Details of the Target

General Information of Target

Target ID LDTP06255
Target Name GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1)
Gene Name GAPVD1
Gene ID 26130
Synonyms
GAPEX5; KIAA1521; RAP6; GTPase-activating protein and VPS9 domain-containing protein 1; GAPex-5; Rab5-activating protein 6
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Target Bioclass
Other
Family
GAPVD1 family
Subcellular location
Membrane
Function
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.
Uniprot ID
Q14C86
Ensemble ID
ENST00000297933.11
HGNC ID
HGNC:23375

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.40  LDD0402  [1]
A-EBA
 Probe Info  		2.72  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y1331(20.00); Y1368(13.97); Y1207(9.09); Y1387(5.12)  LDD0257  [4]
TH216
 Probe Info  		Y1207(20.00)  LDD0259  [4]
ONAyne
 Probe Info  		K1035(1.59)  LDD0274  [5]
Probe 1
 Probe Info  		Y19(44.86); Y86(19.12); Y96(5.41); Y1216(3.73)  LDD3495  [6]
BTD
 Probe Info  		C1396(1.08)  LDD2098  [7]
DA-P3
 Probe Info  		5.57  LDD0182  [8]
AHL-Pu-1
 Probe Info  		C789(4.03); C374(2.31); C568(2.12)  LDD0169  [9]
DBIA
 Probe Info  		C176(4.71); C293(12.72); C176(92.05); C1396(26.86)  LDD0209  [10]
HHS-482
 Probe Info  		Y1207(1.05)  LDD0285  [11]
HHS-475
 Probe Info  		Y1036(0.80); Y460(0.89); Y86(0.95); Y1207(1.17)  LDD0264  [12]
HHS-465
 Probe Info  		Y1036(10.00); Y460(2.92); Y893(9.41)  LDD2237  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
ATP probe
 Probe Info  		K1198(0.00); K1035(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1396(0.00); C568(0.00); C1129(0.00); C275(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C1396(0.00); C568(0.00); C1129(0.00); C275(0.00)  LDD0037  [16]
JW-RF-010
 Probe Info  		C71(0.00); C1129(0.00); C70(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		C374(0.00); C741(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C1253(0.00); C71(0.00); C1220(0.00); C1129(0.00)  LDD0027  [18]
Compound 10
 Probe Info  		C1129(0.00); C568(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		C741(0.00); C789(0.00)  LDD0006  [21]
IPM
 Probe Info  		C568(0.00); C1396(0.00); C293(0.00); C275(0.00)  LDD0005  [21]
SF
 Probe Info  		Y893(0.00); Y1036(0.00)  LDD0028  [22]
STPyne
 Probe Info  		N.A.  LDD0009  [21]
VSF
 Probe Info  		C1129(0.00); C568(0.00); C789(0.00); C741(0.00)  LDD0007  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Acrolein
 Probe Info  		C741(0.00); C568(0.00); C1129(0.00); C789(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [24]
Methacrolein
 Probe Info  		C741(0.00); C568(0.00); C1129(0.00); C70(0.00)  LDD0218  [24]
W1
 Probe Info  		C1253(0.00); C741(0.00)  LDD0236  [25]
AOyne
 Probe Info  		14.90  LDD0443  [26]
NAIA_5
 Probe Info  		C1220(0.00); C1396(0.00); C176(0.00); C1129(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C317
 Probe Info  		6.11  LDD1983  [27]
C320
 Probe Info  		5.62  LDD1986  [27]
C433
 Probe Info  		5.94  LDD2088  [27]
FFF probe3
 Probe Info  		7.06  LDD0465  [28]
Alk-rapa
 Probe Info  		3.44  LDD0213  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C70(20.00)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C789(4.03); C374(2.31); C568(2.12)  LDD0169  [9]
 LDCM0561  Abegg_cp(-)-10 HeLa C1396(2.12)  LDD0312  [18]
 LDCM0214  AC1 HEK-293T C293(0.89); C789(0.99); C1253(1.04); C568(0.99)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C293(0.95); C789(0.98); C1253(1.08); C568(1.03)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C293(1.01); C789(1.05); C1253(0.90); C568(1.00)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C293(0.98); C789(0.95); C1253(0.97); C568(1.05)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C293(0.98); C789(0.95); C1253(0.96); C568(0.94)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C293(1.00); C789(0.97); C1253(1.00); C568(1.00)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C293(0.95); C789(1.00); C1253(1.01); C568(1.03)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C293(0.95); C789(1.01); C1253(1.06); C568(0.97)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C293(0.98); C789(1.13); C1253(1.03); C568(1.05)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C293(0.98); C789(0.98); C1253(0.95); C568(1.12)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C293(0.93); C789(0.96); C1253(0.98); C568(1.00)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C293(1.00); C789(0.96); C1253(0.95); C568(1.03)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C293(0.95); C789(0.94); C1253(0.96); C568(1.03)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C293(1.02); C789(0.99); C1253(0.93); C568(1.05)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C293(0.98); C789(0.95); C1253(0.90); C568(0.99)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C293(0.93); C789(0.96); C1253(0.98); C568(1.01)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C293(0.94); C789(1.03); C1253(1.03); C568(0.95)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C293(0.98); C789(0.96); C1253(1.00); C568(1.12)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C293(0.97); C789(1.05); C1253(1.00); C568(1.07)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C293(0.98); C789(1.04); C1253(0.90); C568(1.04)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C293(1.01); C789(0.99); C1253(1.06); C568(0.99)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C293(0.94); C789(0.95); C1253(0.96); C568(0.97)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C293(1.01); C789(0.96); C1253(0.95); C568(1.06)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C293(0.99); C789(0.97); C1253(0.98); C568(0.99)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C293(0.95); C789(0.99); C1253(1.00); C568(0.91)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C293(0.95); C789(1.03); C1253(1.13); C568(0.92)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C293(0.92); C789(1.00); C1253(0.98); C568(1.04)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C293(0.91); C789(0.98); C1253(1.00); C568(0.98)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C293(0.97); C789(0.97); C1253(0.86); C568(1.08)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C293(0.91); C789(0.92); C1253(0.96); C568(0.93)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C293(0.91); C789(0.98); C1253(0.99); C568(0.92)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C293(0.93); C789(1.03); C1253(1.02); C568(0.99)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C293(0.97); C789(0.91); C1253(0.96); C568(1.10)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C293(0.94); C789(0.99); C1253(0.99); C568(0.99)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C293(0.93); C789(0.96); C1253(0.99); C568(1.13)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C293(0.97); C789(0.99); C1253(0.98); C568(1.13)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C293(0.92); C789(1.01); C1253(1.02); C568(1.03)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C293(1.01); C789(1.01); C1253(0.92); C568(1.04)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C293(0.92); C789(0.91); C1253(0.95); C568(0.86)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C293(0.92); C789(1.02); C1253(0.96); C568(1.00)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C293(0.96); C789(0.97); C1253(0.94); C568(1.13)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C293(0.94); C789(0.96); C1253(0.93); C568(0.99)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C293(1.01); C789(0.94); C1253(0.93); C568(1.09)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C293(0.93); C789(1.00); C1253(1.07); C568(1.23)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C293(1.02); C789(1.00); C1253(1.00); C568(1.07)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C293(0.94); C789(1.01); C1253(0.98); C568(0.96)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C293(0.94); C789(0.99); C1253(0.89); C568(1.06)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C293(0.94); C789(0.93); C1253(1.03); C568(1.07)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C293(0.95); C789(0.97); C1253(0.99); C568(1.14)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C293(0.99); C789(0.95); C1253(0.97); C568(0.95)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C293(0.95); C789(1.02); C1253(0.96); C568(0.95)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C293(0.97); C789(0.97); C1253(1.00); C568(0.93)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C293(0.96); C789(1.00); C1253(1.00); C568(1.05)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C293(0.91); C789(0.93); C1253(0.95); C568(1.12)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C293(0.99); C789(0.99); C1253(1.01); C568(0.97)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C293(0.95); C789(0.98); C1253(1.01); C568(1.04)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C293(0.97); C789(0.96); C1253(1.01); C568(0.88)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C293(1.02); C789(1.03); C1253(1.04); C568(1.08)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C293(1.01); C789(0.95); C1253(0.94); C568(0.87)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C293(0.96); C789(1.01); C1253(0.94); C568(0.95)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C293(0.98); C789(0.96); C1253(1.02); C568(1.03)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C293(0.93); C789(0.95); C1253(0.90); C568(0.98)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C293(0.94); C789(1.03); C1253(1.00); C568(1.07)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C293(0.96); C789(0.92); C1253(0.98); C568(1.17)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 8.96  LDD0185  [8]
 LDCM0108  Chloroacetamide HeLa C741(0.00); C568(0.00); C1129(0.00); C789(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C1129(1.83); C293(1.48); C1160(0.91); C70(0.84)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C293(0.87); C789(0.83); C1253(1.08); C568(0.97)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C293(1.20); C789(0.78); C1253(1.16); C568(1.02)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C293(0.90); C789(0.97); C1253(0.96); C568(1.00)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C293(0.97); C789(1.01); C1253(0.98); C568(1.01)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C293(0.91); C1253(0.87); C568(1.04); C1160(0.84)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C293(0.98); C789(1.01); C1253(1.04); C568(0.93)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C293(0.96); C789(0.94); C1253(1.01); C568(0.90)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C293(0.93); C789(0.99); C1253(0.94); C568(1.03)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C293(0.92); C1253(0.98); C568(0.93); C1160(1.01)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C293(0.97); C789(0.99); C1253(1.05); C568(1.08)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C293(0.95); C789(0.94); C1253(0.98); C568(1.06)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C293(0.88); C789(0.97); C1253(1.00); C568(0.95)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C293(1.10); C789(0.95); C1253(1.02); C568(1.00)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C293(1.00); C1253(0.92); C568(1.06); C1160(1.00)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C293(1.03); C789(0.97); C1253(1.08); C568(1.01)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C293(0.99); C789(0.97); C1253(0.93); C568(1.04)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C293(0.97); C789(0.95); C1253(1.00); C568(0.99)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C293(0.99); C1253(0.98); C568(0.97); C1160(0.61)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C293(0.96); C789(1.00); C1253(1.02); C568(0.98)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C293(0.94); C789(0.95); C1253(0.90); C568(0.99)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C293(0.95); C789(1.02); C1253(0.90); C568(1.01)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C293(0.98); C1253(0.92); C568(1.00); C1160(0.98)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C293(1.00); C789(1.03); C1253(1.07); C568(0.89)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C293(1.05); C789(0.93); C1253(0.94); C568(1.00)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C293(0.96); C789(0.98); C1253(0.96); C568(1.00)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C293(0.98); C789(0.96); C1253(0.98); C568(0.99)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C293(0.94); C1253(0.94); C568(1.00); C1160(0.93)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C293(1.04); C789(0.94); C1253(1.08); C568(0.87)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C293(0.92); C789(0.95); C1253(0.99); C568(0.93)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C293(0.92); C789(0.91); C1253(0.93); C568(1.00)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C293(0.95); C1253(0.96); C568(0.96); C1160(0.80)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C293(0.97); C789(1.04); C1253(1.04); C568(0.92)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C293(0.96); C789(0.93); C1253(0.97); C568(1.00)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C293(0.85); C789(0.95); C1253(0.95); C568(1.23)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C293(0.91); C1253(0.95); C568(0.91); C1160(0.69)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C293(0.88); C789(0.99); C1253(1.11); C568(0.89)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C293(1.05); C789(0.96); C1253(1.01); C568(1.00)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C293(0.86); C789(0.90); C1253(1.11); C568(1.12)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C293(0.93); C789(1.02); C1253(0.99); C568(1.03)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C293(1.00); C789(1.02); C1253(0.99); C568(1.08)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C293(0.95); C1253(0.97); C568(0.93); C1160(0.98)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C293(1.04); C789(0.97); C1253(1.03); C568(1.02)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C293(0.89); C789(0.90); C1253(0.99); C568(0.93)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C293(1.12); C789(0.93); C1253(1.02); C568(1.07)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C293(1.15); C789(1.03); C1253(0.96); C568(0.96)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C293(1.11); C789(1.01); C1253(0.99); C568(1.13)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C293(0.99); C789(0.90); C1253(0.97); C568(0.94)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C293(0.90); C1253(1.00); C568(0.92); C1160(1.00)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C293(0.95); C789(0.99); C1253(1.02); C568(0.92)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C293(0.95); C789(0.93); C1253(0.95); C568(0.93)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C293(0.97); C789(0.98); C1253(1.05); C568(1.02)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C293(0.97); C789(1.05); C1253(1.09); C568(0.98)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C293(1.00); C789(0.99); C1253(1.04); C568(1.24)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C293(1.08); C789(0.99); C1253(1.02); C568(0.91)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C293(1.06); C789(1.05); C1253(0.99); C568(1.05)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C293(0.96); C789(0.97); C1253(1.25); C568(1.02)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C293(1.16); C789(0.95); C1253(1.02); C568(1.01)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C293(1.22); C789(1.04); C1253(1.02); C568(1.06)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C293(1.26); C789(1.00); C1253(1.03); C568(1.05)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C293(0.89); C789(0.95); C1253(1.01); C568(0.94)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C293(0.96); C789(1.00); C1253(1.08); C568(0.93)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C293(0.95); C789(0.95); C1253(0.91); C568(1.04)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C293(0.98); C789(1.02); C1253(0.96); C568(1.08)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C293(0.94); C789(0.98); C1253(0.91); C568(0.98)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C293(1.02); C789(1.08); C1253(1.10); C568(1.22)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C293(1.17); C789(1.00); C1253(1.00); C568(0.93)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C293(1.07); C789(1.03); C1253(1.00); C568(1.06)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C293(0.93); C789(0.95); C1253(0.98); C568(1.17)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C293(1.20); C789(1.10); C1253(1.02); C568(1.04)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C293(1.24); C789(1.01); C1253(1.00); C568(1.01)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C293(1.16); C789(0.99); C1253(1.08); C568(1.19)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C293(0.90); C789(0.94); C1253(0.99); C568(1.05)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C293(0.91); C789(0.95); C1253(0.93); C568(1.11)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C293(0.90); C1253(0.95); C568(0.98); C1160(0.75)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C293(0.95); C789(1.00); C1253(0.94); C568(0.96)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C293(0.93); C789(0.94); C1253(0.99); C568(0.88)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C293(1.00); C789(0.93); C1253(1.13); C568(1.10)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C293(1.05); C789(0.99); C1253(1.01); C568(1.10)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C293(1.05); C789(1.03); C1253(1.01); C568(1.01)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C293(0.89); C789(0.87); C1253(1.02); C568(0.98)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C293(1.08); C789(0.97); C1253(1.14); C568(0.84)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C293(1.13); C789(1.07); C1253(1.01); C568(0.97)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C293(1.00); C789(0.97); C1253(1.08); C568(1.03)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C293(1.13); C789(0.96); C1253(0.99); C568(0.93)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C293(0.88); C789(0.96); C1253(1.03); C568(0.96)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C293(0.88); C1253(0.96); C568(1.04); C1160(0.72)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C293(0.96); C789(1.07); C1253(1.06); C568(0.97)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C293(0.94); C789(0.94); C1253(0.96); C568(0.97)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C293(0.96); C789(1.02); C1253(1.08); C568(0.97)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C293(0.92); C789(1.02); C1253(1.09); C568(0.99)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C293(1.00); C789(1.02); C1253(0.97); C568(0.98)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C293(1.08); C789(1.01); C1253(1.00); C568(0.93)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C293(0.99); C789(0.93); C1253(0.97); C568(0.97)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C293(0.99); C789(0.99); C1253(1.01); C568(0.98)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C293(1.19); C789(0.96); C1253(0.96); C568(1.05)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C293(1.13); C789(1.08); C1253(0.95); C568(1.09)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C293(1.12); C789(0.97); C1253(0.99); C568(1.11)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C293(0.83); C789(0.94); C1253(0.92); C568(1.00)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C293(0.89); C1253(0.96); C568(0.98); C1160(0.84)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C293(0.99); C789(0.96); C1253(1.00); C568(0.98)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C293(0.93); C789(0.92); C1253(1.04); C568(1.01)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C293(0.94); C789(1.01); C1253(1.10); C568(1.27)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C293(1.05); C789(0.96); C1253(0.95); C568(1.10)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C293(1.17); C789(0.74); C1253(1.23); C568(0.92)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C293(0.96); C789(0.98); C1253(1.01); C568(0.99)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C293(0.95); C789(0.99); C1253(0.94); C568(0.97)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C293(1.04); C789(0.95); C1253(0.98); C568(1.01)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C293(1.13); C789(0.96); C1253(1.07); C568(0.98)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C293(1.06); C789(0.91); C1253(0.97); C568(0.96)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C293(0.90); C789(0.99); C1253(0.95); C568(0.91)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C293(0.85); C1253(0.92); C568(0.92); C1160(0.98)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C293(0.97); C789(0.98); C1253(1.06); C568(0.89)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C293(1.01); C789(0.96); C1253(0.88); C568(1.03)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C293(0.96); C789(0.98); C1253(0.97); C568(0.93)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C293(0.95); C789(0.94); C1253(0.97); C568(1.10)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C293(1.06); C789(0.88); C1253(1.03); C568(0.96)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C293(0.99); C789(1.00); C1253(0.93); C568(1.03)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C293(1.00); C789(0.95); C1253(1.01); C568(0.95)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C293(0.92); C789(0.93); C1253(1.01); C568(0.98)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C293(1.02); C789(0.91); C1253(1.00); C568(0.99)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C293(1.00); C789(0.90); C1253(0.95); C568(1.04)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C293(1.01); C789(0.91); C1253(0.96); C568(1.05)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C293(0.90); C789(0.91); C1253(0.95); C568(1.03)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C293(0.91); C1253(0.98); C568(1.02); C1160(0.94)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C293(0.96); C789(0.95); C1253(1.00); C568(0.94)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C293(0.95); C789(1.02); C1253(1.12); C568(0.97)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1129(1.46)  LDD1702  [7]
 LDCM0625  F8 Ramos C568(0.91); C1396(1.21); C1253(1.09); C1189(2.10)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C568(1.01); C1396(2.67); C1253(1.22); 1.51  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C568(0.55); C1253(4.35); 0.96; C1129(1.23)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C568(0.95); C1396(3.43); C1253(2.02); 1.21  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C568(0.67); C1396(1.01); C1253(1.08); C1189(0.71)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C568(0.97); C1396(4.85); C1189(0.65); 1.32  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C568(1.06); C1253(2.00); C1129(0.67)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C568(0.89); C1396(1.22); C1253(1.02); C1189(0.81)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C568(0.98); C1396(0.95); C1253(0.98); C1189(1.22)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C568(0.93); C1396(0.86); C1253(0.96); C1189(1.04)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C568(0.69); C1396(0.87); C1253(0.79); C1189(0.77)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C568(1.07); C1396(1.33); C1253(1.03); C1189(1.15)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C568(0.85); C1396(1.56); C1253(1.30); C1189(1.17)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C568(1.10); C1396(2.30); C1253(1.47); C1189(1.79)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C293(0.94); C789(1.01); C1253(1.04); C568(0.99)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C568(0.94); C1396(1.41); C1253(0.85); C1189(1.44)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C568(0.59); C1396(3.96); C1253(1.41); C1189(1.92)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C293(0.93); C1253(0.95); C568(1.19); C1160(0.89)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C568(0.95); C1396(1.27); C1253(1.16); C1189(1.74)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C568(0.93); C1396(1.01); C1253(0.92); C1189(1.03)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C568(0.85); C1396(2.99); C1253(1.23); C1189(1.45)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C568(0.84); C1253(2.64); C1189(2.17); C1129(0.68)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y1036(0.80); Y460(0.89); Y86(0.95); Y1207(1.17)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y460(0.65); Y1036(0.83); Y1207(0.84); Y86(1.24)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y1207(0.49); Y1036(0.79); Y86(0.83); Y460(3.15)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y460(0.60); Y1036(0.72); Y86(0.90); Y1207(1.25)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y1036(0.82); Y460(0.92); Y1207(1.07); Y86(1.21)  LDD0268  [12]
 LDCM0107  IAA HeLa H73(0.00); H1141(0.00); C1253(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y1207(1.05)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y1207(1.40)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y1036(2.52); Y1207(1.65)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y1207(3.99)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y1207(2.56)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y1036(2.03); Y1207(0.96)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y1207(0.90)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y1207(1.08)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C293(0.95); C789(0.97); C275(0.99); C1253(0.93)  LDD1492  [30]
 LDCM0023  KB03 Jurkat C176(4.71); C293(12.72); C176(92.05); C1396(26.86)  LDD0209  [10]
 LDCM0024  KB05 COLO792 C275(2.78); C789(1.18); C1262(2.52)  LDD3310  [32]
 LDCM0030  Luteolin HEK-293T 5.57  LDD0182  [8]
 LDCM0109  NEM HeLa H1345(0.00); H1347(0.00); H877(0.00)  LDD0223  [24]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1396(1.08)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1396(0.63); C789(1.22)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1396(0.94)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C275(0.92)  LDD2109  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1396(0.86)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C789(1.06)  LDD2125  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1396(1.28)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1396(1.01); C1253(0.73)  LDD2137  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1396(1.21)  LDD2146  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C374(1.25); C568(1.18); C176(0.24)  LDD2206  [33]
 LDCM0032  Oleacein HEK-293T 5.43  LDD0184  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C176(0.78); C71(0.62); C568(0.59)  LDD2207  [33]
 LDCM0090  Rapamycin JHH-7 3.44  LDD0213  [29]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.