Details of the Target

General Information of Target

Target ID LDTP05834
Target Name Eukaryotic translation initiation factor 3 subunit I (EIF3I)
Gene Name EIF3I
Gene ID 8668
Synonyms
EIF3S2; TRIP1; Eukaryotic translation initiation factor 3 subunit I; eIF3i; Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; TRIP-1; eIF-3-beta; eIF3 p36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA
Target Bioclass
Other
Family
EIF-3 subunit I family
Subcellular location
Cytoplasm
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {|HAMAP-Rule:MF_03008}.
Uniprot ID
Q13347
Ensemble ID
ENST00000676801.1
HGNC ID
HGNC:3272
ChEMBL ID
CHEMBL4295814

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.81  LDD0402  [1]
A-EBA
 Probe Info  		3.34  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
C-Sul
 Probe Info  		2.94  LDD0066  [4]
TH211
 Probe Info  		Y300(20.00); Y139(13.70); Y241(12.51); Y308(6.02)  LDD0257  [5]
TH216
 Probe Info  		Y241(20.00); Y300(7.01)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K208(5.00); K264(7.52); K91(10.00)  LDD0277  [7]
AZ-9
 Probe Info  		D134(0.81)  LDD2208  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K2(2.67)  LDD3494  [9]
Probe 1
 Probe Info  		Y308(11.83)  LDD3495  [10]
HHS-482
 Probe Info  		Y308(1.29)  LDD0285  [11]
HHS-475
 Probe Info  		Y118(0.65); Y308(0.68)  LDD0264  [12]
HHS-465
 Probe Info  		Y308(10.00)  LDD2237  [13]
DBIA
 Probe Info  		C76(1.19); C81(1.08)  LDD0078  [14]
ATP probe
 Probe Info  		K213(0.00); K282(0.00); K298(0.00); K208(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C76(0.00); C144(0.00); C160(0.00); C57(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C160(0.00); C81(0.00); C57(0.00); C76(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		C160(0.00); C57(0.00); C81(0.00); C76(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C160(0.00); C81(0.00); C57(0.00); C76(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C76(0.00); C144(0.00); C160(0.00); C57(0.00)  LDD0037  [16]
BTD
 Probe Info  		N.A.  LDD0004  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
WYneO
 Probe Info  		C76(0.00); C81(0.00)  LDD0022  [19]
Compound 10
 Probe Info  		C144(0.00); C160(0.00); C76(0.00); C81(0.00)  LDD2216  [20]
IPM
 Probe Info  		N.A.  LDD0147  [21]
PF-06672131
 Probe Info  		N.A.  LDD0152  [22]
SF
 Probe Info  		K264(0.00); Y308(0.00)  LDD0028  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		K282(0.00); K213(0.00); K298(0.00); K30(0.00)  LDD0228  [25]
1d-yne
 Probe Info  		N.A.  LDD0357  [25]
Acrolein
 Probe Info  		H243(0.00); C76(0.00); H66(0.00); C81(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		C81(0.00); C76(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C76(0.00); C81(0.00)  LDD0218  [26]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		6.20  LDD0443  [28]
NAIA_5
 Probe Info  		C76(0.00); C160(0.00); C81(0.00); C99(0.00)  LDD2223  [29]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		15.45  LDD1865  [30]
C191
 Probe Info  		11.47  LDD1868  [30]
C193
 Probe Info  		5.50  LDD1869  [30]
FFF probe13
 Probe Info  		5.89  LDD0475  [31]
FFF probe2
 Probe Info  		12.15  LDD0463  [31]
FFF probe3
 Probe Info  		5.07  LDD0465  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
pLen
 Probe Info  		3.13  LDD0255  [33]
Diazir
 Probe Info  		N.A.  LDD0011  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C144(0.75)  LDD2142  [34]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C76(0.90)  LDD2112  [34]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C76(0.49)  LDD2095  [34]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C76(1.02); C144(1.01)  LDD2130  [34]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C76(0.63); C81(1.21)  LDD2117  [34]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C76(1.22)  LDD2152  [34]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C76(0.45)  LDD2132  [34]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C76(0.67)  LDD2131  [34]
 LDCM0214  AC1 HCT 116 C144(1.11); C76(1.21); C81(1.66); C99(0.80)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C120(0.78); C76(0.77); C81(1.13); C99(0.54)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C144(0.55); C76(0.83); C81(0.74); C99(0.70)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C144(0.57); C76(0.57); C81(0.64); C99(0.55)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C144(0.76); C76(0.60); C81(0.86); C99(0.44)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C144(0.51); C76(0.37); C81(0.69); C99(0.18)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C144(1.00); C76(0.50); C81(0.86); C99(0.26)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C144(0.63); C76(0.41); C81(0.75); C99(0.23)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C144(0.47); C76(0.39); C81(0.69); C99(0.24)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C144(0.63); C76(0.43); C81(0.77); C99(0.27)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C144(0.51); C76(0.67); C81(0.77); C99(0.41)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C144(0.93); C76(0.71); C81(0.90); C99(0.47)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C120(0.72); C76(0.79); C81(1.35); C99(0.46)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C144(0.44); C76(0.54); C81(0.67); C99(0.51)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C144(0.43); C76(0.51); C81(0.53); C99(0.40)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C144(0.44); C76(0.42); C81(0.48); C99(0.31)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C144(1.51); C76(1.02); C81(1.30)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C144(1.00); C76(0.64); C81(1.01)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C144(0.94); C76(0.55); C81(1.09)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C144(1.01); C76(0.48); C81(1.12)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C144(1.04); C76(0.79); C81(1.07)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C144(1.06); C76(0.85); C81(1.25)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C144(1.00); C76(0.77); C81(1.09)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C120(0.87); C76(1.07); C81(1.38); C99(0.84)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C144(1.05); C76(0.74); C81(0.89)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C144(0.96); C76(1.08); C81(0.86)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C144(1.01); C76(0.94); C81(0.96)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C144(1.21); C76(1.14); C81(0.78)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C144(0.94); C76(1.04); C81(1.03)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C144(1.02); C76(0.76); C81(1.07)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C144(0.93); C76(0.65); C81(0.96)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C144(1.03); C76(0.63); C81(1.10)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C76(0.82); C81(1.89)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C76(1.75); C81(1.83)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C76(0.98); C81(1.71)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C76(1.39); C81(1.07)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C76(1.47); C81(1.01)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C76(0.96); C81(1.52)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C76(0.66); C81(0.81)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C76(0.77); C81(1.18)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C76(0.87); C81(0.98)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C76(1.20); C81(1.05)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C76(0.72); C81(0.50)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C76(0.76); C81(0.61)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C120(0.83); C76(0.98); C81(0.98); C99(0.73)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C76(0.59); C81(0.45)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C76(0.74); C81(0.43)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C76(1.92); C81(0.80)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C76(0.92); C81(0.92); C99(0.81)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C99(0.36); C76(0.63); C81(1.11)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C99(0.85); C76(0.86); C81(0.97)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C99(0.51); C76(0.73); C81(1.08)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C99(0.33); C76(0.54); C81(1.00)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C99(0.17); C76(0.47); C81(1.04)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C99(0.26); C76(0.54); C81(0.93)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C99(0.54); C120(0.68); C76(0.78); C81(1.01)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C99(0.71); C81(1.10); C76(1.26)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C99(0.84); C81(0.97); C76(0.99)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C99(0.26); C76(0.52); C81(1.06)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C99(0.17); C76(0.51); C81(0.82)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C76(0.62); C81(1.02); C99(0.43)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C76(0.70); C81(0.85); C99(0.40)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C76(1.14); C81(1.09); C99(0.90)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C76(1.10); C81(0.90); C99(0.78)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C76(0.92); C81(1.26)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C76(0.64); C81(1.08)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C76(0.80); C81(1.14)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C99(0.72); C144(0.90); C81(0.98); C76(1.00)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C81(0.86); C76(1.00)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C76(0.90); C81(1.12)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C76(0.95); C81(1.12)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C76(0.95); C81(1.16)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C81(0.85); C76(0.90)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C76(0.85); C99(0.86); C81(0.96)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C99(0.60); C76(0.68); C81(0.80)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C76(0.59); C99(0.63); C81(0.81)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C99(0.46); C76(0.63); C81(0.94)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C99(0.55); C76(0.62); C81(0.68)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C99(0.76); C76(1.10); C81(1.32); C144(1.39)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C76(0.51); C81(0.52); C99(0.83)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C76(0.67); C99(0.79); C81(0.85)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C99(0.35); C76(0.45); C81(0.67)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C99(0.55); C76(0.55); C81(0.85)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C99(0.38); C76(0.48); C81(0.63)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C81(1.22); C144(1.34); C76(1.60); C120(1.71)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C81(1.00); C144(1.42); C76(1.55); C99(1.60)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C99(1.24); C120(1.29); C144(1.35); C81(1.45)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C81(0.95); C144(1.08); C76(1.20); C99(1.55)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C120(0.74); C99(0.76); C144(0.96); C81(1.08)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C99(0.55); C76(1.15); C144(1.27); C81(1.46)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C120(0.54); C144(0.62); C99(0.67); C76(0.83)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C81(0.97); C120(1.17); C76(1.21); C99(1.26)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C81(0.82); C144(0.85); C76(0.92); C99(0.95)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C81(0.68); C76(1.07); C144(1.11); C99(1.16)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C144(0.88); C99(0.91); C120(1.00); C76(1.03)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C144(0.56); C99(0.60); C120(0.67); C76(0.80)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C81(0.67); C76(0.90); C120(1.01); C144(1.08)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C120(0.70); C76(0.91); C144(0.94); C81(0.94)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C120(0.70); C81(0.76); C76(1.37); C99(1.47)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C120(0.36); C144(0.42); C99(0.42); C76(0.51)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C99(0.51); C76(1.23); C144(1.23); C81(1.38)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C120(0.41); C144(0.44); C99(0.49); C76(0.52)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C81(0.67); C120(1.17); C76(1.35); C99(1.80)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C81(0.71); C120(0.82); C76(0.86); C144(0.96)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C120(0.54); C144(0.58); C76(0.60); C99(0.63)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C144(0.51); C76(0.62); C120(0.63); C99(0.73)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C99(0.39); C144(0.41); C120(0.45); C76(0.52)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C120(0.34); C144(0.43); C99(0.44); C76(0.47)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C99(0.28); C76(0.73); C120(0.85); C81(1.18)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C99(0.36); C76(0.64); C81(0.90); C120(0.91)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C99(0.20); C120(0.60); C76(0.76); C81(1.16)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C99(0.57); C76(0.62); C120(0.78); C81(0.94)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C99(0.39); C76(0.81); C81(1.06); C120(1.15)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C99(0.60); C76(0.93); C81(1.07); C120(1.43)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C99(0.22); C76(0.73); C120(0.85); C81(1.34)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C99(0.32); C76(0.89); C120(1.04); C81(1.34)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C99(0.19); C76(0.81); C120(0.83); C81(1.24)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C99(0.24); C76(0.68); C81(0.95); C120(1.03)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C99(0.30); C76(0.70); C81(0.98); C120(1.16)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C99(0.11); C120(0.63); C76(0.65); C81(1.01)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C99(0.62); C76(0.71); C81(0.80); C120(0.99)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C99(0.57); C76(0.72); C81(0.94); C120(0.96)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C120(0.69); C99(0.76); C76(0.91); C81(1.21)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C99(0.28); C76(0.54); C81(0.79); C120(0.93)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C99(1.03); C120(1.03); C81(1.06); C76(1.09)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C99(0.53); C76(0.66); C81(0.78); C120(0.84)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C99(0.26); C76(0.48); C120(0.55); C81(0.72)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C99(0.28); C76(0.53); C120(0.70); C81(0.93)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C99(0.28); C76(0.51); C120(0.57); C81(0.86)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C99(0.35); C76(0.57); C120(0.85); C81(1.02)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C99(0.33); C76(0.50); C81(0.74); C120(0.76)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C81(0.85); C99(0.96); C120(1.25); C76(1.27)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C81(0.72); C99(0.73); C76(0.81); C120(1.23)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C99(0.58); C120(0.64); C76(0.82); C81(0.90)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C99(0.47); C76(0.57); C120(0.88); C81(0.99)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C120(0.70); C81(0.90); C76(1.10); C99(1.13)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C99(0.31); C76(0.53); C120(0.89); C81(0.92)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C76(0.45); C81(0.87)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C76(0.49); C81(0.88)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C81(0.83); C76(0.95)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C76(0.68); C81(0.79)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C81(0.82); C76(1.09)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C76(0.71); C81(0.83)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C76(0.49); C81(0.83)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C81(0.84); C76(2.06)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C76(0.48); C81(1.15)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C76(0.45); C81(0.90)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C76(0.80); C81(0.84)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C81(1.19); C76(1.30)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C81(0.81); C76(1.03)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C76(0.69); C81(1.04)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C76(0.46); C81(0.73)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C99(0.09); C76(0.27); C144(0.50); C81(0.57)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C144(0.60); C81(0.67); C76(0.70); C99(0.73)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C76(0.32)  LDD2138  [34]
 LDCM0520  AKOS000195272 MDA-MB-231 C76(0.71)  LDD2113  [34]
 LDCM0248  AKOS034007472 HCT 116 C120(0.67); C76(1.01); C81(1.03); C99(0.96)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C99(0.75); C120(0.77); C76(0.90); C81(1.16)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C99(0.20); C120(0.44); C76(0.45); C81(0.84)  LDD0592  [14]
 LDCM0020  ARS-1620 HCC44 C76(1.19); C81(1.08)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C76(0.36); C144(0.52)  LDD2091  [34]
 LDCM0108  Chloroacetamide HeLa C160(0.00); H243(0.00); C76(0.00); C81(0.00)  LDD0222  [26]
 LDCM0367  CL1 HCT 116 C81(0.93); C76(0.95); C120(1.21); C99(1.36)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C99(0.57); C120(0.64); C76(0.66); C81(1.00)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C99(0.58); C144(1.01); C76(1.03); C81(1.27)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C99(0.41); C76(0.67); C120(0.72); C81(0.84)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C99(0.77); C120(0.80); C76(0.91); C81(1.42)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C99(0.85); C120(0.92); C76(0.97); C81(1.43)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C99(0.87); C76(0.90); C120(0.92); C81(1.12)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C76(0.65); C81(1.37)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C76(0.60); C81(1.34)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C76(0.53); C81(1.38)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C76(0.50); C81(1.42)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C76(0.62); C81(1.21)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C120(0.35); C99(0.37); C76(0.60); C81(1.09)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C76(0.55); C81(1.16)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C76(0.71); C81(1.00)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C99(0.74); C81(0.79); C76(0.97)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C99(0.48); C76(0.51); C81(0.58)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C81(0.50); C99(0.64); C76(0.65)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C81(0.52); C76(0.58); C99(0.58)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C99(0.57); C76(0.63); C81(0.78)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C144(0.37); C99(0.44); C120(0.45); C76(0.61)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C99(0.79); C144(0.87); C81(0.96); C76(1.02)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C144(0.76); C120(0.78); C76(0.85); C99(0.86)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C99(0.33); C120(0.40); C76(0.54); C81(1.03)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C81(0.87); C120(0.92); C76(1.04); C144(1.15)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C76(0.58); C144(0.59); C99(0.63); C120(0.73)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C81(0.72); C99(0.83); C120(0.93); C76(0.94)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C120(0.36); C144(0.49); C76(0.64); C99(0.66)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C99(0.45); C144(0.47); C76(0.48); C120(0.49)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C99(0.77); C81(0.96); C76(0.97); C120(1.11)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C99(0.52); C76(0.78); C81(0.94); C120(1.06)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C99(0.60); C76(0.87); C81(1.05); C120(1.19)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C99(0.21); C120(0.51); C76(0.67); C81(1.05)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C99(0.67); C76(0.80); C120(0.86); C81(1.13)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C120(0.68); C76(0.84); C99(0.85); C81(0.99)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C120(0.52); C99(0.73); C76(0.90); C81(1.11)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C76(0.68); C99(0.72); C81(0.76); C120(0.87)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C99(0.65); C76(0.85); C120(0.98); C81(1.02)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C120(0.96); C99(0.97); C76(1.01); C81(1.24)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C76(0.74); C99(0.75); C120(0.87); C81(1.00)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C76(0.99); C81(0.99); C99(1.19); C120(1.34)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C99(0.44); C76(0.52); C81(0.66); C120(0.69)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C99(0.36); C120(0.50); C76(0.60); C81(0.97)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C99(0.27); C120(0.37); C76(0.47); C81(0.65)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C120(0.54); C76(0.60); C99(0.61); C81(0.84)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C99(0.30); C120(0.48); C76(0.49); C81(0.65)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C120(0.45); C76(0.44); C81(0.70); C99(0.31)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C120(0.71); C76(0.61); C81(0.82); C99(0.60)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C120(0.64); C76(0.69); C81(0.98); C99(0.55)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C120(0.67); C76(0.53); C81(0.71); C99(0.49)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C120(0.74); C76(0.61); C81(0.84); C99(0.48)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C120(0.77); C76(0.91); C81(1.03); C99(1.09)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C120(0.89); C76(0.83); C81(1.13); C99(0.88)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C120(0.85); C76(0.56); C81(2.03); C99(0.69)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C120(1.24); C76(0.65); C99(1.00)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C120(0.67); C76(0.76); C99(0.89)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C120(0.35); C76(0.42); C99(0.35)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C120(0.42); C76(0.45); C99(0.35)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C120(0.35); C76(0.45); C99(0.37)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C120(0.26); C76(0.41); C99(0.31)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C120(0.25); C76(0.45); C99(0.30)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C120(0.89); C76(0.88); C81(1.02); C99(0.84)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C120(0.51); C76(0.43); C99(0.39)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C120(0.50); C76(0.50); C99(0.43)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C120(0.36); C76(0.44); C99(0.22)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C120(0.35); C76(0.39); C99(0.28)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C120(0.47); C76(0.55); C99(0.49)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C120(0.31); C76(0.51); C99(0.36)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C76(1.23); C81(0.87)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C76(1.08); C81(0.86)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C76(1.41); C81(0.98)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C76(0.97); C81(1.07)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C120(0.86); C76(0.89); C81(1.15); C99(0.70)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C76(1.18); C81(0.95)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C76(1.13); C81(0.81)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C76(0.98); C81(0.67)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C76(1.24); C81(0.62)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C76(1.21); C81(0.75)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C76(1.30); C81(0.67)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C76(1.02); C81(0.76)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C76(1.23); C81(0.76)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C76(1.28); C81(0.86)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C76(1.00); C81(0.79)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C120(0.73); C76(0.99); C81(1.00); C99(0.99)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C76(0.95); C81(0.84)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C120(1.02); C144(0.85); C76(0.93); C81(1.05)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C120(0.84); C144(0.78); C76(0.86); C81(0.98)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C120(0.68); C144(0.84); C76(0.81); C81(0.92)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C120(0.39); C144(0.87); C76(0.61); C81(1.06)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C120(0.78); C144(0.99); C76(0.82); C81(1.08)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C120(0.35); C144(0.82); C76(0.50); C81(0.99)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C120(0.57); C144(1.00); C76(0.60); C81(1.26)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C120(0.65); C144(0.92); C76(0.87); C81(0.79)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C120(0.86); C144(0.68); C76(1.13); C81(0.81)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C120(0.48); C76(0.71); C81(1.30); C99(0.42)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C120(0.86); C144(0.68); C76(0.86); C81(0.86)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C120(0.47); C144(0.84); C76(0.69); C81(0.97)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C120(1.11); C144(0.61); C76(0.90); C81(0.68)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C120(0.54); C144(0.76); C76(0.68); C81(0.84)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C120(0.50); C144(0.85); C76(0.67); C81(0.86)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C120(0.46); C76(0.92); C81(0.67); C99(0.88)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C120(1.09); C76(0.88); C81(0.74); C99(1.55)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C120(0.46); C76(0.75); C81(0.67); C99(0.56)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C120(0.44); C76(0.53); C81(0.48); C99(0.38)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C120(0.33); C76(0.49); C81(0.95); C99(0.33)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C120(0.88); C76(0.99); C81(0.63); C99(1.61)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C120(0.75); C76(0.76); C81(0.57); C99(0.51)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C120(0.36); C76(0.53); C81(0.52); C99(0.25)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C120(0.39); C76(0.57); C81(0.48); C99(0.30)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C120(0.38); C76(0.45); C81(0.46); C99(0.24)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C120(0.54); C76(0.71); C81(0.60); C99(0.56)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C120(0.55); C76(1.07); C81(0.62); C99(0.91)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C120(0.49); C76(0.71); C81(0.53); C99(0.51)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C120(0.41); C76(0.63); C81(0.48); C99(0.30)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C120(0.32); C76(0.45); C81(0.47); C99(0.22)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C120(0.66); C76(0.70); C81(0.96); C99(0.69)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C120(0.63); C76(0.97); C81(0.76); C99(0.77)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C144(1.30); C76(0.87); C81(0.93); C99(0.63)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C144(1.04); C76(0.97); C81(0.93); C99(0.68)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C144(1.19); C76(1.14); C81(1.43); C99(0.80)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C144(0.83); C76(1.06); C81(1.28); C99(0.51)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C144(1.22); C76(0.92); C81(1.16); C99(0.51)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C144(1.17); C76(0.96); C81(0.96); C99(0.54)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C144(1.08); C76(0.86); C81(0.98); C99(0.65)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C144(0.89); C76(0.86); C81(1.16); C99(0.47)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C144(1.10); C76(0.95); C81(1.31); C99(0.50)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C76(0.93); C144(0.95); C81(0.90); C57(1.13)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C81(1.83); C76(1.45); C160(1.43); C144(1.38)  LDD1702  [34]
 LDCM0625  F8 Ramos C160(0.38)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C76(0.85); C160(0.68)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C76(1.12); C160(1.14)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C76(1.04); C160(0.61)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C76(1.24); C160(1.84)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C160(0.88)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C76(0.91); C160(0.49)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C76(0.95); C160(1.37)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C76(1.62); C160(2.65)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C76(1.18); C160(1.16)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C76(2.44); C160(1.02)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C76(1.36); C160(0.82)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C76(1.11)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C76(1.12); C160(1.04)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C120(0.67); C144(0.86); C76(0.68); C81(1.01)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C76(1.61); C160(0.70)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C160(0.74)  LDD2184  [36]
 LDCM0427  Fragment51 HCT 116 C120(0.19); C76(0.41); C99(0.21)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C76(1.76)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C76(1.71); C160(1.09)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C160(0.50)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C76(0.72); C160(0.63)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y118(0.65); Y308(0.68)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y308(0.65); Y118(1.11)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y118(0.76); Y308(0.76)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y118(0.54); Y308(0.57)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y118(0.50); Y308(0.59)  LDD0268  [12]
 LDCM0107  IAA HeLa H243(0.00); H66(0.00); H284(0.00); C81(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y308(1.29)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y308(1.79)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y308(0.86)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y308(10.10)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y308(2.49)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y308(0.95)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y308(0.41)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y308(0.87)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C76(1.93); C81(2.30)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C76(2.91); C81(3.11)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C76(1.86); C81(1.85)  LDD0082  [14]
 LDCM0114  Len HEK-293T 3.13  LDD0255  [33]
 LDCM0115  Minimalist HEK-293T 3.95  LDD0256  [33]
 LDCM0109  NEM HeLa H243(0.00); H284(0.00); H222(0.00); H9(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C144(0.87)  LDD2089  [34]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C76(1.03)  LDD2092  [34]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C76(0.72)  LDD2093  [34]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C76(1.85)  LDD2094  [34]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C76(0.27)  LDD2096  [34]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C76(1.52)  LDD2097  [34]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C76(0.47)  LDD2098  [34]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C76(0.78); C144(0.91)  LDD2099  [34]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C76(0.42); C144(0.84)  LDD2100  [34]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C76(0.81)  LDD2101  [34]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C76(0.53)  LDD2104  [34]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C76(1.54); C144(1.02)  LDD2105  [34]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C144(0.62)  LDD2106  [34]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C76(0.85)  LDD2107  [34]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C144(0.76)  LDD2108  [34]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C76(0.44)  LDD2109  [34]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C144(1.00)  LDD2110  [34]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C76(0.89)  LDD2111  [34]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C76(0.67)  LDD2114  [34]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C76(0.42); C144(0.90)  LDD2115  [34]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C76(0.31)  LDD2116  [34]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C76(0.30); C144(0.75)  LDD2118  [34]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C76(2.19)  LDD2119  [34]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C144(1.21)  LDD2120  [34]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C76(0.22)  LDD2122  [34]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C76(0.73)  LDD2123  [34]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C76(0.25); C144(1.13)  LDD2124  [34]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C76(0.58)  LDD2125  [34]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C76(0.20); C144(0.85)  LDD2126  [34]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C76(0.86)  LDD2127  [34]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C144(1.28)  LDD2128  [34]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C76(0.69); C144(1.25)  LDD2129  [34]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C76(0.62)  LDD2133  [34]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C76(0.48)  LDD2134  [34]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C76(0.82); C144(0.95)  LDD2135  [34]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C76(1.02)  LDD2136  [34]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C76(0.87)  LDD2137  [34]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C76(1.06)  LDD1700  [34]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C76(0.59)  LDD2140  [34]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C76(0.42); C144(1.04)  LDD2141  [34]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C76(1.12); C144(1.16)  LDD2143  [34]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C76(2.63)  LDD2144  [34]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C76(0.26); C144(0.99)  LDD2145  [34]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C76(0.65)  LDD2146  [34]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C144(2.94)  LDD2147  [34]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C76(0.52)  LDD2148  [34]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C76(0.27); C144(0.80)  LDD2150  [34]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C76(0.27)  LDD2151  [34]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C76(1.64)  LDD2153  [34]
 LDCM0627  NUDT7-COV-1 HEK-293T C160(0.79)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C160(0.62)  LDD2207  [37]
 LDCM0131  RA190 MM1.R C81(1.69); C160(1.19)  LDD0304  [38]
 LDCM0021  THZ1 HCT 116 C81(1.06)  LDD2173  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit B (EIF3B) EIF-3 subunit B family P55884
Eukaryotic translation initiation factor 3 subunit G (EIF3G) EIF-3 subunit G family O75821
C-type lectin domain family 4 member G (CLEC4G) . Q6UXB4

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Development of Photolenalidomide for Cellular Target Identification. J Am Chem Soc. 2022 Jan 12;144(1):606-614. doi: 10.1021/jacs.1c11920. Epub 2022 Jan 3.
34 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.