Details of the Target

General Information of Target

Target ID LDTP09902
Target Name Kinesin-associated protein 3 (KIFAP3)
Gene Name KIFAP3
Gene ID 22920
Synonyms
KIF3AP; SMAP; Kinesin-associated protein 3; KAP-3; KAP3; Smg GDS-associated protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKS
QLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRK
ETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVP
IQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMD
NDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAI
QNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGK
AIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSH
FNGET
Target Bioclass
Other
Function
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
Uniprot ID
Q92845
Ensemble ID
ENST00000361580.7
HGNC ID
HGNC:17060

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 Deletion: p.G220_I226del .
GAMG SNV: p.V323A .
L428 SNV: p.V341E .
MELJUSO SNV: p.Q209Ter .
NCIH23 SNV: p.D19Y .
NCIH358 SNV: p.T264N; p.V749I DBIA    Probe Info 
OCUG1 SNV: p.L96V DBIA    Probe Info 
PANC1 SNV: p.D101Y DBIA    Probe Info 
PF382 SNV: p.R294H .
TE4 SNV: p.D693V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K302(2.12); K477(6.54)  LDD0277  [1]
BTD
 Probe Info  		C78(0.87)  LDD2125  [2]
DBIA
 Probe Info  		C78(36.23)  LDD0204  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
ENE
 Probe Info  		N.A.  LDD0006  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C78(0.21)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C355(1.00); C436(0.98); C78(1.20)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C355(0.94)  LDD1509  [9]
 LDCM0230  AC113 HCT 116 C78(0.98)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C78(1.01)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C78(1.01)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C78(1.12)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C78(1.03)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C78(1.10)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C78(1.14)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C355(1.01); C436(0.98); C78(1.12)  LDD1510  [9]
 LDCM0238  AC120 HCT 116 C78(1.03)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C78(1.07)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C78(0.93)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C78(1.60)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C78(1.06)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C78(1.09)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C78(1.12)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C78(1.01)  LDD0562  [8]
 LDCM0259  AC14 HEK-293T C355(1.05); C436(1.04); C78(1.25)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C355(0.95); C436(1.13); C78(1.15)  LDD1513  [9]
 LDCM0276  AC17 HCT 116 C78(0.94)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C78(0.98)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C78(0.95)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C78(0.26)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C78(0.91)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C78(1.00)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C78(0.90)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C78(0.89)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C78(0.91)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C355(0.91); C436(0.77)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C355(0.99); C436(0.61); C78(1.15)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C355(1.01)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C355(0.95); C436(0.66); C78(1.26)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C355(0.98); C436(0.75); C78(1.11)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C78(0.28)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C355(0.97); C436(0.98); C78(1.09)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C355(1.02); C436(0.70); C78(1.17)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C355(0.89); C436(0.63); C78(1.05)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C355(1.02); C436(0.77)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C355(1.02); C436(0.61); C78(1.11)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C355(0.92)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C355(0.97); C436(0.74); C78(1.15)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C355(1.01); C436(0.72); C78(1.04)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C355(1.01); C436(1.06); C78(1.24)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C355(1.04); C436(0.75); C78(1.12)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C78(0.29)  LDD0618  [8]
 LDCM0302  AC40 HEK-293T C355(0.90); C436(0.67); C78(2.34)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C355(1.06); C436(0.88)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C355(1.03); C436(0.93); C78(1.16)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C355(0.97)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C355(0.98); C436(0.93); C78(1.17)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C355(1.01); C436(0.89); C78(1.06)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C355(1.11); C436(1.02); C78(1.31)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C355(0.99); C436(0.99); C78(1.11)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C355(0.92); C436(0.91); C78(1.15)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C355(1.03); C436(0.85)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C78(0.29)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C355(1.05); C436(0.67); C78(1.24)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C355(0.92)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C355(0.93); C436(0.72); C78(1.12)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C355(1.01); C436(0.73); C78(1.03)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C355(0.97); C436(0.96); C78(1.12)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C355(0.98); C436(0.72); C78(1.17)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C355(0.91); C436(0.64); C78(1.06)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C355(1.01); C436(0.89)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C355(1.05); C436(0.99); C78(1.04)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C355(0.95)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C355(0.95); C436(0.90); C78(1.25)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C355(0.98); C436(0.92); C78(1.16)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C355(0.99); C436(0.93); C78(1.09)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C355(1.03); C436(0.96); C78(1.29)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C355(1.04); C436(0.95); C78(1.16)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C355(0.93); C436(0.87); C78(1.10)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C355(1.01); C436(1.09); C78(1.18)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C355(0.95); C436(0.88); C78(1.07)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C355(1.04); C436(1.03); C78(1.04)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C355(0.98); C436(0.88)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C355(1.01); C436(1.03); C78(1.17)  LDD1514  [9]
 LDCM0103  BDHI 10 Jurkat C78(5.43)  LDD0205  [3]
 LDCM0102  BDHI 8 Jurkat C78(36.23)  LDD0204  [3]
 LDCM0367  CL1 HCT 116 C78(0.81)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C78(0.46)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C78(0.23)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C355(1.10); C436(1.16)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C355(0.96); C436(1.10); C78(1.13)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C355(1.05); C436(0.97)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C355(1.02); C436(0.99); C78(1.18)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C78(0.95)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C78(1.00)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C78(1.02)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C78(1.11)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C78(1.17)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C78(0.48)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C78(1.24)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C78(1.18)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C355(1.01); C436(0.85); C78(1.17)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C355(1.02); C436(0.84)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C355(0.85); C436(0.83); C78(1.10)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C355(0.99); C436(0.99)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C355(1.01); C436(0.96); C78(1.31)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C355(1.05); C436(0.92)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C355(0.97); C436(0.93); C78(1.08)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C355(1.08); C436(1.17)  LDD1593  [9]
 LDCM0390  CL12 HCT 116 C78(0.42)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C355(0.99); C436(0.99); C78(1.22)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C355(1.02); C436(0.84)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C355(0.93); C436(0.83); C78(1.07)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C355(1.46); C436(0.84)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C355(1.00); C436(0.84); C78(1.15)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C355(1.07); C436(0.93)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C355(0.88); C436(0.94); C78(1.19)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C355(0.97); C436(0.94)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C355(1.01); C436(0.87); C78(1.28)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C78(0.41)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C78(0.45)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C78(0.42)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C355(1.05); C436(1.05); C78(1.26)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C355(0.93); C436(0.82)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C355(1.12); C436(1.22); C78(0.93)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C355(0.97)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C78(0.77)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C355(0.98); C436(1.53); C78(0.93)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C355(1.08); C436(1.49); C78(0.61)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C355(1.09); C436(1.49); C78(0.68)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C355(1.00); C436(1.81); C78(0.68)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C355(1.03); C436(1.50); C78(0.55)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C355(1.10); C436(1.00)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C355(0.90); C436(1.10); C78(1.20)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C355(0.98); C436(0.99)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C355(0.96); C436(0.97); C78(1.20)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C355(1.02); C436(0.90)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C78(0.61)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C355(1.02); C436(1.23); C78(0.95)  LDD1623  [9]
 LDCM0420  CL31 HCT 116 C78(1.04)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C78(0.90)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C78(0.91)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C78(0.90)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C78(1.31)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C78(1.05)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C78(1.10)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C78(0.89)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C78(0.77)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C78(0.89)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C78(0.84)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C78(0.84)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C78(0.73)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C78(0.83)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C78(1.02)  LDD0752  [8]
 LDCM0436  CL46 HEK-293T C355(1.09); C436(1.49); C78(0.62)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C355(0.99); C436(1.63); C78(0.62)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C355(0.96); C436(1.41); C78(0.52)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C355(1.01); C436(0.99)  LDD1643  [9]
 LDCM0440  CL5 HCT 116 C78(0.44)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C355(1.05); C436(1.14); C78(0.98)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C355(1.02); C436(1.02); C78(1.17)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C355(1.01); C436(0.89)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C355(1.93); C436(1.04); C78(0.82)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C355(0.99)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C355(1.08); C436(1.24); C78(0.87)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C355(0.93); C436(1.25); C78(0.63)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C355(1.14); C436(1.70); C78(0.77)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C355(0.99); C436(1.56); C78(0.71)  LDD1653  [9]
 LDCM0451  CL6 HCT 116 C78(0.46)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C355(0.96); C436(1.56); C78(0.53)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C355(1.01); C436(0.92)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C355(0.94); C436(1.02); C78(1.06)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C355(0.99); C436(1.00)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C355(0.91); C436(0.83); C78(1.17)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C355(1.03); C436(0.90)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C355(1.17); C436(1.12); C78(0.96)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C355(0.93)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C355(1.10); C436(1.23); C78(0.87)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C355(1.28); C436(1.36); C78(0.63)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C78(0.33)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C355(1.11); C436(1.45); C78(0.71)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C355(1.02); C436(1.51); C78(0.70)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C355(0.94); C436(1.51); C78(0.60)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C355(0.94); C436(0.90)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C355(0.95); C436(1.06); C78(1.29)  LDD1670  [9]
 LDCM0469  CL76 HCT 116 C78(1.06)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C78(1.25)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C78(0.66)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C78(0.95)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C78(0.49)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C78(0.60)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C78(0.49)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C78(0.37)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C78(0.55)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C78(0.49)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C78(0.49)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C78(0.49)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C78(0.49)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C78(0.61)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C78(0.37)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C78(0.35)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C78(0.66)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C78(0.81)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C78(1.02)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C78(0.63)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C78(0.54)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C78(0.64)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C78(0.67)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C78(0.55)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C78(0.34)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C78(0.25)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C355(1.02); C436(0.99)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C355(1.06); C436(1.01)  LDD1671  [9]
 LDCM0427  Fragment51 HCT 116 C78(0.85)  LDD0744  [8]
 LDCM0022  KB02 HEK-293T C78(1.07); C436(0.87); C355(0.93)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C355(12.45)  LDD0209  [3]
 LDCM0024  KB05 IGR37 C78(5.33)  LDD3314  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C78(0.87)  LDD2125  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C78(0.58)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
N-alpha-acetyltransferase 11 (NAA11) Acetyltransferase family Q9BSU3
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Kinesin-like protein KIF3A (KIF3A) Kinesin family Q9Y496
Kinesin-like protein KIF3B (KIF3B) Kinesin family O15066
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil cytosol factor 2 (NCF2) NCF2/NOXA1 family P19878
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Receptor-transporting protein 5 (RTP5) . Q14D33

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840