Details of the Target

General Information of Target

Target ID LDTP08378
Target Name Serine/threonine-protein kinase VRK2 (VRK2)
Gene Name VRK2
Gene ID 7444
Synonyms
Serine/threonine-protein kinase VRK2; EC 2.7.11.1; Vaccinia-related kinase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVV
KVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMV
MERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPD
QVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCM
LRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAY
DEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLI
EKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKI
SYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLS
EETNADVYYYRIIIPVLLMLVFLALFFL
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.; [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
Uniprot ID
Q86Y07
Ensemble ID
ENST00000340157.9
HGNC ID
HGNC:12719
ChEMBL ID
CHEMBL1649059

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.Y488H .
JURKAT SNV: p.L410Ter .
SG231 SNV: p.G165R DBIA    Probe Info 
SW403 SNV: p.S449Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.04  LDD0402  [1]
DA-P2
 Probe Info  		17.76  LDD0348  [2]
HRP
 Probe Info  		16.09  LDD0347  [2]
IPM
 Probe Info  		C373(0.00); C194(0.00)  LDD0241  [3]
DA-P3
 Probe Info  		6.41  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C373(2.17)  LDD0168  [4]
DBIA
 Probe Info  		C373(1.96); C194(1.66)  LDD0080  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
SF
 Probe Info  		N.A.  LDD0028  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.17  LDD1740  [9]
C112
 Probe Info  		21.86  LDD1799  [9]
C159
 Probe Info  		7.21  LDD1839  [9]
C161
 Probe Info  		10.85  LDD1841  [9]
C349
 Probe Info  		15.35  LDD2010  [9]
C350
 Probe Info  		40.22  LDD2011  [9]
C388
 Probe Info  		44.02  LDD2047  [9]
C407
 Probe Info  		11.47  LDD2064  [9]
OEA-DA
 Probe Info  		20.00  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C373(2.17)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C373(4.39)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C194(1.13); C373(0.83)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C194(0.91); C373(0.61)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C194(1.04); C373(0.98)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C194(0.99); C373(1.04)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C194(0.95); C373(0.90)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C194(1.12); C373(1.04)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C194(1.01); C373(0.99)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C194(1.04); C373(0.98)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C194(0.95); C373(1.13)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C194(0.96); C373(1.07)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C194(0.81); C373(0.95)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C194(0.83); C373(0.93)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C194(0.86); C373(0.91)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C194(0.88); C373(0.84)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C194(0.96); C373(0.95)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C194(0.89); C373(0.93)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C239(1.10); C373(0.90)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C239(1.23); C373(1.30)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C239(0.95); C373(1.05)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C239(1.10); C373(1.52)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C239(0.95); C373(1.12)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C239(1.16); C373(1.10)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C239(1.12); C373(1.01)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C194(0.80); C373(1.00)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C239(1.07); C373(1.31)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C239(0.81); C373(1.05)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C239(1.15); C373(0.98)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C239(0.86); C373(0.91)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C239(0.94); C373(1.01)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C239(1.13); C373(1.00)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C239(1.09); C373(1.10)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C239(1.05); C373(1.17)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C239(1.32); C373(1.05)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C239(1.16); C373(0.91)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C239(1.25); C373(1.03)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C239(1.52); C373(0.92)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C239(1.32); C373(0.88)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C239(1.50); C373(0.91)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C239(1.90); C373(1.10)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C239(1.49); C373(1.00)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C239(1.38); C373(1.05)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C239(1.46); C373(0.94)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C239(1.58); C373(0.90)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C239(1.08); C373(1.14)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C194(0.90); C373(0.85)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C239(1.89); C373(1.05)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C239(1.65); C373(0.97)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C239(1.23); C373(0.86)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C373(0.95)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C373(1.26)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C373(1.13)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C373(1.35)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C373(1.14)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C373(1.68)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C373(1.54)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C373(0.92); C194(1.01)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C373(1.23)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C373(1.12)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C373(1.32)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C373(1.70)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C373(1.22)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C373(1.29)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C373(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C373(1.02)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C194(0.67); C239(0.95); C373(0.96)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C194(0.66); C239(1.04); C373(1.09)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C194(0.66); C239(0.97); C373(1.08)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C194(1.05); C373(1.09)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C194(0.71); C239(1.12); C373(1.15)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C194(0.66); C239(0.93); C373(1.45)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C194(0.65); C239(0.90); C373(1.28)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C194(0.65); C239(1.13); C373(1.13)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C194(0.65); C373(0.90); C239(1.30)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C194(0.73); C239(0.95); C373(1.60)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C194(0.70); C239(0.77); C373(1.32)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C194(0.78); C239(0.99); C373(1.29)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C194(0.73); C239(0.81); C373(1.26)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C194(0.90); C239(1.11); C373(1.22)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C373(0.96); C194(1.09)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C239(0.92); C194(0.99); C373(1.27)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C194(0.60); C239(0.83); C373(1.64)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C239(0.77); C194(0.86); C373(1.69)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C239(0.91); C194(0.92); C373(1.64)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C194(0.78); C239(0.91); C373(1.63)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C194(0.78); C373(1.04)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C194(0.85); C373(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C373(0.64); C194(0.78)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C373(0.76); C194(1.00)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C373(0.75); C194(0.80)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C373(0.91); C194(1.17)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C194(0.86); C373(1.23)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C194(0.52); C373(0.84)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C194(0.53); C373(1.20)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C194(0.47); C373(0.95)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C194(0.50); C373(0.77)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C194(0.48); C373(1.07)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C194(0.77)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C194(0.83)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C194(0.83)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C194(0.86)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C373(1.07); C194(1.24)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C194(0.81)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C194(0.76)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C194(0.81)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C194(0.86)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C194(0.95)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C194(0.86)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C194(0.79)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C239(0.90); C373(1.18)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C239(0.78); C373(0.95)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C239(0.90); C373(1.36)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C373(0.88); C194(0.99)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C239(0.91); C373(1.24)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C239(0.99); C373(1.13)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C239(0.84); C373(1.29)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C239(0.86); C373(1.17)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C239(0.92); C373(1.21)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C239(0.86); C373(1.16)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C373(0.73); C239(0.82)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C239(0.76); C373(1.20)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C239(1.14)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C239(1.12)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C194(0.93); C373(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C239(0.80)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C239(0.90)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C239(0.68)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C239(0.68)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C239(0.76)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C239(0.74)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C239(0.75)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C239(1.29)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C239(0.97)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C239(0.81)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C373(0.93); C194(1.03)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C239(0.77)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C239(0.73)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C239(0.72)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C239(0.97); C194(1.18); C373(1.34)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C239(0.99); C194(1.34); C373(1.54)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C373(1.04); C194(1.07); C239(1.26)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C239(1.05); C373(1.24); C194(1.26)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C194(1.01); C239(1.03); C373(1.25)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C194(0.91); C373(0.97); C239(1.28)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C194(0.95); C373(1.28); C239(1.38)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C194(0.79); C239(1.23); C373(1.26)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C239(0.99); C194(1.01); C373(1.59)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C194(0.95); C239(1.06); C373(1.39)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C194(0.83); C373(1.10); C239(1.22)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C239(0.78); C194(0.84); C373(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C194(0.87); C239(1.19); C373(1.32)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C194(0.83); C239(0.83); C373(1.34)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C194(0.92); C239(1.11); C373(1.33)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C373(1.33); C194(1.35)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C373(0.83); C194(1.03)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C194(0.82); C373(0.96)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C194(0.94); C373(1.23)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C373(0.81); C194(1.19)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 9.73  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C194(0.86)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C194(0.83)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C373(0.91); C194(1.18)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C373(0.81); C194(1.03)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C373(0.82); C194(1.04)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C373(0.79); C194(0.95)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C373(0.79); C194(0.92)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C194(0.81); C239(1.03); C373(1.04)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C194(0.89); C239(0.98); C373(1.22)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C194(0.82); C239(0.88); C373(1.09)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C194(0.79); C239(1.07); C373(1.30)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C194(0.63); C239(1.05); C373(1.28)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C194(0.84)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C194(0.69); C239(1.07); C373(1.26)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C194(0.76); C373(1.02); C239(1.20)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C194(0.62); C239(0.66); C373(1.12)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C194(0.72); C239(0.85); C373(1.43)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C239(0.90); C373(1.01); C194(1.02)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C239(0.70); C194(0.83); C373(1.44)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C239(0.70); C194(0.91); C373(1.57)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C194(0.75); C373(1.79)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C194(0.67); C373(0.78)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C194(0.51); C373(1.10)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C194(0.80)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C194(0.53); C373(0.82)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C194(0.87)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C194(0.84)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C194(1.09)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C194(0.83)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C239(1.07); C373(1.29)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C239(0.92); C373(1.02)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C239(0.91); C373(1.19)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C239(0.89); C373(1.19)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C194(0.75)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C194(0.77)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C194(0.80)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C239(1.17)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C239(1.03)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C239(1.09)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C239(0.96)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C194(0.88)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C239(1.36)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C239(1.20)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C239(1.22)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C239(1.05)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C239(0.91)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C239(0.92)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C239(1.13)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C239(1.16)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C239(0.88)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C239(1.03)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C194(0.92)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C239(1.23)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C194(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C194(0.95)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C194(0.84)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C194(0.82)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C194(0.85)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C194(0.85)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C194(0.87)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C194(0.85)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C194(0.80)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C194(0.90)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C194(0.75)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C194(0.84)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C194(0.80)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C194(0.81)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C194(0.83)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C194(0.99); C239(0.61); C373(1.53)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C194(1.09); C239(0.86); C373(1.20)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C194(0.92); C239(0.61); C373(1.35)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C194(0.95); C239(0.69); C373(1.24)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C194(0.73)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C194(0.90); C239(0.75); C373(1.13)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C194(0.90); C239(0.63); C373(1.33)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C194(1.13); C239(0.67); C373(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C194(0.99); C239(1.75); C373(1.85)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C194(0.93); C239(0.80); C373(1.51)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C194(0.80); C239(0.85); C373(0.92)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C194(0.91); C239(1.13); C373(0.79)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C194(0.94); C239(1.20); C373(0.55)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C194(0.98); C239(0.75); C373(1.09)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C194(0.97); C239(0.81); C373(0.99)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C194(0.55)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C194(0.87); C239(0.59); C373(0.96)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C194(0.96); C239(0.93); C373(0.99)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C194(1.06); C239(0.85); C373(1.06)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C194(0.98); C239(1.05); C373(1.09)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C194(1.17); C239(0.95); C373(0.82)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C194(1.06); C239(1.03); C373(0.89)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C194(1.46); C239(0.85); C373(0.90)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C194(1.28); C239(1.08); C373(1.00)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C194(1.24); C239(0.99); C373(0.80)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C194(0.95); C239(1.09); C373(1.07)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C194(0.51)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C194(0.97); C239(1.12); C373(1.07)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C194(1.17); C239(1.25); C373(1.10)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C194(1.02); C239(1.16); C373(0.94)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C194(1.14); C239(1.21); C373(0.89)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C194(1.02); C239(1.19); C373(1.04)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C194(0.90)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C194(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C194(1.07)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C194(1.19)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C194(0.77)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C194(0.85)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C194(1.10)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C194(1.30)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C194(1.53)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C194(1.51)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C194(1.16)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C194(1.01)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C194(1.16)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C194(1.26)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C194(1.62)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C194(0.69)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C194(1.07)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C194(0.98); C373(0.85)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C194(1.05); C373(0.73)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C194(1.09); C373(0.79)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C194(1.14); C373(0.87)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C194(1.08); C373(0.74)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C194(1.05); C373(0.99)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C194(1.12); C373(1.05)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C194(1.17); C373(0.87)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C194(1.10); C373(0.86)  LDD0811  [5]
 LDCM0028  Dobutamine HEK-293T 10.33  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 6.41  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C194(0.99)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C194(1.05); C239(0.87); C373(0.89)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C194(0.80)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C373(1.96); C194(1.66)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C373(1.30); C194(1.19)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C373(1.92); C194(1.00)  LDD0082  [5]
 LDCM0029  Quercetin HEK-293T 8.83  LDD0181  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) STE Ser/Thr protein kinase family Q02750
Kinase suppressor of Ras 1 (KSR1) TKL Ser/Thr protein kinase family Q8IVT5
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction alpha-5 protein (GJA5) Connexin family P36382
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 205 (TMEM205) TMEM205 family Q6UW68
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) . Q13469
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 88 (TMEM88) TMEM88 family Q6PEY1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402