Details of the Target

General Information of Target

Target ID LDTP14141
Target Name Mannose-1-phosphate guanyltransferase beta (GMPPB)
Gene Name GMPPB
Gene ID 29925
Synonyms
Mannose-1-phosphate guanyltransferase beta; EC 2.7.7.13; GDP-mannose pyrophosphorylase B; GTP-mannose-1-phosphate guanylyltransferase beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDE
TEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESG
YGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQK
YFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGID
FKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKK
KSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFS
SVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQL
VVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHV
VETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPL
NNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKR
EYPKFLKRFTSYVQEKTAGKPILF
Target Bioclass
Enzyme
Family
Transferase hexapeptide repeat family
Subcellular location
Cytoplasm
Function Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
Uniprot ID
Q9Y5P6
Ensemble ID
ENST00000308375.10
HGNC ID
HGNC:22932

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNGM SNV: p.R94C DBIA    Probe Info 
SNU478 SNV: p.S352L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.28  LDD0402  [1]
TH211
 Probe Info  		Y10(19.20)  LDD0257  [2]
Probe 1
 Probe Info  		Y10(16.10); Y144(41.77)  LDD3495  [3]
BTD
 Probe Info  		C149(1.03)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C149(2.89)  LDD0171  [5]
EA-probe
 Probe Info  		C245(0.44)  LDD2210  [6]
DBIA
 Probe Info  		C306(9.76)  LDD0205  [7]
HHS-482
 Probe Info  		Y144(1.05)  LDD0285  [8]
HHS-475
 Probe Info  		Y10(0.93)  LDD0264  [9]
HHS-465
 Probe Info  		Y10(10.00); Y144(10.00)  LDD2237  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C113(0.00); C245(0.00); C306(0.00); C149(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C113(0.00); C245(0.00); C306(0.00); C149(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C230(0.00); C113(0.00); C245(0.00); C306(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C230(0.00); C245(0.00)  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		N.A.  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Acrolein
 Probe Info  		C149(0.00); C245(0.00)  LDD0217  [17]
W1
 Probe Info  		C245(0.00); C149(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C230(0.00); C113(0.00); C306(0.00); C245(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C086
 Probe Info  		5.06  LDD1778  [20]
C143
 Probe Info  		12.82  LDD1825  [20]
C194
 Probe Info  		8.75  LDD1870  [20]
C217
 Probe Info  		6.54  LDD1891  [20]
C218
 Probe Info  		10.93  LDD1892  [20]
C280
 Probe Info  		9.45  LDD1950  [20]
C403
 Probe Info  		14.32  LDD2061  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C149(2.89)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C149(1.03); C306(0.99); C245(1.07); C230(0.90)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C149(0.91); C29(1.12); C306(0.90); C245(1.07)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C149(0.93); C29(0.91); C306(0.99); C245(0.91)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C149(0.94); C29(0.80); C306(0.96); C245(1.03)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C149(1.06); C29(0.81); C306(1.02); C245(0.92)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C149(1.04); C306(1.00); C245(1.00); C230(1.02)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C149(0.99); C306(1.02); C245(1.12); C230(0.86)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C149(1.04); C29(0.89); C306(0.88); C245(1.03)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C149(0.91); C29(0.81); C306(0.79); C245(0.85)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C149(0.88); C29(1.00); C306(0.99); C245(1.05)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C149(0.98); C29(0.78); C306(0.93); C245(0.97)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C149(0.93); C29(0.93); C306(0.98); C245(0.94)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C149(0.92); C29(0.84); C306(0.97); C245(1.20)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C149(0.88); C306(0.93); C245(1.02); C230(1.03)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C149(1.08); C29(0.86); C306(0.96); C245(1.11)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C149(0.96); C306(0.99); C245(1.11); C230(0.87)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C149(0.99); C29(1.04); C306(0.97); C245(0.93)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C149(1.06); C29(0.76); C306(0.98); C245(1.00)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C149(0.90); C29(0.81); C306(0.84); C245(1.02)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C149(1.05); C29(0.82); C306(1.01); C245(0.89)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C149(0.90); C29(0.89); C306(1.02); C245(0.92)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C149(1.00); C29(1.10); C306(0.94); C245(0.90)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C149(0.96); C306(0.96); C245(1.09); C230(0.97)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C149(1.07); C29(0.83); C306(0.94); C245(1.09)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C149(1.02); C306(0.96); C245(1.08); C230(0.88)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C149(1.06); C29(0.97); C306(0.90); C245(1.06)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C149(0.88); C29(0.78); C306(1.06); C245(0.95)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C149(0.93); C29(0.84); C306(0.97); C245(1.02)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C149(1.07); C29(0.98); C306(1.14); C245(1.03)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C149(1.11); C29(0.76); C306(0.96); C245(0.74)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C149(0.95); C306(0.99); C245(1.04); C230(0.95)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C149(0.92); C29(0.81); C306(1.00); C245(1.03)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C149(0.97); C29(0.87); C306(0.94); C245(1.10)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C149(0.93); C306(0.96); C245(1.09); C230(0.92)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C149(0.82); C29(1.02); C306(0.86); C245(1.14)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C149(0.98); C29(0.82); C306(1.12); C245(0.92)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C149(1.18); C29(0.77); C306(1.09); C245(1.05)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C149(1.06); C29(0.86); C306(1.06); C245(1.03)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C149(0.94); C29(0.97); C306(1.09); C245(0.83)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C149(0.98); C306(0.87); C245(1.11); C230(1.22)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C149(0.95); C29(0.85); C306(0.96); C245(1.10)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C149(0.88); C306(0.95); C245(1.03); C230(0.90)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C149(1.04); C29(0.90); C306(1.02); C245(1.04)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C149(0.92); C29(0.98); C306(0.88); C245(0.95)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C149(0.98); C29(0.88); C306(1.16); C245(0.92)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C149(0.93); C29(0.81); C306(1.02); C245(0.96)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C149(0.92); C29(0.83); C306(1.05); C245(1.04)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C149(1.08); C29(0.83); C306(1.01); C245(0.85)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C149(0.94); C306(0.99); C245(1.01); C230(0.94)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C149(1.01); C29(0.84); C306(0.92); C245(1.12)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C149(0.97); C306(0.84); C245(1.20); C230(1.03)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C149(1.01); C29(1.13); C306(1.02); C245(1.12)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C149(0.98); C29(0.88); C306(0.97); C245(0.97)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C149(0.95); C29(0.91); C306(0.96); C245(0.80)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C149(0.96); C29(0.83); C306(0.92); C245(1.03)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C149(1.04); C29(1.03); C306(0.95); C245(1.03)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C149(0.98); C29(0.95); C306(1.04); C245(1.01)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C149(0.99); C306(0.96); C245(1.05); C230(1.06)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C149(1.06); C29(0.88); C306(0.98); C245(1.15)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C149(0.92); C306(0.86); C245(0.93); C230(1.03)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C149(1.06); C29(0.91); C306(0.92); C245(1.02)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C149(0.97); C29(0.92); C306(1.01); C245(1.04)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C149(1.01); C306(0.90); C245(1.07); C230(0.85)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C149(0.97); C29(0.86); C306(0.99); C245(0.99)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0103  BDHI 10 Jurkat C306(9.76)  LDD0205  [7]
 LDCM0630  CCW28-3 231MFP C245(2.07)  LDD2214  [23]
 LDCM0108  Chloroacetamide HeLa C306(0.00); H126(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C149(1.01); C29(0.97); C306(1.39); C245(0.87)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C149(0.86); C29(1.30); C306(0.99); C245(0.63)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C149(0.97); C29(0.86); C306(0.98); C245(0.95)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C149(0.90); C29(0.87); C306(1.00); C245(0.98)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C149(0.94); C29(0.48); C306(0.73); C245(0.95)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C149(0.90); C29(0.76); C306(0.99); C245(1.02)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C149(1.05); C29(0.79); C306(0.98); C245(0.93)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C149(1.02); C29(0.92); C306(1.02); C245(1.02)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C149(1.04); C29(0.96); C306(0.83); C245(0.94)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C149(1.03); C29(0.95); C306(1.00); C245(1.03)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C149(0.95); C29(0.70); C306(1.03); C245(1.05)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C149(0.97); C29(0.93); C306(0.97); C245(0.94)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C149(0.92); C306(0.93); C245(0.75); C230(1.05)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C149(0.87); C29(0.76); C306(0.78); C245(0.92)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C149(0.92); C29(0.82); C306(0.93); C245(0.93)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C149(0.97); C29(0.72); C306(0.92); C245(0.95)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C149(1.01); C29(0.86); C306(1.13); C245(0.98)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C149(0.89); C29(0.74); C306(0.85); C245(1.04)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C149(0.88); C29(0.90); C306(1.08); C245(1.01)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C149(0.93); C29(0.73); C306(1.04); C245(1.02)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C149(0.96); C29(0.83); C306(1.01); C245(1.01)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C149(1.16); C29(0.76); C306(0.83); C245(0.98)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C149(1.04); C29(1.00); C306(1.12); C245(1.00)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C149(0.96); C29(1.88); C306(1.02); C245(0.87)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C149(1.05); C29(0.73); C306(1.01); C245(1.06)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C149(0.95); C29(0.79); C306(1.13); C245(1.00)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C149(0.99); C29(0.92); C306(0.97); C245(1.05)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C149(0.90); C29(0.81); C306(0.89); C245(0.95)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C149(0.89); C29(0.79); C306(0.90); C245(1.00)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C149(0.97); C29(0.90); C306(1.10); C245(1.20)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C149(0.93); C29(0.82); C306(1.08); C245(1.05)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C149(1.01); C29(1.10); C306(0.93); C245(1.06)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C149(0.95); C29(0.88); C306(1.02); C245(1.07)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C149(0.91); C29(1.01); C306(1.02); C245(0.97)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C149(1.01); C29(0.78); C306(1.25); C245(0.94)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C149(0.93); C29(0.93); C306(1.03); C245(0.83)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C149(1.08); C29(1.20); C306(1.09); C245(0.89)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C149(0.94); C306(0.85); C245(0.96); C230(0.74)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C149(0.94); C29(1.24); C306(1.00); C245(1.01)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C149(1.03); C29(1.56); C306(1.08); C245(0.77)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C149(1.09); C29(0.87); C306(1.11); C245(0.99)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C149(0.85); C29(1.74); C306(1.04); C245(0.82)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C149(0.91); C29(1.76); C306(0.92); C245(0.77)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C149(1.02); C29(1.43); C306(1.05); C245(0.74)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C149(1.04); C306(1.02); C245(0.88); C230(0.95)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C149(0.92); C29(1.74); C306(1.02); C245(0.91)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C149(0.96); C29(0.93); C306(1.31); C245(0.90)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C149(1.05); C29(0.76); C306(1.14); C245(1.02)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C149(0.99); C29(0.93); C306(1.03); C245(1.02)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C149(1.08); C29(0.92); C306(0.94); C245(0.92)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C149(1.27); C306(1.04); C245(0.99); C230(1.04)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C149(0.88); C29(1.27); C306(1.12); C245(0.99)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C149(1.13); C29(1.06); C306(0.96); C245(0.88)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C149(0.88); C29(1.45); C306(0.91); C245(0.83)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C149(0.82); C29(1.89); C306(1.03); C245(0.88)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C149(0.85); C29(1.60); C306(0.84); C245(0.72)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C149(1.03); C29(1.41); C306(1.05); C245(0.80)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C149(0.96); C306(0.99); C245(0.79); C230(1.01)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C149(0.90); C29(1.57); C306(0.94); C245(0.80)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C149(0.90); C29(0.94); C306(1.21); C245(1.01)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C149(0.93); C29(0.95); C306(0.95); C245(0.97)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C149(0.93); C29(1.12); C306(1.03); C245(0.97)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C149(1.01); C29(0.91); C306(1.05); C245(0.86)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C149(0.91); C306(0.89); C245(0.98); C230(0.85)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C149(1.01); C29(1.01); C306(0.95); C245(0.89)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C149(1.04); C29(1.54); C306(1.19); C245(0.82)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C149(0.86); C29(1.40); C306(0.99); C245(0.85)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C149(0.96); C29(1.30); C306(0.88); C245(0.87)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C149(0.96); C29(1.90); C306(0.95); C245(0.74)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C149(1.09); C306(0.93); C245(0.82); C230(0.90)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C149(0.98); C29(1.75); C306(0.91); C245(0.82)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C149(0.95); C29(0.95); C306(0.98); C245(0.97)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C149(1.02); C306(1.01); C245(1.07); C230(0.84)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C149(1.03); C29(0.90); C306(1.11); C245(0.97)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C149(1.08); C29(0.94); C306(1.14); C245(0.90)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C149(0.88); C306(0.89); C245(0.92); C230(0.81)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C149(0.93); C29(0.97); C306(0.85); C245(0.92)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C149(0.98); C29(1.50); C306(0.95); C245(0.77)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C149(1.02); C29(1.96); C306(0.96); C245(0.93)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C149(0.90); C29(1.53); C306(0.82); C245(0.77)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C149(1.05); C29(1.91); C306(1.10); C245(0.63)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C149(1.06); C306(0.89); C245(0.73); C230(0.93)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C149(0.99); C29(1.24); C306(1.00); C245(1.11)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C149(1.01); C29(1.54); C306(0.90); C245(0.83)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C149(1.04); C29(0.91); C306(1.27); C245(1.00)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C149(0.95); C29(0.75); C306(1.09); C245(0.96)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C149(1.02); C29(0.84); C306(1.06); C245(0.96)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C149(0.97); C29(0.75); C306(0.93); C245(0.95)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C149(1.04); C306(0.91); C245(1.02); C230(0.84)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C149(1.33); C29(1.05); C306(0.95); C245(0.91)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C149(1.01); C29(1.31); C306(1.12); C245(0.84)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C149(0.94); C29(1.94); C306(1.17); C245(0.85)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C149(0.96); C29(1.56); C306(0.94); C245(0.81)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C149(0.99); C29(1.47); C306(1.06); C245(0.88)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C149(1.04); C29(1.33); C306(1.18); C245(0.74)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C149(1.03); C306(0.99); C245(0.86); C230(1.03)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C149(1.00); C29(1.58); C306(1.01); C245(0.86)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C149(1.04); C29(0.81); C306(0.96); C245(0.93)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C149(1.02); C29(0.73); C306(0.99); C245(1.08)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C149(0.99); C29(0.91); C306(1.01); C245(0.97)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C149(0.86); C306(0.85); C245(1.08); C230(0.81)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C149(1.07); C29(0.96); C306(1.01); C245(0.90)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C149(0.98); C29(1.43); C306(1.19); C245(0.82)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C149(0.74); C29(1.87); C306(0.76); C245(0.80)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C149(0.98); C29(1.66); C306(1.06); C245(0.89)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C149(1.02); C29(1.44); C306(1.11); C245(0.78)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C149(1.03); C29(1.41); C306(1.13); C245(0.74)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C149(1.04); C306(1.04); C245(0.81); C230(0.82)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C149(0.96); C29(1.61); C306(0.92); C245(0.86)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C149(0.96); C29(0.91); C306(0.84); C245(1.09)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C149(0.90); C29(1.03); C306(1.02); C245(1.09)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C149(0.99); C29(1.19); C306(1.05); C245(1.19)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C149(1.02); C29(0.98); C306(1.05); C245(0.94)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C149(1.01); C306(1.00); C245(1.06); C230(0.93)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C149(1.01); C29(1.58); C306(0.94); C245(0.76)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C149(0.71); C29(0.91); C306(0.68); C245(0.95)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C149(1.06); C29(1.18); C306(1.12); C245(0.80)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C149(0.86); C29(1.45); C306(0.92); C245(0.88)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C149(0.94); C29(1.06); C306(1.05); C245(0.81)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C149(1.13); C29(1.28); C306(1.11); C245(0.87)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C149(0.77); C306(0.70); C245(0.79); C230(0.71)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C149(0.95); C29(1.40); C306(0.93); C245(0.97)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C149(0.91); C29(0.95); C306(1.02); C245(1.01)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C149(0.98); C29(0.73); C306(1.08); C245(0.98)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C149(0.96); C29(0.98); C306(0.96); C245(1.09)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C149(1.06); C29(0.83); C306(1.07); C245(0.94)  LDD1698  [22]
 LDCM0175  Ethacrynic acid HeLa C245(0.44)  LDD2210  [6]
 LDCM0625  F8 Ramos C245(1.19); C306(0.72); C149(2.40)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C245(0.99); C149(0.30)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C245(0.08); C306(0.07); C149(1.91)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C245(0.65); C149(2.45)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C245(0.94); C149(0.76)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C245(0.57); C306(0.63); C149(0.71)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C245(0.66); C149(0.61)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C245(0.85); C149(1.33)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C245(1.05); C149(4.54)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C245(0.97); C149(0.80)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C245(1.09); C149(0.39)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C245(0.92); C149(0.94)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C245(0.91); C149(0.84)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C245(4.27); C149(0.55)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C149(0.99); C29(0.82); C306(1.05); C245(1.06)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C245(0.68); C149(0.81)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C245(0.94); C306(0.57); C149(2.52)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C149(1.09); C29(0.91); C306(1.05); C245(0.99)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C245(0.96); C149(0.55)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C245(1.01); C149(1.07)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C245(0.85); C306(0.21); C149(0.23)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C245(0.85); C149(0.29)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y10(0.93)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y10(1.01)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y10(1.14)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y10(1.21)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y10(1.24)  LDD0268  [9]
 LDCM0107  IAA HeLa C306(0.00); C149(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y144(1.05)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y144(0.57)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y144(1.07)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y144(2.10)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y144(1.71)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y144(0.73)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y144(0.33)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y144(1.06)  LDD0292  [8]
 LDCM0022  KB02 HEK-293T C149(1.15); C29(0.93); C306(0.96); C245(1.13)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C306(13.97); C245(4.72)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C230(1.20); C245(1.31); C306(1.13)  LDD3310  [25]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C149(1.03)  LDD2099  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C149(1.31)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C149(0.84)  LDD2125  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C149(1.58)  LDD2140  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C245(0.89)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C245(0.63)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C245(1.08)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Mannose-1-phosphate guanyltransferase alpha (GMPPA) Transferase hexapeptide repeat family Q96IJ6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.