Details of the Target

General Information of Target

Target ID LDTP15834
Target Name Integrator complex subunit 14 (INTS14)
Gene Name INTS14
Gene ID 81556
Synonyms
C15orf44; VWA9; Integrator complex subunit 14; von Willebrand factor A domain-containing protein 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLQGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFVSVGFHMAKPDMIRKLE
QGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLIFINHKKLIKERSNIYGKT
FTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEKFGDSTGWEKSLLNTKHEKIH
PAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECEKSFLMKGMLFTHTRAHRGERTF
EYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKFLCRKPVFIMPQRPQTEEKPFHCPY
CGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGKPFICIDCGKS
FRQKATLTRHHKTHTGEKAYECPQCGSAFRKKSYLIDHQRTHTGEKPYQCNECGKAFIQK
TTLTVHQRTHTGEKPYICNECGKSFCQKTTLTLHQRIHTGEKPYICNECGKSFRQKAILT
VHHRIHTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVHQK
THKVETTGIQ
Target Bioclass
Other
Family
INTS14 family
Subcellular location
Nucleus
Function Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Uniprot ID
Q96SY0
Ensemble ID
ENST00000313182.7
HGNC ID
HGNC:25372

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
PEO1 SNV: p.D341V .
SKMEL24 SNV: p.D241H .
SUPT1 Insertion: p.L488AfsTer8 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y380(45.88)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C193(16.43)  LDD0170  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C156(1.26); C171(1.26)  LDD0531  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C193(0.00); C464(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C218(0.00); C464(0.00); C193(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C218(0.00); C193(0.00); C464(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
AOyne
 Probe Info  		14.80  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.16  LDD1728  [10]
C139
 Probe Info  		12.13  LDD1821  [10]
C178
 Probe Info  		18.13  LDD1857  [10]
C194
 Probe Info  		8.51  LDD1870  [10]
C240
 Probe Info  		8.69  LDD1913  [10]
C269
 Probe Info  		5.74  LDD1939  [10]
C380
 Probe Info  		5.82  LDD2039  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C193(16.43)  LDD0170  [2]
 LDCM0214  AC1 HCT 116 C156(1.26); C171(1.26)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C156(1.53); C171(1.53)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C156(1.08); C171(1.08)  LDD1105  [4]
 LDCM0237  AC12 PaTu 8988t C156(1.11); C171(1.11)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C156(1.06); C171(1.06)  LDD1138  [4]
 LDCM0263  AC143 HCT 116 C156(1.15); C171(1.15)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C156(1.12); C171(1.12)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C156(1.15); C171(1.15)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C156(1.33); C171(1.33)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C156(0.96); C171(0.96)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C156(1.60); C171(1.60)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C156(1.11); C171(1.11)  LDD0586  [4]
 LDCM0270  AC15 PaTu 8988t C156(1.46); C171(1.46)  LDD1149  [4]
 LDCM0271  AC150 HCT 116 C156(1.12); C171(1.12)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C156(1.01); C171(1.01)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C156(1.38); C171(1.38)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C156(1.00); C171(1.00)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C156(1.47); C171(1.47)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C156(1.08); C171(1.08)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C156(0.86); C171(0.86)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C156(0.73); C171(0.73)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C156(0.98); C171(0.98)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C156(0.68); C171(0.68)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C156(0.85); C171(0.85)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C156(1.23); C171(1.23)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C156(1.33); C171(1.33)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C156(1.19); C171(1.19)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C156(0.78); C171(0.78)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C156(1.03); C171(1.03)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C156(3.97); C171(3.97)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C156(1.20); C171(1.20)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C156(0.84); C171(0.84)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C156(0.70); C171(0.70)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C156(0.71); C171(0.71)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C156(0.86); C171(0.86)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C156(1.20); C171(1.20)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C156(1.20); C171(1.20)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C156(0.93); C171(0.93)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C156(0.75); C171(0.75)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C156(1.09); C171(1.09)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C156(0.97); C171(0.97)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C156(1.01); C171(1.01)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C156(0.86); C171(0.86)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C156(1.16); C171(1.16)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C156(1.10); C171(1.10)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C156(1.24); C171(1.24)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C156(1.32); C171(1.32)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C156(0.93); C171(0.93)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C156(0.98); C171(0.98)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C156(1.25); C171(1.25)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C156(1.05); C171(1.05)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C156(1.11); C171(1.11)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C156(0.95); C171(0.95)  LDD1186  [4]
 LDCM0308  AC46 HCT 116 C156(1.03); C171(1.03)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C156(0.65); C171(0.65)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C156(0.60); C171(0.60)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C156(0.71); C171(0.71)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C156(1.24); C171(1.24)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C156(0.99); C171(0.99)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C156(0.78); C171(0.78)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C156(0.65); C171(0.65)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C156(0.93); C171(0.93)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C156(0.88); C171(0.88)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C156(0.93); C171(0.93)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C156(1.20); C171(1.20)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C193(0.96); C464(1.07)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C193(1.00); C464(1.04)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C193(1.00); C464(1.16)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C156(1.16); C171(1.16)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C193(1.02); C464(1.07)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C193(0.95); C464(1.15); C171(1.14)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C193(0.97); C464(1.01); C171(0.98)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C193(0.96); C464(1.14); C218(0.92)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C193(0.99); C464(1.03); C171(0.94)  LDD1567  [11]
 LDCM0334  AC7 PaTu 8988t C156(1.29); C171(1.29)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C156(1.20); C171(1.20)  LDD1224  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C156(1.36); C171(1.36)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C156(1.21); C171(1.21)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C156(1.19); C171(1.19)  LDD1154  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C193(1.30); C464(0.24)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C193(0.95); C464(0.91)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C193(1.04); C464(0.90); C171(0.75)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C156(1.19); C171(1.19)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C156(2.20); C171(2.20)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C156(1.41); C171(1.41)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C156(1.33); C171(1.33)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C156(1.25); C171(1.25)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C156(1.67); C171(1.67)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C156(0.93); C171(0.93)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C156(0.96); C171(0.96)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C156(1.64); C171(1.64)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C156(1.10); C171(1.10)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C193(0.96); C464(1.09); C218(0.97)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C156(1.03); C171(1.03)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C156(1.56); C171(1.56)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C156(0.82); C171(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C156(0.84); C171(0.84)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C156(1.46); C171(1.46)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C156(0.76); C171(0.76)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C156(0.67); C171(0.67)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C156(1.01); C171(1.01)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C156(1.07); C171(1.07)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C156(0.77); C171(0.77)  LDD1268  [4]
 LDCM0390  CL12 HEK-293T C193(0.94); C464(1.00); C171(0.74)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C156(0.82); C171(0.82)  LDD1270  [4]
 LDCM0392  CL121 HCT 116 C156(0.65); C171(0.65)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C156(0.77); C171(0.77)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C156(0.92); C171(0.92)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C156(0.88); C171(0.88)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C193(1.10); C464(1.19)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C193(0.87); C464(0.91)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C193(1.01); C464(1.06)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C193(0.99); C464(1.03)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C193(1.11); C464(1.09)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C193(1.03); C464(0.96)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C193(0.92); C464(0.98)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C156(1.00); C171(1.00)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C156(0.76); C171(0.76)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C156(0.93); C171(0.93)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C156(0.92); C171(0.92)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C193(1.06); C464(0.99)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C156(0.93); C171(0.93)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C156(0.92); C171(0.92)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C156(1.29); C171(1.29)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C156(0.69); C171(0.69)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C156(0.97); C171(0.97)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C156(1.14); C171(1.14)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C156(0.91); C171(0.91)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C156(0.87); C171(0.87)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C156(0.83); C171(0.83)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C156(0.81); C171(0.81)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C193(0.78); C464(1.01)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C156(0.86); C171(0.86)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C193(1.05); C464(0.91)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C193(0.91); C464(0.89)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C193(0.88); C464(0.94); C171(0.87)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C193(1.02); C464(0.95); C171(1.11)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C193(0.88); C464(1.06); C218(0.91)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C193(0.86); C464(0.99); C171(0.62)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C193(0.94); C464(1.00)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C193(0.98); C464(1.09)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C193(1.04); C464(1.15)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C193(1.00); C464(1.04)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C193(0.86); C464(1.00)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C193(0.91); C464(1.02)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C193(0.99); C464(1.02)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C193(0.92); C464(1.02)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C193(1.02); C464(0.97); C171(0.94)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C193(0.98); C464(0.81); C171(1.04)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C193(0.93); C464(1.09); C218(0.83)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C193(0.94); C464(1.05); C171(0.62)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C193(0.99); C464(1.00)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C193(0.94); C464(1.02)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C193(0.94); C464(0.99)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C193(0.87); C464(1.14)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C193(0.86); C464(0.97)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C193(0.87); C464(0.94)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C193(1.03); C464(1.08)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C193(0.96); C464(1.10)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C193(0.86); C464(0.99); C171(0.95)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C193(1.08); C464(0.95); C171(1.10)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C193(0.93); C464(1.04); C218(0.99)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C193(0.96); C464(1.05)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C193(0.93); C464(1.06); C171(0.72)  LDD1655  [11]
 LDCM0453  CL61 HCT 116 C156(0.86); C171(0.86)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C156(0.65); C171(0.65)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C156(0.66); C171(0.66)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C156(1.17); C171(1.17)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C156(0.83); C171(0.83)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C156(1.26); C171(1.26)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C156(1.13); C171(1.13)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C156(1.12); C171(1.12)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C156(0.96); C171(0.96)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C193(1.08); C464(1.08)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C156(1.09); C171(1.09)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C156(0.93); C171(0.93)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C156(1.48); C171(1.48)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C156(0.85); C171(0.85)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C156(0.92); C171(0.92)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C156(0.79); C171(0.79)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C156(0.77); C171(0.77)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C156(0.95); C171(0.95)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C156(0.77); C171(0.77)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C193(0.88); C464(0.93)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C156(0.80); C171(0.80)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C156(1.19); C171(1.19)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C156(0.86); C171(0.86)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C156(0.83); C171(0.83)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C156(1.24); C171(1.24)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C156(0.64); C171(0.64)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C156(0.63); C171(0.63)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C156(0.74); C171(0.74)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C156(1.12); C171(1.12)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C156(0.86); C171(0.86)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C193(1.00); C464(1.10); C171(0.85)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C156(0.52); C171(0.52)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C156(0.99); C171(0.99)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C156(1.06); C171(1.06)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C156(1.33); C171(1.33)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C156(1.27); C171(1.27)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C156(1.17); C171(1.17)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C156(1.13); C171(1.13)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C156(1.47); C171(1.47)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C156(1.32); C171(1.32)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C156(1.68); C171(1.68)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C193(0.98); C464(1.11)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C156(0.94); C171(0.94)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C193(0.98); C464(0.99)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C464(1.02); C193(0.93)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C464(0.99); C193(0.90)  LDD1497  [11]
 LDCM0024  KB05 HMCB C193(4.49)  LDD3312  [12]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0131  RA190 MM1.R C193(1.40)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrator complex subunit 13 (INTS13) Asunder family Q9NVM9
Integrator complex subunit 10 (INTS10) Integrator subunit 10 family Q9NVR2

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.