Details of the Probe

General Information of Probe

Probe ID
LDPC0160
Probe Name
pLen
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 393.403
Lipid-water partition coefficient (xlogp) 1.3517
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H19N5O4
Canonical SMILES
C#CCCC1(CC(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)N=N1
InChI
InChI=1S/C20H19N5O4/c1-2-3-8-20(23-24-20)10-17(27)21-13-4-5-14-12(9-13)11-25(19(14)29)15-6-7-16(26)22-18(15)28/h1,4-5,9,15H,3,6-8,10-11H2,(H,21,27)(H,22,26,28)
InChIKey
CJCQTNAGHVZIEY-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

1 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 2.04  LDD0256 
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1 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Protein cereblon (CRBN) LDTP10826 8.01  LDD0254 
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1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DNA-binding protein Ikaros (IKZF1) LDTP05861 6.86  LDD0254 
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3 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) LDTP04129 2.23  LDD0256 
Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY) LDTP14429 2.23  LDD0256 
Eukaryotic translation initiation factor 3 subunit I (EIF3I) LDTP05834 3.13  LDD0255 
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Competitor(s) Related To This Probe

Competitor ID Name Concentration Cell-system Ref
 LDCM0114  Len 150 uM Human plasma cell myeloma cells (MM1.S) [1]
 LDCM0115  Minimalist 150 uM Human normal cells (HEK-293T) [1]

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
50 uM
Quantitative Method
LFQ
Competitor Name
Len
 Competitor Info 
Competitor Concentration
150 uM
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Plasma cell myeloma [ICD-11:2A83]
Model Name
Human plasma cell myeloma cells (MM1.S)
Interaction Atlas ID
 LDD0254 
Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
50 uM
Quantitative Method
LFQ
Competitor Name
Len
 Competitor Info 
Competitor Concentration
150 uM
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0255 
Download The Altas
  
Experiment 3 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
50 uM
Quantitative Method
LFQ
Competitor Name
Minimalist
 Competitor Info 
Competitor Concentration
150 uM
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0256 
Download The Altas

References

1 Development of Photolenalidomide for Cellular Target Identification. J Am Chem Soc. 2022 Jan 12;144(1):606-614. doi: 10.1021/jacs.1c11920. Epub 2022 Jan 3.