General Information of Target

Target ID LDTP05993
Target Name Exosome complex component RRP4 (EXOSC2)
Gene Name EXOSC2
Gene ID 23404
Synonyms
RRP4; Exosome complex component RRP4; Exosome component 2; Ribosomal RNA-processing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSV
ERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGEL
RRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVK
RQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNC
IISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG
Target Bioclass
Other
Family
RRP4 family
Subcellular location
Cytoplasm
Function
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Uniprot ID
Q13868
Ensemble ID
ENST00000372351.7
HGNC ID
HGNC:17097

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DANG Insertion: p.V233GfsTer2 .
JURKAT Insertion: p.S177LfsTer12
SNV: p.S177P
.
NCIH358 Substitution: p.K12P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
15.00  LDD0402  [1]
DBIA
 Probe Info 
C240(1.82)  LDD3310  [2]
5E-2FA
 Probe Info 
N.A.  LDD2235  [3]
4-Iodoacetamidophenylacetylene
 Probe Info 
C259(0.00); C240(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info 
C259(0.00); C240(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [4]
TFBX
 Probe Info 
N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info 
N.A.  LDD0018  [6]
1c-yne
 Probe Info 
N.A.  LDD0228  [7]
Acrolein
 Probe Info 
N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info 
N.A.  LDD0219  [8]
NAIA_5
 Probe Info 
C240(0.00); C259(0.00); C68(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C317
 Probe Info 
6.87  LDD1983  [10]
VE-P
 Probe Info 
N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C240(0.98); C259(0.82)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C240(1.10); C259(1.01)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C240(1.16); C259(0.94)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C259(1.04)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C240(0.85); C259(0.99)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C240(0.91); C259(1.12)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C240(0.98); C259(0.89)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C240(1.11); C259(0.93)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C240(0.94); C259(0.82)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C240(1.05); C259(1.19)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C259(0.95)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C240(0.95); C259(0.95)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C240(0.97); C259(0.89)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C240(0.90); C259(1.18)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C240(1.04); C259(1.01)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C240(0.96); C259(0.90)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C240(1.04); C259(1.07)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C240(1.10); C259(0.96)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C259(0.89)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C240(1.01); C259(0.96)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C240(1.05); C259(1.06)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C240(0.98); C259(1.00)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C240(0.94); C259(0.90)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C240(0.96); C259(0.98)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C240(1.06); C259(0.76)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C240(1.00); C259(0.89)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C240(1.11); C259(1.00)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C259(1.01)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C240(1.09); C259(0.93)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C240(1.00); C259(1.00)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C240(1.07); C259(0.90)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C259(1.24)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C240(0.93); C259(0.94)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C240(0.97); C259(0.78)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C240(1.03); C259(0.93)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C240(1.05); C259(0.91)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C259(0.99)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C240(1.05); C259(1.04)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C240(1.02); C259(1.09)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C240(1.06); C259(0.97)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C240(1.12); C259(0.93)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C240(1.07); C259(0.81)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C240(1.19); C259(1.00)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C240(1.09); C259(0.83)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C240(1.09); C259(1.00)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C259(1.14)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C240(1.00); C259(0.94)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C240(1.12); C259(1.14)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C240(1.07); C259(0.77)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C240(1.14); C259(1.02)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C240(0.95); C259(0.74)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C240(0.97); C259(0.86)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C240(1.21); C259(0.84)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C240(0.96); C259(1.06)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C259(1.01)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C240(0.90); C259(0.97)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C240(0.89); C259(0.88)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C240(0.89); C259(0.97)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C240(0.99); C259(1.00)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C240(1.07); C259(1.09)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C240(1.00); C259(0.99)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C240(1.13); C259(1.03)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C240(1.02); C259(0.82)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C240(1.07); C259(0.99)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 10.17  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C68(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C240(0.80); C259(0.99)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C240(1.21); C259(0.64)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C240(0.99); C259(1.01); C191(1.14)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C240(0.97); C259(1.05)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C240(1.07); C259(0.97)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C240(0.99); C259(0.97)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C240(1.05); C259(1.27); C191(1.07)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C240(0.34); C259(0.96)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C240(0.91); C259(0.95)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C240(0.97); C259(0.85)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C240(1.18); C259(1.02); C191(1.05)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C240(0.81); C259(1.05)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C240(1.01); C259(1.03)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C240(1.00); C259(0.88)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C240(1.03); C259(0.79)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C240(1.09); C259(1.08); C191(1.02)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C240(0.79); C259(0.92)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C240(0.90); C259(0.89)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C240(1.11); C259(0.94)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C240(0.97); C259(1.05); C191(1.00)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C240(0.82); C259(1.23)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C240(1.06); C259(0.88)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C240(0.98); C259(1.14)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C240(1.00); C259(0.90)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C240(1.11); C259(1.05); C191(1.12)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C240(1.04); C259(1.06)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C240(0.89); C259(0.84)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C240(0.93); C259(0.85)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C240(1.15); C259(1.27); C191(1.00)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C240(0.78); C259(0.86)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C240(0.73); C259(0.88)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C240(0.98); C259(1.06)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C240(1.00); C259(1.03); C191(0.99)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C240(0.73); C259(0.95)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C240(0.79); C259(0.90)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C240(0.97); C259(0.84)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C240(1.07); C259(1.06); C191(0.98)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C240(0.91); C259(0.76)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C240(1.03); C259(0.74)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C240(1.25); C259(0.87)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C240(0.84); C259(1.07)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C259(0.92)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C240(0.84); C259(0.76)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C240(0.99); C259(0.93)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C240(1.22); C259(0.81)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C240(1.07); C259(1.04)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C240(0.86); C259(0.82)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C240(1.01); C259(0.87)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C240(0.96); C259(0.90)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C240(1.04); C259(0.96); C191(1.00)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C240(0.91); C259(0.71)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C240(1.11); C259(1.24)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C240(1.08); C259(0.88)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C240(1.13); C259(0.83)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C259(0.85)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C240(0.96); C259(0.71)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C240(1.09); C259(0.85)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C240(1.09); C259(1.06)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C240(0.92); C259(0.92)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C240(0.87); C259(0.77)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C240(0.85); C259(0.95)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C240(1.12); C259(1.22); C191(1.11)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C240(1.06); C259(0.78); C191(1.05)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C240(0.91); C259(0.64)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C240(1.08); C259(0.80)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C240(1.03); C259(0.96)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C259(0.91)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C240(0.92); C259(0.73)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C240(0.92); C259(0.90)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C240(1.00); C259(0.95)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C240(0.95); C259(0.92)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C240(1.03); C259(1.43)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C240(0.91); C259(1.00)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C240(0.88); C259(0.84)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C240(0.98); C259(1.21); C191(1.14)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C240(0.93); C259(0.69)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C240(0.97); C259(0.88)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C240(1.10); C259(0.92)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C259(0.99)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C240(0.86); C259(0.80)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C240(1.05); C259(0.94)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C240(1.04); C259(0.83)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C240(0.89); C259(0.95)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C240(1.05); C259(0.86)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C240(0.97); C259(1.38)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C240(0.96); C259(0.83)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C240(1.00); C259(0.99)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C240(1.04); C259(1.18); C191(1.06)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C240(0.94); C259(0.79)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C240(0.93); C259(0.84)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C240(1.11); C259(0.92)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C259(0.93)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C240(1.09); C259(0.86)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C240(1.30); C259(0.77)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C240(0.88); C259(0.85)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C240(1.08); C259(0.87)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C240(1.04); C259(0.97)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C240(0.83); C259(0.85)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C240(0.85); C259(0.94)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C240(1.37); C259(1.03); C191(1.02)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C240(0.98); C259(0.64)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C240(1.05); C259(0.77)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C240(1.22); C259(0.90)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C259(0.73)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C259(0.97)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C240(1.00); C259(0.78)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C240(0.94); C259(0.91)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C240(0.97); C259(0.85)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C240(0.96); C259(0.99)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C240(0.84); C259(0.94)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C240(0.88); C259(0.92)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C240(1.06); C259(1.06)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C240(0.89); C259(1.06); C191(1.07)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C240(1.02); C259(0.81)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C240(0.88); C259(1.03)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C240(0.83); C259(0.61)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C240(0.98); C259(1.09)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C259(0.93)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C240(1.13); C259(0.75)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C240(0.93); C259(0.94)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C240(0.91); C259(0.57)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C240(0.91); C259(0.89)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C240(0.73); C259(0.74)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C240(0.93); C259(0.93)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C240(0.84); C259(0.95)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C240(0.91); C259(0.78)  LDD1698  [12]
 LDCM0625  F8 Ramos C240(0.54)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C240(0.60)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C240(1.08)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C240(0.69)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C240(0.98)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C240(0.84)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C240(0.63)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C240(0.93)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C240(1.28)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C240(0.99)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C240(1.30)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C240(0.82)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C240(1.56)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C240(0.55)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C240(0.99); C259(1.02)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C240(0.72)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C240(0.53)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C240(0.97); C259(0.79)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C240(0.86)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C240(0.98)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C240(0.43)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C240(0.59)  LDD2188  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C259(1.15); C240(1.02)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C259(0.91); C240(1.11)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C240(1.82)  LDD3310  [2]
 LDCM0109  NEM HeLa H43(0.00); H25(0.00)  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uncharacterized serine/threonine-protein kinase SBK3 (SBK3) Ser/Thr protein kinase family P0C264
Exosome complex component RRP41 (EXOSC4) RNase PH family Q9NPD3
Exosome complex component RRP42 (EXOSC7) RNase PH family Q15024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
M-phase phosphoprotein 6 (MPHOSPH6) MPP6 family Q99547
Exosome complex component RRP40 (EXOSC3) RRP40 family Q9NQT5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578