Details of the Target

General Information of Target

Target ID LDTP04925
Target Name Pterin-4-alpha-carbinolamine dehydratase (PCBD1)
Gene Name PCBD1
Gene ID 5092
Synonyms
DCOH; PCBD; Pterin-4-alpha-carbinolamine dehydratase; PHS; EC 4.2.1.96; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL
DHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
Target Bioclass
Enzyme
Family
Pterin-4-alpha-carbinolamine dehydratase family
Subcellular location
Cytoplasm
Function
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
Uniprot ID
P61457
Ensemble ID
ENST00000299299.4
HGNC ID
HGNC:8646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		18.62  LDD0066  [1]
BTD
 Probe Info  		C82(1.05)  LDD2092  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C269
 Probe Info  		5.70  LDD1939  [5]
C278
 Probe Info  		61.39  LDD1948  [5]
C280
 Probe Info  		10.56  LDD1950  [5]
C282
 Probe Info  		16.22  LDD1952  [5]
C284
 Probe Info  		29.04  LDD1954  [5]
C348
 Probe Info  		13.74  LDD2009  [5]
C349
 Probe Info  		9.51  LDD2010  [5]
C350
 Probe Info  		26.72  LDD2011  [5]
C353
 Probe Info  		7.46  LDD2014  [5]
C354
 Probe Info  		11.63  LDD2015  [5]
C420
 Probe Info  		10.85  LDD2075  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C82(0.26)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C82(0.42)  LDD2112  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C82(0.59)  LDD2103  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C82(0.81)  LDD2113  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C82(1.11)  LDD2102  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C82(1.05)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C82(2.25)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C82(0.32)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C82(0.94)  LDD2097  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C82(0.60)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C82(0.96)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C82(0.47)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C82(0.81)  LDD2105  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C82(0.46)  LDD2108  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C82(0.80)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C82(0.53)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C82(0.52)  LDD2116  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C82(0.71)  LDD2120  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C82(0.71)  LDD2128  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C82(0.53)  LDD2134  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C82(0.67)  LDD2143  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C82(0.36)  LDD2148  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C82(0.34)  LDD2151  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) . Q9UKV3
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte nuclear factor 1-alpha (HNF1A) HNF1 homeobox family P20823
Hepatocyte nuclear factor 1-beta (HNF1B) HNF1 homeobox family P35680
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
Trefoil factor 3 (TFF3) . Q07654

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-erythro-78-dihydrobiopterin . DB04400

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587