Details of the Target

General Information of Target

Target ID LDTP11927
Target Name Essential MCU regulator, mitochondrial (SMDT1)
Gene Name SMDT1
Gene ID 91689
Synonyms
C22orf32; EMRE; Essential MCU regulator, mitochondrial; Single-pass membrane protein with aspartate-rich tail 1, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASKRKSTTPCMIPVKTVVLQDASMEAQPAETLPEGPQQDLPPEASAASSEAAQNPSSTD
GSTLANGHRSTLDGYLYSCKYCDFRSHDMTQFVGHMNSEHTDFNKDPTFVCSGCSFLAKT
PEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSIPESTSTPDLAGEPSAEGADGQAEII
ITKTPIMKIMKGKAEAKKIHTLKENVPSQPVGEALPKLSTGEMEVREGDHSFINGAVPVS
QASASSAKNPHAANGPLIGTVPVLPAGIAQFLSLQQQPPVHAQHHVHQPLPTAKALPKVM
IPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQG
ISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHVVGQPEG
TGGGLLVTQPLMANGLQATSSPLPLTVTSVPKQPGVAPINTVCSNTTSAVKVVNAAQSLL
TACPSITSQAFLDASIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRK
WFSDRRYHCRNLKGSRAMIPGDHSSIIIDSVPEVSFSPSSKVPEVTCIPTTATLATHPSA
KRQSWHQTPDFTPTKYKERAPEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWF
SERRKKVNAEETKKAEENASQEEEEAAEDEGGEEDLASELRVSGENGSLEMPSSHILAER
KVSPIKINLKNLRVTEANGRNEIPGLGACDPEDDESNKLAEQLPGKVSCKKTAQQRHLLR
QLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLL
VIAPGNRELLQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEKMGEETRAVADTGSE
DQGPGTGELTAVHKGMGDTYSEVSENSESWEPRVPEASSEPFDTSSPQAGRQLETD
Target Bioclass
Transporter and channel
Family
SMDT1/EMRE family
Subcellular location
Mitochondrion inner membrane
Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling.
Uniprot ID
Q9H4I9
Ensemble ID
ENST00000331479.4
HGNC ID
HGNC:25055

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		8.28  LDD1725  [1]
C055
 Probe Info  		79.89  LDD1752  [1]
C056
 Probe Info  		99.73  LDD1753  [1]
C063
 Probe Info  		50.21  LDD1760  [1]
C225
 Probe Info  		14.62  LDD1898  [1]
C226
 Probe Info  		15.56  LDD1899  [1]
C228
 Probe Info  		99.73  LDD1901  [1]
C229
 Probe Info  		15.45  LDD1902  [1]
C231
 Probe Info  		81.01  LDD1904  [1]
C232
 Probe Info  		99.73  LDD1905  [1]
C233
 Probe Info  		19.43  LDD1906  [1]
C234
 Probe Info  		9.99  LDD1907  [1]
C235
 Probe Info  		73.52  LDD1908  [1]
C264
 Probe Info  		27.28  LDD1935  [1]
C265
 Probe Info  		19.97  LDD1936  [1]
C278
 Probe Info  		79.34  LDD1948  [1]
C282
 Probe Info  		18.90  LDD1952  [1]
C285
 Probe Info  		53.08  LDD1955  [1]
C287
 Probe Info  		19.03  LDD1957  [1]
C288
 Probe Info  		9.00  LDD1958  [1]
C289
 Probe Info  		99.73  LDD1959  [1]
C293
 Probe Info  		94.35  LDD1963  [1]
C296
 Probe Info  		50.91  LDD1966  [1]
C429
 Probe Info  		52.71  LDD2084  [1]
C430
 Probe Info  		8.57  LDD2085  [1]
C431
 Probe Info  		91.14  LDD2086  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium uniporter protein, mitochondrial (MCU) MCU (TC 1.A.77) family Q8NE86

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587