Details of the Target

General Information of Target

Target ID LDTP14066
Target Name Hypoxia up-regulated protein 1 (HYOU1)
Gene Name HYOU1
Gene ID 10525
Synonyms
GRP170; ORP150; Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS
LIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV
CRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL
KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH
AHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD
SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK
PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHR
FPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFML
IKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG
AGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQD
SVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILA
GHENSY
Target Bioclass
Transporter and channel
Family
Heat shock protein 70 family
Subcellular location
Endoplasmic reticulum lumen
Function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
Uniprot ID
Q9Y4L1
Ensemble ID
ENST00000530473.6
HGNC ID
HGNC:16931
ChEMBL ID
CHEMBL2216741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAOV3 SNV: p.V432M DBIA    Probe Info 
HCT15 SNV: p.E697D; p.Q947H DBIA    Probe Info 
HEC1B SNV: p.R304C .
HS936T SNV: p.P971S DBIA    Probe Info 
HT SNV: p.T600A .
IPC298 SNV: p.P616L DBIA    Probe Info 
JURKAT SNV: p.A24V .
LS180 Insertion: p.A839GfsTer13 DBIA    Probe Info 
MCAS SNV: p.E998K .
NALM6 SNV: p.R345H DBIA    Probe Info 
NCIH1993 SNV: p.G967Ter ATP probe    Probe Info 
SW620 SNV: p.E605K; p.W781Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y443(13.48); Y99(10.05); Y487(9.62); Y497(6.95)  LDD0257  [1]
TH214
 Probe Info  		Y116(13.03)  LDD0258  [1]
TH216
 Probe Info  		Y99(20.00); Y443(10.68); Y116(10.23)  LDD0259  [1]
ONAyne
 Probe Info  		K94(0.65)  LDD0274  [2]
OPA-S-S-alkyne
 Probe Info  		K797(6.93)  LDD3494  [3]
Probe 1
 Probe Info  		Y99(12.81); Y116(8.31); Y534(89.40); Y755(15.52)  LDD3495  [4]
BTD
 Probe Info  		C805(3.14)  LDD2094  [5]
DBIA
 Probe Info  		C352(24.00)  LDD0209  [6]
HHS-475
 Probe Info  		Y904(1.23)  LDD0265  [7]
HHS-465
 Probe Info  		Y487(4.41); Y904(3.43)  LDD2237  [8]
5E-2FA
 Probe Info  		H542(0.00); H123(0.00); H112(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K883(0.00); K67(0.00); K75(0.00); K529(0.00)  LDD0199  [10]
m-APA
 Probe Info  		H542(0.00); H112(0.00)  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C805(0.00); C352(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C805(0.00); C352(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		K685(0.00); K308(0.00); K398(0.00); K883(0.00)  LDD0035  [14]
1d-yne
 Probe Info  		N.A.  LDD0356  [15]
IPM
 Probe Info  		N.A.  LDD0147  [16]
NHS
 Probe Info  		K685(0.00); K75(0.00); K398(0.00); K686(0.00)  LDD0010  [17]
SF
 Probe Info  		K883(0.00); Y904(0.00)  LDD0028  [18]
STPyne
 Probe Info  		K894(0.00); K883(0.00); K889(0.00)  LDD0009  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
1c-yne
 Probe Info  		K402(0.00); K317(0.00); K340(0.00); K753(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		H123(0.00); C352(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
HHS-482
 Probe Info  		Y99(1.12)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.87  LDD0367  [23]
FFF probe11
 Probe Info  		5.90  LDD0471  [24]
FFF probe12
 Probe Info  		12.91  LDD0473  [24]
FFF probe13
 Probe Info  		15.16  LDD0475  [24]
FFF probe3
 Probe Info  		13.87  LDD0464  [24]
JN0003
 Probe Info  		13.46  LDD0469  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [26]
Diazir
 Probe Info  		N.A.  LDD0011  [17]
OEA-DA
 Probe Info  		3.76  LDD0046  [27]
STS-1
 Probe Info  		N.A.  LDD0068  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C805(0.14)  LDD2142  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C805(1.34)  LDD2117  [5]
 LDCM0214  AC1 PaTu 8988t C352(0.26)  LDD1093  [29]
 LDCM0215  AC10 PaTu 8988t C352(0.42)  LDD1094  [29]
 LDCM0226  AC11 PaTu 8988t C352(0.45)  LDD1105  [29]
 LDCM0230  AC113 HEK-293T C352(3.14)  LDD0828  [29]
 LDCM0231  AC114 HEK-293T C352(2.83)  LDD0829  [29]
 LDCM0232  AC115 HEK-293T C352(1.71)  LDD0830  [29]
 LDCM0233  AC116 HEK-293T C352(1.57)  LDD0831  [29]
 LDCM0234  AC117 HEK-293T C352(1.39)  LDD0832  [29]
 LDCM0235  AC118 HEK-293T C352(1.37)  LDD0833  [29]
 LDCM0236  AC119 HEK-293T C352(2.02)  LDD0834  [29]
 LDCM0237  AC12 PaTu 8988t C352(0.54)  LDD1116  [29]
 LDCM0238  AC120 HEK-293T C352(3.27)  LDD0836  [29]
 LDCM0239  AC121 HEK-293T C352(1.91)  LDD0837  [29]
 LDCM0240  AC122 HEK-293T C352(3.32)  LDD0838  [29]
 LDCM0241  AC123 HEK-293T C352(4.09)  LDD0839  [29]
 LDCM0242  AC124 HEK-293T C352(2.12)  LDD0840  [29]
 LDCM0243  AC125 HEK-293T C352(1.94)  LDD0841  [29]
 LDCM0244  AC126 HEK-293T C352(3.64)  LDD0842  [29]
 LDCM0245  AC127 HEK-293T C352(3.76)  LDD0843  [29]
 LDCM0259  AC14 PaTu 8988t C352(0.48)  LDD1138  [29]
 LDCM0270  AC15 PaTu 8988t C352(0.41)  LDD1149  [29]
 LDCM0276  AC17 PaTu 8988t C805(1.05)  LDD1155  [29]
 LDCM0277  AC18 PaTu 8988t C805(0.81)  LDD1156  [29]
 LDCM0278  AC19 PaTu 8988t C805(0.95)  LDD1157  [29]
 LDCM0279  AC2 PaTu 8988t C352(0.37)  LDD1158  [29]
 LDCM0280  AC20 PaTu 8988t C805(1.03)  LDD1159  [29]
 LDCM0281  AC21 PaTu 8988t C805(0.74)  LDD1160  [29]
 LDCM0282  AC22 PaTu 8988t C805(0.73)  LDD1161  [29]
 LDCM0283  AC23 PaTu 8988t C805(0.82)  LDD1162  [29]
 LDCM0284  AC24 PaTu 8988t C805(1.20)  LDD1163  [29]
 LDCM0285  AC25 HEK-293T C352(0.86)  LDD0883  [29]
 LDCM0286  AC26 HEK-293T C352(1.16)  LDD0884  [29]
 LDCM0287  AC27 HEK-293T C352(1.12)  LDD0885  [29]
 LDCM0288  AC28 HEK-293T C352(1.67)  LDD0886  [29]
 LDCM0289  AC29 HEK-293T C352(1.04)  LDD0887  [29]
 LDCM0290  AC3 PaTu 8988t C352(0.51)  LDD1169  [29]
 LDCM0291  AC30 HEK-293T C352(1.14)  LDD0889  [29]
 LDCM0292  AC31 HEK-293T C352(1.13)  LDD0890  [29]
 LDCM0293  AC32 HEK-293T C352(1.16)  LDD0891  [29]
 LDCM0294  AC33 HEK-293T C352(1.61)  LDD0892  [29]
 LDCM0295  AC34 HEK-293T C352(1.31)  LDD0893  [29]
 LDCM0296  AC35 HCT 116 C805(0.94)  LDD0613  [29]
 LDCM0297  AC36 HCT 116 C805(0.93)  LDD0614  [29]
 LDCM0298  AC37 HCT 116 C805(1.05)  LDD0615  [29]
 LDCM0299  AC38 HCT 116 C805(1.02)  LDD0616  [29]
 LDCM0300  AC39 HCT 116 C805(1.10)  LDD0617  [29]
 LDCM0301  AC4 PaTu 8988t C352(0.57)  LDD1180  [29]
 LDCM0302  AC40 HCT 116 C805(1.01)  LDD0619  [29]
 LDCM0303  AC41 HCT 116 C805(0.80)  LDD0620  [29]
 LDCM0304  AC42 HCT 116 C805(0.94)  LDD0621  [29]
 LDCM0305  AC43 HCT 116 C805(0.96)  LDD0622  [29]
 LDCM0306  AC44 HCT 116 C805(0.94)  LDD0623  [29]
 LDCM0307  AC45 HCT 116 C805(1.06)  LDD0624  [29]
 LDCM0308  AC46 HEK-293T C805(0.77); C352(0.99); C240(0.97)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C805(0.82); C352(0.94)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C805(0.84); C352(0.94)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C805(0.94); C352(1.07); C240(1.04)  LDD1550  [30]
 LDCM0312  AC5 PaTu 8988t C352(0.30)  LDD1191  [29]
 LDCM0313  AC50 HEK-293T C805(0.87); C352(0.81)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C805(0.94); C352(0.99)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C805(0.92); C352(0.88); C240(0.97)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C805(0.95); C352(0.96); C240(1.00)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C805(0.91); C352(1.03); C240(1.21)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C805(0.86); C352(0.93)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C805(0.82); C352(0.98)  LDD1558  [30]
 LDCM0320  AC57 HCT 116 C805(1.42)  LDD0637  [29]
 LDCM0321  AC58 HCT 116 C805(1.35)  LDD0638  [29]
 LDCM0322  AC59 HCT 116 C805(1.29)  LDD0639  [29]
 LDCM0323  AC6 PaTu 8988t C352(0.71)  LDD1202  [29]
 LDCM0324  AC60 HCT 116 C805(1.48)  LDD0641  [29]
 LDCM0325  AC61 HCT 116 C805(1.92)  LDD0642  [29]
 LDCM0326  AC62 HCT 116 C805(1.15)  LDD0643  [29]
 LDCM0327  AC63 HCT 116 C805(1.35)  LDD0644  [29]
 LDCM0328  AC64 HCT 116 C805(1.50)  LDD0645  [29]
 LDCM0329  AC65 HCT 116 C805(1.85)  LDD0646  [29]
 LDCM0330  AC66 HCT 116 C805(1.95)  LDD0647  [29]
 LDCM0331  AC67 HCT 116 C805(0.88)  LDD0648  [29]
 LDCM0332  AC68 HEK-293T C352(1.00)  LDD0930  [29]
 LDCM0333  AC69 HEK-293T C352(0.95)  LDD0931  [29]
 LDCM0334  AC7 PaTu 8988t C352(1.28)  LDD1213  [29]
 LDCM0335  AC70 HEK-293T C352(0.84)  LDD0933  [29]
 LDCM0336  AC71 HEK-293T C352(1.01)  LDD0934  [29]
 LDCM0337  AC72 HEK-293T C352(1.12)  LDD0935  [29]
 LDCM0338  AC73 HEK-293T C352(1.01)  LDD0936  [29]
 LDCM0339  AC74 HEK-293T C352(0.82)  LDD0937  [29]
 LDCM0340  AC75 HEK-293T C352(0.92)  LDD0938  [29]
 LDCM0341  AC76 HEK-293T C352(0.97)  LDD0939  [29]
 LDCM0342  AC77 HEK-293T C352(1.05)  LDD0940  [29]
 LDCM0343  AC78 HEK-293T C352(1.24)  LDD0941  [29]
 LDCM0344  AC79 HEK-293T C352(1.14)  LDD0942  [29]
 LDCM0345  AC8 PaTu 8988t C352(0.67)  LDD1224  [29]
 LDCM0346  AC80 HEK-293T C352(0.90)  LDD0944  [29]
 LDCM0347  AC81 HEK-293T C352(0.94)  LDD0945  [29]
 LDCM0348  AC82 HEK-293T C352(1.14)  LDD0946  [29]
 LDCM0248  AKOS034007472 PaTu 8988t C352(0.44)  LDD1127  [29]
 LDCM0356  AKOS034007680 PaTu 8988t C352(0.69)  LDD1235  [29]
 LDCM0275  AKOS034007705 PaTu 8988t C352(0.51)  LDD1154  [29]
 LDCM0108  Chloroacetamide HeLa H326(0.00); C352(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C352(1.88)  LDD0965  [29]
 LDCM0368  CL10 HEK-293T C352(2.44)  LDD0966  [29]
 LDCM0369  CL100 PaTu 8988t C352(0.63)  LDD1248  [29]
 LDCM0370  CL101 PaTu 8988t C352(0.85)  LDD1249  [29]
 LDCM0371  CL102 PaTu 8988t C352(0.87)  LDD1250  [29]
 LDCM0372  CL103 PaTu 8988t C352(0.39)  LDD1251  [29]
 LDCM0373  CL104 PaTu 8988t C352(0.60)  LDD1252  [29]
 LDCM0374  CL105 PaTu 8988t C805(1.06)  LDD1253  [29]
 LDCM0375  CL106 PaTu 8988t C805(1.02)  LDD1254  [29]
 LDCM0376  CL107 PaTu 8988t C805(1.03)  LDD1255  [29]
 LDCM0377  CL108 PaTu 8988t C805(0.89)  LDD1256  [29]
 LDCM0378  CL109 PaTu 8988t C805(0.91)  LDD1257  [29]
 LDCM0379  CL11 HEK-293T C352(1.87)  LDD0977  [29]
 LDCM0380  CL110 PaTu 8988t C805(0.95)  LDD1259  [29]
 LDCM0381  CL111 PaTu 8988t C805(0.64)  LDD1260  [29]
 LDCM0382  CL112 HEK-293T C352(1.23)  LDD0980  [29]
 LDCM0383  CL113 HEK-293T C352(1.22)  LDD0981  [29]
 LDCM0384  CL114 HEK-293T C352(1.10)  LDD0982  [29]
 LDCM0385  CL115 HEK-293T C352(1.10)  LDD0983  [29]
 LDCM0386  CL116 HEK-293T C352(1.18)  LDD0984  [29]
 LDCM0387  CL117 HCT 116 C805(0.71)  LDD0704  [29]
 LDCM0388  CL118 HCT 116 C805(0.96)  LDD0705  [29]
 LDCM0389  CL119 HCT 116 C805(0.96)  LDD0706  [29]
 LDCM0390  CL12 HEK-293T C352(1.12)  LDD0988  [29]
 LDCM0391  CL120 HCT 116 C805(1.05)  LDD0708  [29]
 LDCM0392  CL121 HEK-293T C805(0.91); C352(0.99)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C805(1.03); C352(0.97)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C805(0.81); C352(1.15)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C805(0.85); C352(0.94)  LDD1599  [30]
 LDCM0396  CL125 HCT 116 C805(1.77)  LDD0713  [29]
 LDCM0397  CL126 HCT 116 C805(1.54)  LDD0714  [29]
 LDCM0398  CL127 HCT 116 C805(1.34)  LDD0715  [29]
 LDCM0399  CL128 HCT 116 C805(1.44)  LDD0716  [29]
 LDCM0400  CL13 HEK-293T C352(1.23)  LDD0998  [29]
 LDCM0401  CL14 HEK-293T C352(1.86)  LDD0999  [29]
 LDCM0402  CL15 HEK-293T C352(1.49)  LDD1000  [29]
 LDCM0403  CL16 HEK-293T C805(0.80); C352(1.06)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C805(0.74); C352(1.01); C240(0.80)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C805(0.79); C352(0.96)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C805(0.84); C352(0.95)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C352(1.73)  LDD1005  [29]
 LDCM0408  CL20 HEK-293T C805(0.95); C352(0.88); C240(0.97)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C805(0.87); C352(0.92); C240(0.81)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C805(0.99); C352(0.97); C240(1.11)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C805(0.88); C352(0.86)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C805(0.96); C352(0.91)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C805(0.89); C352(1.01)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C805(0.88); C352(0.94)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C805(0.85); C352(1.13)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C805(0.91); C352(0.85)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C805(0.88); C352(1.12); C240(1.00)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C352(3.24)  LDD1016  [29]
 LDCM0419  CL30 HEK-293T C805(0.93); C352(1.00)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C352(0.63)  LDD1018  [29]
 LDCM0421  CL32 HEK-293T C352(0.72)  LDD1019  [29]
 LDCM0422  CL33 HEK-293T C352(0.82)  LDD1020  [29]
 LDCM0423  CL34 HEK-293T C352(0.50)  LDD1021  [29]
 LDCM0424  CL35 HEK-293T C352(0.52)  LDD1022  [29]
 LDCM0425  CL36 HEK-293T C352(0.63)  LDD1023  [29]
 LDCM0426  CL37 HEK-293T C352(0.63)  LDD1024  [29]
 LDCM0428  CL39 HEK-293T C352(1.57)  LDD1026  [29]
 LDCM0429  CL4 HEK-293T C352(2.58)  LDD1027  [29]
 LDCM0430  CL40 HEK-293T C352(0.90)  LDD1028  [29]
 LDCM0431  CL41 HEK-293T C352(0.93)  LDD1029  [29]
 LDCM0432  CL42 HEK-293T C352(1.01)  LDD1030  [29]
 LDCM0433  CL43 HEK-293T C352(0.95)  LDD1031  [29]
 LDCM0434  CL44 HEK-293T C352(1.07)  LDD1032  [29]
 LDCM0435  CL45 HEK-293T C352(0.77)  LDD1033  [29]
 LDCM0436  CL46 HEK-293T C352(0.86)  LDD1034  [29]
 LDCM0437  CL47 HEK-293T C352(0.93)  LDD1035  [29]
 LDCM0438  CL48 HEK-293T C352(0.71)  LDD1036  [29]
 LDCM0439  CL49 HEK-293T C352(1.20)  LDD1037  [29]
 LDCM0440  CL5 HEK-293T C352(3.01)  LDD1038  [29]
 LDCM0441  CL50 HEK-293T C352(1.15)  LDD1039  [29]
 LDCM0442  CL51 HEK-293T C352(1.48)  LDD1040  [29]
 LDCM0443  CL52 HEK-293T C352(0.56)  LDD1041  [29]
 LDCM0444  CL53 HEK-293T C352(0.58)  LDD1042  [29]
 LDCM0445  CL54 HEK-293T C352(1.22)  LDD1043  [29]
 LDCM0446  CL55 HEK-293T C352(1.16)  LDD1044  [29]
 LDCM0447  CL56 HEK-293T C352(0.85)  LDD1045  [29]
 LDCM0448  CL57 HEK-293T C352(1.08)  LDD1046  [29]
 LDCM0449  CL58 HEK-293T C352(0.94)  LDD1047  [29]
 LDCM0450  CL59 HEK-293T C352(1.24)  LDD1048  [29]
 LDCM0451  CL6 HEK-293T C352(1.57)  LDD1049  [29]
 LDCM0452  CL60 HEK-293T C352(1.52)  LDD1050  [29]
 LDCM0453  CL61 HCT 116 C805(1.19)  LDD0770  [29]
 LDCM0454  CL62 HCT 116 C805(1.09)  LDD0771  [29]
 LDCM0455  CL63 HCT 116 C805(1.18)  LDD0772  [29]
 LDCM0456  CL64 HCT 116 C805(1.03)  LDD0773  [29]
 LDCM0457  CL65 HCT 116 C805(1.12)  LDD0774  [29]
 LDCM0458  CL66 HCT 116 C805(1.03)  LDD0775  [29]
 LDCM0459  CL67 HCT 116 C805(1.07)  LDD0776  [29]
 LDCM0460  CL68 HCT 116 C805(1.14)  LDD0777  [29]
 LDCM0461  CL69 HCT 116 C805(1.40)  LDD0778  [29]
 LDCM0462  CL7 HEK-293T C352(2.70)  LDD1060  [29]
 LDCM0463  CL70 HCT 116 C805(1.28)  LDD0780  [29]
 LDCM0464  CL71 HCT 116 C805(0.90)  LDD0781  [29]
 LDCM0465  CL72 HCT 116 C805(1.05)  LDD0782  [29]
 LDCM0466  CL73 HCT 116 C805(1.00)  LDD0783  [29]
 LDCM0467  CL74 HCT 116 C805(1.17)  LDD0784  [29]
 LDCM0469  CL76 HCT 116 C805(0.63)  LDD0786  [29]
 LDCM0470  CL77 HCT 116 C805(0.72)  LDD0787  [29]
 LDCM0471  CL78 HCT 116 C805(0.94)  LDD0788  [29]
 LDCM0472  CL79 HCT 116 C805(0.95)  LDD0789  [29]
 LDCM0473  CL8 HEK-293T C352(1.05)  LDD1071  [29]
 LDCM0474  CL80 HCT 116 C805(1.09)  LDD0791  [29]
 LDCM0475  CL81 HCT 116 C805(0.81)  LDD0792  [29]
 LDCM0476  CL82 HCT 116 C805(0.77)  LDD0793  [29]
 LDCM0477  CL83 HCT 116 C805(0.72)  LDD0794  [29]
 LDCM0478  CL84 HCT 116 C805(0.61)  LDD0795  [29]
 LDCM0479  CL85 HCT 116 C805(0.92)  LDD0796  [29]
 LDCM0480  CL86 HCT 116 C805(0.79)  LDD0797  [29]
 LDCM0481  CL87 HCT 116 C805(0.84)  LDD0798  [29]
 LDCM0482  CL88 HCT 116 C805(0.77)  LDD0799  [29]
 LDCM0483  CL89 HCT 116 C805(0.50)  LDD0800  [29]
 LDCM0484  CL9 HEK-293T C352(1.11)  LDD1082  [29]
 LDCM0485  CL90 HCT 116 C805(0.79)  LDD0802  [29]
 LDCM0486  CL91 PaTu 8988t C352(0.55)  LDD1365  [29]
 LDCM0487  CL92 PaTu 8988t C352(0.42)  LDD1366  [29]
 LDCM0488  CL93 PaTu 8988t C352(0.42)  LDD1367  [29]
 LDCM0489  CL94 PaTu 8988t C352(0.38)  LDD1368  [29]
 LDCM0490  CL95 PaTu 8988t C352(0.29)  LDD1369  [29]
 LDCM0491  CL96 PaTu 8988t C352(0.50)  LDD1370  [29]
 LDCM0492  CL97 PaTu 8988t C352(0.47)  LDD1371  [29]
 LDCM0493  CL98 PaTu 8988t C352(0.31)  LDD1372  [29]
 LDCM0494  CL99 PaTu 8988t C352(0.42)  LDD1373  [29]
 LDCM0495  E2913 HEK-293T C805(0.80); C352(0.85)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C352(1.57)  LDD1702  [5]
 LDCM0625  F8 Ramos C805(1.48)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C805(0.99)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C805(2.35)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C805(0.94)  LDD2191  [31]
 LDCM0576  Fragment14 Ramos C805(0.55)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C805(0.90)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C805(1.56)  LDD2195  [31]
 LDCM0578  Fragment27 Ramos C805(1.62)  LDD2197  [31]
 LDCM0588  Fragment30 Ramos C805(1.54)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C805(1.60)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C805(1.06)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C805(1.14)  LDD0785  [29]
 LDCM0566  Fragment4 Ramos C805(1.45)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C352(0.55)  LDD1025  [29]
 LDCM0610  Fragment52 Ramos C805(1.64)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C805(1.75)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C805(0.72)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C805(0.87)  LDD2188  [31]
 LDCM0117  HHS-0201 DM93 Y904(1.23)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y904(4.36)  LDD0266  [7]
 LDCM0120  HHS-0701 DM93 Y904(0.77)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C805(0.91)  LDD1492  [30]
 LDCM0023  KB03 Jurkat C352(24.00)  LDD0209  [6]
 LDCM0024  KB05 Hs 936.T C805(2.68)  LDD3313  [32]
 LDCM0109  NEM HeLa H102(0.00); H123(0.00); H326(0.00)  LDD0223  [20]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C805(3.14)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C805(0.62)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C805(1.26)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C805(0.56)  LDD2100  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C805(0.67)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C805(0.34)  LDD2114  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C805(1.19)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C805(0.85)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C805(1.02)  LDD2125  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C805(0.27)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C805(2.01)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C805(1.83)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C805(1.13)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C805(0.72)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C805(0.19)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C805(0.89)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C805(0.17)  LDD2148  [5]
 LDCM0131  RA190 MM1.R C352(1.11)  LDD0304  [33]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
29 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.