Details of the Target

General Information of Target

Target ID LDTP05590
Target Name Histone-binding protein RBBP4 (RBBP4)
Gene Name RBBP4
Gene ID 5928
Synonyms
RBAP48; Histone-binding protein RBBP4; Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD
FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK
INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG
YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE
SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL
WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE
DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP
EGQGS
Target Bioclass
Other
Family
WD repeat RBAP46/RBAP48/MSI1 family
Subcellular location
Nucleus
Function
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Uniprot ID
Q09028
Ensemble ID
ENST00000373485.5
HGNC ID
HGNC:9887
ChEMBL ID
CHEMBL2189120

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.D99N DBIA    Probe Info 
JURKAT SNV: p.A294T Compound 10    Probe Info 
KELLY Substitution: p.H311T DBIA    Probe Info 
MCC13 SNV: p.K212N DBIA    Probe Info 
MFE319 Deletion: p.G180AfsTer38 DBIA    Probe Info 
SNGM SNV: p.G292Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		6.22  LDD0215  [1]
AZ-5
 Probe Info  		2.35  LDD0394  [2]
FBP2
 Probe Info  		2.07  LDD0323  [3]
TH211
 Probe Info  		Y181(17.84); Y132(9.21)  LDD0257  [4]
TH214
 Probe Info  		Y132(17.15); Y154(5.78)  LDD0258  [4]
TH216
 Probe Info  		Y154(15.07); Y132(6.33); Y181(5.81); Y32(5.38)  LDD0259  [4]
STPyne
 Probe Info  		K26(2.81)  LDD2217  [5]
Probe 1
 Probe Info  		Y21(18.69); Y154(249.37)  LDD3495  [6]
m-APA
 Probe Info  		9.87  LDD0403  [7]
AHL-Pu-1
 Probe Info  		C138(2.08)  LDD0173  [8]
HHS-475
 Probe Info  		Y21(0.94); Y154(1.76)  LDD0264  [9]
HHS-465
 Probe Info  		Y132(4.02); Y21(6.94)  LDD2237  [10]
DBIA
 Probe Info  		C138(1.25)  LDD0080  [11]
5E-2FA
 Probe Info  		H272(0.00); H267(0.00); H239(0.00); H157(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K22(0.00); K156(0.00); K4(0.00); K160(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C203(0.00); C167(0.00); C278(0.00); C138(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C167(0.00); C138(0.00); C278(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		C167(0.00); C203(0.00); C278(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info  		C203(0.00); C278(0.00); C167(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C203(0.00); C278(0.00); C167(0.00); C138(0.00)  LDD0037  [14]
BTD
 Probe Info  		C138(0.00); C167(0.00)  LDD0004  [17]
IPM
 Probe Info  		C138(0.00); C167(0.00)  LDD0025  [18]
JW-RF-010
 Probe Info  		C138(0.00); C167(0.00)  LDD0026  [18]
NAIA_4
 Probe Info  		C138(0.00); C167(0.00); C203(0.00); C278(0.00)  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
NHS
 Probe Info  		N.A.  LDD0010  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
Phosphinate-6
 Probe Info  		C138(0.00); C167(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		W24(0.00); W345(0.00); W325(0.00)  LDD2175  [22]
1c-yne
 Probe Info  		N.A.  LDD0228  [23]
Acrolein
 Probe Info  		C167(0.00); C138(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C138(0.00); C167(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C167(0.00); C138(0.00)  LDD0218  [24]
W1
 Probe Info  		C138(0.00); C167(0.00)  LDD0236  [25]
AOyne
 Probe Info  		12.40  LDD0443  [26]
NAIA_5
 Probe Info  		C138(0.00); C167(0.00); C278(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.93  LDD0475  [27]
FFF probe14
 Probe Info  		5.26  LDD0477  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
Diazir
 Probe Info  		N.A.  LDD0011  [17]
DA-2
 Probe Info  		N.A.  LDD0070  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C167(0.36); C138(0.56)  LDD2142  [31]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C167(0.72)  LDD2112  [31]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C167(0.59)  LDD2095  [31]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C167(0.75)  LDD2130  [31]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C167(0.96); C138(1.04)  LDD2117  [31]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C167(1.40)  LDD2152  [31]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C167(0.43)  LDD2132  [31]
 LDCM0026  4SU-RNA+native RNA HEK-293T C138(2.08)  LDD0173  [8]
 LDCM0214  AC1 HCT 116 C138(1.10)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C138(1.14)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C138(0.86)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C138(0.75)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C138(0.84)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C138(0.79)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C138(0.89)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C138(0.81)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C138(0.81)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C138(0.97)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C138(0.87)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C138(0.85)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C138(1.05)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C138(0.76)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C138(0.69)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C138(0.76)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C138(1.09)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C138(1.08)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C138(1.11)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C138(1.07)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C138(1.09)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C138(1.06)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C138(1.04)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C138(1.19)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C138(1.13)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C138(1.06)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C138(1.07)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C138(1.10)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C138(1.08)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C138(1.08)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C138(1.13)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C138(1.14)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C138(1.05)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C138(0.88)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C138(0.90)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C138(0.85)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C138(0.77)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C138(0.98)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C138(0.78)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C138(0.82)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C138(0.86)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C138(0.88)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C138(0.79)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C138(0.73)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C138(1.05)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C138(0.73)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C138(0.69)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C138(0.82)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C138(0.97)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C138(1.04)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C138(0.93)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C138(0.93)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C138(1.03)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C138(0.97)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C138(0.96)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C138(1.03)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C138(0.97)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C138(1.05)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C138(1.08)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C138(0.96)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C138(1.01)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C138(1.05)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C138(0.95)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C138(1.02)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C138(1.02)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C138(1.12)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C138(1.05)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C138(1.11)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C138(1.00)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C138(1.08)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C138(1.04)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C138(1.02)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C138(1.00)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C138(1.00)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C138(0.92)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C138(1.02)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C138(1.03)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C138(0.88)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C138(1.07)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C138(0.91)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C138(0.95)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C138(0.95)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C138(0.95)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C138(0.99)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C138(1.14)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C138(0.98)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C138(1.07)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C138(0.96)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C138(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C138(1.17)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C138(1.00)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C138(0.96)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C138(1.00)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C138(0.90)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C138(1.03)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C138(1.09)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C138(0.86)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C138(0.99)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C138(0.78)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C138(0.94)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C138(1.11)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C138(0.93)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C138(0.91)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C138(0.92)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C138(0.96)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C138(1.06)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C138(0.96)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C138(0.88)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C138(1.15)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C138(1.05)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C138(1.29)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C138(0.96)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C138(1.15)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C138(0.98)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C138(1.18)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C138(1.23)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C138(1.23)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C138(1.24)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C138(1.15)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C138(0.87)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C138(1.04)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C138(0.99)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C138(1.03)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C138(0.89)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C138(1.02)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C138(0.95)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C138(0.83)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C138(0.91)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C138(0.77)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C138(1.08)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C138(0.97)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C138(1.00)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C138(0.94)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C138(0.98)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C138(1.10)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C138(1.02)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C138(0.56)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C138(1.04)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C138(1.05)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C138(0.98)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C138(0.93)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C138(0.93)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C138(0.94)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C138(0.93)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C138(0.93)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C138(1.09)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C138(1.13)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C138(1.12)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C138(1.00)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C138(0.90)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C138(1.01)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C138(0.99)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C138(0.47)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C138(0.83)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C167(0.52)  LDD2138  [31]
 LDCM0520  AKOS000195272 MDA-MB-231 C167(0.64); C138(0.92)  LDD2113  [31]
 LDCM0248  AKOS034007472 HCT 116 C138(1.07)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C138(1.02)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C138(0.91)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 9.87  LDD0403  [7]
 LDCM0020  ARS-1620 HCC44 C138(1.02)  LDD2171  [11]
 LDCM0498  BS-3668 MDA-MB-231 C167(0.64)  LDD2091  [31]
 LDCM0108  Chloroacetamide HeLa C167(0.00); C138(0.00); H78(0.00); H97(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C138(0.92)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C138(0.90)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C138(1.13)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C138(0.95)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C138(1.02)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C138(1.12)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C138(1.00)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C138(1.06)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C138(0.99)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C138(1.11)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C138(1.12)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C138(1.01)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C138(1.08)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C138(0.93)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C138(0.95)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C138(0.97)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C138(0.95)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C138(0.78)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C138(0.91)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C138(0.95)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C138(1.00)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C138(1.00)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C138(1.02)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C138(1.03)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C138(1.01)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C138(1.07)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C138(0.86)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C138(0.98)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C138(0.96)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C138(1.28)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C138(1.03)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C138(1.10)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C138(1.24)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C138(0.94)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C138(0.87)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C138(0.66)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C138(1.07)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C138(0.96)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C138(0.93)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C138(1.00)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C138(0.95)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C138(1.11)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C138(1.00)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C138(1.18)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C138(1.18)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C138(1.22)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C138(1.20)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C138(1.13)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C138(1.14)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C138(1.03)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C138(1.09)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C138(0.99)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C138(1.11)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C138(0.99)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C138(0.82)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C138(0.81)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C138(0.88)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C138(0.98)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C138(0.95)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C138(0.94)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C138(0.98)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C138(0.93)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C138(0.97)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C138(1.02)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C138(1.00)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C138(0.96)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C138(0.83)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C138(0.83)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C138(1.00)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C138(0.99)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C138(0.95)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C138(0.96)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C138(1.03)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C138(0.94)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C138(0.98)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C138(0.90)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C138(0.91)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C138(0.95)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C138(0.95)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C138(1.04)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C138(0.98)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C138(0.97)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C138(1.00)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C138(0.85)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C138(0.96)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C138(1.09)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C138(1.05)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C138(1.08)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C138(1.09)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C138(1.10)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C138(1.21)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C138(1.16)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C138(1.06)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C138(0.98)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C138(1.08)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C138(1.08)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C138(1.09)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C138(1.05)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C138(1.06)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C138(1.02)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C138(1.02)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C138(0.89)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C138(0.98)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C138(1.03)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C138(0.96)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C138(0.94)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C138(1.05)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C138(1.11)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C138(1.06)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C138(1.07)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C138(1.07)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C138(1.07)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C138(1.02)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C138(1.13)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C138(1.01)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C138(1.01)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C138(0.89)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C138(0.95)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C138(0.95)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C138(0.98)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C138(1.04)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C138(0.96)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C138(1.00)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C138(0.98)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C138(1.06)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C138(1.11)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C138(1.10); C278(0.85); C203(0.96); C167(0.92)  LDD1698  [32]
 LDCM0625  F8 Ramos C138(0.96); C167(1.40)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C138(0.24); C167(0.94)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C138(0.17); C167(3.50); C278(1.91)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C138(0.32); C167(0.75)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C138(0.95)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C138(1.07); C167(1.20); C278(1.62)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C138(0.26); C167(0.65)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C138(0.58); C167(0.34)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C138(0.56); C167(1.64)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C138(0.69); C167(0.82)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C138(0.72); C167(0.70)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C138(0.83); C167(1.60)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C138(1.00); C167(1.45)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C138(0.46); C167(1.00)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C138(1.07)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C138(0.69)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C138(0.97); C167(0.59); C278(0.33)  LDD2184  [33]
 LDCM0427  Fragment51 HCT 116 C138(1.01)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C138(1.39)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C138(1.08); C167(1.02)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C138(0.63); C167(0.69); C278(0.77)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C138(0.19); C167(0.28)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y21(0.94); Y154(1.76)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y21(0.83); Y154(3.80)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y21(0.87); Y154(15.12)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y21(1.02)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y21(0.74); Y154(11.10)  LDD0268  [9]
 LDCM0107  IAA HeLa C167(0.00); K160(0.00); C138(0.00); H97(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C138(1.25)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C138(1.35)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C138(1.21)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C167(0.82)  LDD2121  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C167(0.74)  LDD2089  [31]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C167(1.06)  LDD2092  [31]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C167(0.84)  LDD2093  [31]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C167(1.62)  LDD2094  [31]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C167(0.86)  LDD2096  [31]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C167(1.31)  LDD2097  [31]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C167(0.71)  LDD2098  [31]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C167(1.09); C138(1.10)  LDD2099  [31]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C167(0.44); C138(0.36)  LDD2100  [31]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C167(0.39); C138(0.62)  LDD2104  [31]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C167(1.14)  LDD2105  [31]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C167(0.32)  LDD2106  [31]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C167(1.08); C138(1.03)  LDD2107  [31]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C167(0.54); C138(0.84)  LDD2109  [31]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C167(0.99)  LDD2111  [31]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C167(0.38)  LDD2114  [31]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C167(1.07)  LDD2116  [31]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C167(1.24)  LDD2118  [31]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C167(1.64); C138(1.58)  LDD2119  [31]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C167(0.96)  LDD2120  [31]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C167(0.90)  LDD2122  [31]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C167(0.92); C138(0.86)  LDD2123  [31]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C167(1.02)  LDD2124  [31]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C167(0.69); C138(0.96)  LDD2125  [31]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C167(0.96)  LDD2126  [31]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C167(1.07); C138(1.09)  LDD2127  [31]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C167(0.95)  LDD2128  [31]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C167(0.96)  LDD2129  [31]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C138(0.89)  LDD2133  [31]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C167(0.53); C138(0.48)  LDD2134  [31]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C167(1.08); C138(1.53)  LDD2135  [31]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C167(1.26); C138(1.01)  LDD2136  [31]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C167(0.95); C138(0.67)  LDD2137  [31]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C167(1.65)  LDD1700  [31]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C167(0.81); C138(0.86)  LDD2140  [31]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C167(0.58)  LDD2141  [31]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C167(1.06)  LDD2143  [31]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C167(2.11); C138(2.29)  LDD2144  [31]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C138(0.38)  LDD2145  [31]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C167(0.82); C138(0.91)  LDD2146  [31]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C167(2.09)  LDD2147  [31]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C167(0.53)  LDD2148  [31]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C167(1.09)  LDD2149  [31]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C167(0.38); C138(0.66)  LDD2150  [31]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C167(0.94)  LDD2151  [31]
 LDCM0021  THZ1 HCT 116 C138(1.02)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1) Aldehyde dehydrogenase family P30038
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Histone acetyltransferase type B catalytic subunit (HAT1) HAT1 family O14929
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Caspase-6 (CASP6) Peptidase C14A family P55212
Histone-lysine N-methyltransferase PRDM16 (PRDM16) PRDM16 family Q9HAZ2
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Histone-lysine N-methyltransferase MECOM (MECOM) . Q03112
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) Ligand-gated ion channel family P36544
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZFPM1 (ZFPM1) FOG (Friend of GATA) family Q8IX07
Signal transducer and activator of transcription 5B (STAT5B) Transcription factor STAT family P51692
Metastasis-associated protein MTA1 (MTA1) . Q13330
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Stress-induced-phosphoprotein 1 (STIP1) . P31948
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578