Details of the Target

General Information of Target

Target ID LDTP15132
Target Name 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3)
Gene Name OGFOD3
Gene ID 79701
Synonyms
C17orf101; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3; EC 1.14.11.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLKLKDCEFWYSLHGQVPGLLDWDMRNELFLPCTTDQCSLAEQILAKYRVGVMKPPEMP
QKRRPSPDGDGPPCEPNLWMWVDPNILCPLGSQEAPKPSGKEDLTNISPFPQPPQKDEGS
NCSEDKVVESLPSSSSEQSPLQKQGIHSPSDFELTEEEAEEPDDNSLQSPEMKCYQSQKL
WQINNQEKSWQRPPLNCSHLIALALRNNPHCGLSVQEIYNFTRQHFPFFWTAPDGWKSTI
HYNLCFLDSFEKVPDSLKDEDNARPRSCLWKLTKEGHRRFWEETRVLAFAQRERIQECMS
QPELLTSLFDL
Target Bioclass
Enzyme
Family
OGFOD3 family
Subcellular location
Membrane
Uniprot ID
Q6PK18
Ensemble ID
ENST00000313056.10
HGNC ID
HGNC:26174

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.T118I .
ETK1 SNV: p.D310Y .
MOLT4 SNV: p.R185W IA-alkyne    Probe Info 
NCIH1048 SNV: p.I303V .
RKO SNV: p.V184M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C103(1.57)  LDD3333  [1]
IA-alkyne
 Probe Info  		C103(0.00); C90(0.00)  LDD0162  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		19.03  LDD1753  [4]
C161
 Probe Info  		11.47  LDD1841  [4]
C169
 Probe Info  		85.04  LDD1849  [4]
C236
 Probe Info  		34.30  LDD1909  [4]
C238
 Probe Info  		17.03  LDD1911  [4]
C240
 Probe Info  		8.22  LDD1913  [4]
C251
 Probe Info  		27.47  LDD1924  [4]
C269
 Probe Info  		6.15  LDD1939  [4]
C388
 Probe Info  		64.89  LDD2047  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C103(1.06)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C103(1.02)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C103(1.05)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C103(1.06)  LDD1510  [5]
 LDCM0276  AC17 HEK-293T C103(1.10)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C103(1.03)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C103(1.23)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C103(1.17)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C103(1.07)  LDD1519  [5]
 LDCM0285  AC25 HEK-293T C103(0.95)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C103(1.18)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C103(1.04)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C103(1.02)  LDD1527  [5]
 LDCM0290  AC3 HEK-293T C103(1.02)  LDD1529  [5]
 LDCM0294  AC33 HEK-293T C103(1.06)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C103(1.06)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C103(1.14)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C103(1.03)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C103(1.01)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C103(1.04)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C103(1.00)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C103(1.07)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C103(1.10)  LDD1545  [5]
 LDCM0311  AC49 HEK-293T C103(1.22)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C103(1.09)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C103(1.05)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C103(1.12)  LDD1554  [5]
 LDCM0320  AC57 HEK-293T C103(1.03)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C103(1.12)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C103(1.07)  LDD1561  [5]
 LDCM0324  AC60 HEK-293T C103(1.04)  LDD1563  [5]
 LDCM0356  AKOS034007680 HEK-293T C103(1.05)  LDD1570  [5]
 LDCM0371  CL102 HEK-293T C103(1.10)  LDD1575  [5]
 LDCM0375  CL106 HEK-293T C103(1.01)  LDD1579  [5]
 LDCM0380  CL110 HEK-293T C103(1.09)  LDD1584  [5]
 LDCM0384  CL114 HEK-293T C103(1.29)  LDD1588  [5]
 LDCM0388  CL118 HEK-293T C103(1.22)  LDD1592  [5]
 LDCM0393  CL122 HEK-293T C103(1.21)  LDD1597  [5]
 LDCM0397  CL126 HEK-293T C103(1.15)  LDD1601  [5]
 LDCM0401  CL14 HEK-293T C103(0.98)  LDD1605  [5]
 LDCM0404  CL17 HEK-293T C103(1.19)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C103(0.92)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C103(0.92)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C103(1.18)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C103(1.08)  LDD1612  [5]
 LDCM0414  CL26 HEK-293T C103(1.03)  LDD1618  [5]
 LDCM0417  CL29 HEK-293T C103(0.93)  LDD1621  [5]
 LDCM0419  CL30 HEK-293T C103(1.07)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C103(1.03)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C103(1.04)  LDD1625  [5]
 LDCM0431  CL41 HEK-293T C103(1.23)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C103(1.10)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C103(0.95)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C103(1.13)  LDD1638  [5]
 LDCM0440  CL5 HEK-293T C103(1.19)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C103(1.17)  LDD1645  [5]
 LDCM0444  CL53 HEK-293T C103(1.17)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C103(1.19)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C103(0.94)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C103(1.07)  LDD1650  [5]
 LDCM0451  CL6 HEK-293T C103(1.00)  LDD1654  [5]
 LDCM0454  CL62 HEK-293T C103(1.00)  LDD1657  [5]
 LDCM0457  CL65 HEK-293T C103(1.10)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C103(0.98)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C103(0.93)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C103(1.09)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C103(0.95)  LDD1665  [5]
 LDCM0467  CL74 HEK-293T C103(1.26)  LDD1670  [5]
 LDCM0470  CL77 HEK-293T C103(1.16)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C103(0.93)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C103(1.02)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C103(0.98)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C103(1.17)  LDD1677  [5]
 LDCM0480  CL86 HEK-293T C103(1.07)  LDD1683  [5]
 LDCM0483  CL89 HEK-293T C103(1.02)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C103(1.19)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C103(1.01)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C103(1.18)  LDD1690  [5]
 LDCM0493  CL98 HEK-293T C103(1.10)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C103(1.09)  LDD1631  [5]
 LDCM0022  KB02 Hs 936.T C103(1.54)  LDD2363  [1]
 LDCM0023  KB03 Hs 936.T C103(2.18)  LDD2780  [1]
 LDCM0024  KB05 MOLM-13 C103(1.57)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402