Details of the Target

General Information of Target

Target ID LDTP06444
Target Name Microtubule-associated protein RP/EB family member 1 (MAPRE1)
Gene Name MAPRE1
Gene ID 22919
Synonyms
Microtubule-associated protein RP/EB family member 1; APC-binding protein EB1; End-binding protein 1; EB1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKK
VKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYD
GKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQ
RIVDILYATDEGFVIPDEGGPQEEQEEY
Target Bioclass
Other
Family
MAPRE family
Subcellular location
Cytoplasm, cytoskeleton
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation . Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation. May play a role in cell migration.
Uniprot ID
Q15691
Ensemble ID
ENST00000375571.6
HGNC ID
HGNC:6890

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		6.16  LDD0383  [1]
C-Sul
 Probe Info  		2.88  LDD0066  [2]
FBP2
 Probe Info  		2.14  LDD0323  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K100(1.06); K113(2.69); K148(6.08); K151(8.16)  LDD0277  [5]
AZ-9
 Probe Info  		E225(10.00)  LDD2209  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
Probe 1
 Probe Info  		Y71(11.75); Y119(65.25); Y124(62.55)  LDD3495  [7]
m-APA
 Probe Info  		9.78  LDD0403  [8]
THZ1-DTB
 Probe Info  		C228(1.10)  LDD0460  [9]
BTD
 Probe Info  		C228(1.01)  LDD2089  [10]
DBIA
 Probe Info  		C228(0.94); C39(1.08); C45(1.08)  LDD0531  [11]
ATP probe
 Probe Info  		K174(0.00); K83(0.00); K76(0.00); K122(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C228(0.00); C45(0.00); C39(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C228(0.00); C45(0.00); C39(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K148(0.00); K174(0.00); K220(0.00)  LDD0035  [15]
IPM
 Probe Info  		N.A.  LDD0025  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
NHS
 Probe Info  		K148(0.00); K174(0.00); K76(0.00); K113(0.00)  LDD0010  [19]
SF
 Probe Info  		Y6(0.00); K89(0.00); K151(0.00)  LDD0028  [20]
Ox-W18
 Probe Info  		W110(0.00); W23(0.00)  LDD2175  [21]
1c-yne
 Probe Info  		K148(0.00); K76(0.00); K182(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		C228(0.00); H69(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
W1
 Probe Info  		N.A.  LDD0236  [23]
NAIA_5
 Probe Info  		C39(0.00); C228(0.00); C45(0.00)  LDD2223  [17]
HHS-465
 Probe Info  		K148(0.00); K174(0.00)  LDD2240  [24]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		7.65  LDD0473  [25]
FFF probe13
 Probe Info  		14.94  LDD0475  [25]
FFF probe14
 Probe Info  		12.76  LDD0477  [25]
FFF probe2
 Probe Info  		5.29  LDD0463  [25]
FFF probe3
 Probe Info  		5.41  LDD0464  [25]
FFF probe9
 Probe Info  		6.57  LDD0470  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
Diazir
 Probe Info  		E225(0.00); E232(0.00)  LDD0011  [19]
LD-F
 Probe Info  		L226(0.00); E225(0.00); I227(0.00); N231(0.00)  LDD0015  [27]
Photonaproxen
 Probe Info  		I224(0.00); I227(0.00)  LDD0157  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C228(0.42)  LDD2142  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C228(0.77)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C228(1.53)  LDD2117  [10]
 LDCM0214  AC1 HCT 116 C228(0.94); C39(1.08); C45(1.08)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C228(0.97)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C228(0.80); C39(0.59); C45(0.59)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C228(0.77); C39(0.52); C45(0.52)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C228(0.82); C39(0.45); C45(0.45)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C228(0.74); C39(0.34); C45(0.34)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C228(0.70); C39(0.42); C45(0.42)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C228(0.94); C39(0.45); C45(0.45)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C228(0.82); C39(0.41); C45(0.41)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C228(0.87); C39(0.45); C45(0.41)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C228(0.72); C39(0.54); C45(0.53)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C228(0.71); C39(0.53); C45(0.53)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C228(1.01)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C228(0.79); C39(0.55); C45(0.56)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C228(0.78); C39(0.62); C45(0.54)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C228(0.86); C39(0.49); C45(0.45)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C228(1.01)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C228(0.91)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C228(0.84)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C228(1.06)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C228(0.94)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C228(0.87)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C228(1.09)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C228(0.94)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C228(0.90)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C228(0.88)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C228(0.91)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C228(0.81)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C228(1.00)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C228(0.99)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C228(0.95)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C228(0.96)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C228(0.44)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C228(0.46)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C228(0.43)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C228(0.36)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C228(0.42)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C228(0.38)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C228(0.37)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C228(0.42)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C228(0.43)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C228(0.37)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C228(0.33)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C228(0.40)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C228(1.04)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C228(0.40)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C228(0.39)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C228(0.37)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C39(0.48); C45(0.48); C228(0.86)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C39(0.40); C45(0.40); C228(0.88)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C39(0.42); C45(0.42); C228(0.91)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C39(0.33); C45(0.33); C228(0.95)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C39(0.36); C45(0.36); C228(0.86)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C39(0.29); C45(0.29); C228(1.12)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C39(0.28); C45(0.28); C228(1.01)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C228(1.04)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C39(0.45); C45(0.45); C228(0.85)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C39(0.38); C45(0.38); C228(0.97)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C39(0.37); C45(0.37); C228(0.96)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C39(0.29); C45(0.29); C228(1.22)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C228(1.04); C39(0.32); C45(0.32)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C228(1.00); C39(0.41); C45(0.41)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C228(0.92); C39(0.51); C45(0.51)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C228(1.06); C39(0.75); C45(0.75)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C228(0.65)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C228(0.50)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C228(0.54)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C228(1.08); C39(1.13); C45(1.13)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C228(0.79)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C228(0.69)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C228(0.66)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C228(0.63)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C228(0.59)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C228(1.07)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C228(1.13)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C228(1.17)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C228(0.79)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C228(0.94)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C228(1.06); C39(1.42); C45(1.42)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C228(0.79)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C228(0.74)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C228(0.89)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C228(0.86)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C228(0.71)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C228(0.99)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C228(1.05)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C228(1.28)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C228(1.21)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C228(1.32)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C39(0.99); C45(0.99); C228(1.10)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C228(1.16)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C228(1.07)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C228(1.04)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C228(1.00)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C228(1.21)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C228(1.07)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C39(0.69); C45(0.69); C228(1.56)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C39(0.65); C45(0.65); C228(1.35)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C39(0.38); C45(0.38); C228(1.42)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C39(0.59); C45(0.59); C228(1.09)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C39(1.01); C45(1.01); C228(1.13)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C39(0.55); C45(0.55); C228(1.09)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C39(0.76); C45(0.76); C228(1.19)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C39(0.74); C45(0.74); C228(1.20)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C39(0.50); C45(0.50); C228(1.29)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C39(0.69); C45(0.69); C228(1.36)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C39(0.56); C45(0.56); C228(1.14)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C39(0.44); C45(0.44); C228(1.25)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C39(0.24); C45(0.24); C228(0.86)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C39(0.23); C45(0.23); C228(0.78)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C39(0.26); C45(0.26); C228(0.76)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C228(0.81)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C39(0.21); C45(0.21); C228(0.79)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C39(0.20); C45(0.20); C228(0.69)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C39(0.28); C45(0.28); C228(0.75)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C39(0.25); C45(0.25); C228(0.71)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C39(0.24); C45(0.24); C228(0.73)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C39(0.24); C45(0.24); C228(0.60)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C39(0.23); C45(0.23); C228(0.60)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C39(0.16); C45(0.16); C228(0.56)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C39(0.87); C45(0.87); C228(1.17)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C39(0.82); C45(0.82); C228(1.28)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C228(0.80)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C39(0.66); C45(0.66); C228(1.30)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C39(0.82); C45(0.82); C228(1.28)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C39(0.81); C45(0.81); C228(1.41)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C39(0.75); C45(0.75); C228(1.35)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C39(0.74); C45(0.74); C228(1.14)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C39(0.63); C45(0.63); C228(1.30)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C39(0.83); C45(0.83); C228(1.27)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C39(0.75); C45(0.75); C228(1.30)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C39(0.87); C45(0.87); C228(1.16)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C39(0.86); C45(0.86); C228(1.38)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C228(0.98)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C39(0.83); C45(0.83); C228(1.40)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C39(0.42); C45(0.42); C228(1.27)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C39(0.65); C45(0.65); C228(1.16)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C39(0.55); C45(0.55); C228(1.09)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C39(0.56); C45(0.56); C228(0.98)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C39(0.64); C45(0.64); C228(0.82)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C39(0.82); C45(0.82); C228(1.03)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C39(0.97); C45(0.97); C228(1.09)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C39(0.71); C45(0.71); C228(1.12)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C39(0.73); C45(0.73); C228(1.02)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C228(1.02); C39(1.95); C45(1.95)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C39(0.61); C45(0.61); C228(1.13)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C39(0.61); C45(0.61); C228(1.05)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C39(0.83); C45(0.83); C228(0.91)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C39(0.84); C45(0.84); C228(1.12)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C39(0.90); C45(0.90); C228(1.21)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C39(0.65); C45(0.65); C228(1.04)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C39(0.68); C45(0.68); C228(1.13)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C39(0.23); C45(0.23); C228(0.78)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C39(0.58); C45(0.58); C228(0.85)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C228(0.72)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C228(1.25)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C228(1.04)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C228(1.02)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 9.78  LDD0403  [8]
 LDCM0498  BS-3668 MDA-MB-231 C228(0.83)  LDD2091  [10]
 LDCM0630  CCW28-3 231MFP C228(0.29)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C228(0.00); H69(0.00)  LDD0222  [22]
 LDCM0367  CL1 HCT 116 C39(0.95); C45(0.95)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C39(0.39); C45(0.39)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C39(0.70); C45(0.70); C228(0.97)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C228(0.93)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C228(0.78)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C228(0.91)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C228(0.83)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C228(0.65)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C228(0.60)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C228(0.65)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C228(0.72)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C228(0.60)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C39(0.46); C45(0.46)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C228(0.58)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C228(0.63)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C228(1.18)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C228(0.68)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C228(1.05)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C228(0.87)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C228(0.95)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C228(1.13)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C228(1.01)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C228(1.14)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C39(0.46); C45(0.46)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C228(1.06)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C39(0.58); C45(0.58); C228(1.38)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C39(0.51); C45(0.51); C228(1.36)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C39(0.70); C45(0.70); C228(1.17)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C39(0.48); C45(0.48); C228(1.32)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C39(0.44); C45(0.44); C228(0.84)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C39(0.34); C45(0.34); C228(0.69)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C39(0.36); C45(0.36); C228(0.77)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C39(0.24); C45(0.24); C228(0.84)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C39(0.52); C45(0.52)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C39(0.86); C45(0.86)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C39(0.49); C45(0.49)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C39(0.68); C45(0.68); C228(1.08)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C39(0.62); C45(0.62); C228(0.90)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C39(0.52); C45(0.52); C228(1.02)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C39(0.60); C45(0.60); C228(1.09)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C39(1.17); C45(1.17)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C39(0.55); C45(0.55); C228(0.90)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C39(0.52); C45(0.52); C228(0.95)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C39(0.48); C45(0.48); C228(0.73)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C39(0.58); C45(0.58); C228(1.04)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C39(0.61); C45(0.61); C228(0.94)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C228(0.96); C39(0.55); C45(0.55)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C228(0.90); C39(0.57); C45(0.57)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C228(1.19); C39(0.57); C45(0.57)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C228(1.00); C39(0.58); C45(0.58)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C228(1.14); C39(0.61); C45(0.61)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C39(0.72); C45(0.72)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C228(0.97); C39(0.76); C45(0.76)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C228(0.75); C39(0.71); C45(0.71)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C228(1.11); C39(0.31); C45(0.31)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C228(0.90); C39(0.36); C45(0.36)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C228(0.98); C39(0.34); C45(0.34)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C228(1.01); C39(0.39); C45(0.39)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C228(0.91); C39(0.46); C45(0.46)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C228(1.24); C39(0.45); C45(0.45)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C228(1.01); C39(0.50); C45(0.50)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C39(0.76); C45(0.76)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C228(1.07); C39(0.36); C45(0.36)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C228(1.08); C39(0.33); C45(0.33)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C228(1.07); C39(0.36); C45(0.36)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C228(0.99); C39(0.37); C45(0.37)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C228(1.15); C39(0.42); C45(0.42)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C228(1.16); C39(0.40); C45(0.40)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C228(1.00); C39(1.00); C45(1.00)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C228(1.01); C39(0.86); C45(0.86)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C228(1.13); C39(0.78); C45(0.78)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C228(1.01); C39(1.06); C45(1.06)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C39(0.69); C45(0.69)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C228(1.28); C39(1.03); C45(1.03)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C228(1.38); C39(0.86); C45(0.86)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C228(1.17); C39(0.91); C45(0.91)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C228(1.12); C39(0.94); C45(0.94)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C228(1.13); C39(0.94); C45(0.94)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C228(1.05); C39(0.85); C45(0.85)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C228(1.02); C39(0.97); C45(0.97)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C228(1.33); C39(0.85); C45(0.85)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C228(0.94); C39(0.73); C45(0.73)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C228(1.09); C39(0.93); C45(0.93)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C39(0.63); C45(0.63)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C228(1.06); C39(0.89); C45(0.89)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C228(0.98)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C228(1.10)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C228(1.07)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C228(0.95)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C228(1.05)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C228(1.06)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C228(1.09)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C228(0.90)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C228(0.94)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C39(0.59); C45(0.59)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C228(0.89)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C228(0.87)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C228(1.22)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C228(1.13)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C228(1.06)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C228(0.96); C39(0.97); C45(0.97)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C228(1.14); C39(1.25); C45(1.25)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C228(1.27); C39(1.14); C45(1.14)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C228(1.28); C39(1.18); C45(1.18)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C39(0.39); C45(0.39)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C228(1.46); C39(0.70); C45(0.70)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C228(1.32); C39(1.03); C45(1.03)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C228(1.10); C39(0.95); C45(0.95)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C228(1.05); C39(0.74); C45(0.74)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C228(1.07); C39(0.80); C45(0.80)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C228(1.02); C39(1.36); C45(1.36)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C228(0.99); C39(0.93); C45(0.93)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C228(1.56); C39(1.62); C45(1.62)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C228(1.35); C39(0.92); C45(0.92)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C228(1.09); C39(0.82); C45(0.82)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C39(0.50); C45(0.50)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C228(0.81); C39(1.16); C45(1.16)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C228(0.69); C39(0.95); C45(0.95)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C228(0.81); C39(0.71); C45(0.71)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C228(0.96); C39(0.71); C45(0.71)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C228(1.01); C39(1.14); C45(1.14)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C228(0.80); C39(1.30); C45(1.30)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C228(0.89); C39(1.12); C45(1.12)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C228(0.97); C39(2.02); C45(2.02)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C228(0.87); C39(2.00); C45(2.00)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C228(0.88); C39(1.22); C45(1.22)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C228(0.96); C39(0.95); C45(0.87)  LDD1698  [30]
 LDCM0625  F8 Ramos C228(0.69)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C228(0.55)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C228(0.29)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C228(0.53)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C228(0.91)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C228(0.75)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C228(0.46)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C228(0.95)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C228(0.93)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C228(0.93)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C228(1.08)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C228(0.97)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C228(1.09)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C228(0.55)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C228(1.03)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C228(0.78)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C228(0.60)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C228(0.93); C39(0.45); C45(0.45)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C228(1.00)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C228(1.24)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C228(0.46)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C228(0.49)  LDD2188  [31]
 LDCM0107  IAA HeLa C228(0.00); H69(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C228(1.07); C45(0.99)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C228(1.03); C45(1.20)  LDD1497  [30]
 LDCM0024  KB05 HMCB C228(2.88)  LDD3312  [32]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C228(0.86)  LDD2121  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C228(1.01)  LDD2089  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C228(1.17)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C228(0.47)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C228(0.57)  LDD2101  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C228(1.21)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C228(0.39)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C228(0.75)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C228(0.51)  LDD2110  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C228(0.53)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C228(0.48)  LDD2115  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C228(0.83)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C228(0.42)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C228(0.90)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C228(1.06)  LDD2125  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C228(2.07)  LDD2129  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C228(0.61)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C228(1.92)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C228(1.29)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C228(1.09)  LDD2137  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C228(1.04)  LDD2140  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C228(2.35)  LDD2144  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C228(0.79)  LDD2150  [10]
 LDCM0131  RA190 MM1.R C228(1.23)  LDD0304  [33]
 LDCM0021  THZ1 HeLa S3 C228(1.10)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase epsilon subunit 2 (POLE2) DNA polymerase epsilon subunit B family P56282
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Kinesin-like protein KIF2C (KIF2C) Kinesin family Q99661
E3 ubiquitin-protein ligase MARCHF7 (MARCHF7) . Q9H992
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Desmoplakin (DSP) Plakin or cytolinker family P15924
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 653 (ZNF653) Krueppel C2H2-type zinc-finger protein family Q96CK0
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Adenomatous polyposis coli protein 2 (APC2) Adenomatous polyposis coli (APC) family O95996
CLIP-associating protein 2 (CLASP2) CLASP family O75122
Dynactin subunit 1 (DCTN1) Dynactin 150 kDa subunit family Q14203
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Microtubule-associated protein RP/EB family member 2 (MAPRE2) MAPRE family Q15555
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Speedy protein E2 (SPDYE2) Speedy/Ringo family Q495Y8
Speedy protein E6 (SPDYE6) Speedy/Ringo family P0CI01
CAP-Gly domain-containing linker protein 1 (CLIP1) . P30622
Dystonin (DST) . Q03001
Kelch-like protein 12 (KLHL12) . Q53G59
Myomegalin (PDE4DIP) . Q5VU43
Polyglutamine-binding protein 1 (PQBP1) . O60828
Rhombotin-2 (LMO2) . P25791
Small kinetochore-associated protein (KNSTRN) . Q9Y448
Tastin (TROAP) . Q12815
Telomeric repeat-binding factor 1 (TERF1) . P54274
Uncharacterized protein C20orf202 (C20orf202) . A1L168

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
28 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.