Details of the Target

General Information of Target

Target ID LDTP04369
Target Name Peroxisomal targeting signal 1 receptor (PEX5)
Gene Name PEX5
Gene ID 5830
Synonyms
PXR1; Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASED
ELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQ
EFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTA
TDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQA
EQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAK
RDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEA
AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR
QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR
LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE
AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMS
ENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ
Target Bioclass
Other
Family
Peroxisomal targeting signal receptor family
Subcellular location
Cytoplasm, cytosol
Function
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.; [Isoform 1]: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5.; [Isoform 2]: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal.
Uniprot ID
P50542
Ensemble ID
ENST00000266563.9
HGNC ID
HGNC:9719

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A543V .
MFE319 SNV: p.C566R .
MOLT4 SNV: p.P307H; p.R345H .
SKES1 Deletion: p.M369RfsTer19 DBIA    Probe Info 
SKMEL28 SNV: p.R431G DBIA    Probe Info 
SNGM SNV: p.E168K .
TE10 SNV: p.Q403E .
YSCCC SNV: p.E304Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.19  LDD0403  [1]
DBIA
 Probe Info  		C438(2.87)  LDD3310  [2]
BTD
 Probe Info  		C423(0.55)  LDD2117  [3]
AHL-Pu-1
 Probe Info  		C11(2.05)  LDD0169  [4]
5E-2FA
 Probe Info  		H23(0.00); H438(0.00)  LDD2235  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C566(0.00); C11(0.00)  LDD0165  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
AOyne
 Probe Info  		14.40  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C218
 Probe Info  		11.71  LDD1892  [12]
C266
 Probe Info  		7.57  LDD1937  [12]
C269
 Probe Info  		5.94  LDD1939  [12]
C397
 Probe Info  		9.58  LDD2056  [12]
C403
 Probe Info  		15.56  LDD2061  [12]
C407
 Probe Info  		10.93  LDD2064  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C423(0.55)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C11(2.05)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C510(0.91); C492(1.09); C423(1.04); C11(0.90)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C510(0.97); C492(1.02); C423(1.06); C11(1.07)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C510(1.09); C492(1.07); C423(1.05); C11(0.93)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C510(1.02); C492(0.96); C423(1.01); C11(0.91)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C510(1.01); C492(1.02); C423(1.13); C11(0.97)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C510(1.09); C492(1.34); C423(1.04); C11(0.90)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C510(0.99); C492(1.10); C423(1.08); C11(0.95)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C510(1.05); C492(1.06); C423(1.10); C11(0.99)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C510(0.97); C492(0.89); C423(0.96); C11(1.02)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C510(0.95); C492(0.97); C423(0.94); C11(1.01)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C510(0.97); C492(1.10); C423(1.10); C11(0.98)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C510(0.96); C492(0.89); C423(1.18); C11(1.04)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C510(1.10); C492(0.94); C423(1.15); C11(1.04)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C510(1.05); C492(1.22); C423(1.02); C11(0.99)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C510(0.90); C492(0.97); C423(0.94); C11(1.06)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C510(0.99); C492(1.12); C423(1.02); C11(0.94)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C510(0.98); C492(1.03); C423(1.04); C11(0.99)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C510(1.09); C492(1.25); C423(1.06); C11(1.01)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C510(0.98); C492(0.96); C423(1.09); C11(0.97)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C510(1.05); C492(1.13); C423(1.07); C11(0.96)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C510(1.01); C492(0.99); C423(1.05); C11(1.07)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C510(1.07); C492(0.91); C423(1.11); C11(0.97)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C510(1.00); C492(0.94); C423(1.06); C11(1.01)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C510(1.00); C492(1.04); C423(1.06); C11(0.99)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C510(0.99); C492(1.09); C423(1.04); C11(1.00)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C510(0.99); C492(1.04); C423(1.07); C11(1.02)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C510(0.97); C492(1.11); C423(1.01); C11(1.05)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C510(1.08); C492(0.99); C423(1.07); C11(0.95)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C510(0.89); C492(0.96); C423(1.06); C11(0.88)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C510(0.93); C492(1.06); C423(1.25); C11(0.86)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C510(1.17); C492(1.33); C423(1.16); C11(0.97)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C510(0.93); C492(1.01); C423(1.03); C11(0.86)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C510(1.01); C492(1.03); C423(1.06); C11(0.94)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C510(0.91); C492(1.13); C423(0.99); C11(0.95)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C510(0.89); C492(0.88); C423(1.03); C11(1.07)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C510(1.12); C492(1.24); C423(1.10); C11(0.96)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C510(1.11); C492(1.07); C423(1.05); C11(0.89)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C510(0.95); C492(1.02); C423(1.09); C11(1.00)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C510(0.88); C492(0.91); C423(1.17); C11(0.97)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C510(1.06); C492(1.42); C423(1.09); C11(0.94)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C510(0.90); C492(1.04); C423(1.03); C11(1.07)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C510(0.91); C492(1.11); C423(0.98); C11(0.84)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C510(0.92); C492(1.52); C423(1.13); C11(0.99)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C510(1.04); C492(1.06); C423(1.00); C11(0.99)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C510(0.97); C492(1.07); C423(0.94); C11(0.99)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C510(0.94); C492(0.98); C423(1.08); C11(1.00)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C510(0.85); C492(0.99); C423(1.02); C11(1.03)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C510(0.96); C492(1.00); C423(1.15); C11(1.00)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C510(1.05); C492(1.32); C423(1.08); C11(0.94)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C510(1.10); C492(1.15); C423(1.07); C11(1.05)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C510(0.91); C492(1.04); C423(0.99); C11(0.95)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C510(1.03); C492(1.03); C423(1.06); C11(1.01)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C510(0.97); C492(0.91); C423(0.99); C11(0.88)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C510(0.99); C492(1.06); C423(1.12); C11(0.91)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C510(0.98); C492(0.97); C423(1.01); C11(0.94)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C510(0.91); C492(1.16); C423(1.11); C11(0.95)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C510(1.04); C492(1.08); C423(1.15); C11(0.99)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C510(1.09); C492(1.07); C423(1.08); C11(1.01)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C510(0.98); C492(0.99); C423(1.04); C11(0.97)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C510(1.05); C492(1.15); C423(0.95); C11(0.94)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C510(0.97); C492(0.98); C423(0.98); C11(0.91)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C510(0.91); C492(1.04); C423(1.05); C11(0.94)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C510(0.93); C492(1.05); C423(1.03); C11(0.86)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C510(1.07); C492(1.02); C423(1.04); C11(0.94)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 7.19  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C510(0.97); C492(1.26); C423(1.10); C11(0.91)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C510(0.80); C492(1.21); C423(1.06); C11(0.84)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C510(0.99); C492(1.00); C423(1.01); C11(0.96)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C510(0.92); C492(1.08); C423(1.12); C11(1.00)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C510(1.04); C423(1.01); C11(0.99)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C510(1.10); C492(1.06); C423(1.08); C11(0.99)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C510(1.00); C492(1.01); C423(1.07); C11(0.94)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C510(1.13); C492(1.08); C423(1.03); C11(1.03)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C510(0.99); C423(1.07); C11(1.05)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C510(1.14); C492(1.16); C423(1.02); C11(1.03)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C510(1.15); C492(0.90); C423(0.99); C11(0.99)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C510(0.96); C492(1.06); C423(1.08); C11(0.95)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C510(1.02); C492(1.03); C423(1.01); C11(1.07)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C510(1.03); C423(1.03); C11(0.98)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C510(1.05); C492(1.12); C423(1.05); C11(0.99)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C510(1.10); C492(0.94); C423(1.03); C11(0.98)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C510(1.00); C492(1.08); C423(0.94); C11(0.97)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C510(0.90); C423(1.08); C11(1.00)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C510(0.99); C492(1.02); C423(1.09); C11(0.85)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C510(0.96); C492(0.93); C423(1.07); C11(1.01)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C510(1.13); C492(1.03); C423(0.93); C11(1.01)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C510(1.03); C423(0.96); C11(1.08)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C510(1.13); C492(1.14); C423(1.01); C11(0.95)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C510(1.06); C492(1.24); C423(0.99); C11(0.99)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C510(0.96); C492(1.00); C423(1.00); C11(0.87)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C510(1.18); C492(1.18); C423(1.14); C11(0.96)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C510(1.02); C423(1.07); C11(1.04)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C510(1.02); C492(1.13); C423(1.18); C11(0.90)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C510(1.06); C492(0.97); C423(0.98); C11(0.88)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C510(0.98); C492(1.07); C423(1.16); C11(1.02)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C510(0.98); C423(1.04); C11(0.98)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C510(1.01); C492(1.12); C423(1.06); C11(0.91)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C510(1.02); C492(1.03); C423(1.03); C11(0.99)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C510(0.99); C492(1.14); C423(1.11); C11(0.95)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C510(1.00); C423(1.15); C11(1.04)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C510(1.00); C492(1.21); C423(1.05); C11(0.86)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C510(0.92); C492(1.01); C423(1.11); C11(0.95)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C510(0.87); C492(1.18); C423(1.12); C11(0.97)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C510(1.01); C492(1.22); C423(1.17); C11(1.04)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C510(0.93); C492(1.36); C423(0.93); C11(0.95)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C510(1.02); C423(0.93); C11(0.98)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C510(0.93); C492(1.16); C423(1.04); C11(0.99)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C510(0.86); C492(1.39); C423(1.13); C11(1.00)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C510(0.92); C492(1.02); C423(1.01); C11(1.04)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C510(1.04); C492(1.44); C423(0.95); C11(1.09)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C510(0.96); C492(1.22); C423(0.95); C11(1.07)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C510(1.13); C492(1.14); C423(1.20); C11(0.93)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C510(1.04); C423(1.08); C11(1.06)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C510(1.04); C492(1.26); C423(1.12); C11(1.04)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C510(0.98); C492(0.95); C423(1.13); C11(0.93)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C510(0.93); C492(1.17); C423(1.08); C11(0.87)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C510(1.08); C492(1.20); C423(1.02); C11(0.93)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C510(1.04); C492(1.04); C423(1.12); C11(1.03)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C510(0.93); C492(1.02); C423(1.02); C11(0.93)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C510(0.96); C492(1.15); C423(1.03); C11(1.06)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C510(0.90); C492(1.26); C423(1.15); C11(0.98)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C510(0.94); C492(1.41); C423(1.07); C11(1.09)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C510(1.05); C492(1.60); C423(0.98); C11(1.02)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C510(0.95); C492(1.28); C423(1.00); C11(1.02)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C510(1.20); C492(1.16); C423(1.11); C11(0.99)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C510(1.14); C492(1.18); C423(1.14); C11(0.97)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C510(0.99); C492(0.93); C423(0.91); C11(0.96)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C510(1.11); C492(0.99); C423(1.08); C11(1.05)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C510(0.82); C492(1.01); C423(1.04); C11(0.92)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C510(0.98); C492(1.05); C423(1.13); C11(1.03)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C510(0.96); C492(1.29); C423(1.23); C11(0.95)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C510(0.93); C492(1.18); C423(1.04); C11(1.04)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C510(0.85); C492(1.23); C423(1.12); C11(1.04)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C510(0.86); C492(1.27); C423(1.13); C11(1.10)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C510(1.03); C492(1.49); C423(1.08); C11(1.05)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C510(1.00); C492(1.20); C423(1.10); C11(1.12)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C510(1.24); C492(1.34); C423(1.10); C11(0.88)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C510(0.93); C492(1.09); C423(1.07); C11(1.00)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C510(1.07); C423(1.12); C11(1.05)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C510(1.06); C492(1.15); C423(1.13); C11(0.96)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C510(0.88); C492(1.21); C423(1.08); C11(0.86)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C510(0.99); C492(1.40); C423(1.31); C11(0.95)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C510(0.97); C492(1.49); C423(1.16); C11(0.95)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C510(1.01); C492(1.22); C423(1.11); C11(0.94)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C510(0.81); C492(1.27); C423(1.20); C11(0.99)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C510(0.87); C492(1.22); C423(1.16); C11(0.91)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C510(1.06); C492(1.87); C423(1.04); C11(0.97)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C510(0.90); C492(1.14); C423(1.04); C11(1.00)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C510(0.96); C492(1.29); C423(0.99); C11(1.05)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C510(1.12); C492(1.17); C423(1.13); C11(1.01)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C510(1.02); C423(1.10); C11(0.99)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C510(1.03); C492(1.20); C423(1.09); C11(1.03)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C510(0.89); C492(0.96); C423(1.15); C11(0.93)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C510(0.99); C492(1.13); C423(1.07); C11(0.91)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C510(1.04); C492(1.17); C423(1.14); C11(1.04)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C510(1.04); C492(1.12); C423(1.02); C11(0.98)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C510(0.97); C492(1.24); C423(1.13); C11(0.85)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C510(0.60); C492(1.15); C423(1.18); C11(0.97)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C510(0.99); C492(0.87); C423(0.96); C11(1.00)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C510(0.87); C492(1.18); C423(1.22); C11(1.02)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C510(1.06); C492(1.47); C423(1.02); C11(1.01)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C510(1.05); C492(1.40); C423(1.04); C11(1.03)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C510(1.10); C492(1.12); C423(0.99); C11(0.91)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C510(0.99); C423(1.06); C11(0.96)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C510(0.99); C492(0.87); C423(1.07); C11(1.05)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C510(0.87); C492(1.06); C423(1.08); C11(0.91)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C510(0.87); C492(1.04); C423(1.19); C11(0.99)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C510(1.07); C492(1.20); C423(1.23); C11(0.88)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C510(1.01); C492(1.34); C423(1.26); C11(0.81)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C510(1.16); C492(1.08); C423(1.03); C11(1.00)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C510(1.04); C492(1.38); C423(1.11); C11(1.09)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C510(0.89); C492(1.12); C423(1.00); C11(0.93)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C510(0.99); C492(1.35); C423(1.07); C11(1.02)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C510(0.90); C492(1.09); C423(1.08); C11(0.95)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C510(1.12); C492(1.17); C423(1.11); C11(1.00)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C510(1.05); C423(1.17); C11(0.99)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C510(1.14); C492(1.13); C423(1.13); C11(0.97)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C510(1.03); C492(0.94); C423(1.03); C11(0.92)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C510(0.90); C492(1.06); C423(1.00); C11(0.92)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C510(0.86); C492(1.13); C423(1.18); C11(0.96)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C510(0.92); C492(1.05); C423(1.29); C11(0.96)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C510(1.20); C492(1.18); C423(1.20); C11(0.85)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C510(0.99); C492(1.10); C423(1.20); C11(0.88)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C510(0.88); C492(1.17); C423(1.13); C11(0.84)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C510(0.95); C492(1.27); C423(1.07); C11(0.98)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C510(0.94); C492(1.31); C423(1.22); C11(1.00)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C510(0.91); C492(1.23); C423(1.12); C11(0.99)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C510(1.05); C492(1.20); C423(1.10); C11(0.95)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C510(1.03); C423(1.04); C11(1.00)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C510(1.06); C492(1.11); C423(1.05); C11(0.89)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C510(1.20); C492(1.16); C423(1.14); C11(0.98)  LDD1698  [13]
 LDCM0625  F8 Ramos C11(1.15)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C11(1.19)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C11(0.48)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C11(1.72)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C11(1.08)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C11(1.07)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C11(1.39)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C11(1.05)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C11(1.10)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C11(0.89)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C11(0.72)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C11(1.20)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C11(0.89)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C11(1.52)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C510(1.11); C492(1.02); C423(1.14); C11(0.88)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C11(0.79)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C11(1.03)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C510(1.07); C423(1.07); C11(1.05)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C11(0.96)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C11(1.02)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C11(0.99)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C11(1.14)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C423(0.92); C11(1.01); C566(0.92); C510(1.03)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C423(1.03); C11(1.06); C566(0.91); C510(1.07)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C438(2.87)  LDD3310  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C423(0.67)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C423(0.88)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C423(0.99)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl-coenzyme A thioesterase 8 (ACOT8) C/M/P thioester hydrolase family O14734
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) Glycerophosphoryl diester phosphodiesterase family Q8WTR4
L-lactate dehydrogenase B chain (LDHB) LDH family P07195
Secernin-2 (SCRN2) Peptidase C69 family Q96FV2
Glomulin (GLMN) . Q92990
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Peroxisomal membrane protein PEX14 (PEX14) Peroxin-14 family O75381
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Prosaposin (PSAP) . P07602
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 772 (ZNF772) Krueppel C2H2-type zinc-finger protein family Q68DY9
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caprin-2 (CAPRIN2) Caprin family Q6IMN6
Protein S100-A6 (S100A6) S-100 family P06703
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
AN1-type zinc finger protein 3 (ZFAND3) . Q9H8U3
Coiled-coil domain-containing protein 14 (CCDC14) . Q49A88
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Proline-rich protein 13 (PRR13) . Q9NZ81
Sequestosome-1 (SQSTM1) . Q13501
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578