Details of the Target

General Information of Target

Target ID LDTP09069
Target Name Kinetochore protein Spc24 (SPC24)
Gene Name SPC24
Gene ID 147841
Synonyms
SPBC24; Kinetochore protein Spc24; hSpc24
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEK
EVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLER
QEKEVDEDTTVTIPSAVYVAQLYHQVSKIEWDYECEPGMVKGIHHGPSVAQPIHLDSTQL
SRKFISDYLWSLVDTEW
Target Bioclass
Other
Family
SPC24 family
Subcellular location
Nucleus
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Uniprot ID
Q8NBT2
Ensemble ID
ENST00000592540.6
HGNC ID
HGNC:26913

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.R22H .
HT SNV: p.M1? .
LNCaP clone FGC SNV: p.S181F .
SG231 SNV: p.S11N .
TOV21G SNV: p.Q26Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K60(5.26); K70(2.13)  LDD0277  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C155(1.16)  LDD0080  [4]
5E-2FA
 Probe Info  		H174(0.00); H34(0.00)  LDD2235  [5]
1d-yne
 Probe Info  		N.A.  LDD0358  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.28  LDD1733  [10]
C040
 Probe Info  		7.21  LDD1740  [10]
C070
 Probe Info  		8.57  LDD1766  [10]
C087
 Probe Info  		22.47  LDD1779  [10]
C106
 Probe Info  		30.91  LDD1793  [10]
C107
 Probe Info  		6.23  LDD1794  [10]
C108
 Probe Info  		11.96  LDD1795  [10]
C112
 Probe Info  		18.00  LDD1799  [10]
C158
 Probe Info  		41.93  LDD1838  [10]
C159
 Probe Info  		10.85  LDD1839  [10]
C160
 Probe Info  		10.63  LDD1840  [10]
C161
 Probe Info  		16.80  LDD1841  [10]
C218
 Probe Info  		18.51  LDD1892  [10]
C220
 Probe Info  		17.51  LDD1894  [10]
C232
 Probe Info  		42.22  LDD1905  [10]
C244
 Probe Info  		15.24  LDD1917  [10]
C249
 Probe Info  		18.25  LDD1922  [10]
C264
 Probe Info  		17.63  LDD1935  [10]
C265
 Probe Info  		15.89  LDD1936  [10]
C269
 Probe Info  		7.06  LDD1939  [10]
C278
 Probe Info  		53.82  LDD1948  [10]
C280
 Probe Info  		11.31  LDD1950  [10]
C282
 Probe Info  		17.15  LDD1952  [10]
C284
 Probe Info  		31.56  LDD1954  [10]
C305
 Probe Info  		14.83  LDD1974  [10]
C313
 Probe Info  		28.05  LDD1980  [10]
C314
 Probe Info  		12.38  LDD1981  [10]
C317
 Probe Info  		9.65  LDD1983  [10]
C348
 Probe Info  		12.21  LDD2009  [10]
C350
 Probe Info  		27.67  LDD2011  [10]
C354
 Probe Info  		8.34  LDD2015  [10]
C362
 Probe Info  		25.28  LDD2023  [10]
C363
 Probe Info  		22.63  LDD2024  [10]
C376
 Probe Info  		6.96  LDD2036  [10]
C378
 Probe Info  		8.46  LDD2037  [10]
C380
 Probe Info  		5.43  LDD2039  [10]
C382
 Probe Info  		9.32  LDD2041  [10]
C390
 Probe Info  		41.07  LDD2049  [10]
C391
 Probe Info  		21.41  LDD2050  [10]
C397
 Probe Info  		10.34  LDD2056  [10]
C403
 Probe Info  		21.86  LDD2061  [10]
C407
 Probe Info  		17.39  LDD2064  [10]
FFF probe11
 Probe Info  		20.00  LDD0471  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]
FFF probe3
 Probe Info  		20.00  LDD0464  [11]
OEA-DA
 Probe Info  		20.00  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C155(1.18)  LDD1093  [4]
 LDCM0215  AC10 HCT 116 C155(1.08)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C155(0.93)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C155(1.01)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C155(0.99)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C155(0.98)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C155(0.87)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C155(0.92)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C155(0.93)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C155(0.82)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C155(1.00)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C155(0.92)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C155(1.18)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C155(0.83)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C155(1.03)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C155(0.82)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C155(1.04)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C155(1.00)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C155(1.06)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C155(1.16)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C155(1.20)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C155(1.28)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C155(1.29)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C155(1.03)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C155(1.00)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C155(1.20)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C155(1.17)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C155(0.90)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C155(1.14)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C155(1.09)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C155(0.93)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C155(1.08)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C155(1.00)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C155(1.10)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C155(0.92)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C155(1.15)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C155(1.21)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C155(1.14)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C155(1.19)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C155(1.01)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C155(1.25)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C155(1.19)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C155(0.98)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C155(1.09)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C155(0.98)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C155(0.99)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C155(1.14)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C155(1.04)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C155(0.97)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C155(1.07)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C155(0.94)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C155(0.97)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C155(0.95)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C155(0.97)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C155(1.19)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C155(0.98)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C155(1.13)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C155(1.31)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C155(1.23)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C155(1.11)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C155(1.33)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C155(1.18)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C155(1.25)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C155(1.19)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C155(1.05)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C155(0.92)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C155(0.88)  LDD0595  [4]
 LDCM0279  AC2 PaTu 8988t C155(0.98)  LDD1158  [4]
 LDCM0280  AC20 HCT 116 C155(1.00)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C155(0.97)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C155(1.00)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C155(0.97)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C155(1.10)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C155(1.12)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C155(1.24)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C155(1.21)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C155(1.04)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C155(1.21)  LDD0606  [4]
 LDCM0290  AC3 PaTu 8988t C155(0.82)  LDD1169  [4]
 LDCM0291  AC30 HCT 116 C155(1.18)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C155(1.09)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C155(1.17)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C155(1.09)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C155(1.21)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C155(0.92)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C155(0.90)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C155(1.00)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C155(1.01)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C155(0.92)  LDD0617  [4]
 LDCM0301  AC4 PaTu 8988t C155(0.93)  LDD1180  [4]
 LDCM0302  AC40 HCT 116 C155(1.04)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C155(0.97)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C155(1.06)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C155(1.02)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C155(1.01)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C155(1.07)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C155(1.04)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C155(1.05)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C155(1.07)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C155(1.17)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C155(0.94)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C155(1.19)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C155(0.97)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C155(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C155(0.99)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C155(1.04)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C155(1.29)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C155(1.40)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C155(0.93)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C155(1.05)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C155(1.11)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C155(1.09)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C155(1.29)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C155(1.10)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C155(0.85)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C155(0.92)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C155(1.05)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C155(1.26)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C155(1.42)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C155(1.15)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C155(0.90)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C155(0.85)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C155(1.08)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C155(1.08)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C155(1.04)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C155(1.05)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C155(1.22)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C155(0.99)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C155(1.05)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C155(0.96)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C155(0.92)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C155(0.91)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C155(0.97)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C155(1.07)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C155(1.08)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C155(1.17)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C155(1.08)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C155(1.06)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C155(0.94)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C155(0.94)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C155(0.96)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C155(1.04)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C155(1.01)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C155(1.08)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C155(0.96)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C155(0.98)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C155(0.98)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C155(0.99)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C155(0.95)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C155(1.01)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C155(0.89)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C155(1.02)  LDD0962  [4]
 LDCM0365  AC98 HCT 116 C155(1.07)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C155(0.92)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C155(1.18)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C155(1.02)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C155(1.04)  LDD0592  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C155(3.13)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C155(0.99)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C155(0.91)  LDD1572  [13]
 LDCM0369  CL100 PaTu 8988t C155(0.84)  LDD1248  [4]
 LDCM0370  CL101 HCT 116 C155(1.09)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C155(1.12)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C155(1.04)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C155(1.11)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C155(0.99)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C155(1.02)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C155(0.95)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C155(1.03)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C155(0.98)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C155(1.13)  LDD1583  [13]
 LDCM0380  CL110 HCT 116 C155(1.02)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C155(0.89)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C155(0.97)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C155(1.04)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C155(1.00)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C155(1.00)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C155(1.06)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C155(1.23)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C155(1.14)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C155(1.03)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C155(1.01)  LDD1594  [13]
 LDCM0391  CL120 HCT 116 C155(1.01)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C155(1.26)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C155(0.98)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C155(1.06)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C155(1.03)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C155(1.17)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C155(0.93)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C155(1.02)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C155(1.02)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C155(0.94)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C155(0.97)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C155(0.83)  LDD1606  [13]
 LDCM0403  CL16 PaTu 8988t C155(1.06)  LDD1282  [4]
 LDCM0404  CL17 HCT 116 C155(0.85)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C155(0.88)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C155(1.06)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C155(0.91)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C155(1.05)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C155(1.11)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C155(1.05)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C155(1.24)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C155(1.04)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C155(0.96)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C155(1.01)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C155(1.15)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C155(0.98)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C155(1.00)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C155(0.81)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C155(1.23)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C155(1.04)  LDD0737  [4]
 LDCM0421  CL32 PaTu 8988t C155(1.07)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C155(1.00)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C155(1.15)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C155(1.20)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C155(1.09)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C155(1.58)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C155(1.06)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C155(1.04)  LDD1633  [13]
 LDCM0430  CL40 PaTu 8988t C155(1.08)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C155(1.21)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C155(1.37)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C155(1.81)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C155(1.32)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C155(0.92)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C155(1.09)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C155(1.22)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C155(1.11)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C155(1.00)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C155(0.96)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C155(0.94)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C155(1.10)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C155(0.96)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C155(0.92)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C155(1.18)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C155(1.09)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C155(1.03)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C155(1.08)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C155(1.44)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C155(0.98)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C155(1.19)  LDD1655  [13]
 LDCM0453  CL61 PaTu 8988t C155(0.58)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C155(0.53)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C155(0.74)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C155(0.83)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C155(0.73)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C155(0.69)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C155(0.67)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C155(0.70)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C155(0.97)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C155(1.01)  LDD1665  [13]
 LDCM0463  CL70 PaTu 8988t C155(0.71)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C155(0.61)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C155(0.70)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C155(0.76)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C155(0.58)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C155(1.24)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C155(1.12)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C155(1.30)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C155(1.21)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C155(0.77)  LDD1676  [13]
 LDCM0474  CL80 PaTu 8988t C155(1.19)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C155(1.16)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C155(1.47)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C155(1.35)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C155(1.23)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C155(1.16)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C155(1.21)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C155(1.06)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C155(1.31)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C155(1.11)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C155(1.02)  LDD1687  [13]
 LDCM0485  CL90 PaTu 8988t C155(1.18)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C155(0.92)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C155(0.86)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C155(0.83)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C155(0.88)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C155(1.11)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C155(0.97)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C155(1.11)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C155(1.08)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C155(0.81)  LDD1373  [4]
 LDCM0193  Compound 36 HEK-293T 5.73  LDD0511  [11]
 LDCM0495  E2913 HEK-293T C155(1.05)  LDD1698  [13]
 LDCM0625  F8 Ramos C155(1.13)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C155(0.53)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C155(0.31)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C155(0.71)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C155(0.92)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C155(1.42)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C155(0.47)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C155(0.86)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C155(0.92)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C155(0.93)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C155(0.30)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C155(0.98)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C155(0.93)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C155(0.52)  LDD2201  [14]
 LDCM0468  Fragment33 PaTu 8988t C155(0.74)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C155(1.23)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C155(0.70)  LDD2184  [14]
 LDCM0427  Fragment51 PaTu 8988t C155(1.32)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C155(1.06)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C155(0.77)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C155(0.53)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C155(0.56)  LDD2188  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C155(1.16)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C155(1.16)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C155(1.66)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0131  RA190 MM1.R C155(1.32)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sulfite oxidase, mitochondrial (SUOX) . P51687
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinetochore protein Spc25 (SPC25) SPC25 family Q9HBM1
Whirlin (WHRN) . Q9P202

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.