Details of the Target

General Information of Target

Target ID LDTP06562
Target Name Histone-binding protein RBBP7 (RBBP7)
Gene Name RBBP7
Gene ID 5931
Synonyms
RBAP46; Histone-binding protein RBBP7; Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; RBBP-7; Retinoblastoma-binding protein p46
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDY
ALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKI
NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY
GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES
LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW
DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED
GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSEL
EGQGS
Target Bioclass
Other
Family
WD repeat RBAP46/RBAP48/MSI1 family
Subcellular location
Nucleus
Function
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Uniprot ID
Q16576
Ensemble ID
ENST00000380084.8
HGNC ID
HGNC:9890
ChEMBL ID
CHEMBL3301388

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.T223I DBIA    Probe Info 
HCT116 SNV: p.N17D .
HEC1 SNV: p.R339H .
HEC1B SNV: p.R339H .
MCC13 SNV: p.W300Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y180(20.00); Y283(16.34); Y20(12.72); Y153(6.97)  LDD0257  [3]
TH214
 Probe Info  		Y20(9.94); Y131(8.62); Y153(7.42)  LDD0258  [3]
TH216
 Probe Info  		Y283(18.55); Y153(13.42); Y180(11.58); Y20(7.25)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K119(0.65)  LDD0274  [5]
Probe 1
 Probe Info  		Y131(11.00)  LDD3495  [6]
MCL-4
 Probe Info  		3.20  LDD0049  [7]
AHL-Pu-1
 Probe Info  		C166(4.65)  LDD0168  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
HHS-482
 Probe Info  		Y131(0.94); Y20(0.98)  LDD0285  [10]
HHS-475
 Probe Info  		Y20(0.94); Y131(1.26); Y153(1.76); Y60(2.58)  LDD0264  [11]
HHS-465
 Probe Info  		Y131(8.15); Y20(6.94); Y60(7.36)  LDD2237  [12]
DBIA
 Probe Info  		C97(1.08)  LDD0078  [13]
5E-2FA
 Probe Info  		H70(0.00); H323(0.00); H266(0.00); H156(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K119(0.00); K159(0.00); K155(0.00); K101(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C202(0.00); C166(0.00); C277(0.00); C97(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C277(0.00); C97(0.00); C166(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		C277(0.00); C97(0.00); C166(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C202(0.00); C277(0.00); C166(0.00); C97(0.00)  LDD0037  [16]
BTD
 Probe Info  		C97(0.00); C166(0.00)  LDD0004  [19]
JW-RF-010
 Probe Info  		C97(0.00); C166(0.00)  LDD0026  [20]
NAIA_4
 Probe Info  		C97(0.00); C116(0.00); C166(0.00); C202(0.00)  LDD2226  [21]
WYneN
 Probe Info  		C97(0.00); C166(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C166(0.00); C97(0.00)  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C116(0.00); C97(0.00)  LDD0005  [19]
NHS
 Probe Info  		N.A.  LDD0010  [19]
PF-06672131
 Probe Info  		N.A.  LDD0017  [24]
PPMS
 Probe Info  		N.A.  LDD0008  [19]
SF
 Probe Info  		Y20(0.00); Y131(0.00)  LDD0028  [25]
STPyne
 Probe Info  		K101(0.00); K159(0.00)  LDD0009  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
VSF
 Probe Info  		C97(0.00); C116(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C116(0.00); C97(0.00); C166(0.00)  LDD0018  [26]
Ox-W18
 Probe Info  		W234(0.00); W344(0.00)  LDD2175  [27]
1c-yne
 Probe Info  		K155(0.00); K101(0.00); K142(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C97(0.00); C166(0.00); H137(0.00); H122(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		H122(0.00); C166(0.00)  LDD0219  [28]
Methacrolein
 Probe Info  		C97(0.00); C166(0.00); H122(0.00)  LDD0218  [28]
W1
 Probe Info  		N.A.  LDD0236  [29]
AOyne
 Probe Info  		15.00  LDD0443  [30]
NAIA_5
 Probe Info  		C166(0.00); C116(0.00); C277(0.00); C97(0.00)  LDD2223  [21]
TER-AC
 Probe Info  		N.A.  LDD0426  [31]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C160
 Probe Info  		22.78  LDD1840  [32]
FFF probe13
 Probe Info  		13.07  LDD0475  [33]
FFF probe3
 Probe Info  		5.18  LDD0464  [33]
JN0003
 Probe Info  		5.90  LDD0469  [33]
STS-1
 Probe Info  		N.A.  LDD0136  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [34]
Diazir
 Probe Info  		N.A.  LDD0011  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C166(0.85); C97(0.75)  LDD2142  [35]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C166(0.71); C97(0.82)  LDD2112  [35]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C166(0.66)  LDD2095  [35]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C166(0.75)  LDD2130  [35]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C166(0.97); C97(1.44)  LDD2117  [35]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C166(1.46)  LDD2152  [35]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C166(1.04)  LDD2103  [35]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C166(0.53)  LDD2132  [35]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C166(0.72)  LDD2131  [35]
 LDCM0025  4SU-RNA HEK-293T C166(4.65)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C97(2.16)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C166(0.99); C97(0.87); C277(0.93); C202(1.18)  LDD1507  [36]
 LDCM0215  AC10 HEK-293T C166(0.94); C97(1.07); C277(0.90); C202(1.15)  LDD1508  [36]
 LDCM0226  AC11 HEK-293T C166(0.98); C97(0.93); C277(1.03); C202(0.95)  LDD1509  [36]
 LDCM0237  AC12 HEK-293T C166(1.08); C97(0.92); C277(0.97); C202(1.08)  LDD1510  [36]
 LDCM0259  AC14 HEK-293T C166(0.97); C97(1.00); C277(0.94); C202(1.03)  LDD1512  [36]
 LDCM0270  AC15 HEK-293T C166(0.88); C97(0.91); C277(0.98); C202(0.83)  LDD1513  [36]
 LDCM0276  AC17 HEK-293T C166(0.99); C97(0.99); C277(1.06); C202(1.06)  LDD1515  [36]
 LDCM0277  AC18 HEK-293T C166(1.00); C97(0.97); C277(0.92); C202(1.01)  LDD1516  [36]
 LDCM0278  AC19 HEK-293T C166(1.37); C97(1.18); C277(1.05); C202(1.03)  LDD1517  [36]
 LDCM0279  AC2 HEK-293T C166(0.93); C97(1.05); C277(1.04); C202(1.08)  LDD1518  [36]
 LDCM0280  AC20 HEK-293T C166(1.06); C97(1.01); C277(0.91); C202(1.18)  LDD1519  [36]
 LDCM0281  AC21 HEK-293T C166(1.07); C97(0.99); C277(0.96); C202(1.11)  LDD1520  [36]
 LDCM0282  AC22 HEK-293T C166(1.02); C97(0.98); C277(1.04); C202(1.10)  LDD1521  [36]
 LDCM0283  AC23 HEK-293T C166(0.97); C97(0.93); C277(1.02); C202(0.91)  LDD1522  [36]
 LDCM0284  AC24 HEK-293T C166(0.94); C97(0.98); C277(1.01); C202(1.07)  LDD1523  [36]
 LDCM0285  AC25 HEK-293T C166(1.03); C97(0.96); C277(0.95); C202(1.18)  LDD1524  [36]
 LDCM0286  AC26 HEK-293T C166(0.97); C97(1.05); C277(1.03); C202(1.01)  LDD1525  [36]
 LDCM0287  AC27 HEK-293T C166(0.99); C97(0.98); C277(0.92); C202(0.96)  LDD1526  [36]
 LDCM0288  AC28 HEK-293T C166(0.96); C97(0.99); C277(0.98); C202(1.08)  LDD1527  [36]
 LDCM0289  AC29 HEK-293T C166(1.07); C97(1.03); C277(0.90); C202(1.19)  LDD1528  [36]
 LDCM0290  AC3 HEK-293T C166(1.00); C97(0.97); C277(1.05); C202(0.91)  LDD1529  [36]
 LDCM0291  AC30 HEK-293T C166(1.01); C97(0.93); C277(1.01); C202(0.93)  LDD1530  [36]
 LDCM0292  AC31 HEK-293T C166(0.99); C97(0.89); C277(1.03); C202(0.84)  LDD1531  [36]
 LDCM0293  AC32 HEK-293T C166(0.87); C97(0.95); C277(0.96); C202(1.05)  LDD1532  [36]
 LDCM0294  AC33 HEK-293T C166(0.93); C97(0.95); C277(0.95); C202(1.22)  LDD1533  [36]
 LDCM0295  AC34 HEK-293T C166(0.90); C97(1.03); C277(0.95); C202(1.08)  LDD1534  [36]
 LDCM0296  AC35 HEK-293T C166(0.98); C97(0.90); C277(0.94); C202(0.98)  LDD1535  [36]
 LDCM0297  AC36 HEK-293T C166(0.91); C97(0.93); C277(1.00); C202(1.12)  LDD1536  [36]
 LDCM0298  AC37 HEK-293T C166(0.98); C97(0.96); C277(0.94); C202(1.14)  LDD1537  [36]
 LDCM0299  AC38 HEK-293T C166(1.00); C97(1.01); C277(1.01); C202(0.99)  LDD1538  [36]
 LDCM0300  AC39 HEK-293T C166(0.94); C97(0.90); C277(0.97); C202(0.85)  LDD1539  [36]
 LDCM0301  AC4 HEK-293T C166(1.01); C97(0.94); C277(1.05); C202(1.04)  LDD1540  [36]
 LDCM0302  AC40 HEK-293T C166(0.91); C97(0.92); C277(0.99); C202(1.00)  LDD1541  [36]
 LDCM0303  AC41 HEK-293T C166(0.92); C97(0.88); C277(0.92); C202(1.25)  LDD1542  [36]
 LDCM0304  AC42 HEK-293T C166(0.92); C97(1.05); C277(0.90); C202(1.06)  LDD1543  [36]
 LDCM0305  AC43 HEK-293T C166(0.98); C97(0.90); C277(0.97); C202(0.96)  LDD1544  [36]
 LDCM0306  AC44 HEK-293T C166(1.01); C97(0.92); C277(1.01); C202(0.97)  LDD1545  [36]
 LDCM0307  AC45 HEK-293T C166(1.05); C97(0.98); C277(0.89); C202(1.04)  LDD1546  [36]
 LDCM0308  AC46 HEK-293T C166(0.96); C97(0.98); C277(0.98); C202(1.06)  LDD1547  [36]
 LDCM0309  AC47 HEK-293T C166(0.88); C97(0.91); C277(1.08); C202(0.85)  LDD1548  [36]
 LDCM0310  AC48 HEK-293T C166(0.87); C97(0.90); C277(0.94); C202(1.04)  LDD1549  [36]
 LDCM0311  AC49 HEK-293T C166(0.94); C97(0.92); C277(0.97); C202(0.90)  LDD1550  [36]
 LDCM0312  AC5 HEK-293T C166(1.04); C97(0.98); C277(0.96); C202(1.07)  LDD1551  [36]
 LDCM0313  AC50 HEK-293T C166(1.02); C97(1.00); C277(0.92); C202(0.92)  LDD1552  [36]
 LDCM0314  AC51 HEK-293T C166(0.99); C97(0.96); C277(0.95); C202(0.93)  LDD1553  [36]
 LDCM0315  AC52 HEK-293T C166(1.08); C97(0.94); C277(0.97); C202(0.85)  LDD1554  [36]
 LDCM0316  AC53 HEK-293T C166(1.00); C97(0.98); C277(0.97); C202(1.01)  LDD1555  [36]
 LDCM0317  AC54 HEK-293T C166(0.99); C97(1.05); C277(1.01); C202(0.88)  LDD1556  [36]
 LDCM0318  AC55 HEK-293T C166(0.93); C97(0.94); C277(0.99); C202(0.78)  LDD1557  [36]
 LDCM0319  AC56 HEK-293T C166(0.91); C97(0.89); C277(0.94); C202(0.96)  LDD1558  [36]
 LDCM0320  AC57 HEK-293T C166(1.00); C97(0.88); C277(0.90); C202(0.97)  LDD1559  [36]
 LDCM0321  AC58 HEK-293T C166(0.90); C97(1.00); C277(0.95); C202(0.95)  LDD1560  [36]
 LDCM0322  AC59 HEK-293T C166(0.96); C97(0.89); C277(0.90); C202(0.88)  LDD1561  [36]
 LDCM0323  AC6 HEK-293T C166(0.77); C97(0.99); C277(0.98); C202(0.90)  LDD1562  [36]
 LDCM0324  AC60 HEK-293T C166(1.02); C97(0.92); C277(0.97); C202(1.10)  LDD1563  [36]
 LDCM0325  AC61 HEK-293T C166(1.06); C97(0.97); C277(0.88); C202(0.93)  LDD1564  [36]
 LDCM0326  AC62 HEK-293T C166(1.05); C97(0.94); C277(0.93); C202(0.84)  LDD1565  [36]
 LDCM0327  AC63 HEK-293T C166(0.91); C97(0.93); C277(1.02); C202(0.85)  LDD1566  [36]
 LDCM0328  AC64 HEK-293T C166(0.90); C97(0.87); C277(1.02); C202(0.94)  LDD1567  [36]
 LDCM0334  AC7 HEK-293T C166(0.91); C97(0.91); C277(1.03); C202(0.86)  LDD1568  [36]
 LDCM0345  AC8 HEK-293T C166(0.87); C97(0.89); C277(1.02); C202(1.09)  LDD1569  [36]
 LDCM0545  Acetamide MDA-MB-231 C166(0.36)  LDD2138  [35]
 LDCM0520  AKOS000195272 MDA-MB-231 C166(0.72)  LDD2113  [35]
 LDCM0248  AKOS034007472 HEK-293T C166(1.06); C97(0.92); C277(0.99); C202(0.93)  LDD1511  [36]
 LDCM0356  AKOS034007680 HEK-293T C166(0.94); C97(0.94); C277(0.97); C202(1.11)  LDD1570  [36]
 LDCM0275  AKOS034007705 HEK-293T C166(0.93); C97(0.93); C277(0.96); C202(0.97)  LDD1514  [36]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C97(1.08)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C166(0.50); C97(1.42)  LDD2091  [35]
 LDCM0630  CCW28-3 231MFP C97(1.35)  LDD2214  [37]
 LDCM0108  Chloroacetamide HeLa C97(0.00); C166(0.00); H122(0.00); H137(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C116(0.47)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C166(0.86); C97(0.96); C277(1.10)  LDD1571  [36]
 LDCM0368  CL10 HEK-293T C166(0.94); C97(1.49); C277(1.41); C202(1.85)  LDD1572  [36]
 LDCM0369  CL100 HEK-293T C166(0.95); C97(0.92); C277(1.00)  LDD1573  [36]
 LDCM0370  CL101 HEK-293T C166(0.99); C97(1.02); C277(1.02)  LDD1574  [36]
 LDCM0371  CL102 HEK-293T C166(0.96); C97(0.92); C277(1.06); C202(1.02)  LDD1575  [36]
 LDCM0372  CL103 HEK-293T C166(1.03); C97(0.98); C277(1.04); C202(1.14)  LDD1576  [36]
 LDCM0373  CL104 HEK-293T C166(0.94); C97(0.89); C277(0.99)  LDD1577  [36]
 LDCM0374  CL105 HEK-293T C166(1.00); C97(1.04); C277(0.96)  LDD1578  [36]
 LDCM0375  CL106 HEK-293T C166(1.00); C97(0.91); C277(1.05); C202(0.84)  LDD1579  [36]
 LDCM0376  CL107 HEK-293T C166(0.91); C97(0.97); C277(0.95); C202(1.08)  LDD1580  [36]
 LDCM0377  CL108 HEK-293T C166(1.00); C97(0.95); C277(0.99)  LDD1581  [36]
 LDCM0378  CL109 HEK-293T C166(0.95); C97(1.03); C277(1.02)  LDD1582  [36]
 LDCM0379  CL11 HEK-293T C166(0.86); C97(1.37); C277(1.23); C202(1.03)  LDD1583  [36]
 LDCM0380  CL110 HEK-293T C166(0.97); C97(0.89); C277(1.14); C202(1.03)  LDD1584  [36]
 LDCM0381  CL111 HEK-293T C166(0.90); C97(0.99); C277(0.97); C202(1.15)  LDD1585  [36]
 LDCM0382  CL112 HEK-293T C166(0.95); C97(0.99); C277(1.01)  LDD1586  [36]
 LDCM0383  CL113 HEK-293T C166(0.99); C97(1.01); C277(1.02)  LDD1587  [36]
 LDCM0384  CL114 HEK-293T C166(1.02); C97(0.97); C277(1.08); C202(0.97)  LDD1588  [36]
 LDCM0385  CL115 HEK-293T C166(0.94); C97(0.93); C277(0.92); C202(1.09)  LDD1589  [36]
 LDCM0386  CL116 HEK-293T C166(0.93); C97(0.95); C277(1.02)  LDD1590  [36]
 LDCM0387  CL117 HEK-293T C166(1.00); C97(0.98); C277(1.00)  LDD1591  [36]
 LDCM0388  CL118 HEK-293T C166(1.00); C97(0.97); C277(1.03); C202(0.81)  LDD1592  [36]
 LDCM0389  CL119 HEK-293T C166(0.96); C97(0.90); C277(0.86); C202(0.96)  LDD1593  [36]
 LDCM0390  CL12 HEK-293T C166(0.87); C97(1.27); C277(1.12); C202(1.13)  LDD1594  [36]
 LDCM0391  CL120 HEK-293T C166(0.99); C97(0.87); C277(1.03)  LDD1595  [36]
 LDCM0392  CL121 HEK-293T C166(1.07); C97(0.97); C277(1.01)  LDD1596  [36]
 LDCM0393  CL122 HEK-293T C166(0.97); C97(0.93); C277(1.05); C202(0.88)  LDD1597  [36]
 LDCM0394  CL123 HEK-293T C166(0.86); C97(0.88); C277(0.97); C202(1.09)  LDD1598  [36]
 LDCM0395  CL124 HEK-293T C166(0.91); C97(0.92); C277(1.13)  LDD1599  [36]
 LDCM0396  CL125 HEK-293T C166(0.93); C97(0.99); C277(0.99)  LDD1600  [36]
 LDCM0397  CL126 HEK-293T C166(0.95); C97(0.90); C277(0.97); C202(0.80)  LDD1601  [36]
 LDCM0398  CL127 HEK-293T C166(1.08); C97(0.96); C277(1.01); C202(0.74)  LDD1602  [36]
 LDCM0399  CL128 HEK-293T C166(0.94); C97(0.92); C277(1.04)  LDD1603  [36]
 LDCM0400  CL13 HEK-293T C166(1.06); C97(1.03); C277(1.25)  LDD1604  [36]
 LDCM0401  CL14 HEK-293T C166(0.95); C97(0.88); C277(1.04); C202(0.79)  LDD1605  [36]
 LDCM0402  CL15 HEK-293T C166(1.01); C97(0.88); C277(1.11); C202(1.12)  LDD1606  [36]
 LDCM0403  CL16 HEK-293T C166(0.98); C97(0.92); C277(1.12)  LDD1607  [36]
 LDCM0404  CL17 HEK-293T C166(0.99); C97(0.87); C277(1.19); C202(1.01)  LDD1608  [36]
 LDCM0405  CL18 HEK-293T C166(0.87); C97(0.98); C277(1.04); C202(0.89)  LDD1609  [36]
 LDCM0406  CL19 HEK-293T C166(0.99); C97(0.87); C277(1.07); C202(0.77)  LDD1610  [36]
 LDCM0407  CL2 HEK-293T C166(0.98); C97(0.92); C277(1.02); C202(0.82)  LDD1611  [36]
 LDCM0408  CL20 HEK-293T C166(0.88); C97(1.06); C277(1.13); C202(0.87)  LDD1612  [36]
 LDCM0409  CL21 HEK-293T C166(1.00); C97(1.06); C277(1.24); C202(1.09)  LDD1613  [36]
 LDCM0410  CL22 HEK-293T C166(0.88); C97(1.62); C277(1.17); C202(0.95)  LDD1614  [36]
 LDCM0411  CL23 HEK-293T C166(0.86); C97(1.36); C277(1.43); C202(0.83)  LDD1615  [36]
 LDCM0412  CL24 HEK-293T C166(0.90); C97(1.23); C277(1.28); C202(1.05)  LDD1616  [36]
 LDCM0413  CL25 HEK-293T C166(0.93); C97(0.99); C277(1.19)  LDD1617  [36]
 LDCM0414  CL26 HEK-293T C166(0.97); C97(0.98); C277(0.97); C202(0.85)  LDD1618  [36]
 LDCM0415  CL27 HEK-293T C166(0.97); C97(0.94); C277(0.98); C202(1.06)  LDD1619  [36]
 LDCM0416  CL28 HEK-293T C166(0.92); C97(0.97); C277(1.04)  LDD1620  [36]
 LDCM0417  CL29 HEK-293T C166(1.01); C97(0.98); C277(0.88); C202(1.03)  LDD1621  [36]
 LDCM0418  CL3 HEK-293T C166(1.10); C97(0.94); C277(1.06); C202(1.12)  LDD1622  [36]
 LDCM0419  CL30 HEK-293T C166(0.97); C97(0.96); C277(0.93); C202(0.90)  LDD1623  [36]
 LDCM0420  CL31 HEK-293T C166(0.92); C97(0.93); C277(0.98); C202(0.79)  LDD1624  [36]
 LDCM0421  CL32 HEK-293T C166(1.04); C97(1.12); C277(0.98); C202(0.76)  LDD1625  [36]
 LDCM0422  CL33 HEK-293T C166(1.02); C97(1.04); C277(1.25); C202(1.01)  LDD1626  [36]
 LDCM0423  CL34 HEK-293T C166(0.93); C97(1.47); C277(1.12); C202(0.83)  LDD1627  [36]
 LDCM0424  CL35 HEK-293T C166(0.95); C97(1.49); C277(1.08); C202(0.81)  LDD1628  [36]
 LDCM0425  CL36 HEK-293T C166(0.84); C97(1.22); C277(1.08); C202(1.04)  LDD1629  [36]
 LDCM0426  CL37 HEK-293T C166(0.92); C97(0.99); C277(0.97)  LDD1630  [36]
 LDCM0428  CL39 HEK-293T C166(0.94); C97(0.87); C277(0.85); C202(1.10)  LDD1632  [36]
 LDCM0429  CL4 HEK-293T C166(0.98); C97(0.88); C277(0.99)  LDD1633  [36]
 LDCM0430  CL40 HEK-293T C166(0.91); C97(0.97); C277(0.96)  LDD1634  [36]
 LDCM0431  CL41 HEK-293T C166(0.95); C97(0.98); C277(1.02); C202(1.30)  LDD1635  [36]
 LDCM0432  CL42 HEK-293T C166(1.00); C97(0.89); C277(1.00); C202(0.76)  LDD1636  [36]
 LDCM0433  CL43 HEK-293T C166(0.88); C97(0.89); C277(0.98); C202(0.89)  LDD1637  [36]
 LDCM0434  CL44 HEK-293T C166(1.05); C97(1.08); C277(1.00); C202(0.90)  LDD1638  [36]
 LDCM0435  CL45 HEK-293T C166(0.99); C97(1.10); C277(1.03); C202(1.04)  LDD1639  [36]
 LDCM0436  CL46 HEK-293T C166(1.07); C97(1.54); C277(1.14); C202(0.95)  LDD1640  [36]
 LDCM0437  CL47 HEK-293T C166(0.96); C97(1.39); C277(1.09); C202(0.86)  LDD1641  [36]
 LDCM0438  CL48 HEK-293T C166(0.88); C97(1.27); C277(1.18); C202(0.89)  LDD1642  [36]
 LDCM0439  CL49 HEK-293T C166(0.87); C97(0.98); C277(0.94)  LDD1643  [36]
 LDCM0440  CL5 HEK-293T C166(0.99); C97(0.90); C277(0.99); C202(0.86)  LDD1644  [36]
 LDCM0441  CL50 HEK-293T C166(0.89); C97(0.94); C277(1.00); C202(1.06)  LDD1645  [36]
 LDCM0443  CL52 HEK-293T C166(1.01); C97(0.87); C277(1.05)  LDD1646  [36]
 LDCM0444  CL53 HEK-293T C166(0.91); C97(0.83); C277(0.95); C202(1.09)  LDD1647  [36]
 LDCM0445  CL54 HEK-293T C166(0.82); C97(0.96); C277(0.92); C202(0.92)  LDD1648  [36]
 LDCM0446  CL55 HEK-293T C166(0.97); C97(0.86); C277(0.94); C202(0.92)  LDD1649  [36]
 LDCM0447  CL56 HEK-293T C166(1.00); C97(1.01); C277(1.05); C202(0.95)  LDD1650  [36]
 LDCM0448  CL57 HEK-293T C166(1.10); C97(1.15); C277(1.05); C202(1.19)  LDD1651  [36]
 LDCM0449  CL58 HEK-293T C166(0.94); C97(1.62); C277(1.02); C202(0.79)  LDD1652  [36]
 LDCM0450  CL59 HEK-293T C166(0.84); C97(1.30); C277(1.04); C202(0.79)  LDD1653  [36]
 LDCM0451  CL6 HEK-293T C166(0.92); C97(0.94); C277(1.08); C202(0.89)  LDD1654  [36]
 LDCM0452  CL60 HEK-293T C166(0.90); C97(1.20); C277(1.04); C202(0.96)  LDD1655  [36]
 LDCM0453  CL61 HEK-293T C166(0.93); C97(0.94); C277(0.94)  LDD1656  [36]
 LDCM0454  CL62 HEK-293T C166(0.98); C97(0.90); C277(0.94); C202(1.01)  LDD1657  [36]
 LDCM0455  CL63 HEK-293T C166(0.94); C97(0.91); C277(0.90); C202(0.98)  LDD1658  [36]
 LDCM0456  CL64 HEK-293T C166(0.92); C97(0.89); C277(1.00)  LDD1659  [36]
 LDCM0457  CL65 HEK-293T C166(0.93); C97(0.90); C277(0.90); C202(0.88)  LDD1660  [36]
 LDCM0458  CL66 HEK-293T C166(0.87); C97(0.97); C277(0.90); C202(0.98)  LDD1661  [36]
 LDCM0459  CL67 HEK-293T C166(0.94); C97(0.88); C277(0.99); C202(0.91)  LDD1662  [36]
 LDCM0460  CL68 HEK-293T C166(0.83); C97(1.05); C277(0.94); C202(0.74)  LDD1663  [36]
 LDCM0461  CL69 HEK-293T C166(0.96); C97(1.10); C277(1.01); C202(0.89)  LDD1664  [36]
 LDCM0462  CL7 HEK-293T C166(0.96); C97(0.90); C277(0.99); C202(0.79)  LDD1665  [36]
 LDCM0463  CL70 HEK-293T C166(0.92); C97(1.41); C277(1.08); C202(0.80)  LDD1666  [36]
 LDCM0464  CL71 HEK-293T C166(0.89); C97(1.37); C277(1.05); C202(0.71)  LDD1667  [36]
 LDCM0465  CL72 HEK-293T C166(0.94); C97(1.15); C277(0.91); C202(1.02)  LDD1668  [36]
 LDCM0466  CL73 HEK-293T C166(0.98); C97(0.95); C277(1.01)  LDD1669  [36]
 LDCM0467  CL74 HEK-293T C166(0.99); C97(0.91); C277(1.06); C202(0.81)  LDD1670  [36]
 LDCM0469  CL76 HEK-293T C166(0.93); C97(0.92); C277(1.13)  LDD1672  [36]
 LDCM0470  CL77 HEK-293T C166(0.93); C97(0.99); C277(1.00); C202(1.04)  LDD1673  [36]
 LDCM0471  CL78 HEK-293T C166(0.94); C97(0.99); C277(1.01); C202(0.94)  LDD1674  [36]
 LDCM0472  CL79 HEK-293T C166(0.95); C97(0.87); C277(1.00); C202(0.77)  LDD1675  [36]
 LDCM0473  CL8 HEK-293T C166(0.99); C97(0.91); C277(1.48); C202(1.14)  LDD1676  [36]
 LDCM0474  CL80 HEK-293T C166(1.05); C97(1.04); C277(0.97); C202(0.73)  LDD1677  [36]
 LDCM0475  CL81 HEK-293T C166(0.98); C97(1.08); C277(0.98); C202(0.78)  LDD1678  [36]
 LDCM0476  CL82 HEK-293T C166(0.98); C97(1.34); C277(1.08); C202(0.80)  LDD1679  [36]
 LDCM0477  CL83 HEK-293T C166(0.92); C97(1.32); C277(1.05); C202(0.87)  LDD1680  [36]
 LDCM0478  CL84 HEK-293T C166(0.84); C97(1.10); C277(0.98); C202(0.95)  LDD1681  [36]
 LDCM0479  CL85 HEK-293T C166(0.85); C97(1.14); C277(1.25)  LDD1682  [36]
 LDCM0480  CL86 HEK-293T C166(0.94); C97(0.92); C277(1.09); C202(0.70)  LDD1683  [36]
 LDCM0481  CL87 HEK-293T C166(0.97); C97(0.89); C277(0.96); C202(0.69)  LDD1684  [36]
 LDCM0482  CL88 HEK-293T C166(0.93); C97(0.87); C277(1.10)  LDD1685  [36]
 LDCM0483  CL89 HEK-293T C166(0.92); C97(0.79); C277(1.04); C202(0.76)  LDD1686  [36]
 LDCM0484  CL9 HEK-293T C166(1.08); C97(1.09); C277(1.05); C202(0.95)  LDD1687  [36]
 LDCM0485  CL90 HEK-293T C166(0.97); C97(0.95); C277(0.94); C202(1.17)  LDD1688  [36]
 LDCM0486  CL91 HEK-293T C166(0.94); C97(0.84); C277(1.00); C202(0.62)  LDD1689  [36]
 LDCM0487  CL92 HEK-293T C166(0.92); C97(0.94); C277(1.05); C202(0.81)  LDD1690  [36]
 LDCM0488  CL93 HEK-293T C166(1.00); C97(1.03); C277(0.97); C202(0.91)  LDD1691  [36]
 LDCM0489  CL94 HEK-293T C166(0.93); C97(1.31); C277(1.01); C202(0.87)  LDD1692  [36]
 LDCM0490  CL95 HEK-293T C166(0.96); C97(1.18); C277(1.31); C202(1.01)  LDD1693  [36]
 LDCM0491  CL96 HEK-293T C166(0.83); C97(0.96); C277(0.96); C202(0.73)  LDD1694  [36]
 LDCM0492  CL97 HEK-293T C166(0.78); C97(1.01); C277(1.10)  LDD1695  [36]
 LDCM0493  CL98 HEK-293T C166(0.97); C97(1.00); C277(1.14); C202(1.09)  LDD1696  [36]
 LDCM0494  CL99 HEK-293T C166(0.97); C97(0.89); C277(1.04); C202(1.00)  LDD1697  [36]
 LDCM0634  CY-0357 Hep-G2 C97(0.41)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C166(0.90); C97(0.85); C277(0.93); C202(1.09)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C97(1.39); C166(0.85)  LDD1702  [35]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C116(1.23); C166(1.14); C97(2.15)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C116(0.73); C97(1.04)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C116(0.95); C97(0.01)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C116(0.29); C97(0.54)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C116(0.38); C97(0.40)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C116(0.67); C97(0.60)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C116(0.34); C97(0.77)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C116(0.49); C97(0.39)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C116(0.92); C97(1.24)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C116(0.71); C97(0.92)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C116(0.68); C97(0.73)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C116(0.62); C97(0.62)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C116(0.63); C97(0.66)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C116(0.40); C97(0.91)  LDD2201  [38]
 LDCM0468  Fragment33 HEK-293T C166(0.97); C97(0.91); C277(0.88); C202(0.94)  LDD1671  [36]
 LDCM0596  Fragment38 Ramos C116(0.60); C97(1.41)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C116(0.78); C166(0.81); C97(0.76)  LDD2184  [38]
 LDCM0427  Fragment51 HEK-293T C166(0.97); C97(0.94); C277(1.05); C202(1.02)  LDD1631  [36]
 LDCM0610  Fragment52 Ramos C116(0.55); C97(0.69)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C116(0.54); C97(0.37)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C116(0.83); C166(0.63); C97(0.63)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C116(0.48); C97(0.45)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y20(0.94); Y131(1.26); Y153(1.76); Y60(2.58)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y20(0.83); Y131(1.10); Y153(3.80); Y60(4.96)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y131(0.83); Y20(0.87); Y60(2.55); Y153(15.12)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y20(1.02); Y131(2.79); Y60(3.33)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y20(0.74); Y60(1.31); Y131(1.43); Y153(11.10)  LDD0268  [11]
 LDCM0107  IAA HeLa H84(0.00); H96(0.00); C166(0.00); H122(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y131(0.94); Y20(0.98)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y131(1.62); Y20(0.85)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y131(1.00); Y20(0.80)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y131(2.24); Y20(3.54)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y131(1.67); Y20(1.85)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y131(0.35); Y20(0.82)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y131(1.04); Y20(0.78)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y131(0.81); Y20(0.88)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C166(0.86); C97(0.96); C277(0.99)  LDD1492  [36]
 LDCM0023  KB03 HEK-293T C166(0.91); C97(0.95); C277(1.02)  LDD1497  [36]
 LDCM0024  KB05 HMCB C210(1.87)  LDD3312  [39]
 LDCM0006  Micheliolide M9-ENL1 3.20  LDD0049  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C166(1.04)  LDD2102  [35]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C166(0.57)  LDD2121  [35]
 LDCM0109  NEM HeLa H137(0.00); H122(0.00); H372(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C166(0.58)  LDD2089  [35]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C166(1.07)  LDD2090  [35]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C166(1.06); C97(0.99)  LDD2092  [35]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C166(0.91)  LDD2093  [35]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C166(1.68)  LDD2094  [35]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C166(0.93)  LDD2096  [35]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C166(1.03)  LDD2097  [35]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C166(0.73); C97(0.75)  LDD2098  [35]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C166(1.17)  LDD2099  [35]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C166(0.46); C97(0.88)  LDD2100  [35]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C166(0.90)  LDD2101  [35]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C166(0.58); C97(0.88)  LDD2104  [35]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C166(1.16); C97(1.41)  LDD2105  [35]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C166(0.91)  LDD2106  [35]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C166(0.94); C97(1.38)  LDD2107  [35]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C166(0.64)  LDD2109  [35]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C166(0.58)  LDD2110  [35]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C166(1.02)  LDD2111  [35]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C97(0.99)  LDD2114  [35]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C166(0.56)  LDD2115  [35]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C166(1.13)  LDD2116  [35]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C166(1.23); C97(1.40)  LDD2118  [35]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C166(2.82)  LDD2119  [35]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C166(0.94)  LDD2120  [35]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C166(1.04)  LDD2122  [35]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C166(0.98); C97(1.05)  LDD2123  [35]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C166(1.02)  LDD2124  [35]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C166(0.77); C97(1.37)  LDD2125  [35]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C166(1.03)  LDD2126  [35]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C166(0.94)  LDD2127  [35]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C166(0.95)  LDD2128  [35]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C166(1.14); C97(1.76)  LDD2129  [35]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C166(0.55)  LDD2133  [35]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C166(0.53); C97(0.58)  LDD2134  [35]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C166(1.10); C97(1.59)  LDD2135  [35]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C166(1.42)  LDD2136  [35]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C166(0.85); C97(1.44)  LDD2137  [35]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C166(1.38)  LDD1700  [35]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C166(0.88); C97(1.13)  LDD2140  [35]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C166(0.76); C97(1.05)  LDD2141  [35]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C166(1.11)  LDD2143  [35]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C166(1.80); C97(2.30)  LDD2144  [35]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C166(0.24); C97(3.39)  LDD2145  [35]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C166(0.90)  LDD2146  [35]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C166(0.64)  LDD2148  [35]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C166(1.24)  LDD2149  [35]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C166(0.34); C97(0.97)  LDD2150  [35]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C166(0.96)  LDD2151  [35]
 LDCM0627  NUDT7-COV-1 HEK-293T C97(0.92)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C97(1.46); C116(0.75)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C97(1.79); C277(1.12)  LDD0304  [41]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 827 (ZNF827) Krueppel C2H2-type zinc-finger protein family Q17R98
Metastasis-associated protein MTA2 (MTA2) . O94776
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
32 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
35 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.