDD1977  [17]
C349
 Probe Info  		11.63  LDD2010  [17]
C350
 Probe Info  		29.65  LDD2011  [17]
C355
 Probe Info  		27.10  LDD2016  [17]
C356
 Probe Info  		8.88  LDD2017  [17]
C357
 Probe Info  		5.66  LDD2018  [17]
C366
 Probe Info  		5.21  LDD2027  [17]
C388
 Probe Info  		36.25  LDD2047  [17]
C390
 Probe Info  		32.67  LDD2049  [17]
C399
 Probe Info  		7.21  LDD2058  [17]
C403
 Probe Info  		39.40  LDD2061  [17]
C413
 Probe Info  		11.16  LDD2069  [17]
C430
 Probe Info  		6.19  LDD2085  [17]
C431
 Probe Info  		14.12  LDD2086  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
JN0003
 Probe Info  		20.00  LDD0469  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]
OEA-DA
 Probe Info  		20.00  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.86)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.87); C56(0.92)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C250(0.97); C194(1.30); C56(1.51)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C250(1.25); C194(1.18); C56(1.72)  LDD2152  [8]
 LDCM0214  AC1 HCT 116 C174(1.19); C182(1.22)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C174(0.94); C182(0.74)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C174(1.17); C182(1.15)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C174(0.68); C182(0.75)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C174(0.78); C182(0.81)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C174(0.45); C182(0.53)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C174(0.59); C182(0.59)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C174(0.59); C182(0.56)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C174(0.53); C182(0.60)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C174(0.59); C182(0.60)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C174(0.47); C182(0.69)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C174(0.57); C182(0.70)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C174(0.83); C182(0.67)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C174(0.43); C182(0.70)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C174(0.45); C182(0.68)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C174(0.49); C182(0.57)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C182(1.17)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C182(0.97)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C182(0.93)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C182(1.05)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C182(0.96)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C182(1.00)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C182(1.03)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C174(1.04); C182(0.80)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C182(1.08)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C182(1.13)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C182(1.12)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C182(1.17)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C182(1.21)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C182(1.26)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C182(1.21)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C182(1.21)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C174(1.52); C182(0.32)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C174(1.28); C182(1.58)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C174(1.32); C182(0.61)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C174(1.40); C182(1.45)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C174(1.17); C182(1.67)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C174(1.26); C182(0.89)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C174(1.19); C182(0.72)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C174(1.10); C182(0.71)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C174(0.99); C182(0.93)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C174(1.04); C182(1.21)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C174(0.95); C182(0.90)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C174(0.94); C182(0.98)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C174(1.11); C182(0.71)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C174(0.86); C182(0.81)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C174(0.85); C182(1.04)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C174(0.97); C182(1.49)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C174(0.71); C182(0.87)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C182(0.59); C174(0.70)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C174(0.92); C182(1.09)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C182(0.56); C174(0.68)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C182(0.54); C174(0.65)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C182(0.15); C174(3.16)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C182(0.39); C174(1.46)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C182(0.66); C174(0.97)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C174(1.39); C182(2.18)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C182(0.93); C174(0.99)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C182(0.36); C174(0.63)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C182(0.11); C174(0.73)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C174(0.55); C182(0.52)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C174(0.90); C182(0.91)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C174(0.83); C182(0.94)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C174(0.96); C182(1.16)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C174(1.21); C182(1.24)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C182(0.69); C174(0.82)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C174(0.88); C182(1.02)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C182(1.09); C174(1.39)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C174(1.07); C182(1.24)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C174(0.88); C182(1.13)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C174(0.89); C182(1.26)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C182(1.06); C174(1.18)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C182(1.40); C174(1.79)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C182(0.95); C174(0.97)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C174(0.82); C182(0.87)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C174(0.75); C182(0.91)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C174(0.79); C182(0.94)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C174(0.82); C182(0.86)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C182(1.13); C174(1.18)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C182(0.77); C174(0.80)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C174(0.81); C182(0.99)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C174(0.72); C182(0.72)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C182(0.70); C174(0.81)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C182(0.58); C174(0.84)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C182(1.67)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C182(1.61)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C182(1.40)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C182(1.29)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C182(0.99)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C182(1.21); C174(1.26)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C182(0.53)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C182(1.16)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C182(0.72)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C182(0.85)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C182(0.77)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C182(0.47)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C182(1.00)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C182(1.05)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C182(0.87)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C182(0.41)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C174(1.23); C182(1.32)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C182(0.52)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C182(1.28)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C182(0.98)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C182(0.63)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C182(0.59)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C182(0.50)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C182(0.35)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C182(0.65); C174(0.77)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C182(0.57); C174(0.64)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C182(0.47); C174(0.75)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C182(0.62); C174(0.77)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C182(0.59); C174(0.86)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C182(0.72); C174(0.77)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C182(0.44); C174(0.69)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C182(0.64); C174(0.83)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C182(0.43); C174(0.76)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C182(0.56); C174(0.64)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C182(0.71); C174(0.76)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C182(0.26); C174(0.57)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C182(0.78)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C182(0.67)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C182(0.79); C174(0.94)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C182(0.46)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C182(1.22)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C182(0.70)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C182(0.40)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C182(0.55)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C182(0.45)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C182(0.64)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C182(0.53)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C182(0.87)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C182(0.90)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C182(0.75); C174(0.92)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C182(0.75)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C182(0.91)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C182(0.49)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C182(0.21); C174(0.49)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C182(0.30); C174(0.47)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C174(0.81); C182(0.89)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C174(0.88); C182(1.10)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C174(1.21); C182(1.28)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C182(1.01); C174(1.04)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C182(0.60); C174(0.71)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C174(2.56); C182(2.74)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C182(0.21); C174(0.38)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C182(0.30); C174(0.47)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C174(0.98); C182(1.09)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C174(1.06); C182(1.24)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C174(0.99); C182(1.02)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C182(0.59); C174(0.65)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C182(0.49); C174(0.55)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C182(0.32); C174(0.34)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C174(0.54); C182(0.76)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C250(0.56)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C250(0.75); C194(0.94); C56(0.87)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C174(0.94); C182(0.82)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C182(0.71); C174(0.81)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C182(0.19); C174(0.82)  LDD0592  [9]
 LDCM0498  BS-3668 MDA-MB-231 C250(0.44); C194(0.65)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C250(0.00); C47(0.00); C194(0.00); H352(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C174(0.91); C182(1.21)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C174(0.58); C182(0.72)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C174(1.05); C182(1.10)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C182(0.74); C174(1.21)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C182(0.80); C174(1.34)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C182(1.02); C174(1.39)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C182(1.04); C174(1.35)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C174(0.71); C182(0.92)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C182(0.43); C174(0.85)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C182(0.66); C174(0.82)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C182(0.47); C174(1.05)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C174(0.73); C182(0.98)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C174(0.55); C182(0.59)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C182(0.77); C174(1.44)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C182(1.02); C174(1.06)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C182(1.02); C174(1.10)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C174(0.74); C182(0.81)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C174(0.88); C182(0.93)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C174(0.86); C182(0.88)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C182(0.83); C174(0.91)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C182(0.21)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C182(0.83)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C182(0.69)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C174(0.56); C182(0.57)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C182(1.16)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C182(0.73)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C182(0.80)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C182(0.60)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C182(0.50)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C174(1.06); C182(1.12)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C182(1.01); C174(1.05)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C182(0.88); C174(1.06)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C182(0.63); C174(0.73)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C174(0.63); C182(0.74)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C174(0.79); C182(1.02)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C174(0.75); C182(0.85)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C182(0.84); C174(0.90)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C182(0.77); C174(1.02)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C182(0.69); C174(0.86)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C182(0.63); C174(0.76)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C174(0.96); C182(1.16)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C182(0.47); C174(0.70)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C182(0.45); C174(0.63)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C182(0.31); C174(0.59)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C182(0.61); C174(0.70)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C174(0.45); C182(0.39)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C174(0.56); C182(0.50)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C174(1.12); C182(0.61)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C174(0.80); C182(0.68)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C174(0.65); C182(0.50)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C174(0.62); C182(0.53)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C174(0.85); C182(1.14)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C174(0.86); C182(0.74)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C174(0.87); C182(0.88)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C174(0.85); C182(0.64)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C174(0.91); C182(0.89)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C174(1.22); C182(0.30)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C174(0.90); C182(0.27)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C174(1.09); C182(0.39)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C174(0.74); C182(0.28)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C174(0.79); C182(0.40)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C174(0.91); C182(1.11)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C174(0.83); C182(0.38)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C174(0.89); C182(0.45)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C174(1.00); C182(0.13)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C174(0.66); C182(0.23)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C174(0.81); C182(0.55)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C174(0.84); C182(0.26)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C174(1.38); C182(1.68)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C174(1.37); C182(1.50)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C174(1.50); C182(1.59)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C174(1.24); C182(1.19)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C174(0.91); C182(0.99)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C174(1.18); C182(1.48)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C174(1.20); C182(1.40)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C174(1.15); C182(1.62)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C174(1.26); C182(1.42)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C174(1.21); C182(1.34)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C174(1.37); C182(1.50)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C174(1.02); C182(1.29)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C174(1.18); C182(1.34)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C174(1.33); C182(1.54)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C174(1.14); C182(1.26)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C174(0.67); C182(0.78)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C174(1.23); C182(1.46)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C174(0.98); C182(0.95)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C174(0.84); C182(0.96)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C174(0.85); C182(0.76)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C174(0.76); C182(0.60)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C174(0.98); C182(0.99)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C174(0.61); C182(0.29)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C174(0.69); C182(0.46)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C174(0.71); C182(0.55)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C174(0.90); C182(0.72)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C174(0.64); C182(0.85)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C174(0.77); C182(0.60)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C174(0.75); C182(0.70)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C174(0.91); C182(1.05)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C174(0.85); C182(0.75)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C174(0.84); C182(0.70)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C174(0.69); C182(0.75)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C174(1.03); C182(0.99)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C174(0.82); C182(0.86)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C174(0.42); C182(0.51)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C174(0.52); C182(0.53)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C174(0.74); C182(0.94)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C174(0.72); C182(0.73)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C174(0.19); C182(0.26)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C174(0.26); C182(0.34)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C174(0.14); C182(0.21)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C174(0.73); C182(0.78)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C174(1.11); C182(0.88)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C174(0.81); C182(0.85)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C174(0.33); C182(0.37)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C174(0.11); C182(0.18)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C174(0.83); C182(0.84)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C174(0.95); C182(0.92)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C174(1.34); C182(0.89)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C174(1.36); C182(1.06)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C174(1.24); C182(1.23)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C174(1.25); C182(1.23)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C174(1.17); C182(0.94)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C174(1.25); C182(0.97)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C174(1.27); C182(0.99)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C174(0.93); C182(1.05)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C174(1.08); C182(1.19)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C194(0.92); C84(1.00); C164(0.69); C250(1.01)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C194(2.38); C47(1.98); C250(1.95)  LDD1702  [8]
 LDCM0468  Fragment33 HCT 116 C174(0.83); C182(0.75)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C174(0.69); C182(0.14)  LDD0744  [9]
 LDCM0107  IAA HeLa C194(0.00); H352(0.00); C182(0.00); H201(0.00)  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C194(0.83); C182(0.99)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C194(0.98); C182(0.96)  LDD1497  [21]
 LDCM0024  KB05 HMCB C84(1.58)  LDD3312  [22]
 LDCM0109  NEM HeLa C194(0.00); H201(0.00); C182(0.00); H219(0.00)  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C250(0.68)  LDD2089  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C250(0.68); C56(0.39)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C250(1.00); C194(1.06); C56(0.39)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C250(1.08); C56(1.29)  LDD2094  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C250(1.10); C194(1.20)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C250(0.92); C194(1.48); C56(1.59)  LDD2099  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C250(1.08); C194(1.11)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C250(0.67)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C56(0.67)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C250(0.97); C56(1.13)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C250(0.84); C194(0.83); C56(0.65)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C250(1.06); C194(1.21); C56(0.89)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C250(0.96)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C250(0.80)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C194(0.46)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C250(2.34); C194(1.77); C56(1.21)  LDD2119  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C250(0.99); C194(0.99); C56(0.53)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C250(0.85); C194(1.10); C56(0.89)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C250(1.43); C194(1.69); C56(1.18)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C250(0.89)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C194(0.49); C56(0.34)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C250(0.65); C194(0.48); C56(0.32)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C250(0.99); C56(0.49)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C250(1.31); C194(1.05); C56(1.39)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C250(1.09); C194(0.98); C56(1.09)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C194(3.69); C56(3.05)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C56(0.98)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C250(0.85); C56(1.00)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C56(1.06)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C250(2.33); C194(1.94); C56(2.43)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C194(1.09)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C250(0.98); C56(0.92)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C194(0.53); C56(0.52)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C250(0.38); C194(0.50)  LDD2150  [8]

References

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Mass spectrometry data entry: PXD018580
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
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Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840