Details of the Target

General Information of Target

Target ID LDTP03677
Target Name Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)
Gene Name MAN1A1
Gene ID 4121
Synonyms
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; EC 3.2.1.113; Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA; Alpha-1,2-mannosidase IA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIF
FLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDN
LARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI
GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGAT
IVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEI
FRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHL
SHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLL
KAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGG
MFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEK
YYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDD
VQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 47 family
Subcellular location
Golgi apparatus membrane
Function Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Uniprot ID
P33908
Ensemble ID
ENST00000368468.4
HGNC ID
HGNC:6821
ChEMBL ID
CHEMBL5915

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P546S .
HEC1 SNV: p.R163H; p.R302Ter .
HEC1B SNV: p.R302Ter .
IGR1 SNV: p.W215C .
IM95 SNV: p.A190T .
MDAMB453 SNV: p.K470N .
NCIH1666 SNV: p.S31A .
NCIH1793 SNV: p.G181V .
PF382 SNV: p.P178S .
SG231 SNV: p.R93H .
TOV21G SNV: p.L36I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C579(1.26)  LDD0531  [1]
W1
 Probe Info  		N11(0.73)  LDD0238  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		9.06  LDD1977  [4]
C313
 Probe Info  		20.68  LDD1980  [4]
C314
 Probe Info  		24.25  LDD1981  [4]
C317
 Probe Info  		9.13  LDD1983  [4]
C362
 Probe Info  		27.47  LDD2023  [4]
FFF probe12
 Probe Info  		20.00  LDD0473  [5]
FFF probe2
 Probe Info  		20.00  LDD0463  [5]
OEA-DA
 Probe Info  		20.00  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C579(1.26)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C579(1.00)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C579(1.00)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C579(1.05)  LDD1510  [7]
 LDCM0246  AC128 HCT 116 C579(1.18)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C579(0.84)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C579(0.89)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C579(1.27)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C579(1.62)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C579(0.93)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C579(0.67)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C579(0.84)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C579(1.03)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C579(1.02)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C579(0.93)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C579(0.82)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C579(1.35)  LDD1512  [7]
 LDCM0260  AC140 HCT 116 C579(0.79)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C579(1.09)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C579(0.81)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C579(1.14)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C579(0.98)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C579(0.87)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C579(1.07)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C579(0.91)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C579(0.93)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C579(0.90)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C579(1.04)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C579(1.02)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C579(0.86)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C579(1.14)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C579(0.77)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C579(0.97)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C579(1.25)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C579(1.04)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C579(1.09)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C579(1.04)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C579(1.10)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C579(0.87)  LDD1517  [7]
 LDCM0279  AC2 HCT 116 C579(1.10)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C579(0.92)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C579(1.10); C508(0.87)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C579(1.21)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C579(1.17)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C579(1.08)  LDD1523  [7]
 LDCM0285  AC25 HCT 116 C579(1.07)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C579(1.02)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C579(1.05)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C579(0.96)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C579(1.16)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C579(1.19)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C579(1.12)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C579(1.15)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C579(0.97)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C579(0.98)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C579(1.04)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C579(1.06)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C579(0.92)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C579(1.20); C508(1.05)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C579(1.26)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C579(1.01)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C579(1.29)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C579(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C579(1.07)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C579(0.97)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C579(1.09)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C579(1.05)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C579(1.04); C508(1.08)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C579(0.92)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C579(0.89)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C579(1.38)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C579(0.87)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C579(1.31)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C579(0.95)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C579(0.98)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C579(0.98)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C579(1.03)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C579(0.91)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C579(0.93)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C579(0.70)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C579(0.91)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C579(0.93)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C579(1.07)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C579(1.12)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C579(0.91)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C579(1.09); C508(0.90)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C579(1.16)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C579(1.06)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C579(0.96)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C579(1.27)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C579(1.35)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C579(0.95)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C579(0.91)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C579(1.09)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C579(1.16)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C579(0.97)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C579(1.05)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C579(0.75)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C579(1.18)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C579(1.06)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C579(1.26)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C579(1.09)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C579(1.21)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C579(1.25)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C579(1.19)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C579(0.69)  LDD0665  [1]
 LDCM0248  AKOS034007472 HEK-293T C579(1.12); C508(0.95)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C579(1.10)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C579(1.06)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C579(0.96)  LDD2171  [1]
 LDCM0367  CL1 HEK-293T C579(1.09)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C579(1.23)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C579(1.22)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C579(1.02)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C579(1.12)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C579(1.01)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C579(0.98)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C579(1.14)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C579(1.12)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C579(0.94)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C579(1.03)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C579(1.05)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C579(1.07)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C579(1.00)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C579(0.72)  LDD1585  [7]
 LDCM0382  CL112 HCT 116 C579(1.00)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C579(0.97)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C579(1.06)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C579(1.03)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C579(0.91)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C579(1.05)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C579(1.07)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C579(1.01)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C579(1.24)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C579(0.97)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C579(1.23)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C579(1.02)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C579(0.85)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C579(0.90)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C579(1.19)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C579(1.09)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C579(1.02)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C579(0.94)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C579(1.29)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C579(1.00)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C579(0.93)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C579(0.93)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C579(1.27)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C579(1.20)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C579(1.12)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C579(0.93)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C579(1.11)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C579(1.10)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C579(1.14)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C579(1.21)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C579(1.32)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C579(1.18)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C579(0.82)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C579(1.29)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C579(0.95)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C579(1.41)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C579(1.15)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C579(0.96)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C579(1.15)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C579(1.10)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C579(1.02)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C579(1.02)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C579(1.05)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C579(1.08)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C579(1.10)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C579(0.88)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C579(1.12)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C579(1.04)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C579(0.98)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C579(0.93)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C579(1.10)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C579(1.15)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C579(1.02)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C579(1.29)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C579(1.03)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C579(1.26)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C579(1.08)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C579(1.03)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C579(1.31)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C579(1.02)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C579(1.20)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C579(1.08)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C579(1.12)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C579(1.04)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C579(1.09); C508(1.12)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C579(1.07)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C579(1.13)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C579(1.20)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C579(1.18)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C579(0.64)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C579(0.81)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C579(0.93)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C579(0.69)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C579(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C579(0.83)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C579(0.78)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C579(0.77)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C579(1.01)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C579(1.03)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C579(0.83)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C579(0.69)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C579(0.82)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C579(0.81)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C579(0.77)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C579(1.00)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C579(1.17)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C579(1.05)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C579(1.11)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C579(1.24)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C579(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C579(1.11); C508(1.08)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C579(1.33)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C579(1.15)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C579(1.07)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C579(1.06)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C579(1.08)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C579(0.97)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C579(0.94)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C579(1.09)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C579(1.21); C508(0.98)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C579(1.27)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C579(1.25)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C579(1.36)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C579(1.57)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C579(1.48)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C579(1.09)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C579(1.34)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C579(1.17)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C579(1.27)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C579(1.31)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C579(0.94)  LDD1698  [7]
 LDCM0625  F8 Ramos C579(3.00)  LDD2187  [8]
 LDCM0576  Fragment14 Ramos C579(1.08)  LDD2193  [8]
 LDCM0468  Fragment33 HCT 116 C579(0.88)  LDD0785  [1]
 LDCM0566  Fragment4 Ramos C579(1.69)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C579(1.06)  LDD0744  [1]
 LDCM0569  Fragment7 Ramos C579(1.59)  LDD2186  [8]
 LDCM0022  KB02 HEK-293T C579(0.98)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C579(0.98)  LDD1497  [7]
 LDCM0024  KB05 OPM-2 C579(4.28)  LDD3377  [9]
 LDCM0021  THZ1 HCT 116 C579(0.96)  LDD2173  [1]
 LDCM0111  W14 Hep-G2 N11(0.73)  LDD0238  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840