Details of the Target

General Information of Target

Target ID LDTP12415
Target Name Adenosine 5'-monophosphoramidase HINT3 (HINT3)
Gene Name HINT3
Gene ID 135114
Synonyms
Adenosine 5'-monophosphoramidase HINT3; EC 3.9.1.-; Histidine triad nucleotide-binding protein 3; HINT-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADNSSDECEEENNKEKKKTSQLTPQRGFSENEDDDDDDDDSSETDSDSDDDDEEHGAPL
EGAYDPADYEHLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVP
RPDGKPDNLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAID
TWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTAEIDCSLAEYI
DMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKAFTPSSNSTSQAGDMET
LTFS
Target Bioclass
Enzyme
Family
HINT family
Subcellular location
Cytoplasm
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase. Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro.
Uniprot ID
Q9NQE9
Ensemble ID
ENST00000229633.7
HGNC ID
HGNC:18468

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [2]
CHEMBL5175495
 Probe Info  		9.56  LDD0196  [3]
STPyne
 Probe Info  		K78(7.48)  LDD0277  [4]
AHL-Pu-1
 Probe Info  		C16(4.03)  LDD0171  [5]
DBIA
 Probe Info  		C66(1.81); C73(1.81); C16(2.37); C32(2.37)  LDD0080  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
IPM
 Probe Info  		C16(0.00); C32(0.00)  LDD0025  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		C16(0.00); C32(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C16(0.00); C32(0.00)  LDD0018  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C96(0.00); C32(0.00); C16(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		15.03  LDD1740  [15]
C055
 Probe Info  		13.74  LDD1752  [15]
C056
 Probe Info  		16.34  LDD1753  [15]
C087
 Probe Info  		12.30  LDD1779  [15]
C169
 Probe Info  		21.86  LDD1849  [15]
C218
 Probe Info  		14.62  LDD1892  [15]
C219
 Probe Info  		8.63  LDD1893  [15]
C220
 Probe Info  		28.44  LDD1894  [15]
C228
 Probe Info  		44.32  LDD1901  [15]
C231
 Probe Info  		54.95  LDD1904  [15]
C232
 Probe Info  		86.22  LDD1905  [15]
C233
 Probe Info  		9.65  LDD1906  [15]
C234
 Probe Info  		5.39  LDD1907  [15]
C235
 Probe Info  		22.32  LDD1908  [15]
C264
 Probe Info  		20.25  LDD1935  [15]
C265
 Probe Info  		20.11  LDD1936  [15]
C269
 Probe Info  		6.73  LDD1939  [15]
C270
 Probe Info  		28.44  LDD1940  [15]
C277
 Probe Info  		8.22  LDD1947  [15]
C293
 Probe Info  		17.75  LDD1963  [15]
C346
 Probe Info  		34.30  LDD2007  [15]
C347
 Probe Info  		6.11  LDD2008  [15]
C362
 Probe Info  		25.46  LDD2023  [15]
C363
 Probe Info  		19.84  LDD2024  [15]
C388
 Probe Info  		38.32  LDD2047  [15]
C403
 Probe Info  		26.17  LDD2061  [15]
FFF probe11
 Probe Info  		20.00  LDD0471  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C32(3.37)  LDD0172  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C16(4.03)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C16(1.18); C32(1.18); C66(0.80); C73(0.80)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C16(1.23); C32(1.23); C66(0.80); C73(0.80)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C16(0.93); C32(0.93); C66(0.71); C73(0.71)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C16(0.93); C32(0.93); C66(0.71); C73(0.71)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C16(1.11); C32(1.11); C66(0.79); C73(0.79)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C16(1.19); C32(1.19); C66(0.66); C73(0.66)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C16(1.10); C32(1.10); C66(0.80); C73(0.80)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C16(1.14); C32(1.14); C66(0.72); C73(0.72)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C16(1.23); C32(1.23); C66(0.68); C73(0.68)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C16(1.11); C32(0.92); C66(0.71); C73(0.71)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C16(0.92); C32(0.86); C66(0.70); C73(0.70)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C16(0.88); C32(0.79); C66(0.98); C73(0.98)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C16(1.35); C32(1.35); C66(0.74); C73(0.74)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C16(1.03); C32(0.91); C66(0.75); C73(0.75)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C16(0.97); C32(0.90); C66(0.75); C73(0.75)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C16(1.14); C32(1.01); C66(0.72); C73(0.72)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C16(1.03); C32(1.03); C66(0.82); C73(0.82)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C16(1.14); C32(1.13); C66(0.97); C73(1.09)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C16(1.34); C32(1.34); C66(0.88); C73(1.18)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C16(1.45); C32(1.38); C66(1.00); C73(0.79)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C16(1.12); C32(1.09); C66(0.78); C73(0.92)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C16(1.09); C32(1.03); C66(0.96); C73(0.93)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C16(1.28); C32(1.26); C66(0.92); C73(0.92)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C16(1.07); C32(1.07); C66(1.05); C73(1.05)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C16(1.24); C32(1.20); C66(0.93); C73(0.83)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C16(1.02); C32(1.00); C66(0.78); C73(0.94)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C16(1.17); C32(1.17); C66(0.95); C73(0.76)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C16(0.90); C32(0.92); C66(0.89); C73(1.18)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C16(0.97); C32(0.94); C66(0.74); C73(0.99)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C16(1.10); C32(1.06); C66(0.89); C73(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C16(1.22); C32(1.19); C66(0.98); C73(1.03)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C16(1.17); C32(1.17); C66(0.77); C73(0.77)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C16(1.11); C32(1.11); C66(1.18); C73(1.18)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C16(0.81); C32(0.81); C66(0.87); C73(0.87)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C16(1.01); C32(1.01); C66(0.87); C73(0.87)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C16(0.81); C32(0.81); C66(0.80); C73(0.80)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C16(0.85); C32(0.85); C66(0.80); C73(0.80)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C16(0.89); C32(0.89); C66(0.81); C73(0.81)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C16(0.97); C32(0.97); C66(0.80); C73(0.80)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C16(0.92); C32(0.92); C66(0.80); C73(0.80)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C16(0.91); C32(0.91); C66(0.85); C73(0.85)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C16(0.87); C32(0.87); C66(0.81); C73(0.81)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C16(0.99); C32(0.99); C66(0.71); C73(0.71)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C16(0.92); C32(0.92); C66(0.64); C73(0.64)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C16(1.25); C32(1.25); C66(0.72); C73(0.72)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C16(1.03); C32(1.03); C66(0.59); C73(0.59)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C16(1.04); C32(1.04); C66(0.63); C73(0.63)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C16(0.88); C32(0.88); C66(0.67); C73(0.67)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C16(1.14); C32(1.14); C66(0.75); C73(0.75)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C66(0.46); C73(0.46); C32(1.12); C16(1.13)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C66(0.74); C73(0.74); C32(1.16); C16(1.18)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C66(0.31); C73(0.31); C32(1.19); C16(1.24)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C66(0.42); C73(0.42); C16(1.11); C32(1.12)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C66(0.30); C73(0.30); C32(1.71); C16(1.79)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C66(0.35); C73(0.35); C32(1.30); C16(1.37)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C66(0.80); C73(0.80); C16(1.22); C32(1.22)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C66(0.77); C73(0.77); C32(1.11); C16(1.18)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C66(0.75); C73(0.75); C16(1.22); C32(1.27)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C66(0.37); C73(0.37); C32(1.42); C16(1.44)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C66(0.26); C73(0.26); C32(2.00); C16(2.08)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C16(1.28); C32(1.27); C66(0.48); C73(0.48)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C16(1.47); C32(1.44); C66(0.55); C73(0.55)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C16(1.16); C32(1.11); C66(0.83); C73(0.83)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C16(1.02); C32(0.98); C66(0.96); C73(0.96)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C66(1.01); C73(1.01); C16(1.02); C32(1.02)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C66(0.70); C73(0.70); C16(1.40); C32(1.40)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C66(1.15); C73(1.15); C16(1.17); C32(1.17)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C66(0.88); C73(0.88); C16(1.01); C32(1.01)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C66(0.99); C73(0.99); C16(1.02); C32(1.02)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C66(1.04); C73(1.04); C16(1.19); C32(1.19)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C16(0.96); C32(0.96); C66(1.36); C73(1.36)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C66(1.11); C73(1.11); C16(1.12); C32(1.12)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C16(1.00); C32(1.00); C66(1.30); C73(1.30)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C66(1.08); C73(1.08); C16(1.09); C32(1.09)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C66(0.87); C73(0.87); C16(1.19); C32(1.19)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C66(0.95); C73(0.95); C16(1.27); C32(1.27)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C66(0.93); C73(0.93); C16(1.46); C32(1.46)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C66(0.66); C73(0.66); C16(1.43); C32(1.43)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C16(0.98); C32(0.98); C66(1.07); C73(1.07)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C66(0.70); C73(0.70); C16(1.57); C32(1.57)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C66(0.71); C73(0.71); C16(1.39); C32(1.39)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C66(0.65); C73(0.65); C16(1.67); C32(1.67)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C66(0.95); C73(0.95); C16(1.47); C32(1.47)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C66(1.07); C73(1.07); C16(1.52); C32(1.52)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C16(0.85); C32(0.85); C66(1.30); C73(1.30)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C16(0.91); C32(0.91); C66(1.39); C73(1.39)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C16(1.02); C32(1.02); C66(1.70); C73(1.70)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C16(0.86); C32(0.86); C66(1.38); C73(1.38)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C16(1.08); C32(1.08); C66(1.24); C73(1.24)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C66(0.82); C73(0.82); C16(1.04); C32(1.04)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C66(1.11); C73(1.11); C16(1.16); C32(1.16)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C16(1.04); C32(1.04); C66(1.40); C73(1.40)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C66(1.03); C73(1.03); C16(1.04); C32(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C66(0.76); C73(0.76); C16(1.14); C32(1.14)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C16(1.13); C32(1.13); C66(1.49); C73(1.49)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C66(0.99); C73(0.99); C16(1.33); C32(1.33)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C66(0.86); C73(0.86); C16(1.11); C32(1.11)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C66(0.95); C73(0.95); C16(1.07); C32(1.07)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C66(0.80); C73(0.80); C16(1.19); C32(1.19)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C66(0.72); C73(0.72); C16(1.55); C32(1.55)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C66(0.75); C73(0.75); C16(1.06); C32(1.06)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C66(0.75); C73(0.75); C16(1.61); C32(1.61)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C16(0.94); C32(0.94); C66(0.96); C73(0.96)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C66(1.01); C73(1.01); C16(1.07); C32(1.07)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C66(0.84); C73(0.84); C16(1.40); C32(1.40)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C66(1.12); C73(1.12); C16(1.23); C32(1.23)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C66(0.77); C73(0.77); C16(1.67); C32(1.67)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C66(0.75); C73(0.75); C16(2.76); C32(2.76)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C66(0.84); C73(0.84); C16(1.26); C32(1.26)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C66(0.90); C73(0.90); C16(1.54); C32(1.54)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C66(0.72); C73(0.72); C16(1.48); C32(1.48)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C66(0.72); C73(0.72); C16(1.33); C32(1.33)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C66(0.66); C73(0.66); C16(1.49); C32(1.49)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C66(0.99); C73(0.99); C16(1.41); C32(1.41)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C66(0.80); C73(0.80); C16(1.55); C32(1.55)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C66(0.83); C73(0.83); C16(1.46); C32(1.46)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C66(0.94); C73(0.94); C16(1.48); C32(1.48)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C66(0.76); C73(0.76); C16(1.41); C32(1.41)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C66(0.88); C73(0.88); C16(1.34); C32(1.34)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C66(0.70); C73(0.70); C16(1.61); C32(1.61)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C66(0.83); C73(0.83); C16(1.08); C32(1.08)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C66(0.85); C73(0.85); C16(1.04); C32(1.04)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C66(0.79); C73(0.79); C16(1.18); C32(1.18)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C66(0.76); C73(0.76); C16(1.06); C32(1.06)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C16(0.77); C32(0.77); C66(1.08); C73(1.08)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C66(0.88); C73(0.88); C16(1.05); C32(1.05)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C66(0.67); C73(0.67); C16(1.34); C32(1.34)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C66(0.65); C73(0.65); C16(1.18); C32(1.18)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C66(0.69); C73(0.69); C16(1.81); C32(1.81)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C66(0.97); C73(0.97); C16(1.05); C32(1.05)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C66(0.90); C73(0.90); C16(1.14); C32(1.14)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C66(0.77); C73(0.77); C16(1.05); C32(1.05)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C16(0.95); C32(0.95); C66(1.04); C73(1.04)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C66(0.73); C73(0.73); C16(1.29); C32(1.29)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C16(1.04); C32(1.04); C66(1.14); C73(1.14)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C66(0.98); C73(0.98); C16(1.00); C32(1.00)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C66(0.66); C73(0.66); C16(1.56); C32(1.56)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C66(0.79); C73(0.79); C16(1.56); C32(1.56)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C66(0.87); C73(0.87); C16(1.51); C32(1.51)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C66(0.82); C73(0.82); C16(1.22); C32(1.22)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C66(0.83); C73(0.83); C16(1.20); C32(1.20)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C66(0.81); C73(0.81); C16(1.08); C32(1.08)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C66(0.81); C73(0.81); C16(1.23); C32(1.23)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C66(0.85); C73(0.85); C16(1.41); C32(1.41)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C66(0.85); C73(0.85); C16(1.12); C32(1.12)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C66(1.11); C73(1.11); C16(1.67); C32(1.67)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C66(0.89); C73(0.89); C16(1.61); C32(1.61)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C66(0.82); C73(0.82); C16(1.25); C32(1.25)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C16(1.20); C32(1.20); C66(1.55); C73(1.55)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C66(0.88); C73(0.88); C16(1.14); C32(1.14)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C16(1.46); C32(1.46); C66(1.57); C73(1.57)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C66(0.78); C73(0.78); C16(1.65); C32(1.65)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C66(0.65); C73(0.65); C16(1.79); C32(1.79)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C66(0.71); C73(0.71); C16(0.93); C32(0.93)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C16(1.01); C32(1.01); C66(0.97); C73(0.97)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C66(0.80); C73(0.80); C16(1.12); C32(1.12)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C66(0.64); C73(0.64); C16(1.95); C32(1.95)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 14.36  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C16(1.14); C32(1.14)  LDD2171  [6]
 LDCM0367  CL1 HCT 116 C16(1.01); C32(1.01); C66(1.51); C73(1.51)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C66(1.08); C73(1.08); C16(1.38); C32(1.38)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C66(0.75); C73(0.75); C16(1.12); C32(1.12)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C66(0.77); C73(0.77); C16(1.44); C32(1.44)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C66(0.85); C73(0.85); C16(1.10); C32(1.10)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C66(0.90); C73(0.90); C16(1.13); C32(1.13)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C66(0.86); C73(0.86); C16(1.04); C32(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C66(0.95); C73(0.95); C16(1.29); C32(1.29)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C66(0.57); C73(0.57); C16(1.63); C32(1.63)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C66(0.71); C73(0.71); C16(1.30); C32(1.30)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C66(0.80); C73(0.80); C16(1.35); C32(1.35)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C66(0.83); C73(0.83); C16(1.36); C32(1.36)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C66(1.05); C73(1.05); C16(1.48); C32(1.48)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C66(0.85); C73(0.85); C16(1.53); C32(1.53)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C66(0.74); C73(0.74); C16(1.29); C32(1.29)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C66(0.86); C73(0.86); C16(1.23); C32(1.23)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C66(0.71); C73(0.71); C16(1.59); C32(1.59)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C66(0.60); C73(0.60); C16(1.40); C32(1.40)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C66(0.68); C73(0.68); C16(1.40); C32(1.40)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C66(1.01); C73(1.01); C16(1.27); C32(1.27)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C66(0.68); C73(0.68); C16(1.95); C32(1.95)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C16(1.10); C32(1.10); C66(1.17); C73(1.17)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C66(1.08); C73(1.08); C16(1.18); C32(1.18)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C16(1.33); C32(1.33); C66(1.36); C73(1.36)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C16(1.03); C32(1.03); C66(1.12); C73(1.12)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C66(1.17); C73(1.17); C16(3.40); C32(3.40)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C66(0.74); C73(0.74); C16(1.19); C32(1.19)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C66(0.90); C73(0.90); C16(1.30); C32(1.30)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C66(0.87); C73(0.87); C16(1.44); C32(1.44)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C66(0.65); C73(0.65); C16(1.07); C32(1.07)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C66(0.68); C73(0.68); C16(1.08); C32(1.08)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C66(0.64); C73(0.64); C16(1.10); C32(1.10)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C66(0.89); C73(0.89); C16(1.33); C32(1.33)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C66(0.79); C73(0.79); C16(1.29); C32(1.29)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C16(0.99); C32(0.99); C66(1.39); C73(1.39)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C66(0.96); C73(0.96); C16(1.24); C32(1.24)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C66(0.68); C73(0.68); C16(1.25); C32(1.25)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C66(0.57); C73(0.57); C16(1.22); C32(1.22)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C66(0.49); C73(0.49); C16(1.59); C32(1.59)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C66(0.65); C73(0.65); C16(1.42); C32(1.42)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C16(0.96); C32(0.96); C66(1.79); C73(1.79)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C66(0.68); C73(0.68); C16(1.60); C32(1.60)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C66(0.66); C73(0.66); C16(2.12); C32(2.12)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C66(0.55); C73(0.55); C16(3.88); C32(3.88)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C66(0.71); C73(0.71); C16(1.77); C32(1.77)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C66(0.70); C73(0.70); C16(1.76); C32(1.76)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C16(1.92); C32(1.92); C66(0.55); C73(0.55)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C16(1.37); C32(1.37); C66(0.60); C73(0.60)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C16(1.38); C32(1.38); C66(0.69); C73(0.69)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C16(1.74); C32(1.74); C66(0.54); C73(0.54)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C16(1.58); C32(1.58); C66(0.62); C73(0.62)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C16(0.95); C32(0.95); C66(1.42); C73(1.42)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C16(1.27); C32(1.27); C66(0.70); C73(0.70)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C16(1.10); C32(1.10); C66(0.87); C73(0.87)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C16(1.31); C32(1.31); C66(0.63); C73(0.63)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C16(1.23); C32(1.23); C66(0.65); C73(0.65)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C16(1.77); C32(1.77); C66(0.57); C73(0.57)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C16(1.72); C32(1.72); C66(0.72); C73(0.72)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C16(1.41); C32(1.41); C66(0.64); C73(0.64)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C16(1.66); C32(1.66); C66(0.68); C73(0.68)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C16(1.49); C32(1.49); C66(0.81); C73(0.81)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C16(1.08); C32(1.08); C66(1.61); C73(1.61)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C16(1.51); C32(1.51); C66(0.81); C73(0.81)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C16(1.25); C32(1.25); C66(0.79); C73(0.79)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C16(2.89); C32(2.89); C66(0.79); C73(0.79)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C16(1.86); C32(1.86); C66(0.81); C73(0.81)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C16(1.63); C32(1.63); C66(0.78); C73(0.78)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C16(2.10); C32(2.10); C66(0.63); C73(0.63)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C16(0.91); C32(0.91); C66(0.71); C73(0.71)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C16(0.86); C32(0.86); C66(0.68); C73(0.68)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C16(0.82); C32(0.82); C66(0.72); C73(0.72)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C16(0.91); C32(0.91); C66(0.91); C73(0.91)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C16(1.04); C32(1.04); C66(1.26); C73(1.26)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C16(0.84); C32(0.84); C66(0.84); C73(0.84)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C16(0.87); C32(0.87); C66(0.86); C73(0.86)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C16(0.97); C32(0.97); C66(0.76); C73(0.76)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C16(0.93); C32(0.93); C66(0.70); C73(0.70)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C16(0.91); C32(0.91); C66(0.76); C73(0.76)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C16(0.87); C32(0.87); C66(0.83); C73(0.83)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C16(0.93); C32(0.93); C66(0.85); C73(0.85)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C16(0.82); C32(0.82); C66(0.83); C73(0.83)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C16(0.84); C32(0.84); C66(0.84); C73(0.84)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C16(0.90); C32(0.90); C66(0.84); C73(0.84)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C16(1.23); C32(1.23); C66(0.93); C73(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C16(0.89); C32(0.89); C66(0.75); C73(0.75)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C16(1.03); C32(1.03); C66(0.97); C73(0.97)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C16(1.05); C32(1.05); C66(0.86); C73(0.86)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C16(1.14); C32(1.14); C66(0.79); C73(0.79)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C16(1.30); C32(1.30); C66(0.79); C73(0.79)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C16(1.08); C32(1.08); C66(1.14); C73(1.14)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C16(1.62); C32(1.62); C66(0.97); C73(0.97)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C16(1.21); C32(1.21); C66(1.02); C73(1.02)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C16(1.24); C32(1.24); C66(0.79); C73(0.79)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C16(1.18); C32(1.18); C66(0.72); C73(0.72)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C16(1.15); C32(1.15); C66(0.92); C73(0.92)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C16(1.23); C32(1.23); C66(0.72); C73(0.72)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C16(1.24); C32(1.24); C66(1.05); C73(1.05)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C16(1.04); C32(1.04); C66(1.04); C73(1.04)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C16(1.19); C32(1.19); C66(1.02); C73(1.02)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C16(1.20); C32(1.20); C66(1.30); C73(1.30)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C16(1.26); C32(1.26); C66(0.85); C73(0.85)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C16(1.10); C32(1.10); C66(1.04); C73(1.04)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C16(1.20); C32(1.20); C66(1.13); C73(1.13)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C16(1.37); C32(1.37); C66(1.07); C73(1.07)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C16(1.42); C32(1.42); C66(0.90); C73(0.90)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C16(1.17); C32(1.17); C66(1.15); C73(1.15)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C16(1.10); C32(1.10); C66(1.08); C73(1.08)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C16(1.82); C32(1.82); C66(1.21); C73(1.21)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C16(1.63); C32(1.63); C66(1.19); C73(1.19)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C16(2.59); C32(2.59); C66(1.13); C73(1.13)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C16(1.18); C32(1.18); C66(1.07); C73(1.07)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C16(1.02); C32(1.02); C66(1.06); C73(1.06)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C16(1.26); C32(1.26); C66(1.31); C73(1.31)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C16(1.70); C32(1.70); C66(1.33); C73(1.33)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C16(4.16); C32(4.16); C66(1.59); C73(1.59)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C16(1.11); C32(1.11); C66(1.20); C73(1.20)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C16(0.83); C32(0.83); C66(1.01); C73(1.01)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C16(1.13); C32(1.13); C66(0.77); C73(0.77)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C16(1.02); C32(1.02); C66(0.92); C73(0.92)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C16(0.99); C32(0.99); C66(0.92); C73(0.92)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C16(1.18); C32(1.18); C66(0.89); C73(0.89)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C16(1.24); C32(1.24); C66(0.79); C73(0.79)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C16(1.12); C32(1.12); C66(0.92); C73(0.92)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C16(1.29); C32(1.29); C66(0.85); C73(0.85)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C16(1.17); C32(1.17); C66(0.71); C73(0.71)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C16(1.25); C32(1.25); C66(0.81); C73(0.81)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C32(0.90); C66(1.10)  LDD1698  [17]
 LDCM0625  F8 Ramos C96(8.08)  LDD2187  [18]
 LDCM0573  Fragment11 Ramos C96(2.20)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C96(0.37)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C96(0.62)  LDD2198  [18]
 LDCM0468  Fragment33 HCT 116 C16(1.12); C32(1.12); C66(0.80); C73(0.80)  LDD0785  [6]
 LDCM0566  Fragment4 Ramos C96(0.60)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C16(2.37); C32(2.37); C66(0.50); C73(0.50)  LDD0744  [6]
 LDCM0569  Fragment7 Ramos C96(0.46)  LDD2186  [18]
 LDCM0022  KB02 HCT 116 C66(1.81); C73(1.81); C16(2.37); C32(2.37)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C66(3.53); C73(3.53); C16(1.24); C32(1.24)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C66(1.80); C73(1.80); C16(1.77); C32(1.77)  LDD0082  [6]
 LDCM0021  THZ1 HCT 116 C16(1.14); C32(1.14)  LDD2173  [6]

References

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Mass spectrometry data entry: PXD025140
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578