Details of the Target

General Information of Target

Target ID LDTP04111
Target Name Small ribosomal subunit protein eS10 (RPS10)
Gene Name RPS10
Gene ID 6204
Synonyms
Small ribosomal subunit protein eS10; 40S ribosomal protein S10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE
QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG
EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS10 family
Subcellular location
Cytoplasm
Function Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P46783
Ensemble ID
ENST00000464218.5
HGNC ID
HGNC:10383

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		18.58  LDD0066  [1]
TH216
 Probe Info  		Y127(20.00)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		E149(0.84); E141(0.93); E110(0.98)  LDD2208  [4]
ONAyne
 Probe Info  		K53(0.00); K107(0.00)  LDD0273  [5]
Probe 1
 Probe Info  		Y127(53.17)  LDD3495  [6]
HPAP
 Probe Info  		3.43  LDD0063  [7]
HHS-465
 Probe Info  		Y127(10.00)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
AMP probe
 Probe Info  		N.A.  LDD0200  [10]
ATP probe
 Probe Info  		K139(0.00); K38(0.00); K59(0.00); K31(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
ATP probe
 Probe Info  		K59(0.00); K47(0.00); K139(0.00)  LDD0035  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		Y82(0.00); Y12(0.00); K139(0.00)  LDD0028  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
Ox-W18
 Probe Info  		W69(0.00); W64(0.00)  LDD2175  [15]
1c-yne
 Probe Info  		K139(0.00); K38(0.00); K17(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
W1
 Probe Info  		Y68(0.00); W69(0.00); H66(0.00)  LDD0236  [17]
HHS-482
 Probe Info  		Y12(1.01)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		11.88  LDD1752  [18]
C087
 Probe Info  		7.46  LDD1779  [18]
C244
 Probe Info  		14.22  LDD1917  [18]
C313
 Probe Info  		12.73  LDD1980  [18]
C317
 Probe Info  		6.06  LDD1983  [18]
C354
 Probe Info  		8.57  LDD2015  [18]
C391
 Probe Info  		14.42  LDD2050  [18]
C403
 Probe Info  		17.03  LDD2061  [18]
FFF probe13
 Probe Info  		5.94  LDD0475  [19]
FFF probe3
 Probe Info  		5.99  LDD0464  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [20]
Diazir
 Probe Info  		N.A.  LDD0011  [13]
BD-F
 Probe Info  		N.A.  LDD0024  [21]
LD-F
 Probe Info  		L83(0.00); H84(0.00); D81(0.00)  LDD0015  [21]
DA-2
 Probe Info  		N.A.  LDD0072  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0014  Panhematin K562 3.43  LDD0063  [7]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.