Details of the Target

General Information of Target

Target ID LDTP06261
Target Name Ataxin-7-like protein 3 (ATXN7L3)
Gene Name ATXN7L3
Synonyms
Ataxin-7-like protein 3; SAGA-associated factor 11 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKD
FEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRI
ANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNS
DPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIY
FLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGT
NSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN
Target Bioclass
Other
Family
SGF11 family
Subcellular location
Nucleus
Function
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B. {|HAMAP-Rule:MF_03047}.
Uniprot ID
Q14CW9
Ensemble ID
ENST00000389384.8
HGNC ID
HGNC:25416

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.G319W .
HT SNV: p.A18D .
JURKAT SNV: p.A20T .
LNCaP clone FGC SNV: p.A20T .
NCIH358 SNV: p.G46C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C226(5.13)  LDD0205  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C45(0.98)  LDD1509  [2]
 LDCM0278  AC19 HEK-293T C45(0.99)  LDD1517  [2]
 LDCM0287  AC27 HEK-293T C45(1.10)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C45(1.08)  LDD1529  [2]
 LDCM0296  AC35 HEK-293T C45(0.93)  LDD1535  [2]
 LDCM0305  AC43 HEK-293T C45(1.14)  LDD1544  [2]
 LDCM0314  AC51 HEK-293T C45(0.94)  LDD1553  [2]
 LDCM0322  AC59 HEK-293T C45(1.07)  LDD1561  [2]
 LDCM0103  BDHI 10 Jurkat C226(5.13)  LDD0205  [1]
 LDCM0406  CL19 HEK-293T C45(1.20)  LDD1610  [2]
 LDCM0420  CL31 HEK-293T C45(0.96)  LDD1624  [2]
 LDCM0433  CL43 HEK-293T C45(0.86)  LDD1637  [2]
 LDCM0446  CL55 HEK-293T C45(0.80)  LDD1649  [2]
 LDCM0459  CL67 HEK-293T C45(0.97)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C45(0.98)  LDD1665  [2]
 LDCM0472  CL79 HEK-293T C45(0.84)  LDD1675  [2]
 LDCM0486  CL91 HEK-293T C45(1.08)  LDD1689  [2]
 LDCM0022  KB02 786-O C233(1.27)  LDD2247  [3]
 LDCM0023  KB03 A2058 C233(1.35)  LDD2670  [3]
 LDCM0024  KB05 MOLM-13 C233(0.99)  LDD3333  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription and mRNA export factor ENY2 (ENY2) ENY2 family Q9NPA8

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840