Details of the Target

General Information of Target

Target ID LDTP01454
Target Name SUN domain-containing protein 1 (SUN1)
Gene Name SUN1
Gene ID 23353
Synonyms
KIAA0810; UNC84A; SUN domain-containing protein 1; Protein unc-84 homolog A; Sad1/unc-84 protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT
TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGG
TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAH
NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCYFLLQILRRIGAVGQAVSRT
AWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLF
LLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWH
WMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPR
ETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQL
ELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQ
FVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVN
SALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQ
PDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLEN
EYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVH
GEPVK
Target Bioclass
Transporter and channel
Subcellular location
Nucleus inner membrane
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.
Uniprot ID
O94901
Ensemble ID
ENST00000389574.7
HGNC ID
HGNC:18587

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.71  LDD0402  [1]
HDSF-alk
 Probe Info  		3.06  LDD0197  [2]
DA-P2
 Probe Info  		6.42  LDD0348  [3]
HRP
 Probe Info  		5.22  LDD0347  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
STPyne
 Probe Info  		K195(8.71); K419(6.25); K471(5.88)  LDD0277  [5]
DBIA
 Probe Info  		C799(2.57)  LDD3310  [6]
P12
 Probe Info  		16.88  LDD0202  [7]
Johansson_61
 Probe Info  		_(7.09)  LDD1485  [8]
AHL-Pu-1
 Probe Info  		C657(3.26)  LDD0168  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C773(0.00); C630(0.00); C499(0.00)  LDD0162  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
IPM
 Probe Info  		C63(0.00); C499(0.00)  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C499(0.00); C63(0.00)  LDD0027  [12]
ENE
 Probe Info  		N.A.  LDD0006  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		C63(0.00); C499(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		C63(0.00); C526(0.00)  LDD0217  [16]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C526(0.00); C63(0.00)  LDD0218  [16]
AOyne
 Probe Info  		9.60  LDD0443  [17]
NAIA_5
 Probe Info  		C630(0.00); C499(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.00  LDD1740  [18]
C091
 Probe Info  		14.03  LDD1782  [18]
C092
 Probe Info  		24.42  LDD1783  [18]
C094
 Probe Info  		44.02  LDD1785  [18]
C143
 Probe Info  		13.18  LDD1825  [18]
C187
 Probe Info  		17.88  LDD1865  [18]
C191
 Probe Info  		10.27  LDD1868  [18]
C193
 Probe Info  		5.17  LDD1869  [18]
C231
 Probe Info  		20.97  LDD1904  [18]
C235
 Probe Info  		26.91  LDD1908  [18]
C251
 Probe Info  		34.54  LDD1924  [18]
C252
 Probe Info  		8.69  LDD1925  [18]
C343
 Probe Info  		11.55  LDD2005  [18]
C349
 Probe Info  		14.12  LDD2010  [18]
C350
 Probe Info  		33.59  LDD2011  [18]
C388
 Probe Info  		53.08  LDD2047  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
OEA-DA
 Probe Info  		3.73  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C657(3.26)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C657(2.03)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C630(0.89); C499(1.11); C63(1.02); C220(0.86)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C630(1.07); C499(1.09); C63(0.94); C220(1.03)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C630(1.03); C499(1.09); C63(0.94); C220(0.83)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C499(1.07); C63(1.06); C220(0.76); C773(0.81)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C630(1.10); C499(1.04); C63(1.01); C220(1.12)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C630(1.02); C499(1.05); C63(0.95)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C630(1.03); C499(1.03); C63(1.13); C220(1.03)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C630(0.99); C499(1.02); C63(0.94); C220(0.91)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C630(1.03); C499(1.26); C63(1.16); C220(1.08)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C630(0.87); C499(1.00); C63(0.83); C220(0.87)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C499(1.03); C63(1.04); C220(0.90); C773(0.97)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C630(1.00); C499(1.04); C63(0.99); C220(0.70)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C630(1.01); C499(0.97); C63(1.01); C220(1.41)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C630(1.02); C499(0.95); C63(0.97)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C630(1.03); C499(0.93); C63(0.94); C220(1.00)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C630(0.98); C499(1.09); C63(1.04); C220(1.01)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C630(0.99); C499(1.09); C63(1.10); C220(0.98)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C630(1.02); C499(1.11); C63(0.93); C220(0.96)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C499(1.02); C63(1.00); C220(0.81); C773(0.90)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C630(1.00); C499(1.03); C63(0.96); C220(0.76)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C630(0.94); C499(1.03); C63(0.91); C220(0.88)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C630(1.01); C499(1.04); C63(1.09); C220(0.84)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C630(1.04); C499(1.02); C63(1.09)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C630(1.07); C499(0.98); C63(0.99); C220(0.89)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C630(0.89); C499(1.06); C63(0.93); C220(0.85)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C630(1.02); C499(1.13); C63(0.93); C220(1.14)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C630(0.91); C499(1.01); C63(0.86); C220(0.90)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C499(1.02); C63(0.90); C220(0.74); C773(1.00)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C630(0.99); C499(0.99); C63(0.93); C220(0.85)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C630(0.92); C499(1.02); C63(0.95); C220(1.67)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C630(1.00); C499(0.95); C63(1.01)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C499(0.96); C63(1.02); C220(0.76); C773(0.98)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C630(0.86); C499(1.06); C63(0.98); C220(1.06)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C630(0.96); C499(1.05); C63(0.87); C220(1.02)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C630(0.95); C499(1.15); C63(0.94); C220(0.92)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C630(1.00); C499(1.09); C63(0.92); C220(1.17)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C499(1.02); C63(0.99); C220(0.71); C773(0.98)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C630(1.01); C499(1.01); C63(1.01); C220(0.91)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C630(0.97); C499(1.06); C63(1.03); C220(1.14)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C630(1.04); C499(1.06); C63(0.97)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C630(0.96); C499(1.01); C63(1.03); C220(1.16)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C630(1.00); C499(1.06); C63(1.03); C220(1.06)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C630(0.95); C499(0.96); C63(1.01); C220(0.95)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C630(1.02); C499(1.07); C63(0.97); C220(0.89)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C630(0.96); C499(1.05); C63(0.96); C220(1.03)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C499(1.02); C63(0.97); C220(0.87); C773(0.92)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C630(1.01); C499(1.05); C63(0.96); C220(0.91)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C630(1.05); C499(1.06); C63(0.95); C220(1.18)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C630(1.00); C499(1.03); C63(0.94)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C630(0.92); C499(1.00); C63(1.02); C220(1.04)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C630(0.91); C499(1.06); C63(1.15); C220(1.01)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C630(1.01); C499(1.00); C63(1.02); C220(0.96)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C630(0.94); C499(1.01); C63(0.86); C220(1.03)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C630(0.98); C499(1.02); C63(1.05); C220(1.20)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C499(1.04); C63(1.01); C220(0.81); C773(0.89)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C630(0.94); C499(1.02); C63(1.01); C220(1.04)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C630(1.00); C499(1.07); C63(1.02); C220(1.37)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C630(0.96); C499(1.03); C63(1.01)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C630(0.89); C499(1.03); C63(1.00); C220(0.95)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C630(0.96); C499(1.04); C63(0.96)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C630(0.92); C499(0.95); C63(1.01); C220(1.13)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C630(0.98); C499(1.01); C63(0.98); C220(0.89)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C630(0.98); C499(1.08); C63(1.14); C220(1.07)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C630(0.99); C499(1.02); C63(0.98); C220(1.18)  LDD1514  [21]
 LDCM0088  C45 HEK-293T 16.88  LDD0202  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C630(0.64)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C630(0.81); C499(0.97); C63(0.88); C220(1.05)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C630(0.85); C499(1.49); C63(1.10); C220(1.44)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C630(0.95); C499(1.14); C63(0.96); C220(1.10)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C630(1.02); C499(1.12); C63(0.91); C220(0.94)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C630(0.97); C499(1.27); C63(0.94); C220(1.28)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C630(1.02); C499(1.17); C63(0.96); C220(1.20)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C630(1.09); C499(1.05); C63(0.99); C220(0.93)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C630(0.94); C499(1.09); C63(0.88); C220(0.98)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C630(0.97); C499(1.17); C63(1.01); C220(0.76)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C630(1.02); C499(1.03); C63(0.98); C220(1.00)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C630(1.08); C499(1.01); C63(1.03); C220(0.74)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C630(1.05); C499(1.14); C63(0.91); C220(0.97)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C630(0.93); C499(1.17); C63(0.95)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C630(0.95); C499(1.61); C63(0.97); C220(1.23)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C630(0.99); C499(1.22); C63(0.98); C220(1.28)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C630(0.96); C499(1.14); C63(1.06); C220(0.79)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C630(0.92); C499(0.94); C63(0.89); C220(0.93)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C630(0.87); C499(1.30); C63(1.04); C220(1.37)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C630(0.95); C499(1.07); C63(0.89); C220(1.00)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C630(1.02); C499(1.03); C63(1.00); C220(0.91)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C630(0.93); C499(1.10); C63(0.92); C220(1.03)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C630(1.03); C499(1.11); C63(1.00); C220(0.85)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C630(0.97); C499(1.09); C63(0.94); C220(1.05)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C630(1.00); C499(1.18); C63(1.13); C220(1.34)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C630(1.03); C499(1.12); C63(1.00); C220(0.95)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C630(0.92); C499(1.19); C63(0.97); C220(1.17)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C630(1.02); C499(1.24); C63(1.04); C220(0.88)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C630(0.96); C499(1.45); C63(0.91); C220(1.30)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C630(1.09); C499(1.27); C63(1.04); C220(1.19)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C630(0.98); C499(1.04); C63(0.87); C220(1.03)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C630(0.95); C499(1.10); C63(1.09); C220(0.89)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C630(0.92); C499(1.09); C63(0.93); C220(1.10)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C630(1.05); C499(0.99); C63(1.03); C220(0.89)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C630(0.89); C499(1.01); C63(1.01); C220(1.41)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C630(1.03); C499(1.10); C63(1.13); C220(1.02)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C630(0.90); C499(1.74); C63(0.93); C220(1.73)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C630(1.13); C499(0.98); C63(1.07); C220(0.93)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C630(0.83); C499(1.95); C63(0.92); C220(2.64)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C630(1.20); C499(1.07); C63(0.89); C220(0.85)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C630(1.00); C499(1.08); C63(0.98); C220(0.87)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C630(0.95); C499(1.06); C63(1.14); C220(1.04)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C499(1.00); C63(1.11); C220(0.81); C773(1.09)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C630(1.14); C499(1.45); C63(1.07); C220(1.58)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C630(1.12); C499(1.08); C63(1.10); C220(1.22)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C630(1.04); C499(1.15); C63(1.03)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C630(1.12); C499(1.18); C63(1.10); C220(1.09)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C630(0.91); C499(1.22); C63(0.83); C220(1.22)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C630(1.06); C499(1.06); C63(0.96); C220(0.96)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C630(1.02); C499(1.03); C63(0.98); C220(0.90)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C630(1.09); C499(1.15); C63(1.00); C220(1.04)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C630(1.00); C499(1.08); C63(1.03); C220(0.96)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C630(0.94); C499(1.04); C63(0.92); C220(1.33)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C630(1.12); C499(1.15); C63(0.89); C220(0.99)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C630(1.04); C499(1.17); C63(1.06); C220(1.04)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C499(1.06); C63(1.03); C220(0.94); C773(0.94)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C630(0.86); C499(1.84); C63(0.95); C220(0.63)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C630(1.11); C499(1.17); C63(1.01); C220(1.38)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C630(1.15); C499(1.15); C63(0.94)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C630(1.11); C499(1.18); C63(1.06); C220(1.28)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C630(0.99); C499(1.07); C63(0.88); C220(1.04)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C630(0.99); C499(1.06); C63(0.97); C220(0.90)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C630(1.01); C499(1.10); C63(1.06); C220(1.17)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C630(1.02); C499(1.08); C63(1.06); C220(0.92)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C630(0.90); C499(1.31); C63(1.23); C220(1.43)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C630(1.15); C499(1.10); C63(0.94); C220(0.95)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C630(1.10); C499(1.06); C63(1.01); C220(0.91)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C499(1.08); C63(1.04); C220(0.79); C773(0.90)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C630(1.13); C499(1.23); C63(1.04); C220(1.00)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C630(1.17); C499(1.18); C63(1.08); C220(0.84)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C630(1.17); C499(1.17); C63(1.04)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C630(1.09); C499(1.18); C63(1.09); C220(0.95)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C630(0.88); C499(0.95); C63(0.89); C220(1.13)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C630(0.87); C499(1.02); C63(1.00); C220(1.16)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C630(0.92); C499(1.09); C63(1.06); C220(1.17)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C630(1.00); C499(1.00); C63(0.99); C220(0.94)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C630(0.81); C499(1.62); C63(1.15); C220(2.02)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C630(0.95); C499(1.62); C63(0.93); C220(1.68)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C630(0.90); C499(1.15); C63(1.02); C220(0.88)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C499(1.12); C63(1.10); C220(0.73); C773(0.86)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C630(1.01); C499(1.27); C63(1.12); C220(0.89)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C630(1.11); C499(1.10); C63(1.02); C220(1.59)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C630(1.05); C499(1.25); C63(0.99)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C630(1.12); C499(1.53); C63(0.95); C220(0.51)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C630(1.03); C499(1.20); C63(1.06); C220(1.26)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C630(0.91); C499(0.94); C63(0.88); C220(0.95)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C630(0.98); C499(1.01); C63(1.06); C220(0.97)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C630(1.00); C499(1.01); C63(0.98); C220(1.06)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C630(0.99); C499(1.61); C63(1.03); C220(1.35)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C630(0.89); C499(1.11); C63(0.96); C220(0.96)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C630(0.92); C499(1.07); C63(0.92); C220(1.12)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C630(1.00); C499(1.04); C63(0.99); C220(0.87)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C499(1.10); C63(1.00); C220(0.97); C773(0.91)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C630(1.11); C499(1.20); C63(0.97); C220(1.20)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C630(0.87); C499(1.07); C63(0.99); C220(1.03)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C630(1.12); C499(1.19); C63(1.08); C220(1.35)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C630(1.21); C499(1.22); C63(1.04)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C630(1.04); C499(1.13); C63(1.15); C220(1.05)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C630(0.88); C499(1.15); C63(0.89); C220(1.07)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C630(1.01); C499(1.11); C63(1.05); C220(0.80)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C630(1.04); C499(1.03); C63(1.00); C220(0.79)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C630(1.07); C499(1.55); C63(1.01); C220(1.99)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C630(1.07); C499(1.06); C63(0.99); C220(0.95)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C630(0.97); C499(1.11); C63(0.91); C220(1.13)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C499(2.46); C63(1.06); C220(1.11); C773(0.81)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C499(1.08); C63(0.98); C220(0.53); C773(1.13)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C630(1.14); C499(1.13); C63(0.97); C220(0.74)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C630(1.08); C499(1.09); C63(1.01); C220(0.83)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C630(1.06); C499(1.24); C63(1.01)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C630(0.89); C499(1.45); C63(1.04); C220(2.14)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C630(0.90); C499(0.89); C63(0.84); C220(1.24)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C630(0.92); C499(0.99); C63(0.97); C220(1.03)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C630(0.92); C499(1.04); C63(0.85); C220(1.27)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C630(1.03); C499(0.97); C63(1.04); C220(0.87)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C630(0.89); C499(1.09); C63(0.90); C220(1.28)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C630(1.09); C499(1.13); C63(0.97); C220(0.81)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C630(0.96); C499(1.89); C63(0.99); C220(2.59)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C630(0.91); C499(1.01); C63(0.92); C220(0.98)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C499(1.14); C63(0.90); C220(1.02); C773(0.97)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C630(1.04); C499(1.27); C63(1.00); C220(1.98)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C630(1.01); C499(1.15); C63(1.02); C220(0.78)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C630(0.89); C499(1.86); C63(1.03)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C630(0.92); C499(1.31); C63(1.09); C220(1.54)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C630(0.91); C499(1.21); C63(0.93); C220(1.46)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C630(0.94); C499(1.09); C63(0.91); C220(0.87)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C630(0.90); C499(1.08); C63(0.89); C220(0.92)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C630(0.92); C499(1.10); C63(0.93); C220(1.26)  LDD1698  [21]
 LDCM0625  F8 Ramos C630(1.29); C499(1.94)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C630(1.56)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C630(20.00); C499(1.86)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C630(1.14)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C630(1.90)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C499(1.22)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C630(1.01)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C630(0.19)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C630(1.22)  LDD2196  [22]
 LDCM0586  Fragment28 Ramos C630(2.12)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C630(0.22)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C630(1.12)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C630(2.06)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C630(0.97); C499(0.98); C63(0.86); C220(0.97)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C630(2.27)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C499(0.87)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C630(1.00); C499(1.00); C63(0.97); C220(1.02)  LDD1631  [21]
 LDCM0614  Fragment56 Ramos C630(1.17)  LDD2205  [22]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [8]
 LDCM0569  Fragment7 Jurkat _(7.09)  LDD1485  [8]
 LDCM0571  Fragment9 Ramos C630(1.09)  LDD2188  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C630(0.84); C499(0.76); C63(1.00); C773(1.00)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C630(1.04); C499(0.89); C63(1.00); C773(1.00)  LDD1497  [21]
 LDCM0024  KB05 COLO792 C799(2.57)  LDD3310  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]

References

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3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578