Details of the Target

General Information of Target

Target ID LDTP03711
Target Name Catenin alpha-1 (CTNNA1)
Gene Name CTNNA1
Gene ID 1495
Synonyms
Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV
LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK
RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN
RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER
FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER
SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA
QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA
QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR
TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS
DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED
DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC
MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL
QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS
TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF
KAMDSI
Target Bioclass
Other
Family
Vinculin/alpha-catenin family
Subcellular location
Cytoplasm, cytoskeleton; Cell membrane
Function
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. May play a crucial role in cell differentiation.
Uniprot ID
P35221
Ensemble ID
ENST00000302763.12
HGNC ID
HGNC:2509
ChEMBL ID
CHEMBL4295748

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.E865Ter DBIA    Probe Info 
CORL88 SNV: p.Q206Ter DBIA    Probe Info 
FTC133 SNV: p.S322L DBIA    Probe Info 
HCC1187 SNV: p.Q678Ter DBIA    Probe Info 
HCT15 SNV: p.C767Ter DBIA    Probe Info 
HT115 SNV: p.R451Ter DBIA    Probe Info 
IGROV1 SNV: p.T654M DBIA    Probe Info 
KYSE510 SNV: p.S600T DBIA    Probe Info 
LOXIMVI SNV: p.S515L DBIA    Probe Info 
LS180 SNV: p.R54C DBIA    Probe Info 
MEWO SNV: p.L676P DBIA    Probe Info 
MFE296 SNV: p.D613Y DBIA    Probe Info 
MFE319 SNV: p.S599N DBIA    Probe Info 
NB1 SNV: p.K120Ter .
PF382 SNV: p.E299A; p.A784T .
RKO SNV: p.K867T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.78  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		K695(0.85)  LDD0274  [4]
STPyne
 Probe Info  		K120(5.00); K16(10.00); K181(7.46); K186(5.71)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K199(1.43); K748(2.15); K16(3.72)  LDD3494  [5]
Probe 1
 Probe Info  		Y177(22.25)  LDD3495  [6]
BTD
 Probe Info  		C337(1.99); C772(1.50)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C116(2.41)  LDD0169  [8]
DBIA
 Probe Info  		C526(9.55)  LDD0205  [9]
HHS-475
 Probe Info  		Y779(0.62); Y177(0.72); Y280(0.83)  LDD0264  [10]
5E-2FA
 Probe Info  		H890(0.00); H231(0.00); H5(0.00); H766(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K186(0.00); K737(0.00); K57(0.00); K75(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C526(0.00); C337(0.00); C324(0.00); C438(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C767(0.00); C526(0.00); C337(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C526(0.00); C337(0.00); C324(0.00); C116(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K370(0.00); K45(0.00); K120(0.00)  LDD0035  [15]
IPM
 Probe Info  		N.A.  LDD0025  [16]
TFBX
 Probe Info  		C116(0.00); C337(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C116(0.00); C337(0.00)  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		C116(0.00); C337(0.00)  LDD0006  [17]
NHS
 Probe Info  		K45(0.00); K842(0.00); K186(0.00)  LDD0010  [17]
PF-06672131
 Probe Info  		C116(0.00); C337(0.00)  LDD0152  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C116(0.00); C324(0.00)  LDD0018  [20]
Ox-W18
 Probe Info  		N.A.  LDD2175  [21]
1c-yne
 Probe Info  		K577(0.00); K429(0.00); K45(0.00); K834(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C324(0.00); C438(0.00); C116(0.00); C772(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		C116(0.00); C337(0.00); C767(0.00); C772(0.00)  LDD0218  [23]
W1
 Probe Info  		C116(0.00); C461(0.00)  LDD0236  [24]
AOyne
 Probe Info  		8.10  LDD0443  [25]
NAIA_5
 Probe Info  		C116(0.00); C461(0.00); C228(0.00); C772(0.00)  LDD2223  [26]
HHS-482
 Probe Info  		Y148(1.01)  LDD2239  [27]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		15.04  LDD0475  [28]
FFF probe14
 Probe Info  		12.78  LDD0477  [28]
FFF probe3
 Probe Info  		19.49  LDD0464  [28]
JN0003
 Probe Info  		20.00  LDD0469  [28]
STS-1
 Probe Info  		1.33  LDD0137  [29]
STS-2
 Probe Info  		1.00  LDD0139  [29]
OEA-DA
 Probe Info  		3.17  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C337(0.33); C438(0.35)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C337(0.58); C438(0.54)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C337(0.67); C116(0.96); C438(0.98); C767(0.95)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C772(0.87); C337(1.01)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C772(0.67); C337(0.39); C116(0.59)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C772(0.97); C337(0.61)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C720(2.18)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C116(2.41)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C116(1.04); C228(0.81); C324(1.00); C461(1.03)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C116(0.92); C228(0.99); C324(0.99); C461(0.89)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C116(0.92); C228(0.96); C324(1.02); C461(0.88)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C116(1.02); C228(0.92); C324(1.01); C461(0.95)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C116(0.95); C228(0.95); C324(1.05); C461(0.84)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C116(0.97); C228(0.99); C324(0.95); C461(0.86)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C116(1.05); C228(0.91); C324(0.99); C461(0.90)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C116(0.96); C228(0.89); C324(1.04); C461(0.89)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C116(0.89); C228(0.87); C324(0.99); C461(0.81)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C116(0.96); C228(1.10); C324(1.02); C461(0.98)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C116(1.01); C228(0.93); C324(0.96); C461(0.81)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C116(0.96); C228(0.98); C324(1.09); C461(0.92)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C116(0.81); C228(0.91); C324(1.04); C461(0.94)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C116(0.99); C228(0.92); C324(0.93); C461(0.94)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C116(0.93); C228(0.90); C324(1.14); C461(1.02)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C116(1.08); C228(0.89); C324(0.98); C461(0.83)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C116(0.93); C228(0.95); C324(1.04); C461(0.92)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C116(0.89); C228(0.94); C324(1.00); C461(0.86)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C116(0.99); C228(0.98); C324(1.06); C461(0.80)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C116(1.00); C228(0.94); C324(1.05); C461(0.99)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C116(0.89); C228(1.02); C324(1.07); C461(0.80)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C116(0.94); C228(0.88); C324(1.07); C461(0.88)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C116(0.98); C228(0.99); C324(1.05); C461(1.00)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C116(0.95); C228(0.97); C324(1.06); C461(0.99)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C116(1.01); C228(0.78); C324(0.97); C461(0.94)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C116(1.02); C228(0.92); C324(1.02); C461(0.97)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C116(0.90); C228(0.98); C324(0.95); C461(0.88)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C116(0.92); C228(0.85); C324(1.07); C461(0.93)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C116(0.99); C228(1.06); C324(1.17); C461(0.99)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C116(0.97); C228(0.89); C324(1.03); C461(0.84)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C116(1.01); C228(0.94); C324(0.98); C461(1.00)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C116(0.89); C228(0.97); C324(1.06); C461(0.89)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C116(0.91); C228(0.85); C324(1.02); C461(1.06)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C116(1.00); C228(0.95); C324(0.93); C461(0.87)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C116(0.93); C228(0.93); C324(1.02); C461(0.86)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C116(0.92); C228(1.07); C324(0.99); C461(0.91)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C116(0.98); C228(0.95); C324(0.98); C461(1.02)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C116(1.02); C228(1.03); C324(1.02); C461(0.96)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C116(0.97); C228(0.92); C324(0.98); C461(0.90)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C116(0.98); C228(1.04); C324(1.04); C461(0.94)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C116(0.88); C228(0.92); C324(1.04); C461(0.97)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C116(1.02); C228(0.88); C324(0.99); C461(0.85)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C116(0.98); C228(1.15); C324(1.15); C461(0.96)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C116(0.97); C228(1.01); C324(0.97); C461(0.92)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C116(0.93); C228(1.00); C324(0.97); C461(0.83)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C116(0.97); C228(0.93); C324(1.10); C461(0.87)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C116(0.98); C228(1.07); C324(1.02); C461(0.90)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C116(0.95); C228(0.92); C324(1.02); C461(0.87)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C116(0.99); C228(0.98); C324(0.98); C461(0.99)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C116(0.90); C228(0.87); C324(1.00); C461(0.96)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C116(1.03); C228(0.72); C324(1.03); C461(0.89)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C116(1.04); C228(0.97); C324(1.00); C461(0.95)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C116(0.93); C228(0.97); C324(1.00); C461(0.98)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C116(1.03); C228(0.94); C324(1.04); C461(0.97)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C116(0.97); C228(0.86); C324(0.98); C461(0.84)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C116(1.05); C228(0.90); C324(1.05); C461(0.99)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C116(0.97); C228(0.85); C324(1.05); C461(0.79)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C116(1.05); C228(0.84); C324(0.93); C461(0.96)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C116(0.97); C228(0.83); C324(1.04); C461(1.01)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C116(0.97); C228(1.02); C324(0.98); C461(0.94)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C116(0.99); C228(0.98); C324(1.01); C461(0.98)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C772(0.73); C337(0.50)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C337(0.75); C438(0.70)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C116(0.98); C228(1.07); C324(1.06); C461(1.04)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C116(1.00); C228(0.97); C324(1.01); C461(0.95)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C116(0.95); C228(0.90); C324(0.95); C461(0.92)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0103  BDHI 10 Jurkat C526(9.55)  LDD0205  [9]
 LDCM0498  BS-3668 MDA-MB-231 C772(0.78); C438(0.79)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C116(0.00); C324(0.00); C337(0.00); H59(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C787(2.14); C324(2.12)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C116(0.98); C228(0.94); C324(1.07); C461(0.86)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C116(1.01); C228(0.81); C324(0.99); C461(0.77)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C116(0.89); C228(1.09); C324(1.01); C461(0.82)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C116(1.00); C228(0.98); C324(1.03); C461(0.91)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C116(0.91); C228(1.00); C324(0.97); C461(0.96)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C116(0.91); C228(0.92); C324(1.06); C461(0.81)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C116(0.96); C228(1.09); C324(1.01); C461(0.88)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C116(0.92); C228(0.94); C324(1.01); C461(1.00)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C116(0.92); C228(1.00); C324(0.94); C461(1.06)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C116(0.90); C228(0.90); C324(1.07); C461(0.84)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C116(1.01); C228(0.92); C324(0.98); C461(0.86)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C116(0.98); C228(0.88); C324(1.12); C461(0.94)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C116(1.12); C228(1.01); C324(0.87); C461(1.13)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C116(0.94); C228(0.88); C324(0.85); C461(0.91)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C116(0.87); C228(0.87); C324(1.05); C461(0.83)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C116(0.90); C228(0.94); C324(0.92); C461(0.84)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C116(0.95); C228(0.92); C324(0.99); C461(0.80)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C116(0.91); C228(0.91); C324(0.91); C461(0.88)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C116(0.87); C228(0.99); C324(1.19); C461(0.87)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C116(0.95); C228(0.99); C324(1.01); C461(0.89)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C116(0.95); C228(0.85); C324(0.98); C461(1.11)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C116(1.01); C228(0.93); C324(0.99); C461(0.94)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C116(0.93); C228(0.92); C324(1.10); C461(0.86)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C116(1.38); C228(0.93); C324(1.02); C461(1.01)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C116(0.96); C228(1.03); C324(1.04); C461(0.85)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C116(0.98); C228(0.99); C324(1.04); C461(0.88)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C116(0.97); C228(0.98); C324(1.01); C461(1.03)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C116(0.87); C228(0.82); C324(1.08); C461(0.84)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C116(0.88); C228(1.04); C324(0.98); C461(0.89)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C116(1.00); C228(0.93); C324(0.93); C461(1.02)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C116(0.97); C228(0.83); C324(0.92); C461(1.08)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C116(0.89); C228(0.89); C324(1.12); C461(1.02)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C116(1.01); C228(0.92); C324(0.94); C461(0.92)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C116(1.00); C228(0.94); C324(0.97); C461(0.91)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C116(0.96); C228(0.86); C324(0.98); C461(1.10)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C116(0.82); C228(0.82); C324(1.05); C461(0.83)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C116(1.10); C228(1.01); C324(0.97); C461(0.97)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C116(0.87); C228(0.79); C324(0.86); C461(0.89)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C116(0.98); C228(0.94); C324(1.05); C461(1.15)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C116(1.00); C228(1.05); C324(0.98); C461(1.11)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C116(1.04); C228(1.03); C324(0.97); C461(1.06)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C116(1.27); C228(0.94); C324(0.92); C461(1.09)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C116(1.00); C228(0.84); C324(0.79); C461(0.97)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C116(1.00); C228(0.93); C324(0.99); C461(0.92)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C116(1.02); C228(1.09); C324(0.86); C461(1.07)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C116(1.37); C228(0.92); C324(1.10); C461(1.11)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C116(0.86); C228(0.91); C324(0.98); C461(0.70)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C116(1.00); C228(1.00); C324(1.00); C461(0.98)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C116(0.96); C228(0.96); C324(1.10); C461(0.88)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C116(0.99); C228(1.01); C324(0.96); C461(1.01)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C116(0.92); C228(0.93); C324(0.96); C461(0.91)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C116(0.92); C228(1.01); C324(1.08); C461(0.85)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C116(1.01); C228(1.04); C324(1.00); C461(0.95)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C116(1.02); C228(0.94); C324(1.01); C461(0.98)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C116(1.27); C228(0.93); C324(0.93); C461(0.98)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C116(0.87); C228(0.83); C324(0.99); C461(0.87)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C116(0.89); C228(0.90); C324(0.97); C461(0.82)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C116(1.02); C228(1.02); C324(0.82); C461(1.07)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C116(1.42); C228(0.78); C324(1.01); C461(0.99)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C116(0.88); C228(0.96); C324(1.03); C461(0.96)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C116(0.88); C228(0.86); C324(0.76); C461(1.07)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C116(1.24); C228(1.04); C324(1.01); C461(0.93)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C116(1.00); C228(0.98); C324(0.93); C461(1.10)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C116(0.90); C228(0.77); C324(0.99); C461(0.83)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C116(0.95); C228(0.94); C324(1.01); C461(1.11)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C116(1.07); C228(1.19); C324(0.95); C461(1.08)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C116(1.21); C228(0.96); C324(0.93); C461(0.90)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C116(0.97); C228(0.81); C324(0.97); C461(1.09)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C116(1.05); C228(0.86); C324(0.97); C461(0.77)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C116(1.01); C228(0.99); C324(1.03); C461(1.00)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C116(1.28); C228(0.87); C324(0.99); C461(1.13)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C116(1.05); C228(0.96); C324(1.15); C461(1.02)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C116(1.06); C228(0.92); C324(0.94); C461(1.06)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C116(0.99); C228(0.90); C324(0.96); C461(0.93)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C116(0.97); C228(1.07); C324(0.94); C461(0.96)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C116(0.97); C228(0.82); C324(0.92); C461(0.90)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C116(0.85); C228(0.94); C324(0.90); C461(0.99)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C116(1.01); C228(0.98); C324(0.99); C461(1.18)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C116(1.27); C228(0.87); C324(0.86); C461(1.10)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C116(0.96); C228(0.78); C324(0.95); C461(1.15)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C116(0.98); C228(0.98); C324(0.95); C461(0.88)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C116(1.00); C228(0.95); C324(0.99); C461(1.02)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C116(1.00); C228(0.86); C324(1.05); C461(0.68)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C116(1.27); C228(0.88); C324(0.98); C461(1.18)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C116(0.98); C228(0.99); C324(0.99); C461(0.95)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C116(1.10); C228(1.08); C324(0.96); C461(1.11)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C116(0.92); C228(0.95); C324(1.08); C461(0.96)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C116(0.97); C228(0.88); C324(1.00); C461(0.85)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C116(1.04); C228(0.94); C324(1.00); C461(1.02)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C116(0.95); C228(0.88); C324(1.04); C461(1.01)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C116(1.05); C228(0.93); C324(1.00); C461(0.98)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C116(1.18); C228(0.84); C324(0.95); C461(1.00)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C116(0.99); C228(0.96); C324(1.06); C461(1.05)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C116(1.00); C228(1.12); C324(1.04); C461(1.04)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C116(0.97); C228(0.91); C324(1.02); C461(0.94)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C116(1.01); C228(0.86); C324(0.95); C461(1.02)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C116(1.31); C228(0.91); C324(0.96); C461(1.02)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C116(0.93); C228(0.95); C324(1.04); C461(0.88)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C116(1.03); C228(0.98); C324(0.97); C461(0.98)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C116(0.97); C228(1.03); C324(0.94); C461(0.93)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C116(0.94); C228(0.78); C324(0.96); C461(0.86)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C116(0.97); C228(0.91); C324(1.03); C461(1.06)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C116(0.97); C228(1.12); C324(1.06); C461(1.14)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C116(0.92); C228(0.58); C324(0.81); C461(0.73)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C116(1.16); C228(0.96); C324(1.00); C461(1.11)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C116(1.01); C228(1.04); C324(1.00); C461(1.09)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C116(0.99); C228(0.87); C324(0.97); C461(1.08)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C116(1.08); C228(0.98); C324(0.88); C461(0.99)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C116(1.24); C228(0.90); C324(0.93); C461(1.06)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C116(0.99); C228(0.93); C324(0.97); C461(0.98)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C116(0.94); C228(0.82); C324(1.02); C461(1.02)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C116(0.94); C228(0.92); C324(1.13); C461(0.89)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C116(1.03); C228(1.03); C324(0.97); C461(0.89)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C116(1.07); C228(0.84); C324(1.04); C461(0.95)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C116(1.17); C228(1.10); C324(0.97); C461(1.17)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C116(0.93); C228(0.73); C324(0.85); C461(0.80)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C116(1.05); C228(1.09); C324(1.07); C461(1.05)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C116(1.01); C228(0.83); C324(0.92); C461(0.90)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C116(1.02); C228(0.85); C324(0.98); C461(1.02)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C116(1.19); C228(0.80); C324(1.02); C461(0.85)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C116(0.98); C228(0.80); C324(0.77); C461(0.78)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C116(1.29); C228(0.78); C324(1.09); C461(0.98)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C116(0.95); C228(0.88); C324(1.11); C461(0.81)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C116(0.93); C228(0.94); C324(0.99); C461(0.96)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C116(0.93); C228(0.93); C324(1.01); C461(0.94)  LDD1697  [31]
 LDCM0634  CY-0357 Hep-G2 C116(0.88)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C116(0.92); C228(0.85); C324(1.11); C461(0.98)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C772(2.29); C116(1.40); C337(1.00)  LDD1702  [7]
 LDCM0468  Fragment33 HEK-293T C116(0.87); C228(0.97); C324(1.00); C461(0.84)  LDD1671  [31]
 LDCM0427  Fragment51 HEK-293T C116(0.94); C228(0.95); C324(0.91); C461(1.04)  LDD1631  [31]
 LDCM0116  HHS-0101 DM93 Y779(0.62); Y177(0.72); Y280(0.83)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y779(0.44); Y177(0.50); Y280(2.22)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y177(0.57); Y280(0.61); Y779(0.74)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y177(0.56); Y779(0.94); Y280(1.20)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y177(0.78); Y280(1.04); Y779(1.17)  LDD0268  [10]
 LDCM0107  IAA HeLa C337(0.00); C438(0.00); C324(0.00)  LDD0221  [23]
 LDCM0022  KB02 HEK-293T C767(1.11); C772(1.00); C116(0.96); C526(0.93)  LDD1492  [31]
 LDCM0023  KB03 HEK-293T C767(0.94); C772(1.05); C116(1.00); C526(0.98)  LDD1497  [31]
 LDCM0024  KB05 HMCB C526(2.71); C91(1.34)  LDD3312  [32]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C772(1.07)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C772(0.92); C116(0.99)  LDD2121  [7]
 LDCM0109  NEM HeLa H554(0.00); H59(0.00)  LDD0223  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C337(1.01)  LDD2090  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C772(0.82); C337(1.01)  LDD2093  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C116(1.50)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C337(0.79)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C772(0.46)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C772(0.86); C116(1.00)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C337(0.45)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C337(0.85); C438(0.77)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C337(0.42); C767(0.63)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C772(1.26)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C772(0.58); C337(0.37); C438(0.31); C767(0.62)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C772(0.55); C337(1.12); C116(1.02); C438(1.01)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C772(0.62); C337(0.38)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C337(0.46)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C772(1.03); C337(0.87)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C116(1.21)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C337(0.56); C438(0.43)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C772(0.50); C337(0.44); C438(0.42)  LDD2115  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C337(0.70); C787(0.77)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C772(0.75); C116(1.05)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C116(0.62)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C337(0.69); C116(0.98); C438(1.00)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C116(1.00)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C772(0.62); C337(0.88); C767(0.70); C228(0.55)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C787(0.43)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C772(0.98); C337(0.82)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C337(0.51)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C772(0.51); C337(0.45); C438(0.51)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C337(0.93)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C772(1.03); C116(1.34); C438(1.04); C228(1.26)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C772(0.83); C337(0.75); C116(0.88); C438(1.03)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C337(1.99); C772(1.50)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C772(0.72); C337(0.64); C116(1.02)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C337(0.44); C438(0.46)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C337(2.26); C116(2.01)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C337(2.73)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C772(0.93); C337(0.63); C767(1.07)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C337(1.92); C787(1.02)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C772(0.66); C337(0.52); C438(0.48)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C772(0.95); C116(0.38)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C772(1.96); C337(2.37)  LDD2153  [7]
 LDCM0112  W16 Hep-G2 C116(1.51)  LDD0239  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor alpha (NFKBIA) NF-kappa-B inhibitor family P25963
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Catenin alpha-1 (CTNNA1) Vinculin/alpha-catenin family P35221
Centrosome-associated protein 350 (CEP350) . Q5VT06
LIM domain and actin-binding protein 1 (LIMA1) . Q9UHB6
Protein ECT2 (ECT2) . Q9H8V3
Rac GTPase-activating protein 1 (RACGAP1) . Q9H0H5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840