Details of the Target

General Information of Target

Target ID LDTP04129
Target Name Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)
Gene Name EIF1AX
Gene ID 1964
Synonyms
EIF1A; EIF4C; Eukaryotic translation initiation factor 1A, X-chromosomal; eIF-1A X isoform; eIF1A X isoform; Eukaryotic translation initiation factor 4C; eIF-4C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCH
IRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDT
FGPGDDDEIQFDDIGDDDEDIDDI
Target Bioclass
Other
Family
EIF-1A family
Function
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.
Uniprot ID
P47813
Ensemble ID
ENST00000379607.10
HGNC ID
HGNC:3250

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y106(5.36)  LDD0257  [1]
TH214
 Probe Info  		Y106(5.49)  LDD0258  [1]
TH216
 Probe Info  		Y95(20.00)  LDD0259  [1]
STPyne
 Probe Info  		K104(10.00); K88(9.72)  LDD0277  [2]
AZ-9
 Probe Info  		E111(1.26)  LDD2208  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C51(1.88)  LDD1700  [4]
HHS-482
 Probe Info  		Y106(0.77)  LDD0285  [5]
HHS-475
 Probe Info  		Y106(0.82)  LDD0264  [6]
HHS-465
 Probe Info  		Y106(7.24)  LDD2237  [7]
DBIA
 Probe Info  		C51(1.30)  LDD0080  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
AMP probe
 Probe Info  		N.A.  LDD0200  [10]
ATP probe
 Probe Info  		K88(0.00); K56(0.00); K16(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
OSF
 Probe Info  		N.A.  LDD0029  [13]
SF
 Probe Info  		Y84(0.00); Y106(0.00); K88(0.00)  LDD0028  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
pLen
 Probe Info  		2.23  LDD0256  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C51(0.36)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C51(0.86)  LDD2112  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C51(0.99)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C51(1.86)  LDD2117  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C51(0.35)  LDD2132  [4]
 LDCM0214  AC1 HEK-293T C51(1.06)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C51(0.93)  LDD1508  [17]
 LDCM0216  AC100 HEK-293T C51(1.00)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C51(1.24)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C51(1.09)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C51(1.19)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C51(1.16)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C51(1.25)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C51(1.20)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C51(1.31)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C51(1.03)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C51(1.07)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C51(0.93)  LDD1509  [17]
 LDCM0227  AC110 HEK-293T C51(1.18)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C51(1.10)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C51(1.09)  LDD0827  [8]
 LDCM0237  AC12 HEK-293T C51(0.84)  LDD1510  [17]
 LDCM0263  AC143 HEK-293T C51(1.02)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C51(1.21)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C51(1.34)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C51(1.10)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C51(1.07)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C51(1.15)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C51(1.03)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C51(1.02)  LDD1513  [17]
 LDCM0271  AC150 HEK-293T C51(0.81)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C51(1.08)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C51(1.09)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C51(1.08)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C51(0.87)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C51(1.13)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C51(1.08)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C51(1.00)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C51(0.97)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C51(1.00)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C51(0.82)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C51(0.97)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C51(0.95)  LDD1519  [17]
 LDCM0283  AC23 HEK-293T C51(0.93)  LDD1522  [17]
 LDCM0285  AC25 HEK-293T C51(1.08)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C51(1.00)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C51(0.99)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C51(0.90)  LDD1527  [17]
 LDCM0290  AC3 HEK-293T C51(1.06)  LDD1529  [17]
 LDCM0292  AC31 HEK-293T C51(1.01)  LDD1531  [17]
 LDCM0294  AC33 HEK-293T C51(0.93)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C51(0.88)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C51(0.93)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C51(0.87)  LDD1536  [17]
 LDCM0300  AC39 HEK-293T C51(1.00)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C51(0.98)  LDD1540  [17]
 LDCM0303  AC41 HEK-293T C51(1.12)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C51(0.91)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C51(0.92)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C51(0.83)  LDD1545  [17]
 LDCM0309  AC47 HEK-293T C51(1.05)  LDD1548  [17]
 LDCM0311  AC49 HEK-293T C51(1.00)  LDD1550  [17]
 LDCM0313  AC50 HEK-293T C51(0.95)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C51(1.04)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C51(0.84)  LDD1554  [17]
 LDCM0318  AC55 HEK-293T C51(1.02)  LDD1557  [17]
 LDCM0320  AC57 HEK-293T C51(0.96)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C51(0.95)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C51(0.95)  LDD1561  [17]
 LDCM0324  AC60 HEK-293T C51(0.83)  LDD1563  [17]
 LDCM0327  AC63 HEK-293T C51(0.98)  LDD1566  [17]
 LDCM0334  AC7 HEK-293T C51(1.02)  LDD1568  [17]
 LDCM0349  AC83 HEK-293T C51(0.99)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C51(1.08)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C51(1.23)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C51(1.19)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C51(1.33)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C51(1.34)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C51(1.28)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C51(1.56)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C51(1.12)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C51(1.12)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C51(1.50)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C51(1.13)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C51(1.35)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C51(1.03)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C51(1.19)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C51(1.02)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C51(1.03)  LDD0964  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C51(0.80)  LDD2113  [4]
 LDCM0356  AKOS034007680 HEK-293T C51(0.98)  LDD1570  [17]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0369  CL100 HEK-293T C51(1.00)  LDD1573  [17]
 LDCM0371  CL102 HEK-293T C51(0.91)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C51(0.88)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C51(0.95)  LDD1577  [17]
 LDCM0375  CL106 HEK-293T C51(0.97)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C51(1.04)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C51(0.95)  LDD1581  [17]
 LDCM0379  CL11 HEK-293T C51(1.11)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C51(0.97)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C51(1.06)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C51(0.99)  LDD1586  [17]
 LDCM0384  CL114 HEK-293T C51(0.97)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C51(0.92)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C51(0.89)  LDD1590  [17]
 LDCM0388  CL118 HEK-293T C51(0.93)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C51(0.86)  LDD1593  [17]
 LDCM0391  CL120 HEK-293T C51(0.91)  LDD1595  [17]
 LDCM0393  CL122 HEK-293T C51(0.99)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C51(0.88)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C51(0.92)  LDD1599  [17]
 LDCM0397  CL126 HEK-293T C51(0.88)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C51(0.93)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C51(0.94)  LDD1603  [17]
 LDCM0401  CL14 HEK-293T C51(0.87)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C51(0.77)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C51(1.11)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C51(1.16)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C51(1.22)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C51(1.21)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C51(0.99)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C51(1.26)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C51(1.06)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C51(1.15)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C51(1.18)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C51(0.95)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C51(1.05)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C51(1.19)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C51(1.04)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C51(0.99)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C51(1.35)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C51(0.87)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C51(1.10)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C51(0.99)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C51(0.93)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C51(0.82)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C51(0.95)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C51(0.92)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C51(1.10)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C51(1.14)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C51(0.89)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C51(0.89)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C51(0.99)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C51(0.88)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C51(0.91)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C51(0.94)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C51(1.02)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C51(0.84)  LDD1033  [8]
 LDCM0437  CL47 HEK-293T C51(1.15)  LDD1641  [17]
 LDCM0440  CL5 HEK-293T C51(1.11)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C51(0.92)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C51(0.90)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C51(0.99)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C51(0.86)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C51(1.12)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C51(0.93)  LDD1650  [17]
 LDCM0450  CL59 HEK-293T C51(1.18)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C51(0.91)  LDD1654  [17]
 LDCM0453  CL61 HEK-293T C51(0.87)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C51(0.94)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C51(0.71)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C51(0.86)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C51(1.12)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C51(0.84)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C51(0.94)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C51(1.01)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C51(1.05)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C51(1.01)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C51(0.87)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C51(0.88)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C51(0.93)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C51(0.97)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C51(0.89)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C51(0.91)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C51(1.08)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C51(0.97)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C51(1.00)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C51(0.75)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C51(1.00)  LDD1677  [17]
 LDCM0477  CL83 HEK-293T C51(0.99)  LDD1680  [17]
 LDCM0480  CL86 HEK-293T C51(0.98)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C51(0.99)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C51(0.92)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C51(1.02)  LDD1686  [17]
 LDCM0485  CL90 HEK-293T C51(0.89)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C51(1.02)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C51(0.83)  LDD1690  [17]
 LDCM0490  CL95 HEK-293T C51(0.96)  LDD1693  [17]
 LDCM0493  CL98 HEK-293T C51(1.01)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C51(1.02)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C51(0.79)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C51(0.90)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C51(1.27)  LDD1025  [8]
 LDCM0116  HHS-0101 DM93 Y106(0.82)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y106(0.73)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y106(0.71)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y106(0.73)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y106(0.60)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0123  JWB131 DM93 Y106(0.77)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y106(0.87)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y106(0.99)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y106(2.11)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y106(1.33)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y106(0.99)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y106(0.76)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y106(1.02)  LDD0292  [5]
 LDCM0022  KB02 HCT 116 C51(1.30)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C51(1.50)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C51(1.69)  LDD0082  [8]
 LDCM0115  Minimalist HEK-293T 2.23  LDD0256  [16]
 LDCM0109  NEM HeLa N.A.  LDD0224  [14]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C51(0.94)  LDD2090  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C51(1.69)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C51(0.41)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C51(1.02)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C51(1.52)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C51(0.57)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C51(0.80)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C51(0.58)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C51(1.37)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C51(0.54)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C51(0.68)  LDD2116  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C51(1.34)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C51(1.28)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C51(0.23)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C51(1.18)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C51(0.85)  LDD2126  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C51(0.42)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C51(1.49)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C51(1.62)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C51(0.63)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C51(2.69)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C51(1.77)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C51(1.08)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C51(1.88)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C51(1.09)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C51(0.58)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C51(0.78)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C51(1.61)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C51(0.54)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C51(1.28)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C51(0.95)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C51(0.08)  LDD2151  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ret finger protein-like 3 (RFPL3) . O75679
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin-13 (IPO13) Importin beta family O94829
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit A (EIF3A) EIF-3 subunit A family Q14152
Eukaryotic translation initiation factor 3 subunit C (EIF3C) EIF-3 subunit C family Q99613

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Development of Photolenalidomide for Cellular Target Identification. J Am Chem Soc. 2022 Jan 12;144(1):606-614. doi: 10.1021/jacs.1c11920. Epub 2022 Jan 3.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402