Details of the Target

General Information of Target

Target ID LDTP14142
Target Name Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B)
Gene Name PPP2R3B
Gene ID 28227
Synonyms
PPP2R3L; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; PP2A subunit B isoform PR48; Protein phosphatase 2A 48 kDa regulatory subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVL
EKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAM
VQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSP
AVLQRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQ
PERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSH
SWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Uniprot ID
Q9Y5P8
Ensemble ID
ENST00000390665.9
HGNC ID
HGNC:13417

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.T389HfsTer70 DBIA    Probe Info 
HCT116 Deletion: p.T389HfsTer70 .
HCT15 SNV: p.A272T .
HT1376 SNV: p.P3S .
IGROV1 Deletion: p.T389HfsTer70 .
Ishikawa (Heraklio) 02 ER Deletion: p.T389HfsTer70 DBIA    Probe Info 
JHH4 SNV: p.Y417H .
KYSE410 SNV: p.P175L .
LNCaP clone FGC SNV: p.E573Ter .
LS123 SNV: p.L176P .
MCC26 Substitution: p.R154W .
NALM6 SNV: p.E508Ter DBIA    Probe Info 
NCIH1048 Deletion: p.T389HfsTer70 .
SKMEL2 SNV: p.R260C; p.I453N .
SNU1 Deletion: p.T389HfsTer70 .
SUPT1 Deletion: p.T389HfsTer70 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C35(6.68)  LDD0204  [1]
IPM
 Probe Info  		C283(1.62)  LDD1702  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
CY4
 Probe Info  		N.A.  LDD0247  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		12.40  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C172(1.59)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C172(0.88)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C174(1.25)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C174(0.91)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C174(0.72)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C174(1.10)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C174(1.81)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C174(0.73)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C174(0.65)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C174(0.48)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C174(0.87)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C174(0.31)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C172(1.04)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C174(0.26)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C174(0.54)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C174(0.64)  LDD0827  [8]
 LDCM0237  AC12 HEK-293T C172(0.99)  LDD0835  [8]
 LDCM0259  AC14 HEK-293T C172(0.99)  LDD0857  [8]
 LDCM0263  AC143 HEK-293T C172(1.58)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C172(0.53)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C172(0.62)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C172(0.60)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C172(0.95)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C172(1.18)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C172(1.60)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C172(0.58)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C172(1.26)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C172(0.99)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C172(1.12)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C172(1.11)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C172(0.97)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C172(1.17)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C172(0.84)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C172(1.00)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C174(0.40)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C174(0.54)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C174(0.61)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C172(1.60)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C174(0.46)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C174(0.62)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C174(0.50)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C174(0.36)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C174(0.75)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C35(0.68)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C35(0.88); C283(1.00); C174(0.78)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C35(1.12); C567(1.01)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C35(1.07); C283(0.97)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C35(1.15)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C172(1.49)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C35(1.08)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C35(0.90); C567(1.12)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C35(1.03)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C35(0.85)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C35(1.11); C283(0.94); C174(0.73)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C172(1.00); C174(0.93)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C172(1.25); C174(1.06)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C172(1.08); C174(1.01)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C172(1.02); C174(0.94)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C172(0.78); C174(0.83)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C172(1.27)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C172(1.08); C174(1.00)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C172(1.01); C174(0.98)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C172(0.95); C174(0.95)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C172(0.92); C174(0.83)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C172(1.02); C174(0.98)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C172(0.99); C174(0.94)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C172(1.15); C174(1.05)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C172(0.98); C174(0.86)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C172(0.95); C174(0.78)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C172(0.84); C174(0.69)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C172(0.63)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C172(1.03); C174(0.66)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C172(0.89); C174(0.50)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C172(1.00); C174(0.44)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C172(0.86); C174(0.63)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C172(1.17); C174(0.46)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C172(1.09); C174(0.61)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C172(1.04); C174(0.70)  LDD0917  [8]
 LDCM0320  AC57 PaTu 8988t C172(0.77); C174(0.77)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C172(0.75); C174(0.75)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C172(0.76); C174(0.76)  LDD1201  [8]
 LDCM0323  AC6 HEK-293T C172(0.58)  LDD0921  [8]
 LDCM0324  AC60 PaTu 8988t C172(0.82); C174(0.82)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C172(0.83); C174(0.83)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C172(0.75); C174(0.75)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C172(0.74); C174(0.74)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C172(0.82); C174(0.82)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C172(0.88); C174(0.88)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C172(0.88); C174(0.88)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C172(0.86); C174(0.86)  LDD1210  [8]
 LDCM0332  AC68 HEK-293T C172(1.19)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C172(0.59)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C172(0.71)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C172(0.87)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C172(0.69)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C172(0.79)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C172(0.91)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C172(0.56)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C172(0.73)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C172(1.15)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C172(0.87)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C172(0.89)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C172(1.01)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C172(0.40)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C172(0.81)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C172(0.96)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C172(0.52)  LDD0946  [8]
 LDCM0349  AC83 PaTu 8988t C172(1.01); C174(1.01)  LDD1228  [8]
 LDCM0350  AC84 PaTu 8988t C172(1.12); C174(1.12)  LDD1229  [8]
 LDCM0351  AC85 PaTu 8988t C172(1.04); C174(1.04)  LDD1230  [8]
 LDCM0352  AC86 PaTu 8988t C172(1.04); C174(1.04)  LDD1231  [8]
 LDCM0353  AC87 PaTu 8988t C172(1.02); C174(1.02)  LDD1232  [8]
 LDCM0354  AC88 PaTu 8988t C172(1.12); C174(1.12)  LDD1233  [8]
 LDCM0355  AC89 PaTu 8988t C172(1.16); C174(1.16)  LDD1234  [8]
 LDCM0357  AC90 PaTu 8988t C172(1.19); C174(1.19)  LDD1236  [8]
 LDCM0358  AC91 PaTu 8988t C172(1.06); C174(1.06)  LDD1237  [8]
 LDCM0359  AC92 PaTu 8988t C172(1.00); C174(1.00)  LDD1238  [8]
 LDCM0360  AC93 PaTu 8988t C172(1.32); C174(1.32)  LDD1239  [8]
 LDCM0361  AC94 PaTu 8988t C172(1.05); C174(1.05)  LDD1240  [8]
 LDCM0362  AC95 PaTu 8988t C172(1.00); C174(1.00)  LDD1241  [8]
 LDCM0363  AC96 PaTu 8988t C172(1.41); C174(1.41)  LDD1242  [8]
 LDCM0364  AC97 PaTu 8988t C172(1.30); C174(1.30)  LDD1243  [8]
 LDCM0365  AC98 HEK-293T C174(0.56)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C174(0.63)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C172(1.03)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C172(0.50)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C172(0.57)  LDD0873  [8]
 LDCM0103  BDHI 10 Jurkat C35(6.68)  LDD0205  [1]
 LDCM0102  BDHI 8 Jurkat C35(6.68)  LDD0204  [1]
 LDCM0367  CL1 PaTu 8988t C172(0.80); C174(0.80)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C172(0.67); C174(0.67)  LDD1247  [8]
 LDCM0369  CL100 HEK-293T C172(0.65)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C172(0.40)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C172(0.52)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C172(0.50)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C172(0.41)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C174(0.99)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C174(0.94)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C174(0.71)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C174(0.69)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C174(0.71)  LDD0976  [8]
 LDCM0379  CL11 PaTu 8988t C172(0.82); C174(0.82)  LDD1258  [8]
 LDCM0380  CL110 HEK-293T C174(0.64)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C174(0.82)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C35(1.22)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C35(0.84)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C35(1.11)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C35(0.90)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C35(0.82)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C172(0.93); C174(0.89)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C172(1.33); C174(1.20)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C172(1.21); C174(1.08)  LDD0987  [8]
 LDCM0390  CL12 PaTu 8988t C172(0.84); C174(0.84)  LDD1269  [8]
 LDCM0391  CL120 HEK-293T C172(0.89); C174(0.96)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C172(1.07); C174(0.58)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C172(0.99); C174(0.66)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C172(0.81); C174(0.85)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C172(0.89); C174(0.69)  LDD0993  [8]
 LDCM0396  CL125 PaTu 8988t C172(0.86); C174(0.86)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C172(0.74); C174(0.74)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C172(0.76); C174(0.76)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C172(0.75); C174(0.75)  LDD1278  [8]
 LDCM0400  CL13 PaTu 8988t C172(0.81); C174(0.81)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C172(0.88); C174(0.88)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C172(0.77); C174(0.77)  LDD1281  [8]
 LDCM0403  CL16 HEK-293T C174(0.80)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C174(0.78)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C174(0.64)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C174(0.73)  LDD1004  [8]
 LDCM0407  CL2 PaTu 8988t C172(0.83); C174(0.83)  LDD1286  [8]
 LDCM0408  CL20 HEK-293T C174(0.76)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C174(0.53)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C174(0.54)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C174(0.93)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C174(0.66)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C174(0.61)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C174(0.62)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C174(0.86)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C174(0.77)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C174(0.97)  LDD1015  [8]
 LDCM0418  CL3 PaTu 8988t C172(0.57); C174(0.57)  LDD1297  [8]
 LDCM0419  CL30 HEK-293T C174(0.46)  LDD1017  [8]
 LDCM0420  CL31 PaTu 8988t C172(0.78); C174(0.78)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C172(0.64); C174(0.64)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C172(0.67); C174(0.67)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C172(0.58); C174(0.58)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C172(0.58); C174(0.58)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C172(0.38); C174(0.38)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C172(0.60); C174(0.60)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C172(0.55); C174(0.55)  LDD1307  [8]
 LDCM0429  CL4 PaTu 8988t C172(0.62); C174(0.62)  LDD1308  [8]
 LDCM0430  CL40 PaTu 8988t C172(0.66); C174(0.66)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C172(0.59); C174(0.59)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C172(0.60); C174(0.60)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C172(0.65); C174(0.65)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C172(0.55); C174(0.55)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C172(0.51); C174(0.51)  LDD1314  [8]
 LDCM0436  CL46 HEK-293T C172(0.68); C174(0.98)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C172(0.91); C174(1.17)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C172(0.74); C174(0.99)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C172(0.81); C174(0.98)  LDD1037  [8]
 LDCM0440  CL5 PaTu 8988t C172(0.72); C174(0.72)  LDD1319  [8]
 LDCM0441  CL50 HEK-293T C172(0.69); C174(0.97)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C172(0.73); C174(0.80)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C172(1.02); C174(0.94)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C172(1.03); C174(1.07)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C172(0.84); C174(0.87)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C172(0.78); C174(1.05)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C172(0.85); C174(0.91)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C172(0.80); C174(0.86)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C172(1.04); C174(0.96)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C172(0.65); C174(0.81)  LDD1048  [8]
 LDCM0451  CL6 PaTu 8988t C172(0.70); C174(0.70)  LDD1330  [8]
 LDCM0452  CL60 HEK-293T C172(0.65); C174(0.82)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C172(0.49)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C172(0.57)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C172(0.43)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C172(0.89)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C172(0.51)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C172(0.54)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C172(0.69)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C172(1.11)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C172(0.79)  LDD1059  [8]
 LDCM0462  CL7 PaTu 8988t C172(0.77); C174(0.77)  LDD1341  [8]
 LDCM0463  CL70 HEK-293T C172(0.72)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C172(0.80)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C172(0.59)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C172(1.69)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C172(0.42)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C172(0.94); C174(0.94)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C172(0.77); C174(0.77)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C172(0.81); C174(0.81)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C172(1.02); C174(1.02)  LDD1070  [8]
 LDCM0473  CL8 PaTu 8988t C172(0.73); C174(0.73)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C172(0.90); C174(0.90)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C172(0.89); C174(0.89)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C172(0.99); C174(0.99)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C172(0.86); C174(0.86)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C172(0.70); C174(0.70)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C172(0.69); C174(0.69)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C172(0.80); C174(0.80)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C172(0.61); C174(0.61)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C172(0.47); C174(0.47)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C172(0.74); C174(0.74)  LDD1081  [8]
 LDCM0484  CL9 PaTu 8988t C172(0.77); C174(0.77)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C172(0.79); C174(0.79)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C172(0.72)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C172(1.01)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C172(0.80)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C172(0.38)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C172(0.37)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C172(0.70)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C172(0.94)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C172(0.85)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C172(1.17)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C35(1.09)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C283(1.62)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C172(0.40)  LDD1066  [8]
 LDCM0427  Fragment51 PaTu 8988t C172(0.58); C174(0.58)  LDD1306  [8]
 LDCM0022  KB02 697 C283(1.47)  LDD2245  [10]
 LDCM0023  KB03 697 C283(1.64)  LDD2662  [10]
 LDCM0024  KB05 NALM-6 C283(1.79)  LDD3339  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840