Details of the Target

General Information of Target

Target ID LDTP07577
Target Name Serine/threonine-protein kinase ULK3 (ULK3)
Gene Name ULK3
Gene ID 25989
Synonyms
Serine/threonine-protein kinase ULK3; EC 2.7.11.1; Unc-51-like kinase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL
TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ
LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM
APEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLS
RDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDS
AAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGT
SARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPG
RRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
TTD ID
T16188
Uniprot ID
Q6PHR2
DrugMap ID
TTYENHQ
Ensemble ID
ENST00000440863.7
HGNC ID
HGNC:19703
ChEMBL ID
CHEMBL5047

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1143 SNV: p.D364E .
JHH1 Deletion: p.S339CfsTer2
SNV: p.A392P		 .
MCC13 SNV: p.Q472Ter DBIA    Probe Info 
MCF7 Deletion: p.R422_R423del .
NCIH2052 SNV: p.V465G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C186(0.93)  LDD0531  [1]
ATP probe
 Probe Info  		K170(0.00); K44(0.00); K48(0.00); K139(0.00)  LDD0199  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		44.02  LDD1884  [5]
C266
 Probe Info  		8.63  LDD1937  [5]
C269
 Probe Info  		6.45  LDD1939  [5]
C270
 Probe Info  		6.68  LDD1940  [5]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C186(0.93)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C186(1.07)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C186(1.10); C308(1.08)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C186(1.30); C308(1.19)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C186(0.97); C308(1.13)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C186(1.09); C308(1.25)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C186(0.79); C308(1.02)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C186(1.03); C308(1.19)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C186(1.58); C308(1.03)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C186(1.09); C308(1.09)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C186(1.19); C308(1.10)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C186(1.16); C308(1.12)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C186(1.13)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C186(1.06); C308(1.23)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C186(1.26); C308(1.36)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C186(1.14); C308(1.14)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C186(1.02)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C186(1.06)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C186(0.94)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C186(0.91)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C186(1.05)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C186(0.76)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C186(0.88)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C186(1.11)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C186(0.89)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C186(0.81)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C186(0.81)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C186(0.70)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C186(0.86)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C186(0.83)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C186(0.84)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C186(0.84)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C186(0.97)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C186(1.03)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C186(1.24)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C186(1.13)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C186(1.16)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C186(1.22)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C186(1.23)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C186(1.16)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C186(1.15)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C186(1.15)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C186(1.56)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C186(1.26)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C186(1.01)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C186(1.37)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C186(1.30)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C186(1.19)  LDD0579  [1]
 LDCM0263  AC143 HEK-293T C186(0.93)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C186(1.05)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C186(1.07)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C186(1.06)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C186(1.14)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C186(1.29)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C186(1.05)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C186(1.13)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C186(1.17)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C186(1.11)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C186(0.95)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C186(1.02)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C186(1.01)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C186(0.88)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C186(0.96)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C186(1.12)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C186(0.86)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C186(1.01)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C186(0.90)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C186(1.04)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C186(0.90)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C186(0.86)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C186(0.94)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C186(0.96)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C186(0.88)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C186(0.98); C308(1.02)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C186(0.79); C308(0.97)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C308(0.97); C186(1.09)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C308(0.91); C186(1.16)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C186(0.83); C308(1.06)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C186(0.87)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C186(0.93); C308(1.05)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C308(0.85); C186(1.01)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C186(0.94); C308(1.01)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C186(1.01); C308(1.06)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C186(1.02); C308(1.14)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C308(0.85); C186(0.86)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C186(0.86); C308(0.93)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C186(0.82); C308(0.84)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C186(0.85); C308(0.93)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C186(0.84); C308(0.95)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C186(1.06)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C308(0.92); C186(0.96)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C308(0.73); C186(0.73)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C308(0.86); C186(1.08)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C308(0.74); C186(0.81)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C308(0.85); C186(0.90)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C186(0.85); C308(0.88)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C186(1.07)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C186(1.08)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C186(0.94)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C186(0.96)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C186(0.95)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C186(1.11)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C186(1.04)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C186(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C186(0.92)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C186(0.95)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C186(1.03)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C186(0.97)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C186(1.53)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C186(1.05)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C186(1.41)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C186(1.10)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C186(1.29)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C186(1.51)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C186(1.03)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C186(1.13)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C186(1.22)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C186(1.30)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C186(1.07)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C186(1.58)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C186(0.99)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C186(1.04)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C186(1.08)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C186(1.12)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C186(1.07)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C186(0.95)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C186(1.16)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C186(1.09)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C186(1.23)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C186(1.05)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C186(1.16)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C186(1.10)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C186(1.02)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C186(1.08)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C186(1.28)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C186(1.37)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C186(1.66)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C186(1.34)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C186(1.01)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C186(0.82)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C186(0.91)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C186(1.03)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C186(1.09)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C186(0.92)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C186(0.92)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C186(1.15)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C186(1.15)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C186(1.06)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C186(0.99)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C186(0.89)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C186(0.96)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C186(0.97)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C308(1.07); C186(1.07)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C308(0.92); C186(1.37)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C186(1.07)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C186(1.03)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C186(1.16)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C308(1.11)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C308(1.08)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C186(1.07)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C186(1.03)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C186(1.00)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C186(1.07)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C186(1.06)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C186(0.96)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C186(1.15)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C186(0.91)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C186(0.91)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C186(0.92)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C308(1.20)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C186(0.96)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C186(1.06)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C308(0.82); C186(1.00)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C308(0.98); C186(1.19)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C186(0.74); C308(0.82)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C186(0.98); C308(1.05)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C186(0.90); C308(0.97)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C308(0.92); C186(1.05)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C308(0.83); C186(0.92)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C308(0.84); C186(0.89)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C308(1.31)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C186(0.85); C308(0.88)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C186(1.00)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C186(0.88)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C186(0.87)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C186(0.89)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C186(1.65)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C186(1.22)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C186(1.23)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C186(1.09)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C308(1.06)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C308(1.09)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C308(0.83)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C186(0.74)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C186(1.00)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C186(0.81)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C186(1.18)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C308(0.98)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C186(1.04)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C186(0.89)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C186(1.14)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C186(1.04)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C186(1.07)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C186(1.17)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C186(0.95)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C186(0.83)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C186(0.88)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C186(0.89)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C308(1.06)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C186(1.14)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C186(1.01)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C186(1.02)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C186(0.93)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C186(1.12)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C186(1.20)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C186(1.22)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C186(1.15)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C186(1.15)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C308(1.13)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C186(1.14)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C186(1.08)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C186(1.14)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C186(1.09)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C186(1.12)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C186(0.97)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C186(1.07)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C186(1.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C186(1.05)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C186(1.10)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C308(1.05)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C186(0.99)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C186(1.08)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C186(1.07)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C186(1.04)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C186(1.00)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C186(1.03)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C186(1.05)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C186(1.14)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C186(1.08)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C186(1.00)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C308(0.98)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C186(1.02)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C186(0.90)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C186(0.97)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C186(0.98)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C186(0.99)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C186(0.90)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C186(1.01)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C186(0.94)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C186(0.86)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C186(0.90)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C308(1.04)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C186(0.96)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C186(0.95)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C186(0.97)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C186(0.93)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C186(0.98)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C186(0.85)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C186(0.85)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C186(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C186(0.98)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C308(1.12)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C186(0.89)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C186(0.85)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C186(1.07)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C186(1.05)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C186(1.08)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C186(0.88)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C186(0.77)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C186(0.88)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C186(1.11)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C186(1.30)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C308(0.85)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C186(0.95)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C186(1.20)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C186(1.16)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C186(0.93)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C186(1.03)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C186(0.96)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C186(1.05)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C186(1.15)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C186(1.11)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C186(1.19)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C308(0.97); C186(0.91)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C186(0.83)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C186(1.39)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C186(1.05); C308(0.98)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C186(1.04); C308(0.98)  LDD1497  [7]
 LDCM0024  KB05 NB1 C197(3.37)  LDD3340  [8]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24900237c15 Small molecular drug D0G4CS

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840