Details of the Target

General Information of Target

Target ID LDTP03426
Target Name Protein ITPRID2 (ITPRID2)
Gene Name ITPRID2
Gene ID 6744
Synonyms
CS1; KIAA1927; KRAP; SSFA2; Protein ITPRID2; Cleavage signal-1 protein; CS-1; ITPR-interacting domain-containing protein 2; Ki-ras-induced actin-interacting protein; Sperm-specific antigen 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLP
GAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGA
EANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDP
EEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRF
RQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLS
KLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVK
EEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSD
FNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAP
HVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSC
DSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCN
TIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTH
HILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDL
LKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEE
QELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMS
QSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRV
CSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQE
LQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLEL
QLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSY
LKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKT
PLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGK
LPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
P28290
Ensemble ID
ENST00000320370.11
HGNC ID
HGNC:11319

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V363A DBIA    Probe Info 
EFO27 SNV: p.D560G DBIA    Probe Info 
HCC44 SNV: p.N231H DBIA    Probe Info 
HCT116 SNV: p.S21N DBIA    Probe Info 
HCT15 SNV: p.A981E DBIA    Probe Info 
HS578T Deletion: p.S869RfsTer5 DBIA    Probe Info 
HT115 SNV: p.D514Y DBIA    Probe Info 
JURKAT SNV: p.H617R Compound 10    Probe Info 
KASUMI2 SNV: p.Q389Ter .
KNS81FD SNV: p.L1047P DBIA    Probe Info 
KP4 SNV: p.M1050K DBIA    Probe Info 
MCAS SNV: p.P264S DBIA    Probe Info 
MFE319 SNV: p.K278R DBIA    Probe Info 
TOV21G SNV: p.Q35K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		12.01  LDD0348  [2]
HRP
 Probe Info  		9.03  LDD0347  [2]
STPyne
 Probe Info  		K1227(7.69)  LDD0277  [3]
ONAyne
 Probe Info  		K588(6.52)  LDD0275  [3]
Probe 1
 Probe Info  		Y234(11.79); Y943(41.24)  LDD3495  [4]
DA-P3
 Probe Info  		12.20  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C673(2.39)  LDD0168  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C305(4.32)  LDD0209  [7]
IA-alkyne
 Probe Info  		C1051(0.00); C448(0.00); C901(0.00); C823(0.00)  LDD0162  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		C85(0.00); C612(0.00); C1061(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C887(0.00); C703(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C823(0.00); C305(0.00); C859(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C823(0.00); C831(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		C599(0.00); C305(0.00); C823(0.00); C831(0.00)  LDD0218  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C673(2.39)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C901(2.30); C673(2.18); C1061(5.69)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C1051(0.96); C305(1.06); C448(1.01); C599(1.18)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C1051(0.93); C305(1.02); C448(1.23); C599(0.85)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C1051(0.94); C305(0.82); C448(1.21); C599(0.88)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C1051(1.08); C305(0.92); C448(1.23); C599(1.00)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C1051(0.95); C305(0.95); C448(1.07); C599(1.07)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C1051(1.19); C305(1.01); C448(1.23); C599(1.26)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C1051(0.96); C305(0.93); C448(0.98); C599(1.28)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C1051(1.11); C305(0.92); C448(1.18); C599(1.14)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C1051(1.08); C305(0.99); C448(1.27); C599(1.36)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C1051(1.17); C305(0.93); C448(1.10); C599(1.29)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C1051(0.89); C305(0.99); C448(1.11); C599(0.94)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C1051(0.87); C305(1.05); C448(0.99); C599(0.99)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C1051(1.00); C305(1.01); C448(1.22); C599(1.02)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C1051(1.01); C305(0.97); C448(1.22); C599(1.03)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C1051(1.04); C305(1.11); C448(1.31); C599(1.26)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C1051(1.02); C305(1.21); C448(1.35); C599(1.49)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C1051(0.94); C305(0.95); C448(1.04); C599(1.08)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C1051(0.93); C305(0.95); C448(1.12); C599(1.15)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C1051(0.99); C305(1.11); C448(1.09); C599(1.19)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C1051(1.05); C305(1.19); C448(1.14); C599(1.11)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C1051(1.02); C305(0.96); C448(0.96); C599(1.03)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C1051(1.04); C305(0.95); C448(0.97); C599(0.97)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C1051(1.04); C305(1.09); C448(0.99); C599(1.01)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C1051(0.96); C305(1.09); C448(1.15); C599(0.93)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C1051(1.13); C305(1.09); C448(1.16); C599(1.15)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C1051(1.02); C305(0.85); C448(0.86); C599(0.92)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C1051(1.05); C305(0.93); C448(1.04); C599(1.00)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C1051(0.96); C305(0.81); C448(0.89); C599(0.94)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C1051(0.99); C305(0.81); C448(0.90); C599(0.84)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C1051(1.05); C305(0.85); C448(1.06); C599(0.90)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C1051(0.98); C305(1.05); C448(0.96); C599(1.09)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C1051(1.08); C305(1.02); C448(0.97); C599(1.10)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C1051(0.71); C305(0.53); C448(0.74); C599(1.23)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C1051(0.71); C305(0.61); C448(0.86); C599(0.95)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C1051(0.74); C305(0.68); C448(0.95); C599(1.17)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C1051(0.75); C305(0.58); C448(0.98); C599(1.03)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C1051(0.78); C305(0.69); C448(1.08); C599(0.61)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C1051(0.76); C305(0.65); C448(0.95); C599(0.88)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C1051(1.03); C305(0.73); C448(1.31); C599(1.07)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C1051(0.79); C305(0.67); C448(0.90); C599(0.96)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C1051(0.90); C305(0.76); C448(1.02); C599(0.86)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C1051(0.86); C305(0.74); C448(1.01); C599(0.71)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C1051(1.02); C305(1.01); C448(1.20); C599(0.83)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C1051(0.80); C305(0.87); C448(1.16); C599(0.73)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C1051(1.06); C305(0.80); C448(1.32); C599(1.02)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C1051(0.92); C305(0.92); C448(1.22); C599(0.90)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C1051(0.91); C305(0.85); C448(1.37); C599(0.86)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C1051(0.80); C305(0.70); C448(1.09); C599(0.70)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C305(0.98); C673(0.99); C766(1.09); C901(1.12)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C305(0.79); C448(0.92); C901(1.15); C823(1.16)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C448(0.86); C305(0.86); C599(1.02); C766(1.07)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C305(0.91); C448(0.94); C823(1.07); C703(1.17)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C305(0.91); C448(0.91); C1051(1.22); C766(1.24)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C305(0.80); C448(0.87); C823(1.40); C766(1.47)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C305(0.96); C448(1.00); C823(1.18); C901(1.30)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C823(0.87); C305(0.91); C599(0.91); C1051(0.92)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C305(1.03); C901(1.04); C766(1.06); C448(1.09)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C305(0.87); C823(1.01); C448(1.02); C901(1.13)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C448(0.90); C305(0.90); C823(1.05); C766(1.26)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C305(0.79); C448(0.96); C901(1.58); C823(1.61)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C1051(1.30); C305(0.87); C448(1.04); C599(1.34)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C1051(1.25); C305(0.86); C448(0.97); C599(1.34)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C1051(1.12); C305(0.96); C448(1.04); C599(1.11)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C1051(1.35); C305(0.89); C448(0.95); C599(1.26)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C823(0.65); C766(0.67); C1051(0.79); C305(0.81)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C823(0.66); C673(0.67); C766(0.73); C703(0.77)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C766(0.60); C823(0.64); C703(0.77); C1051(0.80)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C703(0.76); C766(0.88); C1051(0.97); C901(0.99)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C766(0.69); C823(0.70); C305(0.83); C1051(0.86)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C766(0.62); C823(0.66); C1051(0.82); C305(0.86)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C766(0.64); C823(0.76); C1051(0.87); C673(0.95)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C766(0.58); C823(0.61); C1051(0.80); C673(0.82)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C766(0.66); C703(0.69); C823(0.78); C673(0.82)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C448(0.90); C703(0.94); C599(0.99); C1051(1.03)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C703(0.89); C901(0.99); C448(1.01); C1051(1.04)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C448(1.00); C703(1.00); C1051(1.10); C901(1.11)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C703(0.99); C448(0.99); C1051(1.00); C901(1.01)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C703(1.04); C448(1.15); C1051(1.16); C599(1.17)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C703(0.70); C766(0.83); C1051(0.83); C823(0.92)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C703(0.84); C673(0.92); C448(1.09); C1051(1.14)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C901(0.91); C448(0.99); C703(0.99); C599(1.01)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C703(0.98); C901(1.12); C448(1.17); C673(1.20)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C703(0.94); C448(1.00); C901(1.25); C599(1.34)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C703(1.04); C448(1.13); C901(1.19); C1051(1.23)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C673(0.57); C448(0.86); C766(0.94); C305(0.97)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C673(0.58); C766(0.94); C703(0.98); C448(1.00)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C673(0.83); C901(0.94); C599(0.98); C448(0.99)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C673(0.72); C901(0.91); C448(0.95); C766(1.02)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C673(0.67); C766(1.03); C703(1.04); C1051(1.11)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C766(0.72); C1051(0.80); C703(0.87); C901(0.89)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C673(0.64); C766(1.06); C901(1.09); C1051(1.13)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C673(0.67); C901(0.99); C703(1.01); C766(1.10)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C673(0.56); C901(0.97); C766(0.98); C703(1.08)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C673(0.64); C703(0.97); C766(1.08); C1051(1.14)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C673(0.69); C901(1.01); C766(1.03); C703(1.06)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C673(0.72); C766(1.04); C599(1.09); C901(1.15)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C703(0.90); C766(0.98); C901(1.09); C1051(1.11)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C1051(0.96); C703(0.96); C766(1.04); C901(1.04)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C703(0.94); C766(0.97); C1051(0.97); C901(1.01)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C703(0.97); C766(1.03); C305(1.05); C1051(1.12)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C1051(0.69); C703(0.72); C766(0.72); C901(0.78)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C305(1.03); C1051(1.04); C766(1.05); C703(1.07)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C703(0.98); C448(1.02); C766(1.05); C1051(1.08)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C766(0.95); C1051(1.08); C703(1.12); C901(1.12)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C766(1.10); C1051(1.10); C703(1.15); C901(1.19)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C766(0.95); C1051(0.97); C703(1.01); C901(1.15)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C766(1.04); C1051(1.12); C823(1.21); C703(1.22)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C703(1.10); C766(1.15); C1051(1.26); C823(1.46)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C703(0.58); C599(0.81); C448(0.89); C766(0.89)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C703(0.71); C766(0.80); C448(0.88); C599(0.93)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C766(0.83); C703(0.93); C599(0.95); C448(0.96)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C703(0.96); C823(0.98); C305(1.00); C599(1.05)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C703(0.81); C766(0.85); C448(0.95); C599(1.02)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C703(0.82); C448(0.86); C599(0.87); C766(0.92)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C599(0.75); C448(0.83); C766(0.95); C703(0.96)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C703(0.73); C599(0.85); C766(0.91); C448(0.93)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C766(0.80); C703(0.81); C448(0.83); C599(0.84)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C703(0.19); C766(0.63); C673(0.70); C1051(0.91)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C703(0.23); C766(0.62); C673(0.64); C1051(0.87)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C703(0.25); C766(0.64); C448(0.90); C1051(0.92)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C673(0.92); C703(1.01); C448(1.04); C823(1.06)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C448(0.89); C901(1.00); C305(1.07); C703(1.08)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C823(0.66); C599(0.82); C703(0.95); C305(0.96)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C823(0.97); C703(1.02); C673(1.15); C448(1.19)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C823(0.74); C703(0.85); C448(0.87); C599(0.93)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C448(1.02); C901(1.30); C1051(1.32); C703(1.36)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C448(0.95); C1051(1.27); C305(1.42); C901(1.51)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C448(0.84); C305(1.10); C1051(1.14); C901(1.16)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C448(1.16); C1051(1.24); C901(1.28); C305(1.31)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C448(0.87); C305(1.04); C1051(1.13); C901(1.20)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C703(1.09); C823(1.11); C448(1.12); C901(1.16)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C448(1.08); C901(1.16); C599(1.20); C1051(1.20)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C673(1.10); C599(1.16); C703(1.19); C448(1.23)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C703(0.84); C599(0.90); C673(0.94); C901(0.98)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C448(0.90); C1051(1.01); C901(1.03); C305(1.11)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C599(1.02); C703(1.03); C823(1.07); C448(1.11)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C448(0.94); C901(1.07); C305(1.13); C1051(1.16)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C1051(1.12); C766(1.18); C901(1.29); C305(1.35)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C766(0.97); C1051(1.11); C673(1.21); C901(1.30)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C673(0.92); C766(0.98); C1051(1.10); C823(1.23)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C766(0.99); C1051(1.14); C599(1.19); C823(1.20)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C766(0.91); C305(1.04); C673(1.07); C823(1.09)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C766(0.97); C305(1.11); C1051(1.15); C673(1.16)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C1051(1.13); C766(1.13); C305(1.22); C901(1.23)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C703(0.99); C305(0.99); C599(1.07); C1051(1.08)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C1051(1.03); C766(1.11); C305(1.15); C901(1.16)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C766(1.05); C1051(1.10); C305(1.29); C823(1.38)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C766(0.97); C673(1.12); C823(1.14); C1051(1.14)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C673(0.82); C766(0.94); C1051(1.06); C703(1.33)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C766(0.97); C305(1.01); C1051(1.09); C901(1.15)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C766(0.93); C1051(0.96); C901(1.24); C305(1.25)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C766(1.08); C1051(1.18); C305(1.39); C823(1.45)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C823(0.95); C901(1.10); C673(1.13); C305(1.14)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C673(0.65); C599(0.92); C1051(0.92); C823(0.93)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C1051(0.94); C305(0.97); C448(1.04); C599(1.02)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C823(0.76); C901(0.97); C599(0.98); C305(1.03)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C823(0.87); C1051(1.02); C599(1.03); C703(1.04)  LDD0592  [16]
 LDCM0020  ARS-1620 HCC44 C901(1.16); C599(1.17); C878(1.12); C887(1.12)  LDD2171  [16]
 LDCM0087  Capsaicin HEK-293T 4.46  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa C599(0.00); C823(0.00); C305(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C878(20.00); C305(2.34); C448(2.12); C823(0.78)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C599(0.92); C305(0.93); C859(0.94); C766(0.96)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C859(0.84); C766(0.96); C823(0.96); C673(1.01)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C703(0.79); C766(0.79); C1051(0.92); C823(0.99)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C305(0.80); C823(0.87); C599(0.89); C703(0.98)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C823(0.34); C599(0.82); C305(0.86); C673(0.96)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C823(0.75); C305(0.76); C599(0.89); C673(0.90)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C823(0.72); C305(0.81); C599(0.87); C901(0.92)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C823(0.58); C766(0.62); C1051(0.72); C673(0.82)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C823(0.55); C766(0.60); C703(0.73); C1051(0.75)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C823(0.65); C766(0.68); C703(0.80); C1051(0.80)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C823(0.57); C766(0.70); C1051(0.74); C673(0.83)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C766(0.65); C823(0.71); C703(0.77); C1051(0.86)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C859(0.73); C823(0.88); C673(0.90); C448(0.96)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C766(0.48); C823(0.51); C673(0.70); C1051(0.76)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C766(0.43); C823(0.50); C673(0.70); C703(0.75)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C673(0.88); C448(0.89); C599(0.93); C901(0.97)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C673(0.95); C703(1.02); C448(1.08); C901(1.33)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C673(0.87); C703(1.05); C599(1.10); C448(1.12)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C703(0.98); C448(1.08); C673(1.09); C901(1.11)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C703(0.90); C448(1.00); C599(1.08); C673(1.11)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C673(0.85); C766(1.00); C1051(1.07); C599(1.18)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C673(0.61); C448(0.98); C766(0.99); C305(1.00)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C673(0.65); C901(1.02); C766(1.05); C448(1.10)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C823(0.92); C448(1.05); C703(1.06); C1051(1.12)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C673(0.85); C448(0.99); C901(0.99); C703(1.02)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C703(0.85); C766(0.93); C823(0.96); C901(1.11)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C703(0.93); C766(0.96); C673(1.09); C599(1.11)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C766(0.75); C823(0.76); C673(0.85); C1051(0.93)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C703(0.97); C1051(0.99); C766(1.00); C599(1.15)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C703(0.66); C599(0.78); C766(0.79); C901(0.91)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C766(0.62); C703(0.72); C599(0.78); C823(0.87)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C766(0.76); C599(0.82); C448(0.88); C901(0.96)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C599(0.76); C703(0.86); C766(0.87); C448(0.90)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C823(0.82); C703(0.97); C859(0.98); C448(1.02)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C859(0.90); C766(0.94); C599(0.99); C823(1.03)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C823(0.70); C305(0.83); C766(0.86); C673(0.88)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C901(0.89); C766(1.07); C673(1.08); C599(1.09)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C823(0.79); C766(0.83); C305(0.86); C859(0.90)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C823(0.89); C305(0.92); C448(1.05); C1051(1.09)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C305(0.81); C703(0.95); C448(1.01); C859(1.08)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C599(0.97); C305(0.98); C823(1.02); C448(1.05)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C305(0.82); C859(0.98); C703(1.08); C1051(1.15)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C823(0.79); C305(0.80); C766(0.88); C859(0.92)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C305(0.77); C859(0.86); C448(0.89); C673(0.92)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C859(0.95); C1051(0.98); C673(1.00); C823(1.03)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C1051(1.03); C305(0.94); C448(1.07); C599(1.37)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C1051(1.11); C305(1.01); C448(1.06); C599(1.18)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C1051(1.24); C305(1.18); C448(1.18); C599(1.21)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C1051(1.05); C305(0.87); C448(1.06); C599(1.25)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C1051(1.13); C305(0.92); C448(1.10); C599(1.22)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C1051(1.13); C305(0.89); C448(1.10); C599(1.35)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C1051(1.13); C305(0.99); C448(1.00); C599(1.00)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C1051(1.06); C305(0.93); C448(1.15); C599(1.00)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C1051(0.93); C305(1.15); C448(0.91); C599(0.94)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C1051(1.02); C305(1.16); C448(1.22); C599(1.05)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C1051(0.96); C305(1.30); C448(1.27); C599(0.88)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C1051(1.00); C305(1.03); C448(1.09); C599(1.34)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C1051(0.99); C305(1.15); C448(1.08); C599(1.81)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C1051(1.04); C305(1.10); C448(0.94); C599(1.28)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C1051(1.11); C305(1.14); C448(1.04); C599(1.49)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C1051(0.97); C305(1.27); C448(1.07); C599(1.23)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C1051(1.18); C305(0.92); C448(0.96); C599(1.12)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C1051(1.09); C305(1.27); C448(0.97); C599(1.46)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C1051(1.01); C305(1.08); C448(0.90); C599(1.16)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C1051(1.12); C305(1.17); C448(0.91); C599(2.02)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C1051(0.98); C305(1.15); C448(0.96); C599(1.58)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C1051(0.99); C305(1.27); C448(1.00); C599(1.39)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C1051(0.89); C305(1.31); C448(1.01); C599(1.49)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C1051(1.00); C448(0.92); C599(0.79); C673(1.11)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C1051(1.06); C448(0.96); C599(0.72); C673(0.93)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C1051(1.02); C448(0.88); C599(0.90); C673(0.99)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C1051(0.92); C448(0.91); C599(0.98); C673(0.97)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C1051(1.20); C305(0.89); C448(0.92); C599(1.10)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C1051(1.02); C448(0.93); C599(0.86); C673(0.99)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C1051(1.09); C448(0.90); C599(0.89); C673(0.98)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C1051(1.23); C448(0.98); C599(1.09); C673(1.22)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C1051(1.27); C448(0.90); C599(0.99); C673(1.07)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C1051(0.91); C448(0.89); C599(0.94); C673(0.87)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C1051(0.95); C448(0.93); C599(0.97); C673(1.06)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C1051(0.99); C448(1.06); C599(0.91); C673(0.85)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C1051(0.95); C448(0.89); C599(0.76); C673(0.87)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C1051(0.97); C448(0.90); C599(0.94); C673(1.11)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C1051(0.86); C448(0.96); C599(0.92); C673(1.05)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C1051(1.12); C305(0.93); C448(0.98); C599(1.03)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C1051(1.01); C448(0.93); C599(0.81); C673(1.02)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C1051(0.94); C448(1.14); C599(0.93); C673(1.35)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C1051(1.03); C448(1.05); C599(0.89); C673(1.00)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C1051(1.10); C448(1.00); C599(0.97); C673(1.09)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C1051(0.98); C448(1.08); C599(1.05); C673(0.86)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C1051(0.99); C448(1.00); C599(0.96); C673(0.92)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C1051(0.93); C448(0.95); C599(1.01); C673(0.95)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C1051(1.10); C448(1.01); C599(1.18); C673(0.93)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C1051(1.08); C448(1.02); C599(0.98); C673(0.97)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C1051(1.12); C448(1.07); C599(0.91); C673(1.00)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C1051(0.97); C305(0.97); C448(1.06); C599(1.18)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C1051(1.00); C448(1.13); C599(1.05); C673(1.11)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C1051(1.15); C448(1.14); C599(1.12); C673(0.94)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C1051(1.14); C448(1.29); C599(1.13); C673(0.96)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C1051(1.12); C448(1.00); C599(1.07); C673(0.90)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C1051(1.13); C448(1.12); C599(1.24); C673(1.16)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C1051(1.03); C448(0.86); C599(1.11); C673(0.84)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C1051(1.03); C448(0.92); C599(0.84); C673(0.75)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C1051(1.09); C448(0.95); C599(1.11); C673(1.04)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C1051(1.02); C448(0.97); C599(1.28); C673(0.87)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C1051(1.31); C305(1.26); C448(1.02); C599(1.32)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C1051(0.91); C448(0.93); C599(0.94); C673(0.98)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C1051(0.92); C448(0.90); C599(1.19); C673(0.93)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C1051(0.78); C448(0.95); C599(1.18); C673(0.86)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C1051(0.96); C448(0.90); C599(1.15); C673(0.87)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C1051(1.11); C448(0.99); C599(1.41); C673(1.08)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C1051(1.06); C448(0.94); C599(1.03); C673(1.07)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C1051(1.05); C448(0.94); C599(0.83); C673(0.89)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C1051(0.96); C448(0.93); C599(0.79); C673(0.88)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C1051(1.07); C448(0.90); C599(1.14); C673(1.07)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C1051(1.06); C448(0.83); C599(1.58); C673(1.02)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C1051(1.11); C305(1.33); C448(1.10); C599(1.10)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C1051(1.02); C448(0.88); C599(1.07); C673(0.91)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C1051(1.04); C305(1.13); C448(1.10); C599(1.38)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C1051(1.12); C305(0.93); C448(0.92); C599(1.26)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C1051(0.90); C305(0.96); C448(0.89); C599(1.10)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C1051(0.88); C305(1.04); C448(0.89); C599(1.21)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C1051(1.08); C305(1.04); C448(0.98); C599(1.20)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C1051(0.97); C305(0.96); C448(1.00); C599(1.30)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C1051(1.06); C305(1.00); C448(0.99); C599(1.06)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C1051(0.93); C305(1.01); C448(1.04); C599(1.22)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C1051(0.86); C305(1.08); C448(1.03); C599(1.22)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C703(1.25)  LDD2228  [10]
 LDCM0027  Dopamine HEK-293T 12.20  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C823(0.95); C703(1.03); C766(1.03); C448(0.89)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C766(1.47)  LDD1702  [18]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0468  Fragment33 HCT 116 C1051(0.96); C448(1.04); C599(1.05); C673(0.96)  LDD0785  [16]
 LDCM0427  Fragment51 HCT 116 C1051(1.13); C305(1.21); C448(0.88); C599(1.73)  LDD0744  [16]
 LDCM0022  KB02 HEK-293T C703(0.83); C305(0.98); C448(0.88); C823(0.95)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C305(4.32)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C901(2.39); C823(1.48)  LDD3310  [19]
 LDCM0030  Luteolin HEK-293T 9.67  LDD0182  [2]
 LDCM0109  NEM HeLa H893(0.00); H661(0.00)  LDD0227  [14]
 LDCM0032  Oleacein HEK-293T 4.82  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 6.26  LDD0181  [2]
 LDCM0021  THZ1 HCT 116 C901(1.16); C599(1.17); C878(1.12); C887(1.12)  LDD2173  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase HRas (HRAS) Ras family P01112
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840