Details of the Target

General Information of Target

Target ID LDTP15269
Target Name Large ribosomal subunit protein mL55 (MRPL55)
Gene Name MRPL55
Gene ID 128308
Synonyms
Large ribosomal subunit protein mL55; 39S ribosomal protein L55, mitochondrial; L55mt; MRP-L55; Mitochondrial large ribosomal subunit protein bL31m
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKFLLLVLAALGFLTQVIPASAGGSKCVSNTPGYCRTCCHWGETALFMCNASRKCCISYS
FLPKPDLPQLIGNHWQSRRRNTQRKDKKQQTTVTS
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mL55 family
Subcellular location
Mitochondrion
Uniprot ID
Q7Z7F7
Ensemble ID
ENST00000295008.8
HGNC ID
HGNC:16686

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y106(4.71)  LDD3495  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
SF
 Probe Info  		N.A.  LDD0028  [3]
PAL-AfBPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		34.06  LDD1740  [4]
C041
 Probe Info  		15.45  LDD1741  [4]
C059
 Probe Info  		18.13  LDD1756  [4]
C063
 Probe Info  		24.42  LDD1760  [4]
C098
 Probe Info  		17.15  LDD1787  [4]
C100
 Probe Info  		9.99  LDD1789  [4]
C157
 Probe Info  		9.13  LDD1837  [4]
C158
 Probe Info  		13.74  LDD1838  [4]
C160
 Probe Info  		7.57  LDD1840  [4]
C161
 Probe Info  		15.67  LDD1841  [4]
C218
 Probe Info  		60.13  LDD1892  [4]
C229
 Probe Info  		9.06  LDD1902  [4]
C231
 Probe Info  		15.89  LDD1904  [4]
C232
 Probe Info  		73.52  LDD1905  [4]
C233
 Probe Info  		10.41  LDD1906  [4]
C234
 Probe Info  		8.28  LDD1907  [4]
C236
 Probe Info  		6.36  LDD1909  [4]
C238
 Probe Info  		31.56  LDD1911  [4]
C265
 Probe Info  		18.13  LDD1936  [4]
C288
 Probe Info  		12.13  LDD1958  [4]
C289
 Probe Info  		26.72  LDD1959  [4]
C290
 Probe Info  		9.13  LDD1960  [4]
C293
 Probe Info  		17.03  LDD1963  [4]
C296
 Probe Info  		24.59  LDD1966  [4]
C313
 Probe Info  		67.18  LDD1980  [4]
C314
 Probe Info  		29.24  LDD1981  [4]
C317
 Probe Info  		39.40  LDD1983  [4]
C342
 Probe Info  		6.87  LDD2004  [4]
C343
 Probe Info  		45.25  LDD2005  [4]
C346
 Probe Info  		87.43  LDD2007  [4]
C347
 Probe Info  		14.03  LDD2008  [4]
C348
 Probe Info  		36.00  LDD2009  [4]
C349
 Probe Info  		11.39  LDD2010  [4]
C350
 Probe Info  		77.17  LDD2011  [4]
C353
 Probe Info  		9.99  LDD2014  [4]
C354
 Probe Info  		99.73  LDD2015  [4]
C362
 Probe Info  		28.05  LDD2023  [4]
C363
 Probe Info  		91.14  LDD2024  [4]
C364
 Probe Info  		47.50  LDD2025  [4]
C370
 Probe Info  		27.86  LDD2031  [4]
C413
 Probe Info  		59.30  LDD2069  [4]
C430
 Probe Info  		33.59  LDD2085  [4]
C431
 Probe Info  		44.63  LDD2086  [4]
C433
 Probe Info  		57.28  LDD2088  [4]
FFF probe11
 Probe Info  		16.75  LDD0471  [5]
FFF probe13
 Probe Info  		20.00  LDD0475  [5]
FFF probe6
 Probe Info  		20.00  LDD0467  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.