Details of the Target

General Information of Target

Target ID LDTP08543
Target Name GRIP and coiled-coil domain-containing protein 2 (GCC2)
Gene Name GCC2
Gene ID 9648
Synonyms
KIAA0336; RANBP2L4; GRIP and coiled-coil domain-containing protein 2; 185 kDa Golgi coiled-coil protein; GCC185; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS
KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL
EQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV
KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE
LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE
NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN
LKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVE
QHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY
ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL
QGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI
NKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKD
QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL
KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV
NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK
VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK
CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC
KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYK
NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQS
NAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQK
TMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETL
QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQV
EVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF
ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ
TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR
NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNT
DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEE
LVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK
NVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSW
SGLR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Uniprot ID
Q8IWJ2
Ensemble ID
ENST00000309863.11
HGNC ID
HGNC:23218

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.K1113N DBIA    Probe Info 
AU565 SNV: p.E250Q DBIA    Probe Info 
ETK1 SNV: p.K405Q DBIA    Probe Info 
FUOV1 SNV: p.R1684Q DBIA    Probe Info 
HCC1806 SNV: p.M1158I DBIA    Probe Info 
HCT15 SNV: p.E1166G DBIA    Probe Info 
HT115 SNV: p.E54D; p.E354D DBIA    Probe Info 
HT1376 SNV: p.E1345K DBIA    Probe Info 
IGR1 SNV: p.Q292K DBIA    Probe Info 
IM95 Deletion: p.N1218TfsTer9
SNV: p.I724T		 DBIA    Probe Info 
LS180 SNV: p.M256R DBIA    Probe Info 
NCIH82 SNV: p.K929N .
OAW28 SNV: p.L925F DBIA    Probe Info 
ONS76 SNV: p.L873P DBIA    Probe Info 
SNU245 SNV: p.R1298G DBIA    Probe Info 
SSP25 SNV: p.K405Q DBIA    Probe Info 
TE10 Deletion: p.N1394del DBIA    Probe Info 
TKKK SNV: p.L392I DBIA    Probe Info 
TOV21G Deletion: p.Q1534VfsTer7 DBIA    Probe Info 
YSCCC SNV: p.S677C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1136(10.00); K1274(7.20); K1282(6.78); K1332(1.48)  LDD0277  [2]
ONAyne
 Probe Info  		K1274(7.69)  LDD0275  [2]
Probe 1
 Probe Info  		Y357(9.82); Y1323(13.37)  LDD3495  [3]
BTD
 Probe Info  		C798(1.23)  LDD2090  [4]
NAIA_5
 Probe Info  		C416(20.00); C297(3.40)  LDD2227  [5]
AHL-Pu-1
 Probe Info  		C297(2.18)  LDD0169  [6]
DBIA
 Probe Info  		C284(1.04); C817(0.84); C826(0.84)  LDD0078  [7]
N1
 Probe Info  		D663(0.00); Q661(0.00)  LDD0245  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C798(0.00); C1306(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C1306(0.00); C798(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C1061(0.00); C1306(0.00); C92(0.00); C257(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		C798(0.00); C1061(0.00); C92(0.00); C1306(0.00)  LDD0148  [12]
VSF
 Probe Info  		C297(0.00); C399(0.00); C889(0.00); C92(0.00)  LDD0007  [10]
YN-1
 Probe Info  		E1144(0.00); E1146(0.00)  LDD0446  [13]
Acrolein
 Probe Info  		C1306(0.00); C1061(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		C466(0.00); C1061(0.00)  LDD0218  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C48(1.49); C798(1.21)  LDD2152  [4]
 LDCM0025  4SU-RNA DM93 C297(2.64)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C297(2.18)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C297(0.76); C798(0.87); C817(1.78); C826(1.78)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C297(0.78); C416(0.55); C798(1.17); C817(0.95)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C416(0.91); C798(0.79); C817(0.73); C826(0.73)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C416(1.18); C798(0.99); C817(0.72); C826(0.72)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C416(1.12); C798(0.86); C817(0.82); C826(0.82)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C416(1.10); C798(1.13); C817(0.81); C826(0.81)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C416(1.06); C798(0.79); C817(0.89); C826(0.89)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C416(1.01); C798(1.07); C817(0.95); C826(0.95)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C416(1.12); C798(1.04); C817(0.98); C826(0.98)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C416(1.01); C798(0.97); C817(0.86); C826(0.93)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C416(0.89); C798(0.88); C817(0.91); C826(0.79)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C416(1.19); C798(0.80); C817(0.81); C826(0.80)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C297(0.74); C416(0.41); C798(1.16); C817(0.91)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C416(1.03); C798(0.92); C817(0.80); C826(0.78)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C416(1.18); C798(0.89); C817(0.87); C826(0.86)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C416(1.23); C798(0.93); C817(0.81); C826(0.78)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C416(1.00); C798(1.17); C817(1.01); C826(1.01)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C416(0.90); C798(1.19); C817(1.14); C826(1.21)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C416(0.90); C798(1.69); C817(1.22); C826(1.17)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C416(0.99); C798(1.39); C817(1.09); C826(1.17)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C416(0.96); C798(1.30); C817(1.02); C826(1.05)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C416(0.87); C798(1.15); C817(1.06); C826(1.02)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C416(0.91); C798(1.04); C817(0.96); C826(0.99)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C297(0.75); C416(0.56); C798(1.10); C817(0.91)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C416(1.12); C798(0.88); C817(0.84); C826(0.94)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C416(0.89); C798(1.26); C817(1.00); C826(1.03)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C416(0.85); C798(1.39); C817(1.19); C826(1.30)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C416(0.83); C798(0.99); C817(0.93); C826(0.95)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C416(0.83); C798(0.95); C817(0.99); C826(1.01)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C416(0.87); C798(1.31); C817(1.00); C826(1.05)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C416(0.85); C798(1.36); C817(1.06); C826(1.13)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C416(0.77); C798(1.53); C817(1.21); C826(1.21)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C416(0.78); C817(1.62); C826(1.62)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C416(0.86); C817(0.88); C826(0.88)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C416(1.01); C817(1.33); C826(1.33)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C416(1.05); C817(0.91); C826(0.91)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C416(1.01); C817(1.01); C826(1.01)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C416(1.08); C817(1.29); C826(1.29)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C416(1.85); C817(1.24); C826(1.24)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C416(0.93); C817(1.44); C826(1.44)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C416(1.17); C817(1.02); C826(1.02)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C416(1.00); C817(0.99); C826(0.99)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C416(1.62); C817(1.22); C826(1.22)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C416(1.41); C817(1.27); C826(1.27)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C297(0.64); C416(0.64); C798(1.08); C817(1.10)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C416(1.81); C817(1.29); C826(1.29)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C416(1.60); C817(1.10); C826(1.10)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C416(1.38); C817(1.03); C826(1.03)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C416(1.17); C798(1.14); C817(1.08); C826(1.08)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C416(0.89); C817(1.11); C826(1.15); C798(1.31)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C416(0.97); C817(1.04); C826(1.08); C798(1.25)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C416(1.07); C817(1.14); C798(1.25); C826(1.27)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C817(1.17); C826(1.18); C416(1.29); C798(1.40)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C416(0.99); C817(1.51); C826(1.57); C798(1.91)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C416(1.32); C817(1.34); C826(1.42); C798(1.94)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C416(0.72); C297(0.74); C817(1.02); C826(1.02)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C817(0.96); C826(0.99); C798(1.09); C416(1.14)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C798(0.98); C817(1.08); C416(1.09); C826(1.10)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C817(1.11); C798(1.16); C826(1.20); C416(1.49)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C416(1.03); C817(1.59); C826(1.75); C798(1.88)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C416(1.07); C798(1.41); C817(1.08); C826(1.13)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C416(1.03); C798(1.09); C817(1.07); C826(1.12)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C416(0.97); C798(1.12); C817(0.91); C826(0.98)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C416(1.09); C798(1.09); C817(0.92); C826(1.01)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C284(0.78); C817(0.88); C826(0.88); C798(1.09)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C798(0.79); C817(1.10); C826(1.10); C297(1.21)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C284(0.83); C817(1.05); C826(1.05); C798(1.21)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C297(0.88); C798(1.11); C817(1.99); C826(1.99)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C297(1.00); C817(1.03); C826(1.03); C284(1.04)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C798(0.91); C284(0.93); C297(0.96); C416(1.06)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C284(0.71); C416(1.01); C798(1.05); C817(1.08)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C284(0.97); C297(0.99); C416(1.08); C817(1.15)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C284(0.80); C297(0.88); C817(1.05); C826(1.05)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C284(0.92); C416(0.98); C817(0.98); C826(0.98)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C817(0.95); C826(0.95); C416(1.01); C798(1.17)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C817(0.97); C826(0.97); C416(1.30); C284(1.37)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C817(0.92); C826(0.92); C416(1.09); C798(1.10)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C817(0.94); C826(0.94); C798(1.16); C284(1.22)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C297(0.87); C798(1.10); C817(2.80); C826(2.80)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C284(0.80); C817(0.90); C826(0.90); C416(1.31)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C817(1.06); C826(1.06); C416(1.14); C798(1.27)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C817(1.11); C826(1.11); C284(1.41); C416(1.44)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C284(1.17); C817(1.18); C826(1.18); C798(1.23)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C817(1.13); C826(1.13); C798(1.20); C284(1.43)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C798(0.77); C284(0.89); C416(0.96)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C284(0.69); C798(0.98); C416(1.03)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C798(0.87); C284(1.01); C416(1.01)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C284(0.80); C416(1.09); C798(1.16)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C416(1.10); C798(1.21); C284(1.40)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C297(0.83); C798(1.11); C817(2.58); C826(2.58)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C416(0.95); C284(1.02); C798(1.09)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C284(0.59); C798(1.04); C416(1.19)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C416(1.00); C798(1.15); C284(1.15)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C284(0.94); C416(0.98); C798(1.08)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C798(1.06); C416(1.09); C284(1.15)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C284(0.78); C416(1.00); C798(1.08)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C817(0.96); C826(0.96); C416(1.08); C798(1.29)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C416(0.99); C817(1.08); C826(1.08); C798(1.10)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C416(0.94); C817(0.97); C826(0.97); C297(1.31)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C817(0.76); C826(0.76); C297(1.33); C416(1.39)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C297(0.80); C798(1.07); C817(2.34); C826(2.34)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C817(0.95); C826(0.95); C416(1.38); C297(1.38)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C817(0.75); C826(0.75); C798(0.93); C416(1.02)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C817(0.93); C826(0.93); C416(1.00); C297(1.12)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C297(1.09); C817(1.15); C826(1.15); C416(1.21)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C817(0.89); C826(0.89); C297(1.19); C798(1.23)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C297(0.91); C817(1.09); C826(1.09); C416(1.25)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C817(1.01); C826(1.01); C297(1.23); C416(1.49)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C416(0.79)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C416(1.20)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C416(1.20)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C297(0.91); C416(0.99); C817(1.07); C826(1.07)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C416(0.99)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C416(0.80)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C416(0.87)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C416(0.96)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C416(1.15)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C416(0.88)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C416(1.12)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C416(1.07)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C798(0.60); C416(0.78); C817(1.24); C826(1.24)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C798(0.62); C416(0.96); C817(1.31); C826(1.31)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C416(0.67); C297(0.79); C817(0.81); C826(0.81)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C798(0.77); C416(0.90); C817(1.33); C826(1.33)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C798(0.54); C416(0.82); C817(1.15); C826(1.15)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C798(0.72); C416(0.94); C817(1.15); C826(1.15)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C798(0.66); C416(1.03); C817(1.92); C826(1.92)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C798(0.52); C416(0.92); C817(1.68); C826(1.68)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C416(0.76); C798(0.86); C817(2.18); C826(2.18)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C798(0.42); C416(0.69); C817(1.54); C826(1.54)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C798(0.57); C416(0.99); C817(1.74); C826(1.74)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C798(0.58); C416(0.99); C817(1.11); C826(1.11)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C798(0.74); C416(0.94); C817(1.10); C826(1.10)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C416(0.70); C297(0.82); C817(0.94); C826(0.94)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C798(0.49); C416(1.10); C817(1.27); C826(1.27)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C798(0.50); C817(0.89); C826(0.89); C416(1.00)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C798(0.50); C416(0.80); C817(2.36); C826(2.36)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C817(1.03); C826(1.03); C416(1.08); C297(1.10)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C817(0.97); C826(0.97); C297(1.04); C798(1.08)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C817(0.84); C826(0.84); C297(1.11); C798(1.15)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C817(0.91); C826(0.91); C416(1.01); C798(1.15)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C817(0.87); C826(0.87); C416(1.02); C297(1.11)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C817(0.81); C826(0.81); C798(0.98); C416(1.07)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C416(0.96); C817(1.02); C826(1.02); C297(1.16)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C817(0.82); C826(0.82); C416(0.94); C297(1.09)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C416(0.84); C297(1.09); C798(1.09); C817(1.21)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C416(0.83); C817(1.01); C826(1.01); C297(1.03)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C817(0.79); C826(0.79); C416(1.05); C297(1.06)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C416(0.95); C297(0.97); C817(1.14); C826(1.14)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C817(0.87); C826(0.87); C416(1.12); C297(1.23)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C416(0.83); C297(0.97); C817(1.17); C826(1.17)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C817(0.89); C826(0.89); C416(0.95); C297(1.16)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C416(1.05); C817(1.19); C826(1.19); C798(1.34)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C798(0.74); C817(0.75); C826(0.75); C416(0.93)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C48(0.66)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C297(0.79); C416(0.57); C798(1.07); C817(0.84)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C416(0.53); C297(0.69); C817(0.92); C826(0.92)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C817(0.87); C826(0.87); C416(0.89); C297(0.94)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C284(1.04); C817(0.84); C826(0.84)  LDD0078  [7]
 LDCM0103  BDHI 10 Jurkat C798(13.04)  LDD0205  [16]
 LDCM0102  BDHI 8 Jurkat C798(13.04)  LDD0204  [16]
 LDCM0108  Chloroacetamide HeLa C1061(0.00); C1306(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C416(20.00); C297(3.40)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C416(0.84); C798(1.31); C817(1.63); C826(1.63)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C416(0.93); C817(1.22); C826(1.22); C798(1.38)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C297(0.81); C798(0.86); C817(2.19); C826(2.19)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C416(0.73); C297(0.85); C817(0.97); C826(0.97)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C416(0.57); C297(0.82); C817(0.91); C826(0.91)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C416(0.51); C297(0.82); C817(0.96); C826(0.96)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C416(0.69); C297(0.77); C817(0.92); C826(0.92)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C416(1.08); C297(1.27); C798(1.29); C284(1.68)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C297(1.19); C817(1.32); C826(1.32); C798(1.35)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C284(0.89); C817(1.24); C826(1.24); C416(1.29)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C416(1.27); C798(1.32); C297(1.37); C817(1.88)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C416(1.10); C798(1.16); C284(1.23); C297(1.44)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C416(1.00); C817(1.21); C826(1.21); C798(1.31)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C297(1.01); C416(1.07); C798(1.26); C817(2.45)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C798(1.01); C297(1.17); C416(1.20); C817(1.49)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C798(1.09); C416(1.21); C817(1.32); C826(1.32)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C817(0.93); C826(0.93); C284(1.10); C798(1.15)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C416(1.17); C798(1.26); C817(1.42); C826(1.42)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C798(1.08); C817(1.40); C826(1.40); C416(1.43)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C284(0.98); C817(0.99); C826(0.99); C798(1.15)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C416(0.93); C284(1.21); C798(1.46)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C284(0.82); C416(0.95); C798(1.09)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C416(1.00); C284(1.07); C798(1.12)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C416(0.95); C817(1.41); C826(1.41); C798(1.71)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C284(0.79); C416(1.16); C798(1.22)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C416(1.02); C297(1.03); C798(1.08); C817(1.88)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C297(1.04); C798(1.12); C416(1.19); C817(1.28)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C416(0.97); C297(1.06); C798(1.07); C817(1.82)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C817(1.17); C826(1.17); C297(1.18); C416(1.19)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C416(0.87)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C416(1.06)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C416(0.96)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C416(0.86)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C416(0.89); C817(1.08); C826(1.08); C798(1.36)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C416(0.99); C798(1.23); C817(1.84); C826(1.84)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C416(0.92); C798(1.37); C817(2.01); C826(2.01)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C817(0.98); C826(0.98); C798(0.99); C416(1.23)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C798(1.00); C817(1.04); C826(1.04); C416(1.18)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C817(0.88); C826(0.88); C297(1.03); C798(1.07)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C297(1.03); C416(1.05); C798(1.06); C817(1.29)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C416(0.99); C798(1.42); C817(1.77); C826(1.77)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C297(1.16); C798(1.23); C817(1.28); C826(1.28)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C817(0.99); C826(0.99); C416(1.13); C297(1.16)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C297(0.84); C817(1.00); C826(1.00); C416(1.16)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C416(0.90); C798(0.96); C817(1.06); C826(1.06)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C297(0.89); C416(1.14); C798(1.24); C817(1.31)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C284(2.13); C297(0.94); C416(0.96); C798(1.18)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C284(1.11); C297(0.90); C416(1.08); C798(1.03)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C284(1.52); C297(0.94); C416(1.14); C798(1.16)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C284(1.90); C297(1.06); C416(0.96); C798(1.21)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C284(1.48); C297(0.89); C416(1.12); C798(1.34)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C416(1.04); C798(1.01); C817(1.26); C826(1.26)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C284(1.13); C297(0.91); C416(0.72); C798(0.95)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C297(0.94); C416(0.97); C798(1.07)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C297(0.93); C416(1.17); C798(1.10)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C297(1.11); C416(1.08); C798(1.09)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C297(0.93); C416(1.04); C798(1.14)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C297(0.68); C416(1.34); C798(1.04)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C297(0.69); C416(1.30); C798(1.18)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C297(0.70); C416(1.28); C798(1.26)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C297(0.65); C416(1.22); C798(1.02)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C416(1.06); C798(1.07); C817(1.48); C826(1.48)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C297(0.62); C416(1.22); C798(1.01)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C297(0.79); C416(1.23); C798(1.15)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C297(0.60); C416(1.24); C798(1.20)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C297(0.63); C416(1.14); C798(0.99)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C297(0.71); C416(1.10); C798(0.99)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C297(0.73); C416(0.98); C798(1.13)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C416(0.82); C798(1.25); C817(1.47); C826(1.47)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C416(0.97); C798(1.01); C817(1.17); C826(1.17)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C416(0.99); C798(1.00); C817(1.27); C826(1.27)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C416(0.88); C798(1.27); C817(1.02); C826(1.02)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C416(0.85); C798(1.11); C817(1.39); C826(1.39)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C416(0.96); C798(1.23); C817(1.07); C826(1.07)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C416(0.92); C798(1.13); C817(1.22); C826(1.22)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C416(1.10); C798(1.19); C817(1.06); C826(1.06)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C416(1.39); C798(1.31); C817(1.07); C826(1.07)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C416(0.88); C798(1.19); C817(1.21); C826(1.21)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C416(0.90); C798(1.07); C817(1.18); C826(1.18)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C416(1.05); C798(1.08); C817(1.03); C826(1.03)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C416(1.11); C798(1.56); C817(1.37); C826(1.37)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C416(0.80); C798(1.00); C817(1.21); C826(1.21)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C416(0.89); C798(1.26); C817(1.09); C826(1.09)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C416(0.80); C798(1.30); C817(1.67); C826(1.67)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C416(0.82); C798(1.33); C817(1.15); C826(1.15)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C416(0.87); C798(1.14); C817(1.17); C826(1.17)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C416(0.97); C798(1.21); C817(1.23); C826(1.23)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C416(0.98); C798(1.09); C817(1.46); C826(1.46)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C416(0.89); C798(1.16); C817(1.59); C826(1.59)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C416(0.94); C798(1.23); C817(1.09); C826(1.09)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C416(0.91); C798(1.31); C817(1.65); C826(1.65)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C416(0.89); C798(1.12); C817(1.25); C826(1.25)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C416(1.08); C798(1.34); C817(1.82); C826(1.82)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C416(0.96); C798(1.52); C817(2.05); C826(2.05)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C416(0.79); C798(1.18); C817(1.33); C826(1.33)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C416(0.93); C798(1.11); C817(1.22); C826(1.22)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C416(1.02); C798(1.15); C817(1.39); C826(1.39)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C416(1.12); C798(1.12); C817(1.00); C826(1.00)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C416(1.05); C798(1.21); C817(1.42); C826(1.42)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C416(1.03); C798(1.15); C817(1.29); C826(1.29)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C416(1.19); C798(2.00); C817(0.78); C826(0.78)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C416(1.47); C798(1.95); C817(0.67); C826(0.67)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C416(1.20); C798(1.53); C817(0.79); C826(0.79)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C416(1.19); C798(1.74); C817(0.75); C826(0.75)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C416(1.06); C798(1.22); C817(1.53); C826(1.53)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C416(1.03); C798(1.49); C817(0.99); C826(0.99)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C416(1.03); C798(1.45); C817(0.83); C826(0.83)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C416(1.02); C798(0.92); C817(0.74); C826(0.74)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C416(0.95); C798(1.11); C817(0.98); C826(0.98)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C416(1.06); C798(1.07); C817(1.14); C826(1.14)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C416(1.14); C798(1.41); C817(0.69); C826(0.69)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C416(1.09); C798(1.95); C817(0.72); C826(0.72)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C416(1.12); C798(1.76); C817(0.79); C826(0.79)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C416(1.17); C798(1.51); C817(0.64); C826(0.64)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C416(1.18); C798(1.40); C817(0.83); C826(0.83)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C416(0.84); C798(1.11); C817(1.44); C826(1.44)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C416(1.02); C798(1.63); C817(0.69); C826(0.69)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C297(1.11); C798(0.93); C817(1.40); C826(1.40)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C297(1.05); C798(0.89); C817(0.98); C826(0.98)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C297(1.00); C798(0.85); C817(1.13); C826(1.13)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C297(1.00); C798(0.90); C817(1.51); C826(1.51)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C297(0.98); C798(1.01); C817(1.92); C826(1.92)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C297(0.90); C798(0.92); C817(1.13); C826(1.13)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C297(0.95); C798(1.03); C817(1.37); C826(1.37)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C297(0.97); C798(1.09); C817(1.91); C826(1.91)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C297(0.83); C798(0.98); C817(1.96); C826(1.96)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C284(0.74); C416(1.00); C297(1.01); C257(0.92)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C297(1.42)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C416(0.91); C798(1.18); C817(1.51); C826(1.51)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C297(0.47); C416(1.35); C798(0.89)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C284(1.46); C416(1.62)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C284(1.30); C416(1.07)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C284(2.74); C416(1.74)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C798(1.02)  LDD2102  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C798(1.23)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C48(0.96); C798(1.07)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C48(0.83)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C798(1.56)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C48(1.00)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C48(0.85)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C48(0.81); C416(0.88)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C48(0.58); C798(0.86)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C48(0.86); C798(0.91)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C48(1.59)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C48(0.81)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C48(0.75)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C48(0.90)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C48(0.87); C798(0.77)  LDD2129  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C48(1.03)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C48(0.94); C798(0.59)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C48(0.99); C798(0.64)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C48(0.40)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C798(1.96)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C798(0.99)  LDD2153  [4]
 LDCM0021  THZ1 HCT 116 C817(0.99); C826(0.99)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-6A (RAB6A) Rab family P20340
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GRIP and coiled-coil domain-containing protein 2 (GCC2) . Q8IWJ2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402