Details of the Target

General Information of Target

Target ID LDTP10686
Target Name RING finger and CHY zinc finger domain-containing protein 1 (RCHY1)
Gene Name RCHY1
Gene ID 25898
Synonyms
ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RING finger and CHY zinc finger domain-containing protein 1; EC 2.3.2.27; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEMASSAGSWLSGCLIPLVFLRLSVHVSGHAGDAGKFHVALLGGTAELLCPLSLWPGTVP
KEVRWLRSPFPQRSQAVHIFRDGKDQDEDLMPEYKGRTVLVRDAQEGSVTLQILDVRLED
QGSYRCLIQVGNLSKEDTVILQVAAPSVGSLSPSAVALAVILPVLVLLIMVCLCLIWKQR
RAKEKLLYEHVTEVDNLLSDHAKEKGKLHKAVKKLRSELKLKRAAANSGWRRARLHFVAV
TLDPDTAHPKLILSEDQRCVRLGDRRQPVPDNPQRFDFVVSILGSEYFTTGCHYWEVYVG
DKTKWILGVCSESVSRKGKVTASPANGHWLLRQSRGNEYEALTSPQTSFRLKEPPRCVGI
FLDYEAGVISFYNVTNKSHIFTFTHNFSGPLRPFFEPCLHDGGKNTAPLVICSELHKSEE
SIVPRPEGKGHANGDVSLKVNSSLLPPKAPELKDIILSLPPDLGPALQELKAPSF
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B . Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation.; [Isoform 4]: Has no E3 ubiquitin-protein ligase activity.
Uniprot ID
Q96PM5
Ensemble ID
ENST00000324439.10
HGNC ID
HGNC:17479

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FUOV1 SNV: p.A10S DBIA    Probe Info 
KURAMOCHI SNV: p.Y196F DBIA    Probe Info 
MOLT4 SNV: p.R54H; p.G106V IA-alkyne    Probe Info 
OPM2 SNV: p.R15Q DBIA    Probe Info 
TE10 SNV: p.R254H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-482
 Probe Info  		Y23(0.99)  LDD0285  [1]
HHS-475
 Probe Info  		Y23(1.14)  LDD0264  [2]
HHS-465
 Probe Info  		Y23(4.99)  LDD2237  [3]
DBIA
 Probe Info  		C183(0.93); C186(0.93); C119(0.91)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C20(0.00); C243(0.00); C43(0.00); C164(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C136(0.00); C172(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C136(0.00); C172(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
NAIA_5
 Probe Info  		C20(0.00); C136(0.00); C43(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C136(1.32)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C119(0.77)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C119(1.10)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C119(1.10)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C119(1.07)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C119(1.17)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C119(1.08)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C119(1.16)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C119(1.02)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C119(1.07)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C119(1.20)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C119(1.07)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C119(0.79)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C119(1.04)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C119(1.02)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C119(1.08)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C136(0.79)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C136(0.69)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C136(0.91)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C136(0.98)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C136(0.86)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C136(0.94)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C136(1.12)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C119(0.84)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C136(0.79)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C136(0.65)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C136(0.76)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C136(0.57)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C136(0.70)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C136(0.87)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C136(0.63)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C136(0.69)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C119(0.97); C136(0.82)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C119(0.91); C136(1.06)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C119(0.82); C136(1.00)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C119(1.00); C136(0.82)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C119(0.97); C136(0.82)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C119(0.89); C136(0.85)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C119(0.92); C136(0.89)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C119(0.87); C136(0.83)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C119(0.83); C136(0.94)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C119(0.77); C136(1.25)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C119(0.88); C136(1.10)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C119(0.83); C136(0.95)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C119(0.84)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C119(0.89); C136(1.11)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C119(0.92); C136(1.14)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C119(0.75); C136(0.99)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C136(1.04)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C136(1.43)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C136(1.12)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C136(1.10)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C136(1.26)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C136(1.57)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C136(1.33)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C119(0.76)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C136(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C136(1.10)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C136(1.40)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C136(1.87)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C136(1.31)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C136(1.28)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C136(1.15)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C136(1.05)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C136(1.05)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C136(1.00)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C136(0.93)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C136(1.27)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C136(1.14)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C136(0.95)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C136(1.11)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C136(1.03)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C136(1.18)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C136(1.00)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C136(1.29)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C136(1.13)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C136(1.24)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C136(1.26)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C136(1.13)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C136(1.48)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C136(1.28)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C136(1.49)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C136(1.18)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C136(1.05)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C136(1.15)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C136(1.06)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C136(0.94)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C136(0.97)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C136(1.00)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C136(1.31)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C136(1.00)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C136(1.16)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C136(1.12)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C136(0.99)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C136(0.82)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C136(0.82)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C136(1.04)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C136(0.90)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C136(0.86)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C136(1.04)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C136(1.21)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C136(0.97)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C136(0.89)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C136(0.89)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C136(0.87)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C136(0.86)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C136(1.18)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C136(0.87)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C102(1.05); C119(1.00)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C102(0.98); C119(0.95)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C102(1.11); C119(0.93)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C119(0.93)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C102(1.68); C119(0.85)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C102(1.51); C119(1.11)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C102(1.06); C119(0.96)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C102(1.27); C119(1.08)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C102(1.32); C119(1.00)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C102(1.32); C119(1.14)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C102(1.11); C119(0.87)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C102(1.20); C119(1.06)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C136(0.89); C119(0.93)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C136(0.70); C119(1.13)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C119(1.01)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C136(0.87); C119(0.99)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C136(0.82); C119(1.05)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C119(0.89); C136(0.95)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C136(0.81); C119(0.98)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C119(0.83); C136(0.84)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C119(0.87); C136(0.95)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C119(0.79); C136(0.80)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C136(0.76); C119(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C136(0.79); C119(0.89)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C119(0.80); C136(0.93)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C119(0.82)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C136(0.93); C119(0.98)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C136(0.75); C119(0.78)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C119(0.81); C136(1.05)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C119(0.94)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C119(0.87)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C119(0.91)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C119(0.95)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C119(0.86)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C119(0.88)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C119(0.95)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C119(0.96)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C119(0.90)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C119(0.81)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C119(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C119(0.85)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C119(0.99)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C119(0.83)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C119(1.02)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C119(1.17)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C119(1.12)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C119(0.64)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C119(0.80)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C119(0.79)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C183(0.93); C186(0.93); C119(0.91)  LDD0078  [4]
 LDCM0103  BDHI 10 Jurkat C62(7.44)  LDD0205  [10]
 LDCM0367  CL1 HCT 116 C119(0.71); C136(1.37)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C119(0.77); C136(1.31)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C136(0.95)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C119(1.23)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C119(0.77)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C119(0.84)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C119(0.85)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C136(1.07)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C136(0.92)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C136(1.23)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C136(1.09)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C136(0.97)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C119(0.64); C136(0.84)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C136(0.91)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C136(0.91)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C136(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C136(1.11)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C136(1.35)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C136(1.07)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C136(1.11)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C136(0.76)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C136(1.11)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C136(1.10)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C119(0.81); C136(1.07)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C136(1.09)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C136(0.92)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C136(0.74)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C136(0.61)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C136(0.80)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C102(1.11); C119(0.99)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C102(1.17); C119(1.00)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C102(0.95); C119(0.98)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C102(1.16); C119(0.89)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C119(0.72); C136(1.55)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C119(0.77); C136(0.98)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C119(0.67); C136(1.22)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C136(1.01); C119(1.03)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C119(0.76); C136(0.92)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C119(1.14); C136(1.15)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C119(0.95); C136(1.16)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C119(0.83); C136(1.22)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C119(1.02); C136(1.30)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C119(0.74); C136(1.60)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C119(0.87); C136(1.78)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C119(0.89); C136(1.21)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C119(0.91); C136(1.14)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C119(0.84); C136(1.41)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C119(0.94); C136(1.21)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C119(0.80); C136(1.25)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C119(0.91); C136(1.31)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C119(0.84); C136(1.35)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C119(0.85); C136(1.14)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C119(0.95); C136(1.24)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C102(1.22); C62(1.15); C65(1.15)  LDD1018  [4]
 LDCM0421  CL32 HCT 116 C136(1.26)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C136(1.25)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C136(1.48)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C136(1.71)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C136(1.23)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C136(1.95)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C136(1.51)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C119(0.83); C136(0.73)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C136(0.91)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C136(1.21)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C136(0.98)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C136(1.24)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C136(1.47)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C136(1.57)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C62(0.70); C65(0.70)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C62(0.62); C65(0.62)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C62(0.94); C65(0.94)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C62(0.89); C65(0.89)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C119(0.87); C136(1.10)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C62(0.59); C65(0.59)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C62(0.74); C65(0.74)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C62(0.65); C65(0.65)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C62(0.91); C65(0.91)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C62(0.67); C65(0.67)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C62(0.80); C65(0.80)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C62(0.79); C65(0.79)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C62(0.60); C65(0.60)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C62(0.80); C65(0.80)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C62(0.93); C65(0.93)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C119(0.85); C136(0.95)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C62(0.87); C65(0.87)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C136(1.54)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C136(1.39)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C136(1.31)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C136(1.86)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C136(1.78)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C136(1.42)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C136(1.21)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C136(1.35)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C136(1.43)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C119(0.88); C136(1.15)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C136(1.14)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C136(1.50)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C136(1.44)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C136(1.23)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C136(1.26)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C119(0.84); C136(1.11)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C119(0.69); C136(1.15)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C119(0.86); C136(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C119(0.91); C136(1.14)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C119(0.64); C136(1.35)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C119(0.98); C136(0.99)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C119(0.98); C136(1.27)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C119(0.92); C136(1.12)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C119(0.88); C136(0.94)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C119(0.84); C136(1.26)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C119(0.82); C136(1.23)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C119(0.84); C136(1.08)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C119(0.85); C136(1.15)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C119(0.85); C136(1.10)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C119(1.04); C136(1.11)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C119(0.76); C136(1.28)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C119(0.64); C136(0.89)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C136(1.14)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C136(0.87)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C136(1.35)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C136(1.15)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C136(1.28)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C136(1.23)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C136(1.40)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C136(1.26)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C136(1.32)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C243(1.14); C20(1.11); C43(1.04); C136(1.07)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C136(0.99)  LDD1702  [12]
 LDCM0586  Fragment28 Ramos C136(0.78)  LDD2198  [13]
 LDCM0468  Fragment33 HCT 116 C136(1.27)  LDD0785  [4]
 LDCM0566  Fragment4 Ramos C136(0.64)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C136(1.17)  LDD0744  [4]
 LDCM0569  Fragment7 Ramos C136(0.68)  LDD2186  [13]
 LDCM0116  HHS-0101 DM93 Y23(1.14)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y23(0.88)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y23(0.99)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y23(0.89)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y23(1.08)  LDD0268  [2]
 LDCM0123  JWB131 DM93 Y23(0.99)  LDD0285  [1]
 LDCM0124  JWB142 DM93 Y23(0.75)  LDD0286  [1]
 LDCM0125  JWB146 DM93 Y23(1.16)  LDD0287  [1]
 LDCM0126  JWB150 DM93 Y23(2.52)  LDD0288  [1]
 LDCM0127  JWB152 DM93 Y23(1.89)  LDD0289  [1]
 LDCM0128  JWB198 DM93 Y23(1.04)  LDD0290  [1]
 LDCM0129  JWB202 DM93 Y23(0.47)  LDD0291  [1]
 LDCM0130  JWB211 DM93 Y23(1.01)  LDD0292  [1]
 LDCM0022  KB02 HCT 116 C243(1.37); C119(1.09); C136(1.36)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C243(1.50); C119(1.29); C136(1.09)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C243(1.46); C119(1.28); C136(1.08)  LDD0082  [4]
 LDCM0021  THZ1 HCT 116 C183(1.31); C186(1.31); C102(1.27); C105(1.27)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen-induced gene 1 protein (AIG1) AIG1 family Q9NVV5
Beta-hexosaminidase subunit beta (HEXB) Glycosyl hydrolase 20 family P07686
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Serine/threonine-protein kinase NLK (NLK) CMGC Ser/Thr protein kinase family Q9UBE8
ADP-ribosylation factor 4 (ARF4) Arf family P18085
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Semaphorin-4C (SEMA4C) Semaphorin family Q9C0C4
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiopoietin-like protein 8 (ANGPTL8) ANGPTL8 family Q6UXH0
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Protein naked cuticle homolog 2 (NKD2) NKD family Q969F2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Histidine-rich glycoprotein (HRG) . P04196
Kelch-like protein 41 (KLHL41) . O60662
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WD repeat-containing protein 74 (WDR74) . Q6RFH5

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578