Details of the Target

General Information of Target

Target ID LDTP05089
Target Name Immunoglobulin-binding protein 1 (IGBP1)
Gene Name IGBP1
Gene ID 3476
Synonyms
IBP1; Immunoglobulin-binding protein 1; B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEDELQLPRLPELFETGRQLLDEVEVATEPAGSRIVQEKVFKGLDLLEKAAEMLSQLD
LFSRNEDLEEIASTDLKYLLVPAFQGALTMKQVNPSKRLDHLQRAREHFINYLTQCHCYH
VAEFELPKTMNNSAENHTANSSMAYPSLVAMASQRQAKIQRYKQKKELEHRLSAMKSAVE
SGQADDERVREYYLLHLQRWIDISLEEIESIDQEIKILRERDSSREASTSNSSRQERPPV
KPFILTRNMAQAKVFGAGYPSLPTMTVSDWYEQHRKYGALPDQGIAKAAPEEFRKAAQQQ
EEQEEKEEEDDEQTLHRAREWDDWKDTHPRGYGNRQNMG
Target Bioclass
Other
Family
IGBP1/TAP42 family
Subcellular location
Cytoplasm
Function
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
Uniprot ID
P78318
Ensemble ID
ENST00000342206.10
HGNC ID
HGNC:5461

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K166(10.00); K241(2.13); K276(5.36); K44(1.10)  LDD0277  [2]
Probe 1
 Probe Info  		Y277(17.15)  LDD3495  [3]
HHS-475
 Probe Info  		Y259(1.00); Y271(1.23)  LDD0264  [4]
HHS-465
 Probe Info  		Y277(8.55)  LDD2237  [5]
DBIA
 Probe Info  		C118(1.05)  LDD1510  [6]
SF
 Probe Info  		N.A.  LDD0028  [7]
Ox-W18
 Probe Info  		W321(0.00); W324(0.00)  LDD2175  [8]
AOyne
 Probe Info  		14.50  LDD0443  [9]
HHS-482
 Probe Info  		Y259(1.32); Y271(1.12); Y277(1.24)  LDD2239  [5]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.94  LDD1725  [10]
C158
 Probe Info  		13.83  LDD1838  [10]
C252
 Probe Info  		10.63  LDD1925  [10]
C313
 Probe Info  		13.55  LDD1980  [10]
C317
 Probe Info  		6.06  LDD1983  [10]
C363
 Probe Info  		16.56  LDD2024  [10]
C407
 Probe Info  		14.52  LDD2064  [10]
C419
 Probe Info  		17.15  LDD2074  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C118(1.05)  LDD1510  [6]
 LDCM0280  AC20 HEK-293T C118(0.96)  LDD1519  [6]
 LDCM0288  AC28 HEK-293T C118(0.91)  LDD1527  [6]
 LDCM0297  AC36 HEK-293T C118(1.09)  LDD1536  [6]
 LDCM0301  AC4 HEK-293T C118(0.98)  LDD1540  [6]
 LDCM0306  AC44 HEK-293T C118(1.04)  LDD1545  [6]
 LDCM0315  AC52 HEK-293T C118(0.93)  LDD1554  [6]
 LDCM0324  AC60 HEK-293T C118(0.97)  LDD1563  [6]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0372  CL103 HEK-293T C118(1.23)  LDD1576  [6]
 LDCM0376  CL107 HEK-293T C118(1.07)  LDD1580  [6]
 LDCM0381  CL111 HEK-293T C118(1.42)  LDD1585  [6]
 LDCM0385  CL115 HEK-293T C118(1.13)  LDD1589  [6]
 LDCM0389  CL119 HEK-293T C118(1.22)  LDD1593  [6]
 LDCM0394  CL123 HEK-293T C118(1.30)  LDD1598  [6]
 LDCM0398  CL127 HEK-293T C118(1.21)  LDD1602  [6]
 LDCM0402  CL15 HEK-293T C118(1.18)  LDD1606  [6]
 LDCM0408  CL20 HEK-293T C118(1.01)  LDD1612  [6]
 LDCM0415  CL27 HEK-293T C118(1.02)  LDD1619  [6]
 LDCM0418  CL3 HEK-293T C118(1.37)  LDD1622  [6]
 LDCM0421  CL32 HEK-293T C118(0.89)  LDD1625  [6]
 LDCM0428  CL39 HEK-293T C118(1.24)  LDD1632  [6]
 LDCM0434  CL44 HEK-293T C118(0.86)  LDD1638  [6]
 LDCM0447  CL56 HEK-293T C118(0.99)  LDD1650  [6]
 LDCM0455  CL63 HEK-293T C118(1.32)  LDD1658  [6]
 LDCM0460  CL68 HEK-293T C118(0.92)  LDD1663  [6]
 LDCM0473  CL8 HEK-293T C118(0.93)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C118(0.91)  LDD1677  [6]
 LDCM0481  CL87 HEK-293T C118(1.21)  LDD1684  [6]
 LDCM0487  CL92 HEK-293T C118(0.90)  LDD1690  [6]
 LDCM0494  CL99 HEK-293T C118(1.11)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C118(1.67)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C118(1.13)  LDD1671  [6]
 LDCM0116  HHS-0101 DM93 Y259(1.00); Y271(1.23)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y259(0.73); Y271(0.74)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y259(0.11); Y271(0.48)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y259(0.25); Y271(0.88)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y259(1.22); Y271(1.33)  LDD0268  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) PPP phosphatase family P62714
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) PPP phosphatase family P60510
Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) PPP phosphatase family O00743
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
TIP41-like protein (TIPRL) TIP41 family O75663

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587