Details of the Target

General Information of Target

Target ID LDTP09203
Target Name Nucleoporin Nup37 (NUP37)
Gene Name NUP37
Gene ID 79023
Synonyms
Nucleoporin Nup37; p37; Nup107-160 subcomplex subunit Nup37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEG
IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL
EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFK
LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRS
SYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGS
GLSWHRTLPLCVIGGDHKLLFWVTEV
Target Bioclass
Transporter and channel
Subcellular location
Chromosome, centromere, kinetochore
Function
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Uniprot ID
Q8NFH4
Ensemble ID
ENST00000251074.5
HGNC ID
HGNC:29929

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C96(1.36)  LDD3310  [3]
BTD
 Probe Info  		C311(2.14)  LDD1700  [4]
HHS-475
 Probe Info  		Y117(0.70)  LDD0264  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C149(0.00); C96(0.00); C311(0.00); C217(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C149(0.00); C96(0.00); C217(0.00); C311(0.00)  LDD0037  [6]
ENE
 Probe Info  		N.A.  LDD0006  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		C96(0.00); C311(0.00)  LDD0148  [10]
Acrolein
 Probe Info  		C149(0.00); C311(0.00)  LDD0217  [11]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [11]
Crotonaldehyde
 Probe Info  		C149(0.00); C311(0.00)  LDD0219  [11]
Methacrolein
 Probe Info  		C149(0.00); C311(0.00)  LDD0218  [11]
NAIA_5
 Probe Info  		C149(0.00); C96(0.00); C217(0.00); C311(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		K114(0.00); K118(0.00); Y117(0.00)  LDD2240  [13]
HHS-482
 Probe Info  		Y117(1.43)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		11.71  LDD1752  [15]
C087
 Probe Info  		14.32  LDD1779  [15]
C100
 Probe Info  		5.21  LDD1789  [15]
C219
 Probe Info  		6.23  LDD1893  [15]
C225
 Probe Info  		5.54  LDD1898  [15]
C244
 Probe Info  		16.34  LDD1917  [15]
C273
 Probe Info  		5.17  LDD1943  [15]
C293
 Probe Info  		17.63  LDD1963  [15]
C310
 Probe Info  		8.11  LDD1977  [15]
C322
 Probe Info  		6.28  LDD1988  [15]
C338
 Probe Info  		10.56  LDD2001  [15]
C339
 Probe Info  		7.36  LDD2002  [15]
C348
 Probe Info  		10.06  LDD2009  [15]
C349
 Probe Info  		11.00  LDD2010  [15]
C364
 Probe Info  		18.00  LDD2025  [15]
C407
 Probe Info  		12.38  LDD2064  [15]
C413
 Probe Info  		18.90  LDD2069  [15]
C431
 Probe Info  		21.11  LDD2086  [15]
FFF probe11
 Probe Info  		6.28  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		17.79  LDD0463  [16]
FFF probe3
 Probe Info  		7.89  LDD0464  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
Diazir
 Probe Info  		E136(0.00); E139(0.00)  LDD0011  [8]
OEA-DA
 Probe Info  		13.69  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C149(1.14)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C311(0.78)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C311(0.98); C96(1.13)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C311(1.02); C96(1.34); C149(1.24)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C311(1.31)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C311(2.02)  LDD0371  [19]
 LDCM0214  AC1 HEK-293T C149(0.63); C96(0.99); C172(1.22)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C149(1.00); C96(0.94); C172(1.06); C311(0.94)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C149(0.99); C96(0.98); C172(0.92); C311(0.90)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C149(1.05); C96(1.04); C172(1.00); C311(1.03)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C149(1.06); C96(1.06); C172(1.17)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C149(0.94); C96(1.02); C172(0.98); C311(1.05)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C149(0.79); C96(0.99); C172(1.08)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C149(0.97); C96(1.03); C172(0.96); C311(0.97)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C149(0.72); C96(0.85); C172(0.81); C311(0.79)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C149(1.08); C96(0.99); C172(1.14); C311(1.04)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C149(1.08); C96(1.06); C172(1.05); C311(0.96)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C149(0.82); C96(0.98); C172(1.08)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C149(1.06); C96(1.05); C172(1.09)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C149(1.17); C96(1.11); C172(1.01); C311(1.06)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C149(0.94); C96(1.13); C172(1.01)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C149(0.82); C96(0.97); C172(1.15)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C149(1.16); C96(1.00); C172(1.06); C311(0.95)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C149(0.99); C96(1.02); C172(0.98); C311(0.93)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C149(1.05); C96(1.04); C172(1.03); C311(1.00)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C149(0.83); C96(1.03); C172(1.18)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C149(0.92); C96(1.04); C172(0.97); C311(0.86)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C149(0.91); C96(1.10); C172(1.09)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C149(1.13); C96(1.06); C172(0.97); C311(1.04)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C149(1.00); C96(1.04); C172(1.12)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C149(0.87); C96(1.03); C172(1.18)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C149(1.05); C96(1.02); C172(1.03); C311(0.98)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C149(1.02); C96(1.11); C172(0.97); C311(0.90)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C149(1.14); C96(1.17); C172(1.11); C311(0.88)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C149(1.02); C96(1.10); C172(1.08)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C149(0.96); C96(1.09); C172(1.03)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C149(1.07); C96(1.11); C172(1.02); C311(1.04)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C149(1.21); C96(1.11); C172(1.05); C311(0.99)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C149(0.74); C96(1.09); C172(0.99)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C149(1.13); C96(1.02); C172(1.14)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C149(0.95); C96(0.96); C172(1.11); C311(1.02)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C149(0.85); C96(1.00); C172(0.98); C311(0.86)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C149(1.16); C96(1.07); C172(1.06); C311(1.01)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C149(1.00); C96(1.01); C172(1.08)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C149(1.11); C96(1.07); C172(1.09)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C149(1.23); C96(1.08); C172(1.01); C311(1.04)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C149(0.94); C96(1.14); C172(1.04)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C149(1.04); C96(1.01); C172(1.17)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C149(0.96); C96(1.01); C172(1.00)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C149(0.99); C96(0.98); C172(0.93); C311(1.02)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C149(0.94); C96(1.08); C172(1.05); C311(0.98)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C149(0.84); C96(1.10); C172(0.96); C311(1.02)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C149(0.85); C96(1.07); C172(1.05)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C149(1.29); C96(1.07); C172(1.07)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C149(1.17); C96(1.06); C172(0.97); C311(1.00)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C149(0.97); C96(0.99); C172(0.98)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C149(0.89); C96(1.01); C172(1.10)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C149(0.97); C96(1.03); C172(0.97); C311(1.07)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C149(0.79); C96(1.06); C172(0.97); C311(0.95)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C149(1.09); C96(1.01); C172(1.06)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C149(1.02); C96(1.07); C172(1.09); C311(0.93)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C149(0.81); C96(1.07); C172(1.07)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C149(1.00); C96(1.09); C172(1.09)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C149(1.08); C96(1.10); C172(0.96); C311(1.02)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C149(1.21); C96(1.09); C172(1.03)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C149(1.06); C96(1.08); C172(0.95); C311(1.04)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C149(1.18); C96(1.13); C172(1.18)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C149(1.02); C96(1.01); C172(1.12)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C149(0.96); C96(1.00); C172(1.15)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C149(0.98); C96(1.04); C172(0.95)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 13.11  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C311(0.64); C149(0.74)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C149(0.00); C311(0.00)  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C149(1.02); C96(1.00); C172(0.99); C311(1.15)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C149(1.07); C96(0.85); C172(0.72)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C96(0.93); C172(1.04)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C149(0.92); C96(0.94); C172(1.02); C311(1.02)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C149(0.74); C96(0.91); C172(1.20)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C149(0.87); C96(1.02); C172(0.92)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C96(1.05); C172(0.96)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C149(1.00); C96(0.95); C172(0.96); C311(1.08)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C149(0.91); C96(0.99); C172(0.96)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C149(0.88); C96(1.01); C172(0.98)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C96(1.01); C172(1.08)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C149(1.01); C96(0.95); C172(1.05); C311(1.03)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C149(1.01); C96(1.04); C172(0.82); C311(1.08)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C149(1.13); C96(1.06); C172(1.18)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C149(1.10); C96(0.92); C172(0.96)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C96(0.94); C172(1.00)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C149(1.16); C96(1.00); C172(1.05); C311(1.02)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C149(0.85); C96(0.93); C172(0.96)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C149(1.11); C96(0.99); C172(1.04)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C96(1.11); C172(1.00)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C149(1.07); C96(0.93); C172(1.01); C311(1.01)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C149(0.72); C96(1.03); C172(0.94)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C149(0.82); C96(1.06); C172(0.93)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C149(1.17); C96(1.07); C172(0.78)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C96(1.07); C172(1.06)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C149(1.02); C96(0.96); C172(0.94); C311(1.01)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C149(0.83); C96(0.94); C172(0.96)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C149(1.04); C96(0.94); C172(0.91)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C96(0.95); C172(0.93)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C149(0.85); C96(1.05); C172(0.93); C311(1.05)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C149(0.78); C96(1.08); C172(0.91)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C149(1.14); C96(1.06); C172(0.91)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C96(1.02); C172(1.01)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C149(0.76); C96(0.83); C172(0.87); C311(0.99)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C149(0.80); C96(1.05); C172(0.89)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C149(1.03); C96(0.82); C172(0.77)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C96(1.17); C172(0.93)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C149(0.75); C96(0.79); C172(0.95)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C149(1.18); C96(1.02); C172(0.88); C311(1.00)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C149(0.88); C96(0.96); C172(0.83); C311(0.90)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C149(0.84); C96(0.95); C172(0.90)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C149(1.04); C96(1.12); C172(0.90); C311(0.95)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C149(0.76); C96(0.98); C172(0.98)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C149(0.95); C96(1.02); C172(0.74)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C149(1.12); C96(1.17); C172(0.74); C311(0.99)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C149(0.91); C96(1.10); C172(0.71)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C149(0.96); C96(0.91); C172(0.79); C311(1.03)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C149(0.90); C96(1.03); C172(0.94)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C149(0.87); C96(0.93); C172(0.96)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C96(0.99); C172(0.88)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C149(0.76); C96(1.04); C172(1.00)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C149(0.76); C96(0.91); C172(0.90)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C149(0.96); C96(1.07); C172(0.90); C311(1.07)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C149(0.58); C96(0.90); C172(0.83); C311(0.82)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C149(1.07); C96(1.11); C172(0.91); C311(0.94)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C149(0.68); C96(0.95); C172(0.72)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C149(0.91); C96(1.11); C172(0.74)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C149(0.85); C96(1.16); C172(0.75); C311(0.99)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C149(0.91); C96(1.16); C172(0.70)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C149(0.97); C96(1.03); C172(1.10); C311(1.04)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C149(0.95); C96(0.86); C172(0.89)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C96(1.01); C172(0.86)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C96(1.16); C172(1.00)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C149(1.15); C96(1.01); C172(1.02)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C149(0.96); C96(1.03); C172(0.87); C311(1.04)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C149(0.98); C96(1.07); C172(0.80); C311(0.97)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C149(0.97); C96(1.16); C172(0.93); C311(1.05)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C149(0.84); C96(0.95); C172(0.96)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C149(1.12); C96(1.12); C172(0.77)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C149(1.32); C96(1.14); C172(0.74); C311(1.01)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C149(0.78); C96(1.21); C172(0.68)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C149(1.10); C96(0.96); C172(1.00); C311(1.15)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C149(0.90); C96(0.88); C172(1.01)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C149(0.71); C96(0.93); C172(0.95)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C96(1.00); C172(0.92)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C149(1.24); C96(0.88); C172(1.01)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C149(1.42); C96(0.81); C172(0.83); C311(0.83)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C149(1.01); C96(1.01); C172(0.84); C311(1.01)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C149(1.00); C96(1.10); C172(0.84); C311(1.01)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C149(0.70); C96(0.92); C172(0.88)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C149(1.32); C96(1.06); C172(0.75)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C149(1.22); C96(1.12); C172(0.69); C311(0.97)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C149(1.10); C96(0.87); C172(0.81); C311(0.97)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C149(0.78); C96(1.12); C172(0.72)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C149(1.04); C96(0.94); C172(1.02); C311(1.05)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C149(0.85); C96(1.03); C172(1.00)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C149(0.90); C96(1.06); C172(0.95)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C96(0.92); C172(0.93)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C149(1.01); C96(0.98); C172(1.11)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C149(0.86); C96(0.94); C172(0.89); C311(0.96)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C149(1.04); C96(1.12); C172(0.90); C311(0.93)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C149(1.13); C96(1.18); C172(0.82); C311(1.01)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C149(0.91); C96(1.03); C172(0.95)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C149(0.87); C96(0.92); C172(0.84); C311(0.89)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C149(1.00); C96(1.09); C172(0.82)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C149(0.88); C96(1.13); C172(0.79); C311(0.97)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C149(0.89); C96(1.10); C172(0.70)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C149(0.97); C96(0.99); C172(0.94); C311(1.11)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C149(0.98); C96(1.04); C172(0.98)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C96(1.07); C172(0.99)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C149(0.60); C96(0.96); C172(0.94)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C149(1.03); C96(1.02); C172(0.91); C311(0.97)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C149(0.98); C96(1.00); C172(0.86); C311(0.93)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C149(0.80); C96(0.87); C172(0.63); C311(0.85)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C149(1.25); C96(1.21); C172(0.92); C311(1.10)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C149(0.96); C96(1.03); C172(0.98)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C149(1.07); C96(1.25); C172(0.82)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C149(0.96); C96(1.19); C172(0.81); C311(0.99)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C149(0.72); C96(1.08); C172(0.75)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C149(0.89); C96(1.05); C172(1.02); C311(1.08)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C149(0.70); C96(1.02); C172(0.86)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C149(0.81); C96(1.02); C172(0.87)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C96(1.10); C172(0.89)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C149(0.76); C96(1.05); C172(1.02)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C149(0.82); C96(0.94); C172(0.93)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C149(0.96); C96(0.77); C172(0.64); C311(0.77)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C149(0.90); C96(1.12); C172(0.77); C311(0.98)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C149(0.97); C96(1.04); C172(0.90); C311(0.95)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C149(0.82); C96(1.02); C172(1.00)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C149(1.11); C96(1.13); C172(0.84)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C149(0.83); C96(0.83); C172(0.67); C311(0.76)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C149(0.93); C96(1.10); C172(0.78)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C149(0.88); C96(0.88); C172(1.02); C311(1.01)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C149(0.82); C96(0.98); C172(0.99)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C149(0.78); C96(0.91); C172(0.93)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C149(0.72); C96(0.97); C172(0.96)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C311(2.05)  LDD1702  [4]
 LDCM0625  F8 Ramos C149(0.87)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C149(0.37)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C149(1.36)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C149(0.39)  LDD2191  [21]
 LDCM0576  Fragment14 Ramos C149(0.74)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C149(0.31)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C149(2.48)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C149(0.21)  LDD2196  [21]
 LDCM0588  Fragment30 Ramos C149(2.66)  LDD2199  [21]
 LDCM0590  Fragment32 Ramos C149(0.27)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C149(1.08); C96(0.98); C172(0.92)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C149(1.50)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C149(0.40)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C149(1.23); C96(1.04); C172(0.93)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C149(1.15)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C149(0.52)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C149(0.35)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C149(0.23)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y117(0.70)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y117(0.48)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y117(0.68)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y117(0.76)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y117(0.69)  LDD0268  [5]
 LDCM0107  IAA HeLa C311(0.00); H70(0.00); H317(0.00); C149(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C149(0.98); C172(1.07)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C149(0.99); C172(1.02)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C96(1.36)  LDD3310  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C311(0.89)  LDD2121  [4]
 LDCM0109  NEM HeLa C149(0.00); H317(0.00)  LDD0224  [11]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C311(0.90)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C311(1.19)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C311(1.12); C96(1.63); C149(1.59)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C149(0.70)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C149(0.48)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C311(1.26)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C149(0.43)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C96(1.09); C149(1.26)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C311(0.58); C96(0.74); C149(0.84)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C149(0.48)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C149(1.60)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C149(1.03)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C311(1.35)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C311(0.97); C96(1.06); C149(1.09)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C149(0.72)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C311(0.98); C96(1.20); C149(1.01)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C149(0.57)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C311(0.91); C96(1.37)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C311(1.28)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C311(0.43)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C311(1.62)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C311(1.28); C96(1.42)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C311(0.98); C96(1.06); C149(1.31)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C311(2.14)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C311(0.76); C96(1.01); C149(1.11)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C149(0.99)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C311(1.54)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C149(1.46)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C311(1.10)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C311(1.23)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein SEC13 homolog (SEC13) WD repeat SEC13 family P55735

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578