Details of the Target

General Information of Target

Target ID LDTP17159
Target Name Putative heat shock protein HSP 90-beta 4 (HSP90AB4P)
Gene Name HSP90AB4P
Synonyms
Putative heat shock protein HSP 90-beta 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETIQEVEDEYKAFCKSFSKESDDPVACIHFTAEGEVTFKSILFVPTFVPRGLFDEYGS
KKSDYIKLYVRCVFITDDFRDTMPKNLNFVKGVVDSGGLSLNVSCETLQQHKLLKVIRKK
LVHKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTCLAKLLRFQSSHHPADITS
LHQDVERMKEKQDKICLMAGGYEVIYLTEPVVEYCIQALPEFDGKRFQNVAKEGVKFDDS
EKTKESHEAVEKEFEPLPNWVKDKAIKDKIEKAMVSQCLTESLCALVASQYGWSGNMERI
MKAQAYQTGKGISTNYHASRKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVEEPDE
EPEETAEDKEQDKDKEMDVGTDEEKQETAKESTAEKDEL
Target Bioclass
Other
Family
Heat shock protein 90 family
Subcellular location
Cytoplasm
Function Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Uniprot ID
Q58FF6
HGNC ID
HGNC:32538

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D37(0.85); E162(0.89); E457(1.02)  LDD2208  [1]
SAHA-CA-4PAP
 Probe Info  		7.30  LDD0269  [2]
HHS-475
 Probe Info  		Y32(0.78)  LDD0264  [3]
HHS-465
 Probe Info  		Y167(10.00); Y32(8.73)  LDD2237  [4]
AMP probe
 Probe Info  		K458(0.00); K459(0.00)  LDD0200  [5]
ATP probe
 Probe Info  		K458(0.00); K459(0.00); K476(0.00); K161(0.00)  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
NHS
 Probe Info  		N.A.  LDD0010  [8]
OSF
 Probe Info  		N.A.  LDD0029  [9]
SF
 Probe Info  		Y167(0.00); Y32(0.00); Y9(0.00); K476(0.00)  LDD0028  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		1.00  LDD0139  [10]
Diazir
 Probe Info  		E457(0.00); E169(0.00)  LDD0011  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y32(0.78)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y32(0.73)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y32(0.72)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y32(0.79)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y32(0.52)  LDD0268  [3]
 LDCM0096  SAHA K562 7.30  LDD0269  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.