Details of the Target

General Information of Target

Target ID LDTP16896
Target Name POTE ankyrin domain family member J (POTEJ)
Gene Name POTEJ
Gene ID 653781
Synonyms
POTE ankyrin domain family member J
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSK
MGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSNVGAW
GDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLA
SANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGN
TTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNA
LDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDY
KEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMK
KHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKE
KQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIE
EMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQ
KQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRL
ELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAG
FAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWD
DMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAML
SLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRF
TTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEA
LFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAAL
APSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
Target Bioclass
Other
Family
POTE family; Actin family
Uniprot ID
P0CG39
Ensemble ID
ENST00000409602.2
HGNC ID
HGNC:37094

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C700(2.19)  LDD3403  [1]
BTD
 Probe Info  		C880(0.93)  LDD2125  [2]
HHS-475
 Probe Info  		Y754(0.85)  LDD0264  [3]
HHS-465
 Probe Info  		Y1025(4.19); Y754(7.02)  LDD2237  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C880(0.00); C700(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
AZ-9
 Probe Info  		N.A.  LDD0395  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
YN-1
 Probe Info  		N.A.  LDD0447  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [11]
STS-2
 Probe Info  		N.A.  LDD0139  [11]
Diazir
 Probe Info  		E1027(0.00); E1024(0.00); Y1025(0.00)  LDD0011  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C880(0.51)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C880(0.68)  LDD1513  [13]
 LDCM0282  AC22 HEK-293T C880(1.86)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C880(1.05)  LDD1522  [13]
 LDCM0291  AC30 HEK-293T C880(1.35)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C880(1.72)  LDD1531  [13]
 LDCM0299  AC38 HEK-293T C880(2.29)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C880(2.85)  LDD1539  [13]
 LDCM0308  AC46 HEK-293T C880(1.66)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C880(1.47)  LDD1548  [13]
 LDCM0317  AC54 HEK-293T C880(1.28)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C880(1.96)  LDD1557  [13]
 LDCM0323  AC6 HEK-293T C880(2.30)  LDD1562  [13]
 LDCM0326  AC62 HEK-293T C880(1.78)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C880(1.21)  LDD1566  [13]
 LDCM0334  AC7 HEK-293T C880(2.10)  LDD1568  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0368  CL10 HEK-293T C880(1.78)  LDD1572  [13]
 LDCM0379  CL11 HEK-293T C880(1.69)  LDD1583  [13]
 LDCM0410  CL22 HEK-293T C880(1.54)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C880(0.77)  LDD1615  [13]
 LDCM0423  CL34 HEK-293T C880(0.34)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C880(0.66)  LDD1628  [13]
 LDCM0436  CL46 HEK-293T C880(0.39)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C880(0.61)  LDD1641  [13]
 LDCM0449  CL58 HEK-293T C880(0.27)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C880(0.48)  LDD1653  [13]
 LDCM0463  CL70 HEK-293T C880(0.53)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C880(1.11)  LDD1667  [13]
 LDCM0476  CL82 HEK-293T C880(2.45)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C880(1.86)  LDD1680  [13]
 LDCM0489  CL94 HEK-293T C880(1.53)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C880(0.99)  LDD1693  [13]
 LDCM0625  F8 Ramos C880(0.64); 0.69  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C880(0.58); 0.73  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C880(0.09)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C880(0.63); 0.54  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C880(0.59); 0.51  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C880(1.01); 1.11  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C880(0.78); 0.33  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C880(1.10); 0.43  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C880(1.16); 0.35  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C880(0.83); 0.37  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C880(1.11); 0.63  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C880(0.39); 0.38  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C880(0.77); 0.48  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C880(0.61); 0.89  LDD2201  [14]
 LDCM0468  Fragment33 Ramos C880(0.45); 0.60  LDD2202  [14]
 LDCM0596  Fragment38 Ramos C880(0.38); 0.83  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C880(1.19); 0.84  LDD2184  [14]
 LDCM0610  Fragment52 Ramos C880(0.33); 0.92  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C880(0.53); 0.58  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C880(0.84); 0.84  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C880(0.69); 0.61  LDD2188  [14]
 LDCM0116  HHS-0101 DM93 Y754(0.85)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y754(0.70)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y754(0.73)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y754(0.72)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y754(0.69)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 Ramos C880(0.42); 0.68  LDD2182  [14]
 LDCM0023  KB03 Ramos C880(0.65); 1.37  LDD2183  [14]
 LDCM0024  KB05 Reh C700(2.19)  LDD3403  [1]
 LDCM0109  NEM HeLa N.A.  LDD0229  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C880(0.93)  LDD2125  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C880(1.19)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C880(0.55)  LDD2137  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578